The Human Mitochondrial Genome

The Human Mitochondrial Genome
Author: Giuseppe Gasparre,Anna Maria Porcelli
Publsiher: Academic Press
Total Pages: 596
Release: 2020-07-23
ISBN 10: 0128226420
ISBN 13: 9780128226421
Language: EN, FR, DE, ES & NL

The Human Mitochondrial Genome Book Review:

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
Author: Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
Publsiher: Springer Science & Business Media
Total Pages: 271
Release: 2006-09-05
ISBN 10: 3540317899
ISBN 13: 9783540317890
Language: EN, FR, DE, ES & NL

Human Mitochondrial DNA and the Evolution of Homo sapiens Book Review:

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

The Evolution of Human Mitochondrial DNA

The Evolution of Human Mitochondrial DNA
Author: Rebecca Louise Cann
Publsiher: Anonim
Total Pages: 650
Release: 1982
ISBN 10:
ISBN 13: UCAL:C2935263
Language: EN, FR, DE, ES & NL

The Evolution of Human Mitochondrial DNA Book Review:

High-throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics, Function, and Signals of Selection in Cancer

High-throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics, Function, and Signals of Selection in Cancer
Author: Sneha Grandhi
Publsiher: Anonim
Total Pages: 329
Release: 2018
ISBN 10:
ISBN 13: OCLC:1083218398
Language: EN, FR, DE, ES & NL

High-throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics, Function, and Signals of Selection in Cancer Book Review:

Known as the energy powerhouses of the cell, mitochondria carry their own genomes, and encode for key cellular respiration proteins. Carrying multiple copies per cell, a given mitochondrial DNA (mtDNA) variant can be present at varying proportions, termed heteroplasmy. MtDNA is acquired exclusively through maternal inheritance and becomes stochastically replicated and segregated into dividing mitochondria over an organism's lifespan. An individual's constellation of mtDNA variants and their respective heteroplasmy levels can therefore change in response to selective pressures in somatic cells and/or selection that takes place during germline transmission. MtDNA aberrations are associated with many disorders, including cancer. Although mitochondrial genomes accumulate elevated mutation rates in cancer cells, the origin and functional impact of these mutations remain controversial. Here, we queried whole-genome sequencing data from 1,916 patients across 24 cancer types to characterize patterns of mtDNA mutations and elucidate the selective constraints driving their fate. We also tracked changes in per-cell abundances of mtDNA mutations from normal to tumor cells in the same patient. Tumor mitochondrial genomes show distinct mutational patterns and are disproportionately enriched for protein-altering changes. Moreover, protein-altering mtDNA variants that are initially present at low frequencies in normal cells preferentially expand in the altered tumor environment, suggesting selective advantage. Renal chromophobe and thyroid cancers show strong signals of positive selection with higher proportions and per-cell abundances of truncating mtDNA variants. Dramatic tumor- and tissue-specific variations in selective pressures suggest that cancer cells with advantageous levels of damaged mitochondrial genomes will selectively proliferate to facilitate the tumorigenic process.We also cataloged mitochondrial sequence variants and gene expression across 927 cancer cell lines from the Cancer Cell Line Encyclopedia (CCLE). We used this data to create a novel computational method called DoReMi (Donor, Recipient Mitochondrial DNA matching). DoReMi scores candidate mtDNA donor and recipient cell lines for cybridization experiments, which help identify the role of mtDNA variants in-vitro under a controlled nuclear genetic background. This tool allows researchers to design optimized cybrid experiments for querying the role of mutations in their mitochondrial-encoded gene of interest. Researchers may also apply DoReMi to study their own cell lines of interest.

MITOMAP

MITOMAP
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 2001
ISBN 10:
ISBN 13: OCLC:299638771
Language: EN, FR, DE, ES & NL

MITOMAP Book Review:

Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology

Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology
Author: Vivian Edesan Reyes
Publsiher: Anonim
Total Pages: 166
Release: 2008
ISBN 10:
ISBN 13: UCAL:X78842
Language: EN, FR, DE, ES & NL

Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology Book Review:

Mitochondrial DNA

Mitochondrial DNA
Author: Herve Seligmann,Ganesh Warthi
Publsiher: BoD – Books on Demand
Total Pages: 224
Release: 2018-10-31
ISBN 10: 1789842654
ISBN 13: 9781789842654
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Book Review:

The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization.

Mitochondrial DNA, Mitochondria, Disease and Stem Cells

Mitochondrial DNA, Mitochondria, Disease and Stem Cells
Author: Justin C. St. John
Publsiher: Springer Science & Business Media
Total Pages: 190
Release: 2012-09-26
ISBN 10: 1627031014
ISBN 13: 9781627031011
Language: EN, FR, DE, ES & NL

Mitochondrial DNA, Mitochondria, Disease and Stem Cells Book Review:

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer

Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer
Author: Mansoureh Akouchekian
Publsiher: Cuvillier Verlag
Total Pages: 80
Release: 2008
ISBN 10: 3867277591
ISBN 13: 9783867277594
Language: EN, FR, DE, ES & NL

Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer Book Review:

High-yield Cell and Molecular Biology

High-yield Cell and Molecular Biology
Author: Ronald W. Dudek
Publsiher: Lippincott Williams & Wilkins
Total Pages: 254
Release: 2007
ISBN 10: 9780781768870
ISBN 13: 078176887X
Language: EN, FR, DE, ES & NL

High-yield Cell and Molecular Biology Book Review:

This completely revised and updated review book consolidates the most important clinical issues that medical students need to know to be prepared for questions on USMLE Step 1. The book reviews key cell biology concepts needed to study molecular biology, and reviews the key concepts of molecular biology necessary for clinical medical practice, Flow charts provide a clear overview of molecular biology techniques and how they are applied in medicine. A chapter on understanding the research literature provides a solid background in molecular biology protocol so that students can understand the purpose and thinking behind published research articles.

Mitochondrial DNA Mutations in Aging, Disease and Cancer

Mitochondrial DNA Mutations in Aging, Disease and Cancer
Author: Keshav K. Singh
Publsiher: Springer Science & Business Media
Total Pages: 412
Release: 2013-03-09
ISBN 10: 3662125099
ISBN 13: 9783662125090
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Mutations in Aging, Disease and Cancer Book Review:

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

Mitochondrial DNA

Mitochondrial DNA
Author: William C. Copeland
Publsiher: Springer Science & Business Media
Total Pages: 414
Release: 2002
ISBN 10: 1592592848
ISBN 13: 9781592592845
Language: EN, FR, DE, ES & NL

Mitochondrial DNA Book Review:

Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease.

Medical and Health Genomics

Medical and Health Genomics
Author: Dhavendra Kumar,Stylianos Antonarakis
Publsiher: Academic Press
Total Pages: 358
Release: 2016-06-04
ISBN 10: 0127999221
ISBN 13: 9780127999227
Language: EN, FR, DE, ES & NL

Medical and Health Genomics Book Review:

Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Anonim
Total Pages: 329
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

The Seven Daughters of Eve

The Seven Daughters of Eve
Author: Bryan Sykes
Publsiher: Anonim
Total Pages: 367
Release: 2002
ISBN 10: 9780552148764
ISBN 13: 0552148768
Language: EN, FR, DE, ES & NL

The Seven Daughters of Eve Book Review:

In 1994 Professor Bryan Sykes, a leading world authority on DNA and human evolution, was called in to examine the frozen remains of a man trapped in glacial ice in northern Italy. News of the discovery of the Ice Man and his age, which was put at over five thousand years old, fascinated the world. But what made the story particularly extraordinary was that Professor Sykes was also able to track down a living generic relative of the Ice Man, a woman living in Britain today. How was he able to locate a living relative of a man who died thousands of years ago? In The Seven Daughters of Eve, Bryan Sykes gives us a first hand account of his research into a remarkable gene which passes undiluted from generation to generation through the maternal line and shows how it is being used to track our genetic ancestors through time and space. After plotting thousands of DNA sequences from all over the world he found that they had clustered around a handful of distinct groups. In Europe there are only seven. The conclusion: almost everyone of native European descent, wherever they live in the world, can trace their ancestry back to one of seven women, the Seven Daughters of Eve. He has named them Ursula, Xenia, Helena, Velda, Tara, Katrine and Jasmine. In this remarkable scientific adventure story we learn exactly how our origins can be traced, how and where our ancient genetic ancestors lived, what their live were like and how we are each living proof of the almost miraculous strength of our DNA which has survived and prospered over so many thousands of years to reach us today. It is a book that not only presents the story of our evolution in a wholly new light, but also strikes right at the heart of ourselves as individuals and of our sense of identity.

Mitochondrial Diseases

Mitochondrial Diseases
Author: Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publsiher: BoD – Books on Demand
Total Pages: 496
Release: 2018-08-29
ISBN 10: 1789236746
ISBN 13: 9781789236743
Language: EN, FR, DE, ES & NL

Mitochondrial Diseases Book Review:

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor
Author: Terry Lichtor
Publsiher: BoD – Books on Demand
Total Pages: 434
Release: 2015-03-25
ISBN 10: 953512031X
ISBN 13: 9789535120315
Language: EN, FR, DE, ES & NL

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor Book Review:

A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Last Days of Richard III

Last Days of Richard III
Author: John Ashdown-Hill
Publsiher: The History Press
Total Pages: 192
Release: 2010-12-26
ISBN 10: 0752462504
ISBN 13: 9780752462509
Language: EN, FR, DE, ES & NL

Last Days of Richard III Book Review:

What Richard III did in his last five months, what happened to his body, and how his DNA was found in Canada A new and uniquely detailed exploration of Richard’s last 150 days explores these events from the standpoint of Richard himself and his contemporaries. By deliberately avoiding the hindsight knowledge that he will lose the Battle of Bosworth Field, this book presents a new Richard—no passive victim, awaiting defeat and death, but a king actively pursuing his own policies and agenda. It also reexamines the aftermath of Bosworth—the treatment of Richard’s body, his burial, and the construction of his tomb. Based on newly discovered evidence and wider insights it explores the motives underlying these events. And there is the fascinating story of why and how Richard III’s DNA was rediscovered, alive and well, and living in Canada. This is a stimulating and thought-provoking account of the end of Richard’s life—even readers very familiar with his short life will discover a new and fascinating picture of him.

Advanced Topics in Forensic DNA Typing

Advanced Topics in Forensic DNA Typing
Author: John Marshall Butler
Publsiher: Academic Press
Total Pages: 680
Release: 2011
ISBN 10: 0123745136
ISBN 13: 9780123745132
Language: EN, FR, DE, ES & NL

Advanced Topics in Forensic DNA Typing Book Review:

John M. Butler

Encyclopedia of Genetics, Genomics, Proteomics, and Informatics

Encyclopedia of Genetics, Genomics, Proteomics, and Informatics
Author: George P. Rédei
Publsiher: Springer Science & Business Media
Total Pages: 2201
Release: 2008-04-25
ISBN 10: 1402067534
ISBN 13: 9781402067532
Language: EN, FR, DE, ES & NL

Encyclopedia of Genetics, Genomics, Proteomics, and Informatics Book Review:

This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.