The Human Mitochondrial Genome

The Human Mitochondrial Genome
Author: Giuseppe Gasparre,Anna Maria Porcelli
Publsiher: Academic Press
Total Pages: 596
Release: 2020-07-23
ISBN 10: 0128226420
ISBN 13: 9780128226421
Language: EN, FR, DE, ES & NL

The Human Mitochondrial Genome Book Review:

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

The Human Mitochondrial Genome

The Human Mitochondrial Genome
Author: Giuseppe Gasparre,Anna Maria Porcelli
Publsiher: Academic Press
Total Pages: 596
Release: 2020-08-19
ISBN 10: 0128196564
ISBN 13: 9780128196564
Language: EN, FR, DE, ES & NL

The Human Mitochondrial Genome Book Review:

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
Author: Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
Publsiher: Springer Science & Business Media
Total Pages: 271
Release: 2006-09-05
ISBN 10: 3540317899
ISBN 13: 9783540317890
Language: EN, FR, DE, ES & NL

Human Mitochondrial DNA and the Evolution of Homo sapiens Book Review:

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

The Evolution of Human Mitochondrial DNA

The Evolution of Human Mitochondrial DNA
Author: Rebecca Louise Cann
Publsiher: Unknown
Total Pages: 650
Release: 1982
ISBN 10:
ISBN 13: UCAL:C2935263
Language: EN, FR, DE, ES & NL

The Evolution of Human Mitochondrial DNA Book Review:

Mitochondrial DNA

Mitochondrial DNA
Author: Herve Seligmann,Ganesh Warthi
Publsiher: BoD – Books on Demand
Total Pages: 224
Release: 2018-10-31
ISBN 10: 1789842654
ISBN 13: 9781789842654
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Book Review:

The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization.

Mitochondrial Gene Expression

Mitochondrial Gene Expression
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2021
ISBN 10: 9781071608340
ISBN 13: 1071608347
Language: EN, FR, DE, ES & NL

Mitochondrial Gene Expression Book Review:

Evolution of Life

Evolution of Life
Author: Syozo Osawa,Tasuku Honjo
Publsiher: Springer Science & Business Media
Total Pages: 460
Release: 2012-12-06
ISBN 10: 443168302X
ISBN 13: 9784431683025
Language: EN, FR, DE, ES & NL

Evolution of Life Book Review:

Nearly thirty million species of organisms are believed to now live on Earth. In addition to accumulating evidence from classical biology, paleontology and earth science, the recent progress of molecular biology has provided new insights into understanding how present-day organisms have evolved with such tremendous diversity. Molecular biological studies show us that all living forms, including E. coli and human beings, derive from a single ancestor that emerged some 4 billion years ago on Earth. This volume aims to discuss the motifs of organismic evolution from the viewpoints of biogeo-interactions and diversification of the genetic systems. Based on these fundamental understandings, the last section of this volume is devoted to human evolution that includes phylogeny of man as well as evolution of human culture. Such comprehensive discussion will give us a synthesized view of the evolution of life, that is undoubtedly one of the most important problems not only for science but also for human culture in general.

Mitochondrial DNA Mitochondria Disease and Stem Cells

Mitochondrial DNA  Mitochondria  Disease and Stem Cells
Author: Justin C. St. John
Publsiher: Springer Science & Business Media
Total Pages: 190
Release: 2012-09-26
ISBN 10: 1627031014
ISBN 13: 9781627031011
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Mitochondria Disease and Stem Cells Book Review:

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

MITOMAP

MITOMAP
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2001
ISBN 10:
ISBN 13: OCLC:299638771
Language: EN, FR, DE, ES & NL

MITOMAP Book Review:

The Seven Daughters of Eve

The Seven Daughters of Eve
Author: Bryan Sykes
Publsiher: Unknown
Total Pages: 367
Release: 2002
ISBN 10: 9780552148764
ISBN 13: 0552148768
Language: EN, FR, DE, ES & NL

The Seven Daughters of Eve Book Review:

In 1994 Professor Bryan Sykes, a leading world authority on DNA and human evolution, was called in to examine the frozen remains of a man trapped in glacial ice in northern Italy. News of the discovery of the Ice Man and his age, which was put at over five thousand years old, fascinated the world. But what made the story particularly extraordinary was that Professor Sykes was also able to track down a living generic relative of the Ice Man, a woman living in Britain today. How was he able to locate a living relative of a man who died thousands of years ago? In The Seven Daughters of Eve, Bryan Sykes gives us a first hand account of his research into a remarkable gene which passes undiluted from generation to generation through the maternal line and shows how it is being used to track our genetic ancestors through time and space. After plotting thousands of DNA sequences from all over the world he found that they had clustered around a handful of distinct groups. In Europe there are only seven. The conclusion: almost everyone of native European descent, wherever they live in the world, can trace their ancestry back to one of seven women, the Seven Daughters of Eve. He has named them Ursula, Xenia, Helena, Velda, Tara, Katrine and Jasmine. In this remarkable scientific adventure story we learn exactly how our origins can be traced, how and where our ancient genetic ancestors lived, what their live were like and how we are each living proof of the almost miraculous strength of our DNA which has survived and prospered over so many thousands of years to reach us today. It is a book that not only presents the story of our evolution in a wholly new light, but also strikes right at the heart of ourselves as individuals and of our sense of identity.

Mitochondrial DNA

Mitochondrial DNA
Author: William C. Copeland
Publsiher: Springer Science & Business Media
Total Pages: 414
Release: 2002
ISBN 10: 1592592848
ISBN 13: 9781592592845
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Book Review:

Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease.

Last Days of Richard III

Last Days of Richard III
Author: John Ashdown-Hill
Publsiher: The History Press
Total Pages: 192
Release: 2010-12-26
ISBN 10: 0752462504
ISBN 13: 9780752462509
Language: EN, FR, DE, ES & NL

Last Days of Richard III Book Review:

What Richard III did in his last five months, what happened to his body, and how his DNA was found in Canada A new and uniquely detailed exploration of Richard’s last 150 days explores these events from the standpoint of Richard himself and his contemporaries. By deliberately avoiding the hindsight knowledge that he will lose the Battle of Bosworth Field, this book presents a new Richard—no passive victim, awaiting defeat and death, but a king actively pursuing his own policies and agenda. It also reexamines the aftermath of Bosworth—the treatment of Richard’s body, his burial, and the construction of his tomb. Based on newly discovered evidence and wider insights it explores the motives underlying these events. And there is the fascinating story of why and how Richard III’s DNA was rediscovered, alive and well, and living in Canada. This is a stimulating and thought-provoking account of the end of Richard’s life—even readers very familiar with his short life will discover a new and fascinating picture of him.

Energy Conservation in Biological Membranes

Energy Conservation in Biological Membranes
Author: G. Schäfer,M. Klingenberg
Publsiher: Springer Science & Business Media
Total Pages: 288
Release: 2012-12-06
ISBN 10: 3642812872
ISBN 13: 9783642812873
Language: EN, FR, DE, ES & NL

Energy Conservation in Biological Membranes Book Review:

Mitochondrial DNA Mutations in Aging Disease and Cancer

Mitochondrial DNA Mutations in Aging  Disease and Cancer
Author: Keshav K. Singh
Publsiher: Springer Science & Business Media
Total Pages: 412
Release: 2013-03-09
ISBN 10: 3662125099
ISBN 13: 9783662125090
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Mutations in Aging Disease and Cancer Book Review:

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

Who We Are and How We Got Here

Who We Are and How We Got Here
Author: David Reich
Publsiher: Oxford University Press
Total Pages: 368
Release: 2018-03-27
ISBN 10: 0198821255
ISBN 13: 9780198821250
Language: EN, FR, DE, ES & NL

Who We Are and How We Got Here Book Review:

David Reich describes how the revolution in the ability to sequence ancient DNA has changed our understanding of the deep human past. This book tells the emerging story of our often surprising ancestry - the extraordinary ancient migrations and mixtures of populations that have made us who we are.

Somatic Cell Nuclear Transfer

Somatic Cell Nuclear Transfer
Author: Peter Sutovsky
Publsiher: Springer Science & Business Media
Total Pages: 135
Release: 2007-12-22
ISBN 10: 0387377549
ISBN 13: 9780387377544
Language: EN, FR, DE, ES & NL

Somatic Cell Nuclear Transfer Book Review:

This book provides the reader with a unique developmental, molecular and cell biological view of the exciting SCNT technology, while also discussing its pitfalls and possible future directions and detours. The cellular events arising from SCNT procedure, such as the need for nuclear remodeling, disposal of donor cell organelles, presence of foreign mitochondrial DNA and altered mode of oocyte activation are explained.

Mitochondrial Disorders Caused by Nuclear Genes

Mitochondrial Disorders Caused by Nuclear Genes
Author: Lee-Jun C. Wong
Publsiher: Springer Science & Business Media
Total Pages: 372
Release: 2012-09-18
ISBN 10: 1461437210
ISBN 13: 9781461437215
Language: EN, FR, DE, ES & NL

Mitochondrial Disorders Caused by Nuclear Genes Book Review:

Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.

Medical and Health Genomics

Medical and Health Genomics
Author: Dhavendra Kumar,Stylianos Antonarakis
Publsiher: Academic Press
Total Pages: 358
Release: 2016-06-04
ISBN 10: 0127999221
ISBN 13: 9780127999227
Language: EN, FR, DE, ES & NL

Medical and Health Genomics Book Review:

Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems

Mitochondrial Diseases

Mitochondrial Diseases
Author: Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publsiher: BoD – Books on Demand
Total Pages: 496
Release: 2018-08-29
ISBN 10: 1789236746
ISBN 13: 9781789236743
Language: EN, FR, DE, ES & NL

Mitochondrial Diseases Book Review:

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Mitochondrial Function and Biogenesis

Mitochondrial Function and Biogenesis
Author: Carla Koehler,Matthias F. Bauer
Publsiher: Springer Science & Business Media
Total Pages: 333
Release: 2004-05-13
ISBN 10: 9783540214892
ISBN 13: 3540214895
Language: EN, FR, DE, ES & NL

Mitochondrial Function and Biogenesis Book Review:

This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level. (Cover)