The Design and Development of Novel Drugs and Vaccines

The Design and Development of Novel Drugs and Vaccines
Author: Tarun Kumar Bhatt,Surendra Nimesh
Publsiher: Academic Press
Total Pages: 320
Release: 2021-01-15
ISBN 10: 9780128214718
ISBN 13: 0128214716
Language: EN, FR, DE, ES & NL

The Design and Development of Novel Drugs and Vaccines Book Review:

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development

Human Vaccines

Human Vaccines
Author: Kayvon Modjarrad,Wayne C. Koff
Publsiher: Academic Press
Total Pages: 186
Release: 2016-10-15
ISBN 10: 0128025425
ISBN 13: 9780128025420
Language: EN, FR, DE, ES & NL

Human Vaccines Book Review:

Human Vaccines: Emerging Technologies in Design and Development discusses the advances in molecular biology, biophysics, and informatics—among other disciplines—that have provided scientists with the tools to create new vaccines against emerging and re-emerging pathogens. For example, the virus-like particle technologies that led to licensing of highly efficacious HPV vaccines have only come into full realization in the last 10 years. Their success has, in turn, accelerated the pace with which nanoparticle vaccines are being developed Given the rapidity with which the field is changing and the absence of any text documenting this change, there is a need for a resource that surveys these new vaccine technologies, assesses their potential, and describes their applications. This book provides that resource and complements traditional vaccinology books, but also serves as an excellent standalone for researchers and students with basic knowledge in immunology. Introduces new topics in vaccine immunology in the context vaccine design and production Consolidates the growing body of knowledge on new vaccine technologies that have only emerged in the past 2 – 3 decades Reviews the currently licensed vaccines that have utilized leading-edge technologies and how this has translated into improved efficacy and safety Provides a broad overview of innovative vaccine technologies, including immunological aspects

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies

Novel Approaches and Strategies for Biologics  Vaccines and Cancer Therapies
Author: Manmohan Singh,Maya Salnikova
Publsiher: Academic Press
Total Pages: 520
Release: 2014-12-30
ISBN 10: 012416661X
ISBN 13: 9780124166615
Language: EN, FR, DE, ES & NL

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies Book Review:

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics

Nonclinical Development of Novel Biologics  Biosimilars  Vaccines and Specialty Biologics
Author: Lisa Plitnick,Danuta Herzyk
Publsiher: Academic Press
Total Pages: 432
Release: 2013-06-27
ISBN 10: 0123948231
ISBN 13: 9780123948236
Language: EN, FR, DE, ES & NL

Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics Book Review:

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics. Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical Contains the most pertinent international regulatory guidance documents for nonclinical evaluation Covers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars" A multi-authored book with chapters written by qualified experts in their respective fields

Novel Strategies in the Design and Production of Vaccines

Novel Strategies in the Design and Production of Vaccines
Author: Sara Cohen,Avigdor Shafferman
Publsiher: Springer Science & Business Media
Total Pages: 198
Release: 2013-06-29
ISBN 10: 1489913823
ISBN 13: 9781489913821
Language: EN, FR, DE, ES & NL

Novel Strategies in the Design and Production of Vaccines Book Review:

Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).

Vaccine Development and Manufacturing

Vaccine Development and Manufacturing
Author: Emily P. Wen,Ronald Ellis,Narahari S. Pujar
Publsiher: John Wiley & Sons
Total Pages: 464
Release: 2014-11-17
ISBN 10: 0470261943
ISBN 13: 9780470261941
Language: EN, FR, DE, ES & NL

Vaccine Development and Manufacturing Book Review:

Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

Post Genomic Approaches in Drug and Vaccine Development

Post Genomic Approaches in Drug and Vaccine Development
Author: Kishore R. Sakharkar,Meena K. Sakharkar ,Ramesh Chandra
Publsiher: River Publishers
Total Pages: 450
Release: 2015-04-11
ISBN 10: 8793102844
ISBN 13: 9788793102842
Language: EN, FR, DE, ES & NL

Post Genomic Approaches in Drug and Vaccine Development Book Review:

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: Drug discoveryTarget identification and prioritizationHypothesis driven multi-target drug designGenomics in vaccine developmentGene regulatory networks Vaccine design and developmentPrediction of drug side effects in silico

Development of Novel Vaccines

Development of Novel Vaccines
Author: Alexander von Gabain,Christoph Klade
Publsiher: Springer Science & Business Media
Total Pages: 306
Release: 2012-04-23
ISBN 10: 3709107091
ISBN 13: 9783709107096
Language: EN, FR, DE, ES & NL

Development of Novel Vaccines Book Review:

“Development of novel vaccines” gives an overview of the tasks in basic research leading to the final product – the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.

Development of Vaccines

Development of Vaccines
Author: Manmohan Singh,Indresh K. Srivastava
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2011-10-11
ISBN 10: 9781118023631
ISBN 13: 1118023633
Language: EN, FR, DE, ES & NL

Development of Vaccines Book Review:

Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experiences of toxicology testing and regulatory filing for vaccines is also included.

Preventing Chemical Weapons

Preventing Chemical Weapons
Author: Michael Crowley,Malcolm Dando,Lijun Shang
Publsiher: Royal Society of Chemistry
Total Pages: 652
Release: 2018-08-20
ISBN 10: 1788014723
ISBN 13: 9781788014724
Language: EN, FR, DE, ES & NL

Preventing Chemical Weapons Book Review:

The life and chemical sciences are in the midst of a period of rapid and revolutionary transformation that will undoubtedly bring societal benefits but also have potentially malign applications, notably in the development of chemical weapons. Such concerns are exacerbated by the unstable international security environment and the changing nature of armed conflict, which could fuel a desire by certain States to retain and use existing chemical weapons, as well as increase State interest in creating new weapons; whilst a broader range of actors may seek to employ diverse toxic chemicals as improvised weapons. Stark indications of the multi-faceted dangers we face can be seen in the chemical weapons attacks against civilians and combatants in Iraq and Syria, and also in more targeted chemical assassination operations in Malaysia and the UK. Using a multi-disciplinary approach, and drawing upon an international group of experts, this book analyses current and likely near-future advances in relevant science and technology, assessing the risks of their misuse. The book examines the current capabilities, limitations and failures of the existing international arms control and disarmament architecture – notably the Chemical Weapons Convention – in preventing the development and use of chemical weapons. Through the employment of a novel Holistic Arms Control methodology, the authors also look beyond the bounds of such treaties, to explore the full range of international law, international agreements and regulatory mechanisms potentially applicable to weapons employing toxic chemical agents, in order to develop recommendations for more effective routes to combat their proliferation and misuse. A particular emphasis is given to the roles that chemical and life scientists, health professionals and wider informed activist civil society can play in protecting the prohibition against poison and chemical weapons; and in working with States to build effective and responsive measures to ensure that the rapid scientific and technological advances are safeguarded from hostile use and are instead employed for the benefit of us all.

Pharmaceutical Biotechnology

Pharmaceutical Biotechnology
Author: Carlos A. Guzmán,Giora Z. Feuerstein
Publsiher: Springer Science & Business Media
Total Pages: 276
Release: 2010-01-01
ISBN 10: 9781441911322
ISBN 13: 1441911324
Language: EN, FR, DE, ES & NL

Pharmaceutical Biotechnology Book Review:

Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.

Koenig and Schultz s Disaster Medicine

Koenig and Schultz s Disaster Medicine
Author: Kristi L. Koenig,Carl H. Schultz
Publsiher: Cambridge University Press
Total Pages: 782
Release: 2016-04-18
ISBN 10: 1107040752
ISBN 13: 9781107040755
Language: EN, FR, DE, ES & NL

Koenig and Schultz s Disaster Medicine Book Review:

This is the definitive reference on disaster medicine, outlining areas of proficiency for health care professionals handling mass casualty crises.

Vaccinology

Vaccinology
Author: Alan D. T. Barrett
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2015-02-16
ISBN 10: 0470656166
ISBN 13: 9780470656167
Language: EN, FR, DE, ES & NL

Vaccinology Book Review:

Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Pharmaceutical Design And Development

Pharmaceutical Design And Development
Author: T V Ramabhadran
Publsiher: CRC Press
Total Pages: 354
Release: 1994-03-31
ISBN 10: 0203984153
ISBN 13: 9780203984154
Language: EN, FR, DE, ES & NL

Pharmaceutical Design And Development Book Review:

This volume aims to introduce researchers in pharmaceutical and allied industries to the concepts and latest developments in the application of biotechnology recombinant DNA and monoclonal antibodies to drug development.

Biopharmaceutical Drug Design and Development

Biopharmaceutical Drug Design and Development
Author: Susanna Wu-Pong,Yon Rojanasakul
Publsiher: Springer Science & Business Media
Total Pages: 375
Release: 2010-01-11
ISBN 10: 9781597455329
ISBN 13: 1597455326
Language: EN, FR, DE, ES & NL

Biopharmaceutical Drug Design and Development Book Review:

This book provides a comprehensive examination of the newest biopharmaceutical drugs. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, and contains a review of the Human Genome Project.

Molecular Farming of Plants and Animals for Human and Veterinary Medicine

Molecular Farming of Plants and Animals for Human and Veterinary Medicine
Author: L. Erickson,W.-J. Yu,J. Brandle,R. Rymerson
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2002-09-30
ISBN 10: 9781402008351
ISBN 13: 140200835X
Language: EN, FR, DE, ES & NL

Molecular Farming of Plants and Animals for Human and Veterinary Medicine Book Review:

Until recently, agriculture was seen as a minor customer of the pharmaceutical industry. However, as this book amply demonstrates, agriculture may be poised to become a much more important supplier rather than consumer of pharmaceuticals. This book is the most comprehensive and up-to-date compilation of bio-farming strategies to provide health products that are both safer and lower-cost than those produced conventionally. The style and information presented assumes a university undergraduate level of genetics and biology. Technical information regarding the methods used and the results, as well as perspectives on commercialization and regulation, is provided by scientists prominent in this diverse and burgeoning field. This book is an invaluable resource for undergraduate and graduate students, university faculty, and researchers in government and corporate labs, as well as research managers, planners, and consultants in biotechnology.

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
Author: Darren R. Flower,Yvonne Perrie
Publsiher: Springer Science & Business Media
Total Pages: 314
Release: 2012-12-09
ISBN 10: 1461450705
ISBN 13: 9781461450702
Language: EN, FR, DE, ES & NL

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines Book Review:

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles
Author: Pavan Muttil,Nitesh K. Kunda
Publsiher: Springer Nature
Total Pages: 277
Release: 2020-03-18
ISBN 10: 3030359107
ISBN 13: 9783030359102
Language: EN, FR, DE, ES & NL

Mucosal Delivery of Drugs and Biologics in Nanoparticles Book Review:

Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Parasites Molecular Biology Drug and Vaccine Design

Parasites  Molecular Biology  Drug and Vaccine Design
Author: Nina Agabian,Anthony Cerami
Publsiher: Anonim
Total Pages: 504
Release: 1990
ISBN 10:
ISBN 13: UOM:39015017994354
Language: EN, FR, DE, ES & NL

Parasites Molecular Biology Drug and Vaccine Design Book Review:

This wide-ranging collection of edited papers examines the many mechanisms that allow parasites to survive and interact in a host environment. The research explains how a more knowledgeable understanding of host-parasite interactions aids in the development of unique strategies for vaccine design and applied research in clinical diagnostics and therapeutics. Divided into five parts, the text covers gene expression during parasite differentiation and development; the potential for molecular genetics in parasite systems; molecules of the parasite membrane; molecular modeling and parasite drug design; and vaccines.

Modulation of Host Gene Expression and Innate Immunity by Viruses

Modulation of Host Gene Expression and Innate Immunity by Viruses
Author: Peter Palese,Jean-Pierre Changeux
Publsiher: Springer Science & Business Media
Total Pages: 304
Release: 2005-03-08
ISBN 10: 9781402032417
ISBN 13: 1402032412
Language: EN, FR, DE, ES & NL

Modulation of Host Gene Expression and Innate Immunity by Viruses Book Review:

"Infection of a naive (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. Thi sinterplay of host and virus respresents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents."--BACK COVER.