The Orexin Hypocretin System

The Orexin Hypocretin System
Author: Jim R. Fadel,Joshua A. Burk
Publsiher: Academic Press
Total Pages: 188
Release: 2019-01-03
ISBN 10: 0128137525
ISBN 13: 9780128137529
Language: EN, FR, DE, ES & NL

The Orexin Hypocretin System Book Review:

The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists. Provides an overview of new research on orexins/hypocretins Includes an overview of intracellular signaling and orexin physiology Discusses the effects on arousal, appetite, cognition, addiction and anxiety Examines orexin based therapies and their potential use in disorders Explores orexin receptors for drug development

The Orexin Hypocretin System

The Orexin Hypocretin System
Author: Seiji Nishino,Takeshi Sakurai
Publsiher: Springer Science & Business Media
Total Pages: 416
Release: 2007-11-22
ISBN 10: 1592599508
ISBN 13: 9781592599509
Language: EN, FR, DE, ES & NL

The Orexin Hypocretin System Book Review:

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

The Orexin hypocretin System

The Orexin hypocretin System
Author: Anantha Shekhar
Publsiher: Elsevier
Total Pages: 196
Release: 2012
ISBN 10: 0444594892
ISBN 13: 9780444594891
Language: EN, FR, DE, ES & NL

The Orexin hypocretin System Book Review:

"In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations." "Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding and body weight regulation."--Résumé de l'éditeur.

Hypocretins

Hypocretins
Author: Luis De Lecea,J. Gregor Sutcliffe
Publsiher: Springer Science & Business Media
Total Pages: 441
Release: 2007-04-25
ISBN 10: 0387254463
ISBN 13: 9780387254463
Language: EN, FR, DE, ES & NL

Hypocretins Book Review:

The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Orexin and Sleep

Orexin and Sleep
Author: Takeshi Sakurai,S.R. Pandi-Perumal,Jaime M. Monti
Publsiher: Springer
Total Pages: 410
Release: 2015-09-22
ISBN 10: 3319230786
ISBN 13: 9783319230788
Language: EN, FR, DE, ES & NL

Orexin and Sleep Book Review:

This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.

The Genetic Basis of Sleep and Sleep Disorders

The Genetic Basis of Sleep and Sleep Disorders
Author: Paul Shaw,Mehdi Tafti,Michael J. Thorpy
Publsiher: Cambridge University Press
Total Pages: 432
Release: 2013-10-24
ISBN 10: 1107435617
ISBN 13: 9781107435612
Language: EN, FR, DE, ES & NL

The Genetic Basis of Sleep and Sleep Disorders Book Review:

The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists.

Narcolepsy

Narcolepsy
Author: Christian R. Baumann,Claudio L. Bassetti,Thomas E. Scammell
Publsiher: Springer Science & Business Media
Total Pages: 428
Release: 2011-07-01
ISBN 10: 9781441983909
ISBN 13: 1441983902
Language: EN, FR, DE, ES & NL

Narcolepsy Book Review:

The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder but also includes a DVD that offers a unique and large collection of movies displaying the symptoms of narcolepsy in people and animals. Written by some of the best experts in the field, the book focuses on the pathophysiology of the problem and also provides critical, up-to-date insights on the key clinical issues: how to diagnose the disorder, how to treat it, and how to best manage psychosocial problems. The first and only guide to span the latest advances in narcolepsy, this reference provides sections in etiology, neurochemistry, the role of the hypocretins in sleep-wake regulation, animal models in narcolepsy, the key role of the hypothalamus, REM-sleep dysregulation, diagnosis and classification, and treatment. Compiled by an international group of more than 30 authors, Narcolepsy: Pathophysiology, Diagnosis, and Treatment is an indispensable resource for all clinicians and scientists with an interest in narcolepsy.

Interactions of the Orexin hypocretin Neurones and the Histaminergic System

Interactions of the Orexin hypocretin Neurones and the Histaminergic System
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2014
ISBN 10:
ISBN 13: OCLC:1051373414
Language: EN, FR, DE, ES & NL

Interactions of the Orexin hypocretin Neurones and the Histaminergic System Book Review:

Abstract Histaminergic and orexin/hypocretin systems are components in the brain wake‐promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurones are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurones is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models.

Hypothalamus in Health and Diseases

Hypothalamus in Health and Diseases
Author: Stavros Baloyannis,Jan Gordeladze
Publsiher: BoD – Books on Demand
Total Pages: 142
Release: 2018-12-05
ISBN 10: 1789844444
ISBN 13: 9781789844443
Language: EN, FR, DE, ES & NL

Hypothalamus in Health and Diseases Book Review:

The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement of mnemonic processes, emotional control, mood stability, and cognitive-emotional interactions. It also has a role to play in behavioral disorders, panic reactions, cluster headache, gelastic epilepsy, mental deficiency, periodic disorders, depression, autism, and schizophrenia, and in a substantial number of neurodegenerative diseases. It enlarges greatly the dimensions of the hypothalamic contribution in controlling psychosomatic equilibrium and retaining internal unity of the human existence.

Encyclopedia of Molecular Pharmacology

Encyclopedia of Molecular Pharmacology
Author: Stefan Offermanns,W. Rosenthal
Publsiher: Springer Science & Business Media
Total Pages: 1505
Release: 2008-08-14
ISBN 10: 3540389164
ISBN 13: 9783540389163
Language: EN, FR, DE, ES & NL

Encyclopedia of Molecular Pharmacology Book Review:

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Sleep Hormones

Sleep Hormones
Author: Gerald Litwack
Publsiher: Academic Press
Total Pages: 370
Release: 2012
ISBN 10: 0123946239
ISBN 13: 9780123946232
Language: EN, FR, DE, ES & NL

Sleep Hormones Book Review:

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on sleep hormones. Contributions from leading authorities Informs and updates on all the latest developments in the field

Neuroscience of Nicotine

Neuroscience of Nicotine
Author: Victor R. Preedy
Publsiher: Academic Press
Total Pages: 566
Release: 2019-03-20
ISBN 10: 0128130369
ISBN 13: 9780128130360
Language: EN, FR, DE, ES & NL

Neuroscience of Nicotine Book Review:

Neuroscience of Nicotine: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse. With an estimated one billion individuals worldwide classified as tobacco users—and tobacco use often being synonymous with nicotine addiction—nicotine is one of the world’s most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of nicotine use, along with its effects on neurobiological function Discusses nicotine use as a component of dual-use and poly addictions and outlines numerous screening and treatment strategies for misuse Covers both the physical and psychological effects of nicotine use and withdrawal to provide a fully-formed view of nicotine dependency and its effects

Narcolepsy

Narcolepsy
Author: Meeta Goswami,Seithikurippu Ratnas Pandi-Perumal,Michael J. Thorpy
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2011-04-08
ISBN 10: 1441908552
ISBN 13: 9781441908551
Language: EN, FR, DE, ES & NL

Narcolepsy Book Review:

Narcolepsy serves as a prototype of how the interaction of high quality clinical research and groundbreaking basic science can collaborate to defne the cause of a disease and change forever how we evaluate and treat it. There is scarcely a topic in this book that would have been covered in the same way 10 years ago as it is d- cussed today. We are also fortunate that many of the players in this dramatic tu- around have contributed to this volume, so that the result is a tapestry of the events that have transformed the feld over the last decade that is both authentic and detailed. The frst section of the book provides much of the basic science background. As described in the frst two chapters, the dramatic convergence of lines of evidence from two different laboratories frst demonstrated in 1999 that narcolepsy is a disease of loss of neurotransmission by lateral hypothalamic neurons making the peptides that have been called orexins or hypocretins. These fndings did much to clarify and unify a feld that had puzzled for decades over the fundamental nature of this puzzling disease, as refected in the chapters that review its epidemiology and neuroanatomical and imaging fndings.

Handbook of Biologically Active Peptides

Handbook of Biologically Active Peptides
Author: Abba Kastin,Abba J. Kastin
Publsiher: Elsevier
Total Pages: 1640
Release: 2011-04-28
ISBN 10: 9780080463797
ISBN 13: 0080463797
Language: EN, FR, DE, ES & NL

Handbook of Biologically Active Peptides Book Review:

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar. *Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.

Encyclopedia of Signaling Molecules

Encyclopedia of Signaling Molecules
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 19??
ISBN 10: 9781461464389
ISBN 13: 1461464382
Language: EN, FR, DE, ES & NL

Encyclopedia of Signaling Molecules Book Review:

Sleep and Mental Illness

Sleep and Mental Illness
Author: S. R. Pandi-Perumal,Milton Kramer
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2010-04-01
ISBN 10: 1139483706
ISBN 13: 9781139483704
Language: EN, FR, DE, ES & NL

Sleep and Mental Illness Book Review:

The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

Behavioral Neuroscience of Orexin Hypocretin

Behavioral Neuroscience of Orexin Hypocretin
Author: Andrew J Lawrence,Luis de Lecea
Publsiher: Springer
Total Pages: 322
Release: 2017-05-29
ISBN 10: 331957535X
ISBN 13: 9783319575353
Language: EN, FR, DE, ES & NL

Behavioral Neuroscience of Orexin Hypocretin Book Review:

This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal states, critical for higher order functioning. From a clinical perspective, genetic polymorphisms in hypocretin/orexin and orexin receptors are implicated in a number of psychiatric disorders. In addition, advanced clinical trials are currently underway for orexin receptor antagonists in the treatment of insomnia and sleep disorders. We aim to capture a broad audience of basic scientists and clinicians.

The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption

The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption
Author: Anonim
Publsiher: Academic Press
Total Pages: 304
Release: 2017-10-31
ISBN 10: 0128124741
ISBN 13: 9780128124741
Language: EN, FR, DE, ES & NL

The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption Book Review:

The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption, Volume 136 in the International Review of Neurobiology series, provides an overview of the top candidate neuropeptides in the modulation of alcohol and drug abuse, also covering eating disorders and obesity. Topics covered in this latest release include Corticotropin Releasing Factor (CRF) and Addictive Behaviors, Dynorphin/Kappa Opioid Receptor Signaling in Pre-clinical Models of Alcohol, Drug, and Food Addiction, The Role of Ghrelin Signaling in Additive Behaviors, The Role of the Melanocortin System in Drug and Eating Disorders, Substance P and the Neurokinin-1 Receptor: The New CRH, and the Role of Neuropeptide Y (NPY) in Drug and Eating Disorders. The book uniquely highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders. Presents a recent overview of some of the top candidate neuropeptides in the modulation of alcohol and drug abuse, and in eating disorders and obesity Highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders Contains chapters that focus on a specific neuropeptide

Drug Treatment of Sleep Disorders

Drug Treatment of Sleep Disorders
Author: Antonio Guglietta
Publsiher: Springer
Total Pages: 297
Release: 2014-11-28
ISBN 10: 3319115146
ISBN 13: 9783319115146
Language: EN, FR, DE, ES & NL

Drug Treatment of Sleep Disorders Book Review:

Following reviews on sleep physiology, regulation, pharmacology, and the neuronal networks regulating sleep and awakening, as well as a classification of sleep disorders, this book presents a number of major breakthroughs in the treatment of those disorders. These include recently approved drugs for treating insomnia, such as Doxepin; variations on previously approved molecules, e.g. Zolpidem sublingual preparation; or new chemical entities in advanced stages of clinical development, e.g. Orexin antagonists. Further topics discussed include drugs acting on the GABA receptor, such as Lorediplon and Eszopiclone; the treatment of excessive daytime drowsiness with cell therapy and drugs such as Modafinil, Armodafinil and Sodium oxybate; and the use of Tasimelteon in the treatment of circadian sleep disorders.

Neuropeptide GPCRs in neuroendocrinology

Neuropeptide GPCRs in neuroendocrinology
Author: Jae Young Seong,Hubert Vaudry
Publsiher: Frontiers E-books
Total Pages: 329
Release: 2014-11-07
ISBN 10: 2889192679
ISBN 13: 9782889192670
Language: EN, FR, DE, ES & NL

Neuropeptide GPCRs in neuroendocrinology Book Review:

The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.