Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development
Author: Yurong Lai
Publsiher: Woodhead Publishing
Total Pages: 780
Release: 2014-08-22
ISBN 10: 190881828X
ISBN 13: 9781908818287
Language: EN, FR, DE, ES & NL

Transporters in Drug Discovery and Development Book Review:

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

Transporters in Drug Development

Transporters in Drug Development
Author: Yuichi Sugiyama,Bente Steffansen
Publsiher: Springer Science & Business Media
Total Pages: 317
Release: 2013-09-16
ISBN 10: 1461482291
ISBN 13: 9781461482291
Language: EN, FR, DE, ES & NL

Transporters in Drug Development Book Review:

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Membrane Transporters in Drug Discovery and Development

Membrane Transporters in Drug Discovery and Development
Author: Qing Yan
Publsiher: Humana
Total Pages: 365
Release: 2010-04-26
ISBN 10:
ISBN 13: STANFORD:36105211741215
Language: EN, FR, DE, ES & NL

Membrane Transporters in Drug Discovery and Development Book Review:

This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.

Drug Transporters

Drug Transporters
Author: Guofeng You,Marilyn E. Morris
Publsiher: John Wiley & Sons
Total Pages: 528
Release: 2014-07-07
ISBN 10: 1118704983
ISBN 13: 9781118704981
Language: EN, FR, DE, ES & NL

Drug Transporters Book Review:

This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters • Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery • Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials • Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers

Oral Bioavailability Assessment

Oral Bioavailability Assessment
Author: Ayman F. El-Kattan
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2017-06-06
ISBN 10: 1118916697
ISBN 13: 9781118916698
Language: EN, FR, DE, ES & NL

Oral Bioavailability Assessment Book Review:

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

ADME Enabling Technologies in Drug Design and Development

ADME Enabling Technologies in Drug Design and Development
Author: Donglu Zhang,Sekhar Surapaneni
Publsiher: John Wiley & Sons
Total Pages: 800
Release: 2012-04-13
ISBN 10: 1118180763
ISBN 13: 9781118180761
Language: EN, FR, DE, ES & NL

ADME Enabling Technologies in Drug Design and Development Book Review:

A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery,particularly in the area of absorption, distribution, metabolism,and excretion (ADME). ADME-Enabling Technologies in Drug Design and Developmentfocuses on the current state of the art in the field, presenting acomprehensive review of the latest tools for generating ADME datain drug discovery. It examines the broadest possible range ofavailable technologies, giving readers the information they need tochoose the right tool for a given application, a key requisite forobtaining favorable results in a timely fashion for regulatoryfilings. With over thirty contributed chapters by an internationalteam of experts, the book provides: A thorough examination of current tools, covering bothelectronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including keyparameters, optimal conditions for intended results, protocols, andcase studies Detailed discussion of emerging tools and techniques, from stemcells and genetically modified animal models to imagingtechnologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology,medicinal chemistry, pharmaceutics, toxicology, and bioanalyticalscience will find ADME-Enabling Technologies in Drug Design andDevelopment an invaluable guide to the entire drug developmentprocess, from discovery to regulatory issues.

Transporters and Drug Metabolizing Enzymes in Drug Toxicity

Transporters and Drug Metabolizing Enzymes in Drug Toxicity
Author: Albert P. Li
Publsiher: John Wiley & Sons
Total Pages: 512
Release: 2021-08-24
ISBN 10: 1119170842
ISBN 13: 9781119170846
Language: EN, FR, DE, ES & NL

Transporters and Drug Metabolizing Enzymes in Drug Toxicity Book Review:

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug metabolism in toxicity evaluation

Transporters as Drug Targets

Transporters as Drug Targets
Author: Gerhard F. Ecker,Rasmus P. Clausen,Gerd Folkers,Harald H. Sitte,Raimund Mannhold,Helmut Buschmann
Publsiher: John Wiley & Sons
Total Pages: 354
Release: 2017-04-10
ISBN 10: 3527333843
ISBN 13: 9783527333844
Language: EN, FR, DE, ES & NL

Transporters as Drug Targets Book Review:

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

Pharmacogenomics of Human Drug Transporters

Pharmacogenomics of Human Drug Transporters
Author: Toshihisa Ishikawa,Richard B. Kim,Jörg König
Publsiher: John Wiley & Sons
Total Pages: 440
Release: 2013-03-11
ISBN 10: 1118353250
ISBN 13: 9781118353257
Language: EN, FR, DE, ES & NL

Pharmacogenomics of Human Drug Transporters Book Review:

Sets the foundation for safer, more effective drugtherapies With this book as their guide, readers will discover how toapply our current understanding of the pharmacogenomics of drugtransporters to advance their own drug discovery and developmentefforts. In particular, the book explains how new findings in thefield now enable researchers to more accurately predict druginteractions and adverse drug reactions. Moreover, it sets thefoundation for the development of drug therapies that are tailoredto an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as acomprehensive guide to how transporters regulate the absorption,distribution, and elimination of drugs in the body as well as howan individual's genome affects those processes. The book's eighteenchapters have been authored by a team of leading pioneers in thefield. Based on their own laboratory and clinical experience aswell as a thorough review of the literature, these authors exploreall facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and theirclinical significance Principles of altered drug transport in drug–druginteractions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of geneticpolymorphisms Clinical aspects of genetic polymorphisms in major drugtransporter genes Future research directions of drug transporter pharmacogenomicsand the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens thedoor to new drug discovery and development breakthroughs leading tosafer and more effective customized drug therapies.The book isrecommended for pharmaceutical scientists, biochemists,pharmacologists, clinicians, and genetics and genomicsresearchers.

Drug Transporters

Drug Transporters
Author: Martin F. Fromm,Richard B. Kim
Publsiher: Springer Science & Business Media
Total Pages: 454
Release: 2010-11-19
ISBN 10: 9783642145414
ISBN 13: 3642145418
Language: EN, FR, DE, ES & NL

Drug Transporters Book Review:

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Drug Transporters

Drug Transporters
Author: Glynis Nicholls,Kuresh Youdim
Publsiher: Royal Society of Chemistry
Total Pages: 477
Release: 2015-12-31
ISBN 10: 1782620699
ISBN 13: 9781782620693
Language: EN, FR, DE, ES & NL

Drug Transporters Book Review:

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Transporters and Drug Metabolizing Enzymes in Drug Toxicity

Transporters and Drug Metabolizing Enzymes in Drug Toxicity
Author: Albert P. Li
Publsiher: John Wiley & Sons
Total Pages: 528
Release: 2021-06-29
ISBN 10: 1119170990
ISBN 13: 9781119170990
Language: EN, FR, DE, ES & NL

Transporters and Drug Metabolizing Enzymes in Drug Toxicity Book Review:

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug metabolism in toxicity evaluation

Membrane Transporters and Channels as Targets for Drugs

Membrane Transporters and Channels as Targets for Drugs
Author: Graça Soveral,Cesare Indiveri
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-01-03
ISBN 10: 2889633578
ISBN 13: 9782889633579
Language: EN, FR, DE, ES & NL

Membrane Transporters and Channels as Targets for Drugs Book Review:

Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.

Drug Transporters

Drug Transporters
Author: Glynis Nicholls,Kuresh Youdim
Publsiher: Royal Society of Chemistry
Total Pages: 239
Release: 2016-08-17
ISBN 10: 1782628703
ISBN 13: 9781782628705
Language: EN, FR, DE, ES & NL

Drug Transporters Book Review:

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Ocular Transporters and Receptors

Ocular Transporters and Receptors
Author: Ashim K Mitra
Publsiher: Elsevier
Total Pages: 276
Release: 2013-10-31
ISBN 10: 190881831X
ISBN 13: 9781908818317
Language: EN, FR, DE, ES & NL

Ocular Transporters and Receptors Book Review:

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Drug Transporters Molecular Characterization and Role in Drug Disposition Third Edition

Drug Transporters  Molecular Characterization and Role in Drug Disposition  Third Edition
Author: John Wiley & Sons Canada, Limited
Publsiher: Unknown
Total Pages: 600
Release: 2022-07-06
ISBN 10: 9781119737551
ISBN 13: 1119737559
Language: EN, FR, DE, ES & NL

Drug Transporters Molecular Characterization and Role in Drug Disposition Third Edition Book Review:

Unique in the field of pharmaceutical science, this revised 3rd edition takes into account that knowledge in transporters as drug targets for diseases has expanded. Since publication of the second edition, there have been significant advances in the field: in-depth understanding of membrane transporters in pediatric pharmacotherapy, new insights into the impact of these transporters on drug efficacy and safety, and more sophisticated model systems and sensitive assay methods that have been developed. This edition considers the current advances in the field and includes three new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, and the transporters as therapeutic targets for diseases. With newly emerging discoveries in transporter science, this book offers both fundamental and updated knowledge of drug transporters. As a result, this new edition reflects where the field is today and also gives a perspective on the directions for the foreseeable future.

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
Author: Benjamin E. Blass
Publsiher: Academic Press
Total Pages: 712
Release: 2021-05-25
ISBN 10: 0128172150
ISBN 13: 9780128172155
Language: EN, FR, DE, ES & NL

Basic Principles of Drug Discovery and Development Book Review:

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Drug Metabolism in Drug Design and Development

Drug Metabolism in Drug Design and Development
Author: Donglu Zhang,Mingshe Zhu,William G. Humphreys
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2007-11-16
ISBN 10: 9780470191682
ISBN 13: 0470191686
Language: EN, FR, DE, ES & NL

Drug Metabolism in Drug Design and Development Book Review:

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Evaluation of Drug Candidates for Preclinical Development

Evaluation of Drug Candidates for Preclinical Development
Author: Chao Han,Charles B. Davis,Binghe Wang
Publsiher: John Wiley & Sons
Total Pages: 304
Release: 2010-01-06
ISBN 10: 9780470574881
ISBN 13: 0470574887
Language: EN, FR, DE, ES & NL

Evaluation of Drug Candidates for Preclinical Development Book Review:

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

Handbook of Drug Metabolism Third Edition

Handbook of Drug Metabolism  Third Edition
Author: Paul G. Pearson,Larry C. Wienkers
Publsiher: CRC Press
Total Pages: 750
Release: 2019-05-20
ISBN 10: 1482262045
ISBN 13: 9781482262049
Language: EN, FR, DE, ES & NL

Handbook of Drug Metabolism Third Edition Book Review:

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.