The Endocannabinoid System

The Endocannabinoid System
Author: Eric Murillo-Rodríguez
Publsiher: Academic Press
Total Pages: 256
Release: 2017-05-12
ISBN 10: 0128096675
ISBN 13: 9780128096673
Language: EN, FR, DE, ES & NL

The Endocannabinoid System Book Review:

The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. Provides an introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain Presents information on neurobiological and cellular studies on the role of the cannabinoid signaling system and its implications in human diseases Includes well-written overviews of the basics of endocannabinoid system structure and function Contains well-illustrated material, with diagrams, charts, and tables Explores compelling case studies and their application to chapters written by experts

The Endocannabinoid System

The Endocannabinoid System
Author: Eric Murillo-Rodríguez
Publsiher: Academic Press
Total Pages: 450
Release: 2017-06-01
ISBN 10: 9780128096666
ISBN 13: 0128096667
Language: EN, FR, DE, ES & NL

The Endocannabinoid System Book Review:

The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field, and shed light on the many brain disorders this biological system is involved in. Written by world-leading experts in the field, the topics covered in this book will have a positive impact in the area of molecular biology, including but not limited to cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. An introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain Provides information on neurobiological and cellular studies on the role of the cannabinoid signalling system and its implications in human diseases Includes well-written overviews of the basics of endocannabinoid system structure and function written by expert authors from all over the world. Well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Medical Cannabis Handbook for Healthcare Professionals

Medical Cannabis Handbook for Healthcare Professionals
Author: Christine Nazarenus
Publsiher: Springer Publishing Company
Total Pages: 300
Release: 2020-01-15
ISBN 10: 0826135730
ISBN 13: 9780826135735
Language: EN, FR, DE, ES & NL

Medical Cannabis Handbook for Healthcare Professionals Book Review:

Helps healthcare professionals to navigate the maze of information and disinformation about medical cannabis Written for all healthcare professionals who are considering including medical cannabis in their treatment plans, this is the first handbook to disseminate all the information needed to advise patients safely and legally. Replete with evidence-based guidelines firmly grounded in the most up-to-date research, this resource covers the historical, legal, and biological context of medical cannabis so healthcare professionals can confidently discuss possible plans with their patients. Medical Cannabis Handbook for Healthcare Professionals delves into the biology of the endocannabinoid system addressing how cannabis interacts with the body, its effects and side effects, and how to manage cannabis-drug interactions. Chapters discuss in detail how to talk to patients, what language providers can and cannot use, protocols for patient-centered dosing, and the variety of available cannabinoid pharmaceuticals. Based on the latest research, this book demonstrates the efficacy of cannabis in treating a broad range of symptoms and conditions. Written for any healthcare professional who might have to answer patient questions about medical cannabis, this handbook dispels common myths and confirms little-known facts about medical cannabis. KEY FEATURES: Delivers the most up-to-date, evidence-based research on medical cannabis to enhance understanding of this complex topic Provides historical, legal, and biological content so that healthcare providers can confidently discuss medical cannabis with patients Dispels common cannabis myths and misinformation Discusses pain management regarding cannabis and opioids Co-published with Medical Marijuana 411, the leading medical cannabis education provider to offer online CME, CPE and CNE courses to health professionals worldwide; and required certifications for dispensary consultants

The endocannabinoid system a key modulator of emotions and cognition

The endocannabinoid system  a key modulator of emotions and cognition
Author: Patrizia Campolongo
Publsiher: Frontiers E-books
Total Pages: 135
Release: 2021
ISBN 10: 2889190854
ISBN 13: 9782889190850
Language: EN, FR, DE, ES & NL

The endocannabinoid system a key modulator of emotions and cognition Book Review:

Behavioral Neurobiology of the Endocannabinoid System

Behavioral Neurobiology of the Endocannabinoid System
Author: Dave Kendall,Stephen Alexander
Publsiher: Springer Science & Business Media
Total Pages: 420
Release: 2009-08-14
ISBN 10: 9783540889557
ISBN 13: 3540889558
Language: EN, FR, DE, ES & NL

Behavioral Neurobiology of the Endocannabinoid System Book Review:

The endocannabinoid signaling system is a key modulator of central nervous function. This volume, essential reading for interested neuroscientists, provides in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior.

Cannabinoids in Health and Disease

Cannabinoids in Health and Disease
Author: Rosaria Meccariello,Rosanna Chianese
Publsiher: BoD – Books on Demand
Total Pages: 258
Release: 2016-06-15
ISBN 10: 9535124293
ISBN 13: 9789535124290
Language: EN, FR, DE, ES & NL

Cannabinoids in Health and Disease Book Review:

This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.

New Tools to Interrogate Endocannabinoid Signalling

New Tools to Interrogate Endocannabinoid Signalling
Author: Mauro Maccarrone
Publsiher: Royal Society of Chemistry
Total Pages: 458
Release: 2020-11-13
ISBN 10: 1839160853
ISBN 13: 9781839160851
Language: EN, FR, DE, ES & NL

New Tools to Interrogate Endocannabinoid Signalling Book Review:

Legalization of cannabis extracts around the world has led to a resurgence of interest into research surrounding endocannabinoids (eCBs) and the endocannabinoid system. This system is formed of a complex array of receptors, metabolic enzymes and transporters that finely tune the manifold biological activities of eCBs and there is an urgent need for the development of selective drugs to dissect the contribution of eCBs to the aetiology of various diseases. New Tools to Interrogate Endocannabinoid Signalling comprehensively covers the innovative research into both natural and synthetic compounds that affect this pathway and taking a target-based approach, assesses their potential for therapeutic use. With contributions from global leaders in the field, this timely volume will be a valuable resource to pharmaceutical researchers and medicinal chemists working in natural products and endocannabinoid drug discovery in academia and industry.

The Endocannabinoid System and Cannabis

The Endocannabinoid System and Cannabis
Author: Scott A. Johnson
Publsiher: Scott A. Johnson Professional Writing Services LLC
Total Pages: 168
Release: 2019-03-07
ISBN 10: 9780997548754
ISBN 13: 0997548754
Language: EN, FR, DE, ES & NL

The Endocannabinoid System and Cannabis Book Review:

Improve your physical, mental, and emotional health with the plant that is rewriting medicine as we know it. An ancient system designed to protect and heal, the endocannabinoid system is a group of receptors, molecules, and enzymes crucial to optimum health. The Endocannabinoid System and Cannabis: A Perfect Partnership for Self-Regulation and Healing explores how this ancient system works and how the cannabis plant provides molecules that can heal and regulate multiple body functions. Whether an experienced cannabis user or a first-time explorer, you'll be empowered to use cannabis to improve your health and feel better.

Cannabis as Medicine

Cannabis as Medicine
Author: Betty Wedman-St.Louis
Publsiher: CRC Press
Total Pages: 312
Release: 2019-09-26
ISBN 10: 0429620047
ISBN 13: 9780429620041
Language: EN, FR, DE, ES & NL

Cannabis as Medicine Book Review:

For hundreds of years cannabis has been used as a therapeutic medicine around the world. Cannabis was an accepted medicine during the second half of the 19th century, but its use declined because single agent pain medications were advocated by physicians who demanded standardization of medicines. It was not until 1964 when the chemical structure of THC (delta 9-tetrahydrocannabinol) was elucidated and its pharmacological effects began to be understood. Numerous therapeutic effects of cannabis have been reviewed, but cannabis-based medicines are still an enigma because of legal issues. Many patients could benefit from cannabinoids, terpenoids and flavonoids found in Cannabis sativa L. These patients suffer from medical conditions including chronic pain, chronic inflammatory diseases, neurological disorders, and other debilitating illnesses. As more states are legalizing medical cannabis, prescribers need a reliable source which provides clinical information in a succinct format. This book focuses on the science of cannabis as an antioxidant and anti-inflammatory supplement. It discusses cannabis uses in the human body for bone health/osteoporosis; brain injury and trauma; cancer; diabetes; gastrointestinal conditions; mental health disorders; insomnia; pain; anxiety disorders; depression; migraines; eye disorders; and arthritis and inflammation. There is emphasis on using the whole plant — from root to raw leaves and flowers discussing strains, extraction and analysis, and use of cannabis-infused edibles. Features: Provides an understanding of the botanical and biochemistry behind cannabis as well as its use as a dietary supplement. Discusses endocannabinoid system and cannabinoid receptors. Includes information on antioxidant benefits, pain receptors using cannabinoids, and dosage guidelines. Presents research on cannabis treatment plans, drug-cannabis interactions and dosing issues, cannabis vapes, edibles, creams, and suppositories. Multiple appendices including a glossary of cannabis vocabulary, how to use cannabis products, a patient guide and recipes as well as information on cannabis for pets.

The Body Systems and the Endocannabinoid System ECS

The Body Systems and the Endocannabinoid System  ECS
Author: Elise Bailey
Publsiher: ECS Training Alliance Press
Total Pages: 45
Release: 2020-02-16
ISBN 10: 1928374650XXX
ISBN 13: 9182736450XXX
Language: EN, FR, DE, ES & NL

The Body Systems and the Endocannabinoid System ECS Book Review:

This exciting little book is a unique reference guide to the different body systems and the role that the endocannabinoid system (ECS) plays in each. With so many people using cannabinoids and terpenes it is important to understand how these things can influence body signaling. This book is easy to follow with beautiful visual diagrams and important scientific references. It is great for anyone wanting to learn how to better understand the role of the ECS in each body system. The information is intended to assist the reader to gain a basic understanding of the influential role the ECS plays in the body. It has been created for those that want to tap into the ECS using cannabinoids, terpenes, therapeutic grade essential oils, and vital nutrients. It is biology made easy and created for a consumer market. Created by Biologist Elise Bailey The ECS Training Alliance

Role of the Endocannabinoid System in Islets of Langerhans

Role of the Endocannabinoid System in Islets of Langerhans
Author: Chen Li,King's College London. Guy's, King's and St. Thomas's School of Biomedical Sciences. Division of Reproduction & Endocrinology. Diabetes Research Group
Publsiher: Unknown
Total Pages: 458
Release: 2010
ISBN 10: 1928374650XXX
ISBN 13: OCLC:757402354
Language: EN, FR, DE, ES & NL

Role of the Endocannabinoid System in Islets of Langerhans Book Review:

The endocannabinoid system is composed of a family of locally produced endogenous cannabimimetic phospholipid derivatives, the cannabinoid receptors and enzymes for endocannabinoid biosynthesis and degradation. Two subtypes of cannabinoid receptor, CB1 and CB2, have been cloned, and their activation is coupled to inhibition of adenylate cyclase or alterations in Ca2+ levels. The well-known appetite-inducing effects of cannabis are mediated by activation of cannabinoid receptors and the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol (2-AG) are abundantly present in key brain areas participating in the regulation of food intake and satiety. CB1 receptors have been pharmacologically targeted to provide therapies for appetite suppression and there is considerable interest in the regulatory role of CB1 receptors in metabolic balance. Currently, there is little information available on the functional roles of CB2 receptors, nor on the related GPR55 receptor which has been identified as a novel cannabinoid receptor. Given the key roles of islet [3-cells in maintaining fuel homeostasis and the established involvement of the central endocannabinoid system in energy balance regulation, the experiments described in this thesis were designed to investigate the role of the cannabinoid receptors in islet function. -- Initial studies indicated that mRNAs encoding the classical (CB1, CB2) and novel (GPRS5) cannabinoid receptors were expressed by mouse insulinoma (MIN6) (3-cells, and by mouse and human islets as well as enzymes involved in endocannabinoid biosynthesis (DAG-lipase) and degradation (FAAH and MGL). Receptor proteins of both CB1 and CB2 receptors were also found to be present in mouse and human islets by western blotting.

The Endocannabinoidome

The Endocannabinoidome
Author: Vincenzo Di Marzo,Jenny Wang
Publsiher: Academic Press
Total Pages: 208
Release: 2014-09-18
ISBN 10: 0128004290
ISBN 13: 9780128004296
Language: EN, FR, DE, ES & NL

The Endocannabinoidome Book Review:

The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is dedicated to the latest research and studies on endocannabinoids and cannabinoid receptors to illustrate their important role in the discovery of new, endocannabinoid-related, lipid mediators. Written by leading experts across different disciplines, this book focuses on the biochemical and anlayticial aspects of novel lipid signals, their pharmacological activities and their potential utilization for the development of new and effective therapeutic strategies. The first book of its kind, The Endocannabinoidome is a meaningful reference for all those involved in experimental efforts to further the development of this field. Explores the novel and exciting aspects of several endocannabinoid-like molecules for which researchers are still seeking a function Discusses the novel metabolic pathways for endocannabinoids in order to explain the failure of some clinical trials with inhibitors of more conventional metabolic pathways Incorporates pharmacology, biochemistry and potential clinical applications to provide researchers with a complete look at endocannabinoids

Healing with Cannabis

Healing with Cannabis
Author: Cheryl Pellerin
Publsiher: Simon and Schuster
Total Pages: 256
Release: 2020-08-04
ISBN 10: 1510751904
ISBN 13: 9781510751903
Language: EN, FR, DE, ES & NL

Healing with Cannabis Book Review:

An Informative Read for an Audience Interested in Why and How Medical Cannabis Helps Treat a Range of Illnesses—Maybe All of Them With cannabis approved in fourteen states (including the District and two US territories), medical cannabis approved in at least 35 states, and hemp (very-low-THC cannabis) off the controlled substances list, millions now treat their ills with medical cannabis or non-intoxicating cannabinoids like CBD. But lots of them don’t know why or how cannabis works in the body. Healing with Cannabis informs readers about an ancient biological system newly discovered in every vertebrate on the planet—the endocannabinoid system. This system is the only reason cannabis works in the body, and it’s why cannabis is effective in a broad range of disorders. The book offers an informal tone, a little humor, interviews with some of the most knowledgeable cannabinoid scientists, color images, and a selection of research and clinical trials to recount the story of the endocannabinoid system, its origins in the earliest forms of life on Earth, the evolution of its elements, and the discoveries, millions of years later, of more of its elements over time. Healing with Cannabis explains the surprising reasons evolution conserved the endocannabinoid system over a billion years and tells specifically how cannabis has positive effects on some of society’s most devastating illnesses, including neurodegenerative diseases, post-traumatic stress disorder, pain, movement disorders, cancer and chemotherapy, and addiction. The book also shows how medical cannabis, widely available, will change the face of public health, and how nearly everyone can benefit from this versatile medicine that has a 5,000-year history of safe and effective use.

Endocannabinoid Signaling

Endocannabinoid Signaling
Author: Mauro Maccarrone
Publsiher: Humana Press
Total Pages: 267
Release: 2016-03-11
ISBN 10: 9781493935376
ISBN 13: 1493935372
Language: EN, FR, DE, ES & NL

Endocannabinoid Signaling Book Review:

This volume encompasses all major methodologies to interrogate endocannabinoid systems (ECS) and endocannabinoids (eCBs) signaling. With increasing interest towards the manifold activities of eCBs, this book discusses the chemical, biochemical, and molecular biological assays, and activity of distinct elements of the ECS. These include membrane, nuclear receptors, biosynthetic and hydrolytic enzymes, and membrane transporters and oxidative enzymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Timely and cutting edge, Endocannabinoid Signaling: Methods and Protocols is a valuable resource and will help chemists, drug designers, biochemists, molecular biologists, cell biologists, pharmacologists, and (electro) physiologists navigate the mare magnum of endocannabinoid research.

The Endocannabinoid System in Local and Systemic Inflammation

The Endocannabinoid System in Local and Systemic Inflammation
Author: Melanie E. M. Kelly,Christian Lehmann,Juan Zhou
Publsiher: Biota Publishing
Total Pages: 192
Release: 2017-03-29
ISBN 10: 1615047492
ISBN 13: 9781615047499
Language: EN, FR, DE, ES & NL

The Endocannabinoid System in Local and Systemic Inflammation Book Review:

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Endocannabinoids Molecular Pharmacological Behavioral and Clinical Features

Endocannabinoids  Molecular  Pharmacological  Behavioral and Clinical Features
Author: Eric Murillo-Rodríguez,Emmanuel S. Onaivi,Nissar A. Darmani,Edward Wagner
Publsiher: Bentham Science Publishers
Total Pages: 223
Release: 2013-09-10
ISBN 10: 1608050289
ISBN 13: 9781608050284
Language: EN, FR, DE, ES & NL

Endocannabinoids Molecular Pharmacological Behavioral and Clinical Features Book Review:

The endocannabinoid system comprises at least two G-protein-coupled receptors (the cannabinoid CB1 and CB2 receptors) activated by marijuana’s psychoactive principle ∆9-tetrahydrocannabinol (THC) and the endogenous ligands known as endocannabinoids. The apex of endocannabinoid research seems to have been reached with the clinical development, and also in some cases, the marketing, of synthetic or natural pharmaceuticals targeting this signalling system, which followed the understanding of the physiological and pathological role of endocannabinoids in several conditions, a role that was investigated first in rodent experimental models and then in humans. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail.

Cannabinoids and Pain

Cannabinoids and Pain
Author: Samer N. Narouze
Publsiher: Springer Nature
Total Pages: 339
Release: 2021
ISBN 10: 3030691861
ISBN 13: 9783030691868
Language: EN, FR, DE, ES & NL

Cannabinoids and Pain Book Review:

This book presents a well-balanced view of the potential medical use of cannabinoids in pain. It comprehensively covers the current challenges with medical cannabis utilization and provides recommendations for research and future directions. Organized into nine sections, the book begins with an introduction to medical cannabis, including its history, regulations, and the general attitudes of pain physicians on cannabis. Section two explores the biological effects of marijuana via the endocannabinoid system and its complex structure of receptors and enzymes. Sections three, four, and five then delve further into pharmacology and the mechanisms of action applicable to cannabinoids in managing pain. Timely and socially conscious, section six examines the benefits of substituting opioids with cannabinoids for preoperative management. Echoing the book's well-rounded content, sections seven and eight consider the challenges with medical cannabis, including safety and quality control, brain development risks, vaping hazards, and withdrawal. The book then closes with a look at the future of cannabis in medical research. Thoroughly and equitably composed, Cannabinoids and Pain is an invaluable resource for primary care physicians, pain and palliative care physicians, and oncologists.

Abdominal Obesity and the Endocannabinoid System

Abdominal Obesity and the Endocannabinoid System
Author: Jean-Pierre Despres,Vincenzo Di Marzo
Publsiher: CRC Press
Total Pages: 264
Release: 2008-11-24
ISBN 10: 9781420060843
ISBN 13: 1420060848
Language: EN, FR, DE, ES & NL

Abdominal Obesity and the Endocannabinoid System Book Review:

This internationally renowned author team provides a unique and thorough analysis and distillation of the endocannabinoid system and its relationship to abdominal obesity, diabetes, and cardiovascular disease. The endocannabinoid system (ECS) plays an important role in cardiometabolic risk, as well as modulating energy balance, feeding behavior, hepatic lipogenesis, and perhaps glucose homeostasis. Evidence suggests that the ECS is overactive in human obesity and dyslipidemia. Critical to the management of cardiometabolic risk, this new, timely book provides practical overviews and management guidance on many important topics, including: abdominal obesity and the metabolic syndrome the endocannabinoid system and energy balance: functions and dysfunctions abdominal obesity, the EC system, and cardiometabolic risk

Translational Pain Research

Translational Pain Research
Author: Lawrence Kruger,Alan R Light
Publsiher: CRC Press
Total Pages: 432
Release: 2009-11-24
ISBN 10: 1439812101
ISBN 13: 9781439812105
Language: EN, FR, DE, ES & NL

Translational Pain Research Book Review:

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Endocannabinoids

Endocannabinoids
Author: Emmanuel S Onaivi,Takayuki Sugiura,Vincenzo Di Marzo
Publsiher: CRC Press
Total Pages: 584
Release: 2005-11-01
ISBN 10: 9781420023640
ISBN 13: 1420023640
Language: EN, FR, DE, ES & NL

Endocannabinoids Book Review:

Over the past decade, there have been major advances in understanding the mechanisms whereby marijuana interacts with the brain in producing psychoactive and potentially therapeutic effects. The discovery of specific gene coding for cannabinoid receptors activated by smoking marijuana, and the finding of endogenous cannabinoids, which also activate the receptors, have transformed cannabinoid research into mainstream science with significant implications in human health and disease Endocannabinoids: The Brain and Body’s Marijuana and Beyond documentsadvances in the discovery and functioning of naturally occurring marijuana-like substances in human biology. It explores recent findings that point to the existence of an endocannabinoid physiological control system (EPCS) that directly impacts human development, health, and disease. While cannabinoid effects on the brain have received the greatest attention throughout the literature, this work looks at research on the endogenous cannabinoid system’s association across all of human physiology, including the immune, endocrine, and reproductive systems. With thoroughly researched and exceptionally insightful contributions from more than three-dozen top-flight researchers representing a cross-section of disciplines from molecular biology, genetics, and neurology to gynecology, physiology, and pharmacology, this work explores a range of topics as wide as the human body is complex. These topics include the EPCS’s relation to cell development and regulation, CNS function, immune function modulation, reproduction, and digestion, as well as its function in mental illness, neurodegenerative diseases, and cancer. The final section in the book considers the significance of endogenous cannabinoids found in some of the simplest multicellular organisms in the animal kingdom, as well as in mammalian cells at the earliest stages of development, all of which suggests that they play a fundamental role in human biology. Enocannabinoids: The Brain and Body’s Marijuana and Beyond explores areas that few books have ventured into, providing cutting-edge information that will ultimately help us better understand human biology at the systemic and perhaps even cellular level, as well as lead to the development of a whole new range of medications.