The Human Microbiome in Early Life

The Human Microbiome in Early Life
Author: Omry Koren,Samuli Rautava
Publsiher: Academic Press
Total Pages: 326
Release: 2020-09-18
ISBN 10: 0128180986
ISBN 13: 9780128180983
Language: EN, FR, DE, ES & NL

The Human Microbiome in Early Life Book Review:

The Human Microbiome in Early Life: Implications to Health and Disease presents recent research advances that have highlighted the significance of early life, possibly beginning before birth, in the establishment of both the microbiome and its role in health and disease. The book reviews current knowledge on the origins of the human microbiota in early life, presents exposures which may disturb normal microbial colonization, and covers their implications to the risk of disease. Finally, emerging means to modify the early human microbiome to improve health are discussed. Examines the timeline of the human microbiome, from before conception to infancy, with an emphasis on clinical implications Evaluates the effort to understand not only the composition but also the origin of the microbiome Proves the emerging means to modify the human microbiome and particularly ‘the first 1000 days of life’ improve human health and prevent disease Generates resources to facilitate characterization of the human microbiota to further our understanding of how the microbiome impacts human health and disease

The Developing Microbiome

The Developing Microbiome
Author: Erika Chiong Claud
Publsiher: Academic Press
Total Pages: 240
Release: 2020-05-23
ISBN 10: 0128206179
ISBN 13: 9780128206171
Language: EN, FR, DE, ES & NL

The Developing Microbiome Book Review:

The Developing Microbiome: Lessons from Early Life focuses on the establishment of the microbiome in early life, exposing it as a key mediator of diseases and health throughout the lifecycle. The content presents a comprehensive view of the status of the field and draws real-world correlations to health and disease states. It collates the significant research being done in the pediatric microbiome research space and bridges the knowledge gap showing the factors that impact health and disease states throughout the lifecycle. Finally, it offers knowledge on how the microbiome is and can be manipulated to promote change. This is a perfect reference for both researchers and clinical scientists who are interested in the role of the infant microbiome in health and disease, as well as gastroenterologists and pediatricians looking to affect change in their patients. Provides comprehensive coverage of the factors that influence microbiome development Links research in pediatric patients to later life stages Examines increasing evidence on the impact of the microbiome beyond the gut

The Gut Microbiome in Health and Disease

The Gut Microbiome in Health and Disease
Author: Dirk Haller
Publsiher: Springer
Total Pages: 356
Release: 2018-07-27
ISBN 10: 3319905457
ISBN 13: 9783319905457
Language: EN, FR, DE, ES & NL

The Gut Microbiome in Health and Disease Book Review:

The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

The Human Microbiome Diet and Health

The Human Microbiome  Diet  and Health
Author: Food Forum,Food and Nutrition Board,Institute of Medicine
Publsiher: National Academies Press
Total Pages: 161
Release: 2013-02-27
ISBN 10: 030926586X
ISBN 13: 9780309265867
Language: EN, FR, DE, ES & NL

The Human Microbiome Diet and Health Book Review:

The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

Let Them Eat Dirt

Let Them Eat Dirt
Author: B. Brett Finlay,Marie-Claire Arrieta
Publsiher: Algonquin Books
Total Pages: 304
Release: 2016-09-20
ISBN 10: 1616206713
ISBN 13: 9781616206710
Language: EN, FR, DE, ES & NL

Let Them Eat Dirt Book Review:

“A must-read . . . Takes you inside a child’s gut and shows you how to give kids the best immune start early in life.” —William Sears, MD, coauthor of The Baby Book Like the culture-changing Last Child in the Woods, here is the first parenting book to apply the latest cutting-edge scientific research about the human microbiome to the way we raise our children. In the two hundred years since we discovered that microbes cause infectious diseases, we’ve battled to keep them at bay. But a recent explosion of scientific knowledge has led to undeniable evidence that early exposure to these organisms is beneficial to a child’s well-being. Our modern lifestyle, with its emphasis on hyper-cleanliness, is taking a toll on children’s lifelong health. In this engaging and important book, microbiologists Brett Finlay and Marie-Claire Arrieta explain how the trillions of microbes that live in and on our bodies influence childhood development; why an imbalance of those microbes can lead to obesity, diabetes, and asthma, among other chronic conditions; and what parents can do--from conception on--to positively affect their own behaviors and those of their children. They describe how natural childbirth, breastfeeding, and solid foods influence children’s microbiota. They also offer practical advice on matters such as whether to sterilize food implements for babies, the use of antibiotics, the safety of vaccines, and why having pets is a good idea. Forward-thinking and revelatory, Let Them Eat Dirt is an essential book in helping us to nurture stronger, more resilient, happy, and healthy kids.

Microbiota in health and disease from pregnancy to childhood

Microbiota in health and disease  from pregnancy to childhood
Author: Pamela D. Browne,Eric Claassen,Michael D. Cabana
Publsiher: Wageningen Academic Publishers
Total Pages: 344
Release: 2017-07-20
ISBN 10: 9086868398
ISBN 13: 9789086868391
Language: EN, FR, DE, ES & NL

Microbiota in health and disease from pregnancy to childhood Book Review:

This book offers a state-of-the-art overview of the vital relationship between human microbiota and infant and child health. Renowned clinical-experimental experts in this field discuss the development of microbiota during early life and review the environmental inputs that affect the developing infant’s gut microbiota, such as early diet and (postnatal) medical interventions. They further describe the interplay between gut microbiota and functional systems of the body, from the immune system to the central nervous system. The book discusses a range of infant and childhood diseases that are associated with microbial changes or dysbiosis, such as gastrointestinal disorders, allergic diseases, autoimmune disorders and respiratory disorders. Additionally mechanisms by which microbial dysbiosis may influence behaviour in infants are discussed. Other topics include the use of current tools in molecular microbiology for microbiota-related research and clinical practice. In the management of particular paediatric disorders, the potential of microbial manipulation with pre- and probiotics during infancy and childhood is increasingly being investigated. This book presents the evidence supporting their use in practice and reviews safety aspects. Microbiota in health and disease: from pregnancy to childhood has the ambition to provide the reader with an overview of the most recent and stunning advances in the field of infant and child microbiota and their role in health, disease and prevention. As such, it is an excellent resource for health care professionals, students and researchers in the field of life sciences.

Adiposity

Adiposity
Author: Jan Gordeladze
Publsiher: BoD – Books on Demand
Total Pages: 296
Release: 2017-03-22
ISBN 10: 953512997X
ISBN 13: 9789535129974
Language: EN, FR, DE, ES & NL

Adiposity Book Review:

This book is the second in a series of two, featuring the Adiposity - Omics and Molecular Understanding, serving as an introduction to modern views on how the adipocytes are reciprocally interacting with organ systems in order to explain the biology of the body's fat cells and how they are integrated with other organ systems, like muscle cells and the liver, in order to control the lipid metabolism in our bodies, to finally preserve a positive balance between white and brown/beige adipocyte tissues (WAT and BAT). The understanding of the "omics" of obesity will therefore enable clinicians and researchers to better pursue the untoward incidents of metabolic deviations from a defined and health-bringing homeostasis, with fully responding WAT and BAT, being able to preserve a healthy balance between fat-producing and fat-metabolizing tissues for the benefit of the host, and thus longevity (optimal health with healthy, well-functioning organ systems) throughout a lifetime.

Environmental Chemicals the Human Microbiome and Health Risk

Environmental Chemicals  the Human Microbiome  and Health Risk
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Publsiher: National Academies Press
Total Pages: 122
Release: 2018-03-01
ISBN 10: 0309468698
ISBN 13: 9780309468695
Language: EN, FR, DE, ES & NL

Environmental Chemicals the Human Microbiome and Health Risk Book Review:

A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

Missing Microbes

Missing Microbes
Author: Martin Blaser
Publsiher: Harper Collins
Total Pages: 288
Release: 2014-04-08
ISBN 10: 1443420255
ISBN 13: 9781443420259
Language: EN, FR, DE, ES & NL

Missing Microbes Book Review:

A critical call to arms about the harmful effects of some of our most revered modern medical practices. Welcome to the wilds of the microbiome, where for hundreds of thousands of years bacterial and human cells have co-existed in a peaceful symbiosis that is responsible for the equilibrium and health of our bodies. But now this invisible Eden is under assault. Our overreliance on medical advances such as antibiotics and Cesarean sections is threatening the extinction of these irreplaceable microbes and leading to severe health problems. In Missing Microbes, Dr. Martin Blaser goes back to the discovery of antibiotics, which ushered in a golden age of medicine, and traces how our subsequent overuse of these supposed wonder drugs has left its mark on our systems and contributed to the rise of what Blaser calls our modern plagues: obesity, asthma, allergies, diabetes and certain forms of cancer. Blaser's studies suggest that antibiotic use during early childhood poses the greatest risk to long-term health; alarmingly, American children receive on average seventeen courses of antibiotics before they are twenty years old. His studies also suggest that C-sections deprive babies of important contact with their mothers' microbiomes. Taking us into the lab to explain his groundbreaking studies, Blaser not only provides elegant support for his theories but guides us toward avoiding even more catastrophic health problems in the future.

Gut Microbiota

Gut Microbiota
Author: Edward Ishiguro,Natasha Haskey,Kristina Campbell
Publsiher: Academic Press
Total Pages: 208
Release: 2018-01-10
ISBN 10: 0128105429
ISBN 13: 9780128105429
Language: EN, FR, DE, ES & NL

Gut Microbiota Book Review:

Gut Microbiota: Interactive Effects on Nutrition and Health provides a detailed account of gut microbiota research, an exploration of how diet influences gut microbiota and the implications of gut microbiota for health. The book provides a summary of how diet interacts with the gut microbiome and presents practical applications focused on food, supplements and safety. This book provides scientists and clinicians who have an interest in the microbiome with an understanding of the future potential—and limitations—of this tool, as they strive to make use of evidence-based diet information for the maintenance of good health. Consolidates new research on how gut microbiota affects nutrition Identifies how the research applies to food, supplements and safety Provides diet recommendations to improve health Includes case studies from clinical populations Explores how diet influences gut microbiota

The Human Microbiota and Chronic Disease

The Human Microbiota and Chronic Disease
Author: Luigi Nibali,Brian Henderson
Publsiher: John Wiley & Sons
Total Pages: 544
Release: 2016-09-26
ISBN 10: 1118982878
ISBN 13: 9781118982877
Language: EN, FR, DE, ES & NL

The Human Microbiota and Chronic Disease Book Review:

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

The Gut Brain Axis

The Gut Brain Axis
Author: Niall Hyland,Catherine Stanton
Publsiher: Academic Press
Total Pages: 508
Release: 2016-05-13
ISBN 10: 0128025441
ISBN 13: 9780128025444
Language: EN, FR, DE, ES & NL

The Gut Brain Axis Book Review:

The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders. Focuses on specific areas in which the microbiota has been implicated in gut-brain communication Examines common mechanisms and pathways by which the microbiota may influence brain and behavior Identifies novel therapeutic strategies targeted toward the microbiota in the management of brain activity and behavior

10 Human

10  Human
Author: Alanna Collen
Publsiher: HarperCollins
Total Pages: 352
Release: 2015-05-05
ISBN 10: 0062346008
ISBN 13: 9780062346001
Language: EN, FR, DE, ES & NL

10 Human Book Review:

You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony. Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them. In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes. Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.

The Human Microbiota in Health and Disease

The Human Microbiota in Health and Disease
Author: Mike Wilson
Publsiher: Garland Science
Total Pages: 472
Release: 2018-09-03
ISBN 10: 1351068350
ISBN 13: 9781351068352
Language: EN, FR, DE, ES & NL

The Human Microbiota in Health and Disease Book Review:

A human being consists of a mammalian component and a multiplicity of microbes, collectively referred to as the "microbiota" or "microbiome," with which it has a symbiotic relationship. The microbiota is comprised of a variety of communities, the composition of each being dependent on the body site it inhabits. This community variation arises because the numerous locations on a human being provide very different environments, each of which favors the establishment of a distinct microbial community. Each community consists of bacteria, fungi and viruses with, in some cases, archaea and/or protozoa. It is increasingly being recognized that the indigenous microbiota plays an important role in maintaining the health of its human host. However, changes in the overall composition of a microbial community at a body site, or an increase in the proportion of a particular species in that community, can result in disease or other adverse consequences for the host. The Human Microbiota in Health and Disease: An Ecological and Community-Based Approach describes the nature of the various communities inhabiting humans as well as the important roles they play in human health and disease. It discusses techniques used to determine microbial community composition and features a chapter devoted to the many factors that underlie this mammalian–microbe symbiosis. Uniquely, the book adopts an ecological approach to examining the microbial community’s composition at a particular body site and why certain factors can shift a community from a eubiotic to a dysbiotic state. The book is for undergraduates and postgraduates on courses with a module on the indigenous microbiota of humans. It will also be useful to scientists, clinicians, and others seeking information on the human microbiota and its role in health and disease.

The Whole Body Microbiome

The Whole Body Microbiome
Author: B. Brett Finlay OC, PhD,Jessica M. Finlay PhD
Publsiher: Douglas & McIntyre
Total Pages: 329
Release: 2019-02-02
ISBN 10: 1771622210
ISBN 13: 9781771622219
Language: EN, FR, DE, ES & NL

The Whole Body Microbiome Book Review:

Science has made huge leaps in prolonging life through disease prevention and treatment, but microbiologist Brett Finlay and gerontologist Jessica Finlay offer a different—and truly revolutionary—approach to the quest for the fountain of youth. Microbes are the oldest and smallest forms of life on earth, and encompass bacteria, viruses, protozoa, fungi and other microscopic organisms. While some bacteria and viruses can make us sick, normally we coexist peacefully with microbes. In fact, they are essential to our everyday health. Microbes help break down food in the digestive tract, support immune function and protect us from the pathogens we come into contact with on a daily basis. Our well-being is intimately tied to the microbes that surround us—on our cellphones, kitchen sponges, houseplants, pets and desks. In this groundbreaking volume, the authors present current and emerging research on microbial interventions for the full gamut of age-related conditions, from sun spots and wrinkles to Alzheimer’s disease, cancer, osteoporosis, menopause, chronic inflammation and more. The good news is that simple changes to nutrition and lifestyle can promote the right kind of microbial exposure, to improve health whether we’re eighteen or eighty. Incorporating interviews with leading microbiologists, scientific researchers and medical professionals, and with a compelling and proactive approach to cutting-edge science, The Whole-Body Microbiome will appeal to anyone looking to grow old as healthfully and gracefully as possible.

The Human Microbiome

The Human Microbiome
Author: Rebecca E. Hirsch
Publsiher: Twenty-First Century Books
Total Pages: 112
Release: 2016-08-01
ISBN 10: 151241140X
ISBN 13: 9781512411409
Language: EN, FR, DE, ES & NL

The Human Microbiome Book Review:

Trillions and trillions of microbial cells live on and inside your body. A small number of these microbes are unhealthy germs. But most belong on your body and perform essential jobs. Microbes help digest your food, protect you from dangerous germs, and help your body fight disease. Using techniques such as DNA sequencing, scientists are uncovering the many secrets of the human microbiome. Scientists are learning how the foods we eat and the medicines we take, such as microbe-killing antibiotics, can affect the bugs in our bodies. They are learning more and more about this system that keeps us healthy and how we can protect it in return.

Microbiota of the Human Body

Microbiota of the Human Body
Author: Andreas Schwiertz
Publsiher: Springer
Total Pages: 157
Release: 2016-05-09
ISBN 10: 3319312480
ISBN 13: 9783319312484
Language: EN, FR, DE, ES & NL

Microbiota of the Human Body Book Review:

Microbes can now be found in nearly every niche the human body offers. However, the complexity of the microbiota of a given site depends on the particular environmental condition thereof. Only microbes which are able to grow under these conditions, will prevail. Recent publications imply that the microorganisms do not only have multiple, critical consequences for host physiological processes such as postnatal development, immunomodulation and energy supply, but also effects on neurodevelopment, behavior and cognition. Within this book we will focus on the techniques behind these developments, epigenomics and on the various parts of the human body which are inhabited by microorganism such as the mouth, the gut, the skin and the vagina. In addition, chapters are dedicated to the possible manipulations of the microbiota by probiotics, prebiotics and faecal transplantation.

The Microbiome in Prenatal and Neonatal Life

The Microbiome in Prenatal and Neonatal Life
Author: Josef Neu
Publsiher: Academic Press
Total Pages: 160
Release: 2021-01-18
ISBN 10: 0128206098
ISBN 13: 9780128206096
Language: EN, FR, DE, ES & NL

The Microbiome in Prenatal and Neonatal Life Book Review:

The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed. Discusses the critical nonredundant timeframe in a newborn's life during which many factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life Proves that the fetus and uterine membranes are exposed to not only microbes in close proximity but also to microbial products from metabolism of microbes in the mother Shows that since early life periods are a critical window for development, epigenetic and/or immunologic alterations may occur that can affect not only the infant during his/her lifetime but also subsequent generations Gives insight into factors that may affect the newborn microbiome and subsequent development

I Contain Multitudes

I Contain Multitudes
Author: Ed Yong
Publsiher: HarperCollins
Total Pages: 368
Release: 2016-08-09
ISBN 10: 0062368621
ISBN 13: 9780062368621
Language: EN, FR, DE, ES & NL

I Contain Multitudes Book Review:

Joining the ranks of popular science classics like The Botany of Desire and The Selfish Gene, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since Darwin—a “microbe’s-eye view” of the world that reveals a marvelous, radically reconceived picture of life on earth. Every animal, whether human, squid, or wasp, is home to millions of bacteria and other microbes. Ed Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squid with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. It will change both our view of nature and our sense of where we belong in it.

Animal Models for Microbiome Research

Animal Models for Microbiome Research
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publsiher: National Academies Press
Total Pages: 114
Release: 2018-05-23
ISBN 10: 0309463882
ISBN 13: 9780309463881
Language: EN, FR, DE, ES & NL

Animal Models for Microbiome Research Book Review:

The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli, and as a result, researchers have been conducting microbiome studies in other animals. To examine the different animal models researchers employ in microbiome studies and to better understand the strengths and weaknesses of each of these model organisms as they relate to human and nonhuman health and disease, the Roundtable on Science and Welfare in Laboratory Animal Use of the National Academies of Sciences, Engineering, and Medicine convened a workshop in December 2016. The workshop participants explored how to improve the depth and breadth of analysis of microbial communities using various model organisms, the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research, the predictability and translatability of preclinical studies to humans, and strategies for expanding the infrastructure and tools for conducting studies in these types of models. This publication summarizes the presentations and discussions from the workshop.