The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Richard B. Silverman
Publsiher: Elsevier
Total Pages: 422
Release: 2012-12-02
ISBN 10: 0080571239
ISBN 13: 9780080571232
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Review:

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Richard B. Silverman
Publsiher: Elsevier
Total Pages: 617
Release: 2012-12-02
ISBN 10: 0080513379
ISBN 13: 9780080513379
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Review:

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Richard B. Silverman
Publsiher: Academic Press
Total Pages: 617
Release: 2004-01-26
ISBN 10: 9780126437324
ISBN 13: 0126437327
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Review:

Standard medicinal texts are organized by classes of drugs with an emphasis on descriptions of their pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalized drug action and allows the reader to extrapolate to many related classed of drug molecules.

Chemistry and Molecular Aspects of Drug Design and Action

Chemistry and Molecular Aspects of Drug Design and Action
Author: E. A. Rekka,P. N. Kourounakis
Publsiher: CRC Press
Total Pages: 384
Release: 2008-04-28
ISBN 10: 1420008277
ISBN 13: 9781420008272
Language: EN, FR, DE, ES & NL

Chemistry and Molecular Aspects of Drug Design and Action Book Review:

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Sam Springer
Publsiher: Unknown
Total Pages: 329
Release: 2018
ISBN 10: 9781684690671
ISBN 13: 1684690676
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Review:

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
Author: Jie Jack Li
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2013-04-26
ISBN 10: 1118354435
ISBN 13: 9781118354438
Language: EN, FR, DE, ES & NL

Heterocyclic Chemistry in Drug Discovery Book Review:

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

The Organic Chemistry Of Drug Design And Drug Action 2E

The Organic Chemistry Of Drug Design And Drug Action  2E
Author: R. B. Silverman
Publsiher: Unknown
Total Pages: 617
Release: 2004-01-01
ISBN 10: 9788181474506
ISBN 13: 8181474503
Language: EN, FR, DE, ES & NL

The Organic Chemistry Of Drug Design And Drug Action 2E Book Review:

Drug discovery, design and development. Receptors. Enzymes. Enzyme inhibition and inactivation. DNA-interactive agents. Drug metabolism. Prodrugs and drug delivery systems.

Molecules and Medicine

Molecules and Medicine
Author: E. J. Corey,Barbara Czakó,László Kürti
Publsiher: John Wiley & Sons
Total Pages: 272
Release: 2012-02-28
ISBN 10: 1118361733
ISBN 13: 9781118361733
Language: EN, FR, DE, ES & NL

Molecules and Medicine Book Review:

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Transformative Concepts for Drug Design Target Wrapping

Transformative Concepts for Drug Design  Target Wrapping
Author: Ariel Fernandez
Publsiher: Springer Science & Business Media
Total Pages: 230
Release: 2010-04-28
ISBN 10: 9783642117923
ISBN 13: 3642117929
Language: EN, FR, DE, ES & NL

Transformative Concepts for Drug Design Target Wrapping Book Review:

In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Author: Bimal K. Banik
Publsiher: Elsevier
Total Pages: 1044
Release: 2020-03-27
ISBN 10: 0128175931
ISBN 13: 9780128175934
Language: EN, FR, DE, ES & NL

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book Review:

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

An Introduction to Medicinal Chemistry

An Introduction to Medicinal Chemistry
Author: Graham L. Patrick
Publsiher: Oxford University Press
Total Pages: 789
Release: 2013-01-10
ISBN 10: 0199697396
ISBN 13: 9780199697397
Language: EN, FR, DE, ES & NL

An Introduction to Medicinal Chemistry Book Review:

This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry
Author: Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
Publsiher: Elsevier
Total Pages: 902
Release: 2015-07-01
ISBN 10: 012417213X
ISBN 13: 9780124172135
Language: EN, FR, DE, ES & NL

The Practice of Medicinal Chemistry Book Review:

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Drug Design and Action

Drug Design and Action
Author: Joaquín M. Campos Rosa,M. Encarnación Camacho Quesada
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 186
Release: 2017-08-21
ISBN 10: 3110528487
ISBN 13: 9783110528480
Language: EN, FR, DE, ES & NL

Drug Design and Action Book Review:

This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents.

Pharmacokinetics and Metabolism in Drug Design

Pharmacokinetics and Metabolism in Drug Design
Author: Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Publsiher: John Wiley & Sons
Total Pages: 207
Release: 2006-05-01
ISBN 10: 9783527313686
ISBN 13: 3527313680
Language: EN, FR, DE, ES & NL

Pharmacokinetics and Metabolism in Drug Design Book Review:

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Textbook of Drug Design and Discovery Third Edition

Textbook of Drug Design and Discovery  Third Edition
Author: Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen
Publsiher: CRC Press
Total Pages: 592
Release: 2002-07-25
ISBN 10: 9780415282888
ISBN 13: 0415282888
Language: EN, FR, DE, ES & NL

Textbook of Drug Design and Discovery Third Edition Book Review:

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

The Organic Chemistry of Medicinal Agents

The Organic Chemistry of Medicinal Agents
Author: Adam Renslo
Publsiher: McGraw Hill Professional
Total Pages: 608
Release: 2015-11-23
ISBN 10: 0071797270
ISBN 13: 9780071797276
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Medicinal Agents Book Review:

The most concise and streamlined textbook available on organic chemistry for the pharmacy student Organic Chemistry for Pharmacy is a textbook written specifically for the students taking the required Organic/Medical Pharmacy course. Using a building-block approach, the book delivers a basic, yet thorough discussion of the mode of action, therapeutic applications, and limitations of various pharmaceutical agents. Organic Chemistry for Pharmacy is especially written for students who have a limited background in chemistry. In order to make the learning/teaching experience as efficient as possible, Organic Chemistry for Pharmacy includes outstanding pedagogical features such as chapter outlines, chapter summaries, boxed “take away points”, quick-reference tables, and problems within each chapter. The focus and presentation of this text is particularly suited for Organic/Medical Pharmacy courses which are weighted heavily towards Organic, rather than Medical Pharmacy.

Organic Chemistry Concepts and Applications for Medicinal Chemistry

Organic Chemistry Concepts and Applications for Medicinal Chemistry
Author: Joseph E. Rice
Publsiher: Academic Press
Total Pages: 224
Release: 2014-04-14
ISBN 10: 0128008326
ISBN 13: 9780128008324
Language: EN, FR, DE, ES & NL

Organic Chemistry Concepts and Applications for Medicinal Chemistry Book Review:

Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material

Small Molecule Drug Discovery

Small Molecule Drug Discovery
Author: Andrea Trabocchi,Elena Lenci
Publsiher: Elsevier
Total Pages: 356
Release: 2019-11-23
ISBN 10: 0128183500
ISBN 13: 9780128183502
Language: EN, FR, DE, ES & NL

Small Molecule Drug Discovery Book Review:

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Contemporary Drug Synthesis

Contemporary Drug Synthesis
Author: Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Publsiher: John Wiley & Sons
Total Pages: 240
Release: 2004-12-27
ISBN 10: 9780471686736
ISBN 13: 0471686735
Language: EN, FR, DE, ES & NL

Contemporary Drug Synthesis Book Review:

An integrated and insightful look at successful drug synthesis intoday's drug discovery market The pharmaceutical industry is unquestionably vibrant today,with drug synthesis making a vital contribution. Whether in theearly developmental stages of identifying and optimizing a lead, orthe latter stages of process development and cost-effectivescale-up, the ability to design elegant and economical syntheticroutes is often a major factor in the eventual viability andcommercial success of a drug. Contemporary Drug Synthesis examines how leadingresearchers and manufacturers have integrated chemistry, biology,pharmacokinetics, and a host of other disciplines in the creationand development of leading drugs. Authored by four of the pharmaceutical industry's most respectedscientists, this timely volume: Focuses on the processes that resulted in high-profile drugsincluding Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, andover a dozen others Provides an in-depth introduction to each drug, followed by adetailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarityand ease of use Process chemists provide an essential bridge between chemistry andthe marketplace, creating scientifically practical drug processeswhile never losing sight of the commercial viability of thoseprocesses. Contemporary Drug Synthesis meets the needs of agrowing community of researchers in pharmaceutical research anddevelopment, and is both a useful guide for practicingpharmaceutical scientists and an excellent text for medicinal andorganic chemistry students.

Ligand Macromolecular Interactions in Drug Discovery

Ligand Macromolecular Interactions in Drug Discovery
Author: Ana Cecília A. Roque
Publsiher: Humana
Total Pages: 297
Release: 2010-03-23
ISBN 10:
ISBN 13: STANFORD:36105211741447
Language: EN, FR, DE, ES & NL

Ligand Macromolecular Interactions in Drug Discovery Book Review:

In this authoritative book, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds. This is as an ideal guide to those striving to further our knowledge of medicines.