Target Discovery and Validation

Target Discovery and Validation
Author: Alleyn T. Plowright
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2019-12-31
ISBN 10: 3527345299
ISBN 13: 9783527345298
Language: EN, FR, DE, ES & NL

Target Discovery and Validation Book Review:

The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Target Validation in Drug Discovery

Target Validation in Drug Discovery
Author: Brian W. Metcalf,Susan Dillon
Publsiher: Elsevier
Total Pages: 296
Release: 2011-04-28
ISBN 10: 9780080465975
ISBN 13: 0080465978
Language: EN, FR, DE, ES & NL

Target Validation in Drug Discovery Book Review:

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
Author: Jurgen Moll,Riccardo Colombo
Publsiher: Humana Press
Total Pages: 388
Release: 2016-05-01
ISBN 10: 9781493962785
ISBN 13: 1493962787
Language: EN, FR, DE, ES & NL

Target Identification and Validation in Drug Discovery Book Review:

This Methods in Molecular Biology book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports."

In Silico Technologies in Drug Target Identification and Validation

In Silico Technologies in Drug Target Identification and Validation
Author: Darryl Leon,Scott Markel
Publsiher: CRC Press
Total Pages: 504
Release: 2006-06-13
ISBN 10: 1420015737
ISBN 13: 9781420015737
Language: EN, FR, DE, ES & NL

In Silico Technologies in Drug Target Identification and Validation Book Review:

The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Identification and Validation addresses the challenge of testing a growing number of new potential targets and reviews currently available in silico approaches for identifying and validating these targets. The book emphasizes computational tools, public and commercial databases, mathematical methods, and software for interpreting complex experimental data. The book describes how these tools are used to visualize a target structure, identify binding sites, and predict behavior. World-renowned researchers cover many topics not typically found in most informatics books, including functional annotation, siRNA design, pathways, text mining, ontologies, systems biology, database management, data pipelining, and pharmacogenomics. Covering issues that range from prescreening target selection to genetic modeling and valuable data integration, In Silico Technologies in Drug Target Identification and Validation is a self-contained and practical guide to the various computational tools that can accelerate the identification and validation stages of drug target discovery and determine the biological functionality of potential targets more effectively. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 118
Release: 2014-02-06
ISBN 10: 0309292492
ISBN 13: 9780309292498
Language: EN, FR, DE, ES & NL

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book Review:

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Target Discovery and Validation

Target Discovery and Validation
Author: Mouldy Sioud
Publsiher: Springer Science & Business Media
Total Pages: 384
Release: 2007
ISBN 10: 1597451657
ISBN 13: 9781597451659
Language: EN, FR, DE, ES & NL

Target Discovery and Validation Book Review:

Annotation These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.

Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
Author: Jürgen Moll,Sebastian Carotta
Publsiher: Humana Press
Total Pages: 318
Release: 2019-04-12
ISBN 10: 9781493991440
ISBN 13: 1493991442
Language: EN, FR, DE, ES & NL

Target Identification and Validation in Drug Discovery Book Review:

This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Fully updated and authoritative, Target Identification and Validation in Drug Discovery: Methods and Protocols, Second Edition is an ideal guide for molecular and cellular biologists, pharmacologists, pathologists, bioinformaticians, clinical researchers, or investigators, as well as experts in other fields that need a quick overview of these state-of-the-art technologies.

Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
Author: Pierfausto Seneci
Publsiher: Elsevier
Total Pages: 194
Release: 2018-06-05
ISBN 10: 008099928X
ISBN 13: 9780080999289
Language: EN, FR, DE, ES & NL

Chemical Sciences in Early Drug Discovery Book Review:

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery. Reviews the key application of chemistry in drug discovery for both medicinal and non-medicinal chemists, clarifying and explaining the role of medicinal chemistry in supporting the modern drug discovery pipeline Shows how a wider medicinal chemistry view is essential for anyone in an integrated drug discovery project looking to reduce costs and save time Provides the critical success factors needed to successfully identify hits from both biological and chemical perspectives

Comprehensive Analysis of Parasite Biology

Comprehensive Analysis of Parasite Biology
Author: Sylke M?ller,Rachel Cerdan,Ovidiu Radulescu,Paul M. Selzer
Publsiher: John Wiley & Sons
Total Pages: 576
Release: 2016-10-17
ISBN 10: 3527339043
ISBN 13: 9783527339044
Language: EN, FR, DE, ES & NL

Comprehensive Analysis of Parasite Biology Book Review:

Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation
Author: Anonim
Publsiher: Academic Press
Total Pages: 690
Release: 2017-11-21
ISBN 10: 0128130709
ISBN 13: 9780128130704
Language: EN, FR, DE, ES & NL

Platform Technologies in Drug Discovery and Validation Book Review:

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique for its treatment of platform technologies for medicinal chemistry and target validation Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field Presents state-of-the-art summaries of platform technologies

Ion Channel Drug Discovery

Ion Channel Drug Discovery
Author: Brian Cox,Martin Gosling
Publsiher: Royal Society of Chemistry
Total Pages: 384
Release: 2014-09-03
ISBN 10: 1849735085
ISBN 13: 9781849735087
Language: EN, FR, DE, ES & NL

Ion Channel Drug Discovery Book Review:

Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.

Phenotypic Drug Discovery

Phenotypic Drug Discovery
Author: Beverley Isherwood,Angelique Augustin
Publsiher: Royal Society of Chemistry
Total Pages: 272
Release: 2020-12-10
ISBN 10: 1839160799
ISBN 13: 9781839160790
Language: EN, FR, DE, ES & NL

Phenotypic Drug Discovery Book Review:

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

Neurobiology of Huntington s Disease

Neurobiology of Huntington   s Disease
Author: Donald C. Lo,Robert E. Hughes
Publsiher: CRC Press
Total Pages: 338
Release: 2010-07-02
ISBN 10: 1420008250
ISBN 13: 9781420008258
Language: EN, FR, DE, ES & NL

Neurobiology of Huntington s Disease Book Review:

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Anti fibrotic Drug Discovery

Anti fibrotic Drug Discovery
Author: Jehrod Brenneman,Malliga R Iyer
Publsiher: Royal Society of Chemistry
Total Pages: 340
Release: 2020-02-17
ISBN 10: 1839160519
ISBN 13: 9781839160516
Language: EN, FR, DE, ES & NL

Anti fibrotic Drug Discovery Book Review:

Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

Bioinformatics and Computational Biology in Drug Discovery and Development

Bioinformatics and Computational Biology in Drug Discovery and Development
Author: William T. Loging
Publsiher: Cambridge University Press
Total Pages: 248
Release: 2016-02-29
ISBN 10: 0521768004
ISBN 13: 9780521768009
Language: EN, FR, DE, ES & NL

Bioinformatics and Computational Biology in Drug Discovery and Development Book Review:

A comprehensive overview of the use of computational biology approaches in the drug discovery and development process.

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery
Author: Alexander Hillisch,Rolf Hilgenfeld
Publsiher: Birkhäuser
Total Pages: 292
Release: 2012-11-28
ISBN 10: 3034879970
ISBN 13: 9783034879972
Language: EN, FR, DE, ES & NL

Modern Methods of Drug Discovery Book Review:

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Drug Discovery in Africa

Drug Discovery in Africa
Author: Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa
Publsiher: Springer Science & Business Media
Total Pages: 440
Release: 2012-08-09
ISBN 10: 3642281753
ISBN 13: 9783642281754
Language: EN, FR, DE, ES & NL

Drug Discovery in Africa Book Review:

Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development
Author: Ali S. Faqi
Publsiher: Academic Press
Total Pages: 986
Release: 2016-11-03
ISBN 10: 0128036214
ISBN 13: 9780128036211
Language: EN, FR, DE, ES & NL

A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book Review:

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Artificial Neural Network for Drug Design Delivery and Disposition

Artificial Neural Network for Drug Design  Delivery and Disposition
Author: Munish Puri,Yashwant Pathak,Vijay Kumar Sutariya,Srinivas Tipparaju,Wilfrido Moreno
Publsiher: Academic Press
Total Pages: 440
Release: 2015-10-15
ISBN 10: 0128017449
ISBN 13: 9780128017449
Language: EN, FR, DE, ES & NL

Artificial Neural Network for Drug Design Delivery and Disposition Book Review:

Artificial Neural Network for Drug Design, Delivery and Disposition provides an in-depth look at the use of artificial neural networks (ANN) in pharmaceutical research. With its ability to learn and self-correct in a highly complex environment, this predictive tool has tremendous potential to help researchers more effectively design, develop, and deliver successful drugs. This book illustrates how to use ANN methodologies and models with the intent to treat diseases like breast cancer, cardiac disease, and more. It contains the latest cutting-edge research, an analysis of the benefits of ANN, and relevant industry examples. As such, this book is an essential resource for academic and industry researchers across the pharmaceutical and biomedical sciences. Written by leading academic and industry scientists who have contributed significantly to the field and are at the forefront of artificial neural network (ANN) research Focuses on ANN in drug design, discovery and delivery, as well as adopted methodologies and their applications to the treatment of various diseases and disorders Chapters cover important topics across the pharmaceutical process, such as ANN in structure-based drug design and the application of ANN in modern drug discovery Presents the future potential of ANN-based strategies in biomedical image analysis and much more

Designing Multi Target Drugs

Designing Multi Target Drugs
Author: J. Richard Morphy,C John Harris
Publsiher: Royal Society of Chemistry
Total Pages: 394
Release: 2012-03-28
ISBN 10: 1849734917
ISBN 13: 9781849734912
Language: EN, FR, DE, ES & NL

Designing Multi Target Drugs Book Review:

Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered accidentally. Written by world renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements and the challenges of the field and importantly the lessons learned by researchers to date and their application to future MTDD.