The Value of BCG and TNF in Autoimmunity

The Value of BCG and TNF in Autoimmunity
Author: Denise Faustman
Publsiher: Academic Press
Total Pages: 200
Release: 2018-08-01
ISBN 10: 0081025904
ISBN 13: 9780081025901
Language: EN, FR, DE, ES & NL

The Value of BCG and TNF in Autoimmunity Book Review:

The Value of BCG and TNF in Autoimmune Diseases, Second Edition provides an overview on the current research related to TNF induction and the use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and first edition of this book (2014), the field of BCG research has grown considerably. This new edition contains updates on MS and diabetes, and features at least eight additional chapters on new prevention and treatment trials in autoimmunity and allergy, along with a new understanding of the genetics of BCGs. Brings a different perspective on treatment approaches for certain autoimmune conditions Gives insight into the how the BCG vaccine impacts gene expression and the durability of the BCG vaccines in long lasting clinic effects Discusses TNF induction, rather than anti-TNF, as a therapeutic pathway for autoimmunity treatment Covers new topics, such as the Epigenetics of tuberculosis, BCG in neurological disease, BCG in early childhood and allergy, BCG in large prevention trials, Gene expression of BCG and re-methylation of genes, and more

The Value of BCG and TNF in Autoimmunity

The Value of BCG and TNF in Autoimmunity
Author: Denise Faustman
Publsiher: Academic Press
Total Pages: 164
Release: 2014
ISBN 10: 9780127999647
ISBN 13: 0127999647
Language: EN, FR, DE, ES & NL

The Value of BCG and TNF in Autoimmunity Book Review:

The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science of TNF signaling to research in diverse autoimmune disciplines, such as type 1 diabetes and multiple sclerosis. Overall, the book focuses on the lessons that can be learned from the researchers' individual experiences and data, and provides a rationale for bringing the inexpensive, generic BCG vaccine to the forefront of clinical trials in different forms of autoimmunity. Editor awarded 2005: Oprah Achievement Award," Top Health Breakthrough by a Female Scientist" Brings into one resource the international scientific literature on a unique way to treat autoimmunity Provides a different perspective on treatment approaches for certain autoimmune conditions Discusses TNF induction, rather than anti-TNF, as a therapeutic pathway for autoimmunity treatment

Idiotypes in Medicine Autoimmunity Infection and Cancer

Idiotypes in Medicine  Autoimmunity  Infection and Cancer
Author: R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
Publsiher: Elsevier
Total Pages: 540
Release: 1997-11-19
ISBN 10: 9780080534435
ISBN 13: 0080534430
Language: EN, FR, DE, ES & NL

Idiotypes in Medicine Autoimmunity Infection and Cancer Book Review:

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Nutrition and Cardiovascular Health

Nutrition and Cardiovascular Health
Author: Paramjit S. Tappia,Heather Blewett
Publsiher: MDPI
Total Pages: 278
Release: 2020-06-17
ISBN 10: 3039288873
ISBN 13: 9783039288878
Language: EN, FR, DE, ES & NL

Nutrition and Cardiovascular Health Book Review:

There is unequivocal experimental, epidemiological, and clinical evidence demonstrating a correlation between diet and increased risk of cardiovascular disease (CVD). While nutritionally-poor diets can have a significant negative impact on cardiovascular health, dietary interventions with specific nutrients and/or functional foods are considered cost-effective and efficient components of prevention strategies. It has been estimated that nutritional factors may be responsible for approximately 40% of all CVD. Indeed, in one of the seminal studies conducted on modifiable risk factors and heart health (the INTERHEART study), >90% of all myocardial infarctions were attributed to preventable environmental factors with nutrition identified as one of the important determinants of CVD. There is an increasing public interest in and scientific investigation into establishing dietary approaches that can be undertaken for the prevention and treatment of CVD. This Special Issue provides an insight into the influential role of nutrition and dietary habits on cardiovascular health and disease, as well as their mechanisms of therapeutic and preventive action.

Vaccines

Vaccines
Author: Stanley A. Plotkin,Walter Orenstein,Paul A. Offit
Publsiher: Elsevier Health Sciences
Total Pages: 1748
Release: 2008-02-11
ISBN 10: 1437721583
ISBN 13: 9781437721584
Language: EN, FR, DE, ES & NL

Vaccines Book Review:

Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination-from development to use in reducing disease. It provides authoritative information on vaccine production, available preparations, efficacy, and safety...recommendations for vaccine use, with rationales...data on the impact of vaccination programs on morbidity and mortality...and more. And now, as an Expert Consult title, it includes a companion web site offering this unparalleled guidance where and when you need it most! Provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well an epidemiology and public health issues. Offers comprehensive coverage of both existing vaccines and vaccines currently in the research and development stage. Examines vaccine stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease control strategies. Analyses the cost-benefit and cost-effectiveness of vaccines. Discusses the proper use of immune globulins and antitoxins. Illustrates concepts and objective data with approximately 600 tables and figures. Includes access to a companion web site offering the complete contents of the book - fully searchable - for rapid consultation from anyplace with an Internet connection.

Heterologous Immunity Implications and Applications in Vaccines and Immunotherapies

Heterologous Immunity  Implications and Applications in Vaccines and Immunotherapies
Author: Babita Agrawal,Stephanie Yanow,Shakti Singh
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-08-27
ISBN 10: 2889639657
ISBN 13: 9782889639656
Language: EN, FR, DE, ES & NL

Heterologous Immunity Implications and Applications in Vaccines and Immunotherapies Book Review:

Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis
Author: Rupinder K. Sodhi,Jitender Madan
Publsiher: Academic Press
Total Pages: 432
Release: 2020-10-30
ISBN 10: 0128157631
ISBN 13: 9780128157633
Language: EN, FR, DE, ES & NL

Clinical Perspectives and Targeted Therapies in Apoptosis Book Review:

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

TNF Pathophysiology

TNF Pathophysiology
Author: George Kollias,Petros P. Sfikakis
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 215
Release: 2010-01-01
ISBN 10: 380559383X
ISBN 13: 9783805593830
Language: EN, FR, DE, ES & NL

TNF Pathophysiology Book Review:

TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems.

Canadian Immunization Guide

Canadian Immunization Guide
Author: Canada. National Advisory Committee on Immunization,Canada. Comité consultatif national de l'immunisation
Publsiher: Unknown
Total Pages: 372
Release: 2006
ISBN 10: 9780660193922
ISBN 13: 0660193922
Language: EN, FR, DE, ES & NL

Canadian Immunization Guide Book Review:

The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization.

Tuberculosis

Tuberculosis
Author: Barry R. Bloom
Publsiher: Amer Society for Microbiology
Total Pages: 653
Release: 2014-06-24
ISBN 10: 9781555819101
ISBN 13: 1555819109
Language: EN, FR, DE, ES & NL

Tuberculosis Book Review:

The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease.

Novel Vaccination Strategies

Novel Vaccination Strategies
Author: Stefan H. E. Kaufmann
Publsiher: John Wiley & Sons
Total Pages: 670
Release: 2006-01-24
ISBN 10: 3527606092
ISBN 13: 9783527606092
Language: EN, FR, DE, ES & NL

Novel Vaccination Strategies Book Review:

The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Guidelines on the Management of Latent Tuberculosis Infection

Guidelines on the Management of Latent Tuberculosis Infection
Author: WHO,World Health Organization
Publsiher: World Health Organization
Total Pages: 34
Release: 2015-01-15
ISBN 10: 9241548908
ISBN 13: 9789241548908
Language: EN, FR, DE, ES & NL

Guidelines on the Management of Latent Tuberculosis Infection Book Review:

BACKGROUND: Latent tuberculosis infection (LTBI), defined as a state of persistent immune response to prior-acquired Mycobacterium tuberculosis antigens without evidence of clinically manifested active TB, affects about one-third of the world's population. Approximately 10% of people with LTBI will develop active TB disease in their lifetime, with the majority developing it within the first five years after initial infection. Currently available treatments have an efficacy ranging from 60% to 90%. Systematic testing and treatment of LTBI in at-risk populations is a critical component of WHO's eight-point framework adapted from the End TB Strategy to target pre-elimination and, ultimately, elimination in low incidence countries. OVERVIEW: Recognizing the importance of expanding the response to LTBI, in 2014 WHO developed Guidelines on the Management of Latent Tuberculosis Infection. The guidelines are primarily targeted at high-income or upper middle-income countries with an estimated TB incidence rate of less than 100 per 100 000 population, because they are most likely to benefit from it due to their current TB epidemiology and resource availability. The overall objective of the guidelines is to provide public health approach guidance on evidence-based practices for testing, treating and managing LTBI in individuals with the highest risk of progression to active disease. Specific objectives include identifying and prioritizing at-risk population groups for targeted intervention of LTBI testing and treatment, including defining an algorithm, and recommending specific treatment options. The guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management based on available resources, epidemiology of TB including intensity of transmission, the health-care delivery system of the country, and other national and local determinants.

Vaccines and Autoimmunity

Vaccines and Autoimmunity
Author: Yehuda Shoenfeld,Nancy Agmon-Levin,Lucija Tomljenovic
Publsiher: John Wiley & Sons
Total Pages: 384
Release: 2015-07-07
ISBN 10: 1118663438
ISBN 13: 9781118663431
Language: EN, FR, DE, ES & NL

Vaccines and Autoimmunity Book Review:

In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

Psoriasis

Psoriasis
Author: Anca Chiriac
Publsiher: BoD – Books on Demand
Total Pages: 246
Release: 2017-07-05
ISBN 10: 9535132512
ISBN 13: 9789535132516
Language: EN, FR, DE, ES & NL

Psoriasis Book Review:

In 2014, psoriasis was recognized as a serious noncommunicable disease in the World Health Assembly Resolution WHA67.9, with a great negative impact on patients' quality of life. Psoriasis is a worldwide chronic disease, affecting all ages and all races, and a serious global health problem. Psoriasis is a complex disease with still unknown etiology and no specific curative treatment. The chapters provide comprehensive and new description of some issues related to psoriasis research and for understanding of clinical correlations, genetic aspects, experimental research, and potential therapeutic interventions. The book could be a source of information for clinicians and researchers from different fields in raising awareness of the disease.

Autoimmune Diseases of the Skin

Autoimmune Diseases of the Skin
Author: Michael Hertl
Publsiher: Springer Science & Business Media
Total Pages: 469
Release: 2005-12-05
ISBN 10: 3211273778
ISBN 13: 9783211273777
Language: EN, FR, DE, ES & NL

Autoimmune Diseases of the Skin Book Review:

Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The second edition has been extended by chapters on autoimmune pigmentary disorders (vitiligo), hairloss (alopecia areata) and cutaneous symptoms of rheumatic disorders.

Biology of Myelomonocytic Cells

Biology of Myelomonocytic Cells
Author: Anirban Ghosh
Publsiher: BoD – Books on Demand
Total Pages: 172
Release: 2017-05-10
ISBN 10: 9535131230
ISBN 13: 9789535131236
Language: EN, FR, DE, ES & NL

Biology of Myelomonocytic Cells Book Review:

Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.

Immunization Safety Review

Immunization Safety Review
Author: Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
Publsiher: National Academies Press
Total Pages: 152
Release: 2002-08-02
ISBN 10: 0309083281
ISBN 13: 9780309083287
Language: EN, FR, DE, ES & NL

Immunization Safety Review Book Review:

By two years of age, healthy infants in the United States can receive up to 20 vaccinations to protect against 11 diseases. Although most people know that vaccines effectively protect against serious infectious diseases, approximately one-quarter of parents in a recent survey believe that infants get more vaccines than are good for them, and that too many immunizations could overwhelm an infant's immune system. The Immunization Safety Review Committee reviewed the evidence regarding the hypothesis that multiple immunizations increase the risk for immune dysfunction. Specifically, the committee looked at evidence of potential biological mechanisms and at epidemiological evidence for or against causality related to risk for infections, the autoimmune disease type 1 diabetes, and allergic disorders.

Cancer and Autoimmunity

Cancer and Autoimmunity
Author: M.E. Gershwin,Yehuda Shoenfeld
Publsiher: Elsevier
Total Pages: 468
Release: 2000-03-27
ISBN 10: 9780080528458
ISBN 13: 0080528457
Language: EN, FR, DE, ES & NL

Cancer and Autoimmunity Book Review:

Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike. The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival. This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art. This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Equine Dermatology E Book

Equine Dermatology   E Book
Author: Danny W. Scott,William H. Miller
Publsiher: Elsevier Health Sciences
Total Pages: 552
Release: 2010-12-01
ISBN 10: 1437709214
ISBN 13: 9781437709216
Language: EN, FR, DE, ES & NL

Equine Dermatology E Book Book Review:

Diagnose, treat, and manage equine skin disorders with the most comprehensive reference available! With 900 full-color photos, Equine Dermatology covers skin diseases ranging from those that merely annoy the horse to others that interfere with the horse's ability to function in riding, working, or show. Thorough coverage includes essential basics and practical diagnostic methods, therapies, and specific abnormalities and defects. The book describes the structure and function of the skin, and discusses disorders including bacterial, fungal, parasitic, viral, protozoal, allergic, immune-mediated, endocrine, metabolic, and nutritional diseases. It also covers congenital and hereditary defects, pigmentation abnormalities, keratinization defects, environmental skin diseases, and skin tumors. Written by renowned equine dermatologists Danny Scott and Bill Miller, this all-inclusive resource covers the latest dermatologic topics and the newest therapies. Current, comprehensive coverage includes every known equine dermatosis. An emphasis on differential diagnosis includes key differentials and breed predilections for each disease, especially helpful when you have only a specimen and an incomplete history to work with. A consistent format makes it easy to locate information on each skin disorder, including a clinical description, its cause and pathogenesis, clinical features, clinical management, diagnosis, treatment, and any zoonotic aspects. Expert authors Danny W. Scott, DVM, and William H. Miller, Jr., VMD, offer years of knowledge, experience, and their vast image collections. Diagnostic tables in each chapter provide a quick reference for identifying lesions and disorders. An extensive list of references at the end of each chapter includes recommendations for further reading. New coverage of dermatologic conditions includes the latest topics and emerging disorders such as chronic progressive lymphedema, herpesvirus-2-associated dermatitis, salmonella-associated dermatoses, and nodular auricular chondropathy. Updated Diagnostic Methods chapter covers multiple methods of developing a differential diagnosis list based on breed, lesion type, patterns, and location. A focus on common clinical problems highlights the conditions most likely to be seen in practice. Almost 1,000 full-color photos of skin disorders make it easy to distinguish clinical characteristics and variations of normal and abnormal for accurate diagnosis and therapy.

Immunopathogenesis and Immune based Therapy for Selected Autoimmune Disorders

Immunopathogenesis and Immune based Therapy for Selected Autoimmune Disorders
Author: Mourad Aribi
Publsiher: BoD – Books on Demand
Total Pages: 182
Release: 2017-03-22
ISBN 10: 9535130218
ISBN 13: 9789535130215
Language: EN, FR, DE, ES & NL

Immunopathogenesis and Immune based Therapy for Selected Autoimmune Disorders Book Review:

The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.