YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer

YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer
Author: Benjamin Bonavida
Publsiher: Academic Press
Total Pages: 360
Release: 2020-11-02
ISBN 10: 0128226366
ISBN 13: 9780128226360
Language: EN, FR, DE, ES & NL

YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer Book Review:

YY1 Is Pivotal in the Control of the Pathogenesis and Drug Resistance of Cancer: A Critical Therapeutic Target describes the current state-of-the-art of the transcription factor YY1 that is overexpressed in the majority of cancers and a central factor that regulates all of the major features and characteristics of human cancers. This book emphasizes the biochemical, molecular and genetic underlying mechanisms by which YY1 regulates its pro-cancerous activities. In addition, it also describes the role of YY1 in the regulation of tumor cell resistance to conventional chemo and immunotherapies and the important role of inhibiting YY1 in cancer. This book is a valuable source for cancer researchers, oncologists and several members of medical and biomedical field who are interested in understanding further the role of YY1 in cancer. Provides a thorough understanding of the underlying mechanisms by which YY1 regulates cancer cell phenotype and unique characteristics Discusses the novel mechanisms of YY1 regulation of tumor cell resistance and means to overcome resistance Encompasses new examples of newly developed non-toxic and selective inhibitors targeting YY1

Prognostic and Therapeutic Applications of Rkip in Cancer

Prognostic and Therapeutic Applications of Rkip in Cancer
Author: Benjamin Bonavida,Stavroula Baritaki
Publsiher: Academic Press
Total Pages: 504
Release: 2020-03-02
ISBN 10: 0128196122
ISBN 13: 9780128196120
Language: EN, FR, DE, ES & NL

Prognostic and Therapeutic Applications of Rkip in Cancer Book Review:

Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides an update from experts in the field on diagnostics, prognostics and therapeutics Brings a clear overview of recent findings and references, as well as summaries, significant molecular pathways, and conclusions in each chapter Provides a general introductory chapter on contributions in the field and a chapter summary, with synthesized findings and a projection of future goals

Sensitization of Cancer Cells for Chemo Immuno Radio therapy

Sensitization of Cancer Cells for Chemo Immuno Radio therapy
Author: Benjamin Bonavida
Publsiher: Springer Science & Business Media
Total Pages: 420
Release: 2008-07-31
ISBN 10: 9781597454742
ISBN 13: 1597454745
Language: EN, FR, DE, ES & NL

Sensitization of Cancer Cells for Chemo Immuno Radio therapy Book Review:

This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.

Molecular Therapies of Cancer

Molecular Therapies of Cancer
Author: Georg F. Weber
Publsiher: Springer
Total Pages: 488
Release: 2015-07-22
ISBN 10: 3319132784
ISBN 13: 9783319132785
Language: EN, FR, DE, ES & NL

Molecular Therapies of Cancer Book Review:

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Current Applications for Overcoming Resistance to Targeted Therapies

Current Applications for Overcoming Resistance to Targeted Therapies
Author: Myron R. Szewczuk,Bessi Qorri,Manpreet Sambi
Publsiher: Springer
Total Pages: 320
Release: 2019-07-15
ISBN 10: 303021477X
ISBN 13: 9783030214777
Language: EN, FR, DE, ES & NL

Current Applications for Overcoming Resistance to Targeted Therapies Book Review:

Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.

Autophagy and Cancer

Autophagy and Cancer
Author: Hong-Gang Wang
Publsiher: Springer Science & Business Media
Total Pages: 261
Release: 2013-03-30
ISBN 10: 1461465613
ISBN 13: 9781461465614
Language: EN, FR, DE, ES & NL

Autophagy and Cancer Book Review:

With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​

Epigenetics and Cancer

Epigenetics and Cancer
Author: Fazlul H. Sarkar
Publsiher: Springer Science & Business Media
Total Pages: 287
Release: 2013-05-29
ISBN 10: 9400766122
ISBN 13: 9789400766129
Language: EN, FR, DE, ES & NL

Epigenetics and Cancer Book Review:

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Endocytosis and Signaling

Endocytosis and Signaling
Author: Christophe Lamaze,Ian Prior
Publsiher: Springer
Total Pages: 329
Release: 2018-08-10
ISBN 10: 3319967045
ISBN 13: 9783319967042
Language: EN, FR, DE, ES & NL

Endocytosis and Signaling Book Review:

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.

Resistance to Photodynamic Therapy in Cancer

Resistance to Photodynamic Therapy in Cancer
Author: Valentina Rapozzi,Giulio Jori
Publsiher: Springer
Total Pages: 248
Release: 2014-12-11
ISBN 10: 3319127306
ISBN 13: 9783319127309
Language: EN, FR, DE, ES & NL

Resistance to Photodynamic Therapy in Cancer Book Review:

This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

MicroRNAs in Development

MicroRNAs in Development
Author: Eran Hornstein
Publsiher: Academic Press
Total Pages: 301
Release: 2012
ISBN 10: 0123870380
ISBN 13: 9780123870384
Language: EN, FR, DE, ES & NL

MicroRNAs in Development Book Review:

This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on microRNAs in development Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA With an international team of authors, this volume is a must-have addition for researchers and students alike

Cancer Metastasis

Cancer Metastasis
Author: Yasemin Basbinar,Gizem Calibasi Kocal
Publsiher: BoD – Books on Demand
Total Pages: 152
Release: 2018-12-05
ISBN 10: 1789846323
ISBN 13: 9781789846324
Language: EN, FR, DE, ES & NL

Cancer Metastasis Book Review:

Metastasis of cancer cells from primary tumor site to secondary locations is considered a late event in multistep tumorigenesis, and causes most cancer-related mortality. The process from the spreading of cancer cells to the seeding of newly formed tumor colonizations is governed by sequential events, including local invasion, intravasation into stroma and blood vessels, survival in circulation, extravasation, and colonization at secondary tumor sites. Cancer research provides information on the fate of metastatic cancer cells in each sequential movement or heterogeneous tumor microenvironment. However, the complexity of this mechanism remains the most stringent concept of cancer management. This book provides information for cancer researchers on metastatic phenotypes of cancer cells, and diverse promoting factors and molecular mechanisms of metastasis.

Tumor Microenvironment and Cellular Stress

Tumor Microenvironment and Cellular Stress
Author: Constantinos Koumenis,Ester Hammond,Amato Giaccia
Publsiher: Springer Science & Business Media
Total Pages: 290
Release: 2013-11-23
ISBN 10: 146145915X
ISBN 13: 9781461459156
Language: EN, FR, DE, ES & NL

Tumor Microenvironment and Cellular Stress Book Review:

The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Melanoma Development

Melanoma Development
Author: Anja K. Bosserhoff
Publsiher: Springer
Total Pages: 447
Release: 2017-01-20
ISBN 10: 3319413198
ISBN 13: 9783319413198
Language: EN, FR, DE, ES & NL

Melanoma Development Book Review:

This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics. Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better understanding of its development will help in finding sophisticated targeted therapies. The second revised edition features the latest research findings and offers updates on the latest advances and potential novel melanoma therapies. It is a valuable resource for researchers and clinicians working in the fields of melanoma, cancer research and therapy as well as dermatology.

Human Herpesviruses

Human Herpesviruses
Author: Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2007-08-16
ISBN 10: 1139461648
ISBN 13: 9781139461641
Language: EN, FR, DE, ES & NL

Human Herpesviruses Book Review:

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Nutrition and Skeletal Muscle

Nutrition and Skeletal Muscle
Author: Stéphane Walrand
Publsiher: Academic Press
Total Pages: 568
Release: 2018-10-24
ISBN 10: 0128104104
ISBN 13: 9780128104101
Language: EN, FR, DE, ES & NL

Nutrition and Skeletal Muscle Book Review:

Nutrition and Skeletal Muscle provides coverage of the evidence of dietary components that have proven beneficial for bettering adverse changes in skeletal muscle from disuse and aging. Skeletal muscle is the largest tissue in the body, providing elements of contraction and locomotion and acting as an important contributor to whole body protein and amino metabolism, glucose disposal and lipid metabolism. However, muscle loss, atrophy or weakness can occur when there are metabolic imbalances, disuse or aging. This book addresses the topic by providing insight and research from international leaders, making it the go-to reference for those in skeletal muscle physiology. Provides an understanding of the crucial role of skeletal muscle in global metabolic homeostasis regulation Delivers the information needed to understand the utilization of crucial supplements for the preservation of skeletal muscle Presents insights on research from international leaders in the field

Vascular Development

Vascular Development
Author: Derek J. Chadwick,Jamie A. Goode
Publsiher: John Wiley & Sons
Total Pages: 260
Release: 2007-08-20
ISBN 10: 0470319429
ISBN 13: 9780470319420
Language: EN, FR, DE, ES & NL

Vascular Development Book Review:

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Obesity Inflammation and Cancer

Obesity  Inflammation and Cancer
Author: Andrew J. Dannenberg,Nathan A. Berger
Publsiher: Springer Science & Business Media
Total Pages: 433
Release: 2013-05-21
ISBN 10: 1461468191
ISBN 13: 9781461468196
Language: EN, FR, DE, ES & NL

Obesity Inflammation and Cancer Book Review:

In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.

Nitric Oxide Donor Induced in Chemosensitization

Nitric Oxide  Donor Induced  in Chemosensitization
Author: Benjamin Bonavida
Publsiher: Academic Press
Total Pages: 248
Release: 2017-06-28
ISBN 10: 012811021X
ISBN 13: 9780128110218
Language: EN, FR, DE, ES & NL

Nitric Oxide Donor Induced in Chemosensitization Book Review:

Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations

Suicide Phenomenology and Neurobiology

Suicide  Phenomenology and Neurobiology
Author: Keri E. Cannon,Thomas J. Hudzik
Publsiher: Springer
Total Pages: 314
Release: 2014-10-06
ISBN 10: 3319099647
ISBN 13: 9783319099644
Language: EN, FR, DE, ES & NL

Suicide Phenomenology and Neurobiology Book Review:

This book addresses the phenomenology, demographics, and neurobehavioral aspects of suicidal behavior and its risk factors, underscoring common neurobehavioral threads among different approaches which may underlie such extreme behavior. It additionally provides an overview of new approaches, such as imaging techniques to identify at-risk individuals or in response to drug treatment associated with suicidal behavior, neurodevelopmental approaches, genetic and epigenetic linkages to suicidal behavior, animal models of specific risk factors, as well as potential biomarkers being employed to help assess risk.

Tumor Suppressor Genes in Human Cancer

Tumor Suppressor Genes in Human Cancer
Author: David E. Fisher
Publsiher: Springer Science & Business Media
Total Pages: 386
Release: 2000-10-26
ISBN 10: 1592592309
ISBN 13: 9781592592302
Language: EN, FR, DE, ES & NL

Tumor Suppressor Genes in Human Cancer Book Review:

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.