Translational Glycobiology in Human Health and Disease

Translational Glycobiology in Human Health and Disease
Author: Michelle Kilcoyne,Lokesh Joshi
Publsiher: Academic Press
Total Pages: 480
Release: 2020-11-15
ISBN 10: 9780128196557
ISBN 13: 0128196556
Language: EN, FR, DE, ES & NL

Translational Glycobiology in Human Health and Disease Book Review:

Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment. Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences. Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology's growing role in human health and disease study Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciencess

Sialic Acids and Sialoglycoconjugates in the Biology of Life Health and Disease

Sialic Acids and Sialoglycoconjugates in the Biology of Life  Health and Disease
Author: Shyamasree Ghosh
Publsiher: Academic Press
Total Pages: 362
Release: 2020-01-08
ISBN 10: 0128161272
ISBN 13: 9780128161272
Language: EN, FR, DE, ES & NL

Sialic Acids and Sialoglycoconjugates in the Biology of Life Health and Disease Book Review:

Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease enables the reader to understand the role of sialylation as a post translational modification. The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations have been associated with several diseases including cancer. In the post genomics and proteomics era, sialoglybiology has become more and more important in deciphering health and disease conditions. Discusses the sialic acids and their role in different diseases (other than cancer) Provides an understanding of sialylations as post translational modifications (PTM) Demonstrates the impact sialylation has on infectious diseases, the autoimmune system and health Gives insights on the importance of sialic acid biology through animal models

Proteases in Health and Disease

Proteases in Health and Disease
Author: Enrico Di Cera
Publsiher: Academic Press
Total Pages: 328
Release: 2011-03-07
ISBN 10: 0123855055
ISBN 13: 9780123855053
Language: EN, FR, DE, ES & NL

Proteases in Health and Disease Book Review:

Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Gangliosides in Health and Disease

Gangliosides in Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 480
Release: 2018-04-25
ISBN 10: 0128123427
ISBN 13: 9780128123423
Language: EN, FR, DE, ES & NL

Gangliosides in Health and Disease Book Review:

Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field. Contains accessible content that is ideal for students and researchers alike Written by leading authorities in the field

Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science
Author: Anonim
Publsiher: Academic Press
Total Pages: 418
Release: 2019-03-22
ISBN 10: 012817739X
ISBN 13: 9780128177396
Language: EN, FR, DE, ES & NL

Progress in Molecular Biology and Translational Science Book Review:

Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Post Translational Modifications in Health and Disease

Post Translational Modifications in Health and Disease
Author: Cecilio J. Vidal
Publsiher: Springer Science & Business Media
Total Pages: 490
Release: 2010-10-13
ISBN 10: 1441963820
ISBN 13: 9781441963826
Language: EN, FR, DE, ES & NL

Post Translational Modifications in Health and Disease Book Review:

Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 288
Release: 2020-04-08
ISBN 10: 0128178205
ISBN 13: 9780128178201
Language: EN, FR, DE, ES & NL

Genome Plasticity in Health and Disease Book Review:

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Essentials of Glycobiology

Essentials of Glycobiology
Author: Ajit Varki,Maarten J. Chrispeels
Publsiher: CSHL Press
Total Pages: 653
Release: 1999
ISBN 10: 9780879696818
ISBN 13: 0879696818
Language: EN, FR, DE, ES & NL

Essentials of Glycobiology Book Review:

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Microbiota in health and disease from pregnancy to childhood

Microbiota in health and disease  from pregnancy to childhood
Author: Pamela D. Browne,Eric Claassen,Michael D. Cabana
Publsiher: Wageningen Academic Publishers
Total Pages: 344
Release: 2017-07-20
ISBN 10: 9086868398
ISBN 13: 9789086868391
Language: EN, FR, DE, ES & NL

Microbiota in health and disease from pregnancy to childhood Book Review:

This book offers a state-of-the-art overview of the vital relationship between human microbiota and infant and child health. Renowned clinical-experimental experts in this field discuss the development of microbiota during early life and review the environmental inputs that affect the developing infant’s gut microbiota, such as early diet and (postnatal) medical interventions. They further describe the interplay between gut microbiota and functional systems of the body, from the immune system to the central nervous system. The book discusses a range of infant and childhood diseases that are associated with microbial changes or dysbiosis, such as gastrointestinal disorders, allergic diseases, autoimmune disorders and respiratory disorders. Additionally mechanisms by which microbial dysbiosis may influence behaviour in infants are discussed. Other topics include the use of current tools in molecular microbiology for microbiota-related research and clinical practice. In the management of particular paediatric disorders, the potential of microbial manipulation with pre- and probiotics during infancy and childhood is increasingly being investigated. This book presents the evidence supporting their use in practice and reviews safety aspects. Microbiota in health and disease: from pregnancy to childhood has the ambition to provide the reader with an overview of the most recent and stunning advances in the field of infant and child microbiota and their role in health, disease and prevention. As such, it is an excellent resource for health care professionals, students and researchers in the field of life sciences.

The Role of Glycosylation in Health and Disease

The Role of Glycosylation in Health and Disease
Author: Gordan Lauc,Irena Trbojević-Akmačić
Publsiher: Springer Nature
Total Pages: 376
Release: 2021-09-08
ISBN 10: 3030701158
ISBN 13: 9783030701154
Language: EN, FR, DE, ES & NL

The Role of Glycosylation in Health and Disease Book Review:

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Lung Inflammation in Health and Disease Volume I

Lung Inflammation in Health and Disease  Volume I
Author: Yong-Xiao Wang
Publsiher: Springer Nature
Total Pages: 409
Release: 2021-03-31
ISBN 10: 3030630463
ISBN 13: 9783030630461
Language: EN, FR, DE, ES & NL

Lung Inflammation in Health and Disease Volume I Book Review:

Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Glycosaminoglycans in Development Health and Disease

Glycosaminoglycans in Development  Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 408
Release: 2010-10-28
ISBN 10: 9780123812834
ISBN 13: 0123812836
Language: EN, FR, DE, ES & NL

Glycosaminoglycans in Development Health and Disease Book Review:

Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Proceedings of 3rd Glycobiology World Congress 2017

Proceedings of 3rd Glycobiology World Congress 2017
Author: ConferenceSeries
Publsiher: ConferenceSeries
Total Pages: 79
Release: 2022
ISBN 10: 1928374650XXX
ISBN 13: 9182736450XXX
Language: EN, FR, DE, ES & NL

Proceedings of 3rd Glycobiology World Congress 2017 Book Review:

June 26-28, 2017 London, UK Key Topics : Glycoprotein Technologies, Glyco Bioinformatics, Glycans in Drug Design, Glyco Immunology, Glyco Biomarkers, Glycobiology and Biotechnology, Glycans in Diseases and Therapeutics, Glycobiology in Personalized Medicine, Glycans in Genetic Disorders, Glycobiology and Structural Biology, Glyco Proteomics, Glycomics and Metabolomics, Mass Spectrometry in Proteome Research, Glycobiology, Genomics and Computational Systems Biology, Glycobiochemistry,

Myofilament Function in Health and Disease

Myofilament Function in Health and Disease
Author: Julien Ochala
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2017-05-22
ISBN 10: 2889451860
ISBN 13: 9782889451869
Language: EN, FR, DE, ES & NL

Myofilament Function in Health and Disease Book Review:

The present E-book, consisting of a compilation of original articles and reviews, presents how myofilaments are regulated in cardiac and skeletal muscles and trigger contraction. Additionally, this E-book gives insights into their dysregulation in a number of muscle disorders.

ATP gated P2X receptors in health and disease

ATP gated P2X receptors in health and disease
Author: Andrea Nistri,Geoffrey Burnstock,Baljit S Khakh,Rashid Giniatullin
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2015-01-05
ISBN 10: 2889194051
ISBN 13: 9782889194056
Language: EN, FR, DE, ES & NL

ATP gated P2X receptors in health and disease Book Review:

Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases.

Sialobiology Structure Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

Sialobiology  Structure  Biosynthesis and Function  Sialic Acid Glycoconjugates in Health and Disease
Author: Joe Tiralongo,Ivan Martinez-Duncker
Publsiher: Bentham Science Publishers
Total Pages: 531
Release: 2013-02-13
ISBN 10: 1608053865
ISBN 13: 9781608053865
Language: EN, FR, DE, ES & NL

Sialobiology Structure Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease Book Review:

This ebook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The importance of substitution by the sugar sialic acid and the role played by sialylated structures (eg. glycoproteins, glycolipids, glycoconjugates) in immune recognition, neural cell growth, embryogenesis and disease development including microbial pathogenesis and cancer progression, has become well-established. Since 1995, the field of sialobiology has expanded greatly as many of the key enzymes involved in sialic acid biosynthesis, as well as the vast majority of sialic acid binding lectins involved in immune recognition, have only been cloned, characterised and structural eluciated after the publication of earlier works on the subject. This e-book also covers these recent developments. Chapters in this e-book have been contributed by eminent sialobiologists. Therefore, a book of this nature is timely and will prove to be a definitive volume with a high impact in this field for glycobiologists and cell biologists.

Lipids in Health and Disease

Lipids in Health and Disease
Author: Peter Quinn,Xiaoyuan Wang
Publsiher: Springer Science & Business Media
Total Pages: 598
Release: 2008-08-27
ISBN 10: 1402088310
ISBN 13: 9781402088315
Language: EN, FR, DE, ES & NL

Lipids in Health and Disease Book Review:

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.

Chemical Glycobiology

Chemical Glycobiology
Author: Randall Halcomb,American Chemical Society. Meeting,American Chemical Society. Division of Carbohydrate Chemistry,Peng George Wang
Publsiher: Amer Chemical Society
Total Pages: 325
Release: 2008
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015075633399
Language: EN, FR, DE, ES & NL

Chemical Glycobiology Book Review:

Although the process of understanding the biological functions of carbohydrates has developed slowly due to the lack of efficient approaches in obtaining and studying these structures, in the past two decades, remarkable advances have been made in chemical and chemoenzymatic synthesis of carbohydrates and glycoconjugates. The material presented in this volume shows how a better understanding of the structure and the function of carbohydrate-containing bacterial cell wall has revealed that carbohydrate-containing molecules and carbohydrate-like structures are useful as carbohydrate-based anti-microbial vaccines, anti-viral drugs, anti-coagulants, anti-cancer drugs, and potential anti-cancer vaccines. In addition, the text explores the important roles that novel glycolipids have been found to play in the immune system. Metabolic engineering has demonstrated itself as an efficient approach to probe and manipulate biological functions of carbohydrates both in vitro and in vivo. Automated glycan analysis, carbohydrate microarrays, and novel high-throughput screening methods have hastened the analysis and the understanding of carbohydrate-containing structures. Polypeptide-based glycopolymers have been developed for the study of multivalent binding events of carbohydrates and proteins. This text presents examples of these recent developments in using chemical techniques and tools to study glycobiology. This is an excellent reference book for upper-division undergraduate students, graduate students, and researchers who are interested in carbohydrate-related medicinal chemistry, organic chemistry, biology, and chemical biology.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease
Author: Monte Willis,Jonathon W. Homeister,James R. Stone
Publsiher: Academic Press
Total Pages: 338
Release: 2013-12-23
ISBN 10: 0124055257
ISBN 13: 9780124055254
Language: EN, FR, DE, ES & NL

Cellular and Molecular Pathobiology of Cardiovascular Disease Book Review:

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Australian Journal of Chemistry

Australian Journal of Chemistry
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015055717501
Language: EN, FR, DE, ES & NL

Australian Journal of Chemistry Book Review: