The Developing Microbiome

The Developing Microbiome
Author: Erika Chiong Claud
Publsiher: Academic Press
Total Pages: 240
Release: 2020-05-23
ISBN 10: 0128206179
ISBN 13: 9780128206171
Language: EN, FR, DE, ES & NL

The Developing Microbiome Book Review:

The Developing Microbiome: Lessons from Early Life focuses on the establishment of the microbiome in early life, exposing it as a key mediator of diseases and health throughout the lifecycle. The content presents a comprehensive view of the status of the field and draws real-world correlations to health and disease states. It collates the significant research being done in the pediatric microbiome research space and bridges the knowledge gap showing the factors that impact health and disease states throughout the lifecycle. Finally, it offers knowledge on how the microbiome is and can be manipulated to promote change. This is a perfect reference for both researchers and clinical scientists who are interested in the role of the infant microbiome in health and disease, as well as gastroenterologists and pediatricians looking to affect change in their patients. Provides comprehensive coverage of the factors that influence microbiome development Links research in pediatric patients to later life stages Examines increasing evidence on the impact of the microbiome beyond the gut

The Human Microbiome in Early Life

The Human Microbiome in Early Life
Author: Omry Koren,Samuli Rautava
Publsiher: Academic Press
Total Pages: 326
Release: 2020-09-18
ISBN 10: 0128180986
ISBN 13: 9780128180983
Language: EN, FR, DE, ES & NL

The Human Microbiome in Early Life Book Review:

The Human Microbiome in Early Life: Implications to Health and Disease presents recent research advances that have highlighted the significance of early life, possibly beginning before birth, in the establishment of both the microbiome and its role in health and disease. The book reviews current knowledge on the origins of the human microbiota in early life, presents exposures which may disturb normal microbial colonization, and covers their implications to the risk of disease. Finally, emerging means to modify the early human microbiome to improve health are discussed. Examines the timeline of the human microbiome, from before conception to infancy, with an emphasis on clinical implications Evaluates the effort to understand not only the composition but also the origin of the microbiome Proves the emerging means to modify the human microbiome and particularly ‘the first 1000 days of life’ improve human health and prevent disease Generates resources to facilitate characterization of the human microbiota to further our understanding of how the microbiome impacts human health and disease

Microbiota in health and disease from pregnancy to childhood

Microbiota in health and disease  from pregnancy to childhood
Author: Pamela D. Browne,Eric Claassen,Michael D. Cabana
Publsiher: Wageningen Academic Publishers
Total Pages: 344
Release: 2017-07-20
ISBN 10: 9086868398
ISBN 13: 9789086868391
Language: EN, FR, DE, ES & NL

Microbiota in health and disease from pregnancy to childhood Book Review:

This book offers a state-of-the-art overview of the vital relationship between human microbiota and infant and child health. Renowned clinical-experimental experts in this field discuss the development of microbiota during early life and review the environmental inputs that affect the developing infant’s gut microbiota, such as early diet and (postnatal) medical interventions. They further describe the interplay between gut microbiota and functional systems of the body, from the immune system to the central nervous system. The book discusses a range of infant and childhood diseases that are associated with microbial changes or dysbiosis, such as gastrointestinal disorders, allergic diseases, autoimmune disorders and respiratory disorders. Additionally mechanisms by which microbial dysbiosis may influence behaviour in infants are discussed. Other topics include the use of current tools in molecular microbiology for microbiota-related research and clinical practice. In the management of particular paediatric disorders, the potential of microbial manipulation with pre- and probiotics during infancy and childhood is increasingly being investigated. This book presents the evidence supporting their use in practice and reviews safety aspects. Microbiota in health and disease: from pregnancy to childhood has the ambition to provide the reader with an overview of the most recent and stunning advances in the field of infant and child microbiota and their role in health, disease and prevention. As such, it is an excellent resource for health care professionals, students and researchers in the field of life sciences.

The Role of the Developing Microbiome in Mucosal Defense of the Neonatal Gut

The Role of the Developing Microbiome in Mucosal Defense of the Neonatal Gut
Author: Emily G. Blosser
Publsiher: Unknown
Total Pages: 90
Release: 2014
ISBN 10: 1928374650XXX
ISBN 13: OCLC:978270843
Language: EN, FR, DE, ES & NL

The Role of the Developing Microbiome in Mucosal Defense of the Neonatal Gut Book Review:

Neonatal late-onset sepsis is invasive infection occurring after the first 48 hours of life, and one of the leading causes of death among preterm infants in the United States and abroad. Infections with Gram-negative bacteria, such as Klebsiella pneumoniae, occurring when bacteria translocate across premature gut epithelium into the bloodstream, can be particularly severe. Preterm infants in the neonatal intensive care unit undergo intense antibiotic regimens due to high risk of infection. Paradoxically, prolonged exposure of preterm infants to empiric antibiotic therapy early in the hospital stay is associated with increased risk of intestinal infection and death after adjustment for covariates. Bacterial translocation rates across mature gut epithelium are determined by complex interactions between the host’s commensal microbiota and immune system, and pathogens. Commensal microbes are believed to confer protection from bacterial translocation by competing with pathogens for space and resources, and by inducing gut immune system development directly. This study explores the role of gut microbial colonization early in life in protecting neonates from invading pathogens and in inducing gut maturation. The execution of these studies relies heavily on a mouse model of lateonset sepsis we developed in which an engineered bioluminescent strain of Klebsiella pneumoniae can be imaged in real-time within live animals. MiSeq high-throughput sequencing for bacterial 16S was used to elucidate the kinetics of colonization in pups from birth to weaning age. Sequencing revealed an important trend in colonization that early colony founders are hearty, ubiquitous species that may help prime the gut environment for colonization by microbes with stricter environmental or nutritional limitations, such as anaerobes. Importantly, our analyses demonstrate that although the maternal-derived colonization plays a critical role in early colonization of her pups, exposure to vaginal flora is not necessary for successful early colonization. Further, maternal antibiotics were found to drastically change the microbial landscape in young pups with downstream detrimental effects on resistance to Klebsiella challenge depending on the type of antibiotic administered. This novel mouse model affords us the opportunity to examine gut and colony maturation more closely. Data acquired from these studies provides new insights into the etiology of neonatal late-onset sepsis that may become important for treatment and prevention of the human disease.

Let Them Eat Dirt

Let Them Eat Dirt
Author: B. Brett Finlay,Marie-Claire Arrietta
Publsiher: Greystone Books
Total Pages: 999
Release: 2016-09-06
ISBN 10: 1771642556
ISBN 13: 9781771642552
Language: EN, FR, DE, ES & NL

Let Them Eat Dirt Book Review:

Our over-sanitized world threatens children’s health, but parents can change their environment into one where they’ll thrive. Babies and young kids are being raised in surroundings that are increasingly cleaner, more hyper hygienic, and more disinfected than ever before. As a result, the beneficial bacteria in their bodies is being altered, promoting conditions and diseases such as obesity, diabetes, asthma, allergies, and autism. As Let Them Eat Dirt shows, there is much that parents can do about this, including breastfeeding if possible, getting a dog, and avoiding antibiotics unless necessary—and yes, it is OK to let kids get a bit dirty.

The Microbiome in Prenatal and Neonatal Life

The Microbiome in Prenatal and Neonatal Life
Author: Josef Neu
Publsiher: Academic Press
Total Pages: 160
Release: 2021-01-13
ISBN 10: 0128206098
ISBN 13: 9780128206096
Language: EN, FR, DE, ES & NL

The Microbiome in Prenatal and Neonatal Life Book Review:

The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed. Discusses the critical nonredundant timeframe in a newborn's life during which many factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life Proves that the fetus and uterine membranes are exposed to not only microbes in close proximity but also to microbial products from metabolism of microbes in the mother Shows that since early life periods are a critical window for development, epigenetic and/or immunologic alterations may occur that can affect not only the infant during his/her lifetime but also subsequent generations Gives insight into factors that may affect the newborn microbiome and subsequent development

Development of the Preterm Infant Gut Microbiome

Development of the Preterm Infant Gut Microbiome
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2014
ISBN 10: 1928374650XXX
ISBN 13: OCLC:930078106
Language: EN, FR, DE, ES & NL

Development of the Preterm Infant Gut Microbiome Book Review:

The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. In conclusion, the study speculates about how the VLBW infants' gut microbiome might function through host-microbe interactions to contribute to the sequelae of preterm birth, including its influence on growth, development, and general health of the infant host.

The Human Microbiome Diet and Health

The Human Microbiome  Diet  and Health
Author: Food Forum,Food and Nutrition Board,Institute of Medicine
Publsiher: National Academies Press
Total Pages: 161
Release: 2013-02-27
ISBN 10: 030926586X
ISBN 13: 9780309265867
Language: EN, FR, DE, ES & NL

The Human Microbiome Diet and Health Book Review:

The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

Gut Feelings

Gut Feelings
Author: Alessio Fasano,Susie Flaherty
Publsiher: MIT Press
Total Pages: 552
Release: 2021-03-16
ISBN 10: 0262044277
ISBN 13: 9780262044271
Language: EN, FR, DE, ES & NL

Gut Feelings Book Review:

Why the microbiome--our rich inner ecosystem of microorganisms--may hold the keys to human health. We are at the dawn of a new scientific revolution. Our understanding of how to treat and prevent diseases has been transformed by knowledge of the microbiome--the rich ecosystem of microorganisms that is in and on every human. These microbial hitchhikers may hold the keys to human health. In Gut Feelings, Alessio Fasano and Susie Flaherty show why we must go beyond the older, myopic view of microorganisms as our enemies to a broader understanding of the microbiome as a parallel civilization that we need to understand, respect, and engage with for the benefit of our own health.

Skin Microbiome Handbook

Skin Microbiome Handbook
Author: Nava Dayan
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2020-08-11
ISBN 10: 1119593042
ISBN 13: 9781119593041
Language: EN, FR, DE, ES & NL

Skin Microbiome Handbook Book Review:

The idea to compile and edit the book is the result of over a decade of work by the editor, Dr. Nava Dayan, on various projects related to skin barrier, innate immunity, microbiome, developing products, testing methods and paths of products to the market, both for pharmaceutical and the cosmetic industries. The book is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome and oral-skin interaction, skin microbiome observational research, skin microbiome in disequilibrium and disease, skin’s innate immunity, testing and study design, regulatory and legal aspects for skin microbiome related products. The 18 chapters of the book are written by carefully selected leaders in the academia, industry exhibiting extensive experience and understanding in the areas of interest.

The Microbiome

The Microbiome
Author: Anonim
Publsiher: Academic Press
Total Pages: 194
Release: 2020-10-23
ISBN 10: 0128207981
ISBN 13: 9780128207987
Language: EN, FR, DE, ES & NL

The Microbiome Book Review:

The Microbiome, Volume 176, assembles known facts and provides guidance for their implementation on topics relating to associations between the gut microbiome and personality traits, depression, anxiety, autism, schizophrenia, cognition, dementia and neurodegeneration. Additionally, this volume considers the influence of the maternal microbiome on brain development, with chapters covering Intervention, prevention, and the brain: prebiotics, probiotics, and fecal transplants, The microbiota-gut-brain axis: focus on the fundamental communication pathways, and Microbiome composition and locations. Provides a comprehensive review of the bidirectional interactions between gut microbes and the brain Includes data across the lifespan Focuses on microbiome related therapies with broad appeal within, and beyond, the medical and scientific community

The Gut Brain Axis

The Gut Brain Axis
Author: Niall Hyland,Catherine Stanton
Publsiher: Academic Press
Total Pages: 508
Release: 2016-05-13
ISBN 10: 0128025441
ISBN 13: 9780128025444
Language: EN, FR, DE, ES & NL

The Gut Brain Axis Book Review:

The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders. Focuses on specific areas in which the microbiota has been implicated in gut-brain communication Examines common mechanisms and pathways by which the microbiota may influence brain and behavior Identifies novel therapeutic strategies targeted toward the microbiota in the management of brain activity and behavior


Author: Jan Gordeladze
Publsiher: BoD – Books on Demand
Total Pages: 296
Release: 2017-03-22
ISBN 10: 953512997X
ISBN 13: 9789535129974
Language: EN, FR, DE, ES & NL

Adiposity Book Review:

This book is the second in a series of two, featuring the Adiposity - Omics and Molecular Understanding, serving as an introduction to modern views on how the adipocytes are reciprocally interacting with organ systems in order to explain the biology of the body's fat cells and how they are integrated with other organ systems, like muscle cells and the liver, in order to control the lipid metabolism in our bodies, to finally preserve a positive balance between white and brown/beige adipocyte tissues (WAT and BAT). The understanding of the "omics" of obesity will therefore enable clinicians and researchers to better pursue the untoward incidents of metabolic deviations from a defined and health-bringing homeostasis, with fully responding WAT and BAT, being able to preserve a healthy balance between fat-producing and fat-metabolizing tissues for the benefit of the host, and thus longevity (optimal health with healthy, well-functioning organ systems) throughout a lifetime.

Colorectal Neoplasia and the Colorectal Microbiome

Colorectal Neoplasia and the Colorectal Microbiome
Author: Martin H. Floch
Publsiher: Academic Press
Total Pages: 270
Release: 2020-08-15
ISBN 10: 0128225610
ISBN 13: 9780128225615
Language: EN, FR, DE, ES & NL

Colorectal Neoplasia and the Colorectal Microbiome Book Review:

Colorectal Neoplasia and the Microbiome: Dysplasia, Probiotics, and Fusobacteria provides foundational knowledge on the gut microbiome and evidence for an association with colorectal neoplasia. It covers the role of microbiota in causing adenomatous polyps and colorectal cancer as well as the modulatory effect of diet and probiotics. Chapters explain a foundational history of microbiology in the colon, the epidemiology of colon polyps and cancer, dysbiosis, the role of immunology and bacteria, and the diet. The book combines medical and scientific aspects to show mechanistic aspects between microbiota and hosts, clearly presenting the association between microbiota, colonic lesions and possible causal links. The book is essential reading for everyone working with human microbiota including basic scientists, physiologists of the intestine, experts in intestinal microbiota, gastroenterologists, oncologists and surgeon. Provides foundational background on the complete history of microbiology in the colon Offers thorough coverage of the connection between fusobacterium nucleatum, diet and bacteria on colon health Presents the connection between immunology and bacteria in the colon

Dirt Is Good

Dirt Is Good
Author: Jack Gilbert,Rob Knight
Publsiher: St. Martin's Press
Total Pages: 288
Release: 2017-06-06
ISBN 10: 1250132622
ISBN 13: 9781250132628
Language: EN, FR, DE, ES & NL

Dirt Is Good Book Review:

From two of the world’s top scientists and one of the world’s top science writers (all parents), Dirt Is Good is a q&a-based guide to everything you need to know about kids & germs. “Is it OK for my child to eat dirt?” That’s just one of the many questions authors Jack Gilbert and Rob Knight are bombarded with every week from parents all over the world. They've heard everything from “My two-year-old gets constant ear infections. Should I give her antibiotics? Or probiotics?” to “I heard that my son’s asthma was caused by a lack of microbial exposure. Is this true, and if so what can I do about it now?” Google these questions, and you’ll be overwhelmed with answers. The internet is rife with speculation and misinformation about the risks and benefits of what most parents think of as simply germs, but which scientists now call the microbiome: the combined activity of all the tiny organisms inside our bodies and the surrounding environment that have an enormous impact on our health and well-being. Who better to turn to for answers than Drs. Gilbert and Knight, two of the top scientists leading the investigation into the microbiome—an investigation that is producing fascinating discoveries and bringing answers to parents who want to do the best for their young children. Dirt Is Good is a comprehensive, authoritative, accessible guide you've been searching for.

Diet Microbiome and Health

Diet  Microbiome and Health
Author: Alexandru Mihai Grumezescu,Alina-Maria Holban
Publsiher: Academic Press
Total Pages: 526
Release: 2018-01-02
ISBN 10: 0128114924
ISBN 13: 9780128114926
Language: EN, FR, DE, ES & NL

Diet Microbiome and Health Book Review:

Diet, Microbiome and Health, Volume 11, in the Handbook of Food Bioengineering series, presents the most up-to-date research to help scientists, researchers and students in the field of food engineering understand the different microbial species we have in our guts, why they are important to human development, immunity and health, and how to use that understanding to further promote research to create healthy food products. In addition, the book provides studies that clearly demonstrate how dietary preferences and social behavior significantly impact the diversity of microbial species in the gut and their numeric values, which may balance health and disease. Highlights research discoveries on how gut microbiota influence and are impacted by health and disease Includes information on and examples of healthy foods Discusses gut microbiota in autism, GI disease, neuropsychiatric disorders, obesity and metabolic disease Explores the barrier function of the gut Examines how food preferences impact gut microbiota

Intestinal Microbiome Functional Aspects in Health and Disease

Intestinal Microbiome  Functional Aspects in Health and Disease
Author: E. Isolauri,P.M. Sherman,W.A. Walker
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 176
Release: 2017-03-27
ISBN 10: 3318060313
ISBN 13: 9783318060317
Language: EN, FR, DE, ES & NL

Intestinal Microbiome Functional Aspects in Health and Disease Book Review:

The intestinal microbiome is especially important during the first thousand days of life. Exposure to microbes in utero significantly impacts fetal development, in part through epigenetic processes and in part through hormonal influences which cause a change in the mother's intestinal microbiome. The nature of delivery and perinatal antibiotic treatment, as well as diet (especially in the postpartum period), can also influence initial microbial colonization and the development of appropriate intestinal defense mechanisms. These, in turn, can affect the expression of allergy, autoimmune disease, and brain function, among other things, later in life. The first part of this publication focuses on the development of the human microbiome in utero and the importance of normal colonization of the newborn gut in immune development and disease prevention. The second section deals with the normal development of gut microbiota and with clinical conditions associated with dysbiosis. The final chapters cover various aspects of human milk evolution and oligosaccharides.

The Microbiome Diet

The Microbiome Diet
Author: Raphael Kellman
Publsiher: Da Capo Lifelong Books
Total Pages: 272
Release: 2014-07-01
ISBN 10: 0738217662
ISBN 13: 9780738217666
Language: EN, FR, DE, ES & NL

The Microbiome Diet Book Review:

The groundbreaking program that connects the microbiome and gut health to healthy weight loss, complete with a 3-phase plan and recipes Cutting-edge science has shown that the microbiome is the key to overall mental and physical health--and the secret behind healthy, sustainable weight loss. Drawing on nearly two decades of experience as a specialist in functional medicine and intestinal health, Dr. Raphael Kellman has developed the first diet based on these scientific breakthroughs. Offering a proven program to heal your gut and reset your metabolism, along with meal plans and 50 delicious chef-created recipes, The Microbiome Diet is the key to safe, sustainable weight loss and a lifetime of good health. "Dr. Kellman masterfully presents a life enhancing, actionable plan based on this emerging science in a way that is user-friendly, for all of us." --Dr. David Perlmutter, New York Times bestselling author of Grain Brain

Environmental Chemicals the Human Microbiome and Health Risk

Environmental Chemicals  the Human Microbiome  and Health Risk
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Publsiher: National Academies Press
Total Pages: 122
Release: 2018-03-01
ISBN 10: 0309468698
ISBN 13: 9780309468695
Language: EN, FR, DE, ES & NL

Environmental Chemicals the Human Microbiome and Health Risk Book Review:

A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

Molecular Mechanisms of Inflammation Induction Resolution and Escape by Helicobacter pylori

Molecular Mechanisms of Inflammation  Induction  Resolution and Escape by Helicobacter pylori
Author: Steffen Backert
Publsiher: Springer
Total Pages: 359
Release: 2019-05-23
ISBN 10: 3030151387
ISBN 13: 9783030151386
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Inflammation Induction Resolution and Escape by Helicobacter pylori Book Review:

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world’s population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.