Systems and Synthetic Metabolic Engineering

Systems and Synthetic Metabolic Engineering
Author: Yanfeng Liu,Guocheng Du,Long Liu
Publsiher: Academic Press
Total Pages: 294
Release: 2020-07-10
ISBN 10: 0128217529
ISBN 13: 9780128217528
Language: EN, FR, DE, ES & NL

Systems and Synthetic Metabolic Engineering Book Review:

Systems and Synthetic Metabolic Engineering provides an overview of the development of metabolic engineering within medicine that is fueled by systems and synthetic biology. These newly developed, successful strategies of metabolic engineering guide the audience on how to propose and test proper strategies for metabolic engineering research. In addition to introductory, regulatory and challenges in the field, the book also covers dynamic control and autonomous regulation to control cell metabolism, along with computational modeling and industrial applications. The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area. Discusses the current progress of metabolic engineering, focusing on systems biology and synthetic biology Covers introductory, regulatory, strategies, production and challenges in the field Written technically for synthetic biologists, researchers, students, industrialists, policymakers and stakeholders

Systems Metabolic Engineering

Systems Metabolic Engineering
Author: Christoph Wittmann,Sang Yup Lee
Publsiher: Springer Science & Business Media
Total Pages: 388
Release: 2012-06-15
ISBN 10: 9400745346
ISBN 13: 9789400745346
Language: EN, FR, DE, ES & NL

Systems Metabolic Engineering Book Review:

Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.

Synthetic Biology Metabolic Engineering

Synthetic Biology     Metabolic Engineering
Author: Huimin Zhao,An-Ping Zeng
Publsiher: Springer
Total Pages: 322
Release: 2017-10-27
ISBN 10: 3319553186
ISBN 13: 9783319553184
Language: EN, FR, DE, ES & NL

Synthetic Biology Metabolic Engineering Book Review:

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Systems Biology and Synthetic Biology

Systems Biology and Synthetic Biology
Author: Pengcheng Fu,Sven Panke
Publsiher: John Wiley & Sons
Total Pages: 672
Release: 2009-08-13
ISBN 10: 9780470437971
ISBN 13: 0470437979
Language: EN, FR, DE, ES & NL

Systems Biology and Synthetic Biology Book Review:

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.

Systems and Synthetic Biology

Systems and Synthetic Biology
Author: Vikram Singh,Pawan K. Dhar
Publsiher: Springer
Total Pages: 385
Release: 2014-12-15
ISBN 10: 9401795142
ISBN 13: 9789401795142
Language: EN, FR, DE, ES & NL

Systems and Synthetic Biology Book Review:

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Yeast Metabolic Engineering

Yeast Metabolic Engineering
Author: Valeria Mapelli
Publsiher: Humana Press
Total Pages: 316
Release: 2014-04-18
ISBN 10: 9781493905621
ISBN 13: 1493905627
Language: EN, FR, DE, ES & NL

Yeast Metabolic Engineering Book Review:

Yeast Metabolic Engineering: Methods and Protocols provides the widely established basic tools used in yeast metabolic engineering, while describing in deeper detail novel and innovative methods that have valuable potential to improve metabolic engineering strategies in industrial biotechnology applications. Beginning with an extensive section on molecular tools and technology for yeast engineering, this detailed volume is not limited to methods for Saccharomyces cerevisiae, but describes tools and protocols for engineering other yeasts of biotechnological interest, such as Pichia pastoris, Hansenula polymorpha and Zygosaccharomyces bailii. Tools and technologies for the investigation and determination of yeast metabolic features are described in detail as well as metabolic models and their application for yeast metabolic engineering, while a chapter describing patenting and regulations with a special glance at yeast biotechnology closes the volume. Written in the highly successful Methods in Molecular Biology series format, most chapters include an introduction to their respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Yeast Metabolic Engineering: Methods and Protocols aims to familiarize researchers with the current state of these vital and increasingly useful technologies.

Systems Biology

Systems Biology
Author: Bor-Sen Chen,Chia-Chou Wu
Publsiher: Unknown
Total Pages: 275
Release: 2014-01-01
ISBN 10: 9781633215887
ISBN 13: 1633215881
Language: EN, FR, DE, ES & NL

Systems Biology Book Review:

Systems biology sits at the heart of new integrative paradigm in the 21st century, the book could gain an insight into (i) system structure and the mechanism of biological networks such as gene regulation, protein interactions, signaling, and metabolic pathways; (ii) system dynamics of biological networks, which provides an understanding of stability, robustness, and transduction ability through system identification, and through system analysis methods; (iii) system control methods at different levels of biological networks, which provide an understanding of systematic mechanisms to robustly control system states, minimize malfunctions, and provide potential therapeutic targets in disease treatment; (iv) systematic design methods for the modification and construction of biological networks with desired behaviors, which provide system design principles and system simulations for synthetic biology designs and systems metabolic engineering. This book not only describes the current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers but also discusses challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering.

Metabolic Engineering

Metabolic Engineering
Author: Sang Yup Lee,E. Terry Papoutsakis
Publsiher: CRC Press
Total Pages: 450
Release: 2020-10-29
ISBN 10: 1000148769
ISBN 13: 9781000148763
Language: EN, FR, DE, ES & NL

Metabolic Engineering Book Review:

This unique reference/text presents the basic theory and practical applications of metabolic engineering (ME). It offers systematic analysis of complex metabolic pathways and ways of employing recombinant DNA techniques to alter cell behavior, metabolic patterns, and product formation. Treating ME as a distinct subfield of genetic engineering, the book demonstrates new means of enabling cells to produce valuable proteins, polypeptides, and primary and secondary metabolites. Written by more than 35 leading international experts in the field, this book discusses metabolic engineering in plant and mammalian cells, bacteria, and yeasts and assesses metabolic engineering applications in agriculture, pharmaceuticals, and environmental systems. It illuminates the potential of the "cell factory" model for production of chemicals and therapeutics and examines methods for developing new antiviral and antibacterial molecules and effective gene and somatic-cell therapies. Metabolic Engineering also addresses the use of metabolic flux analysis, metabolic control analysis, and online metabolic flux analysis.

Systems and Synthetic Biotechnology for Production of Nutraceuticals

Systems and Synthetic Biotechnology for Production of Nutraceuticals
Author: Long Liu,Jian Chen
Publsiher: Springer Nature
Total Pages: 208
Release: 2020-01-03
ISBN 10: 9811504466
ISBN 13: 9789811504464
Language: EN, FR, DE, ES & NL

Systems and Synthetic Biotechnology for Production of Nutraceuticals Book Review:

This book discusses systems and synthetic biotechnologies for the production of nutraceuticals, and summarizes recent advances in nutraceutical research in terms of the physiological effects on health, potential applications, drawbacks of traditional production processes, characteristics of production strains, and advances in microbial production based on systems and synthetic biotechnology. It also examines future directions in the microbial production of nutraceuticals using systems and synthetic biology. The book is intended for researchers and graduate students in the field of molecular biology and industrial biotechnology as well as staff working in the nutraceutical industry.

Systems Biology and Biotechnology of Escherichia coli

Systems Biology and Biotechnology of Escherichia coli
Author: Sang Yup Lee
Publsiher: Springer Science & Business Media
Total Pages: 462
Release: 2009-03-20
ISBN 10: 1402093942
ISBN 13: 9781402093944
Language: EN, FR, DE, ES & NL

Systems Biology and Biotechnology of Escherichia coli Book Review:

Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms. This book will be a complete resource for anyone interested in systems biology and biotechnology.

Synthetic Metabolic Pathways

Synthetic Metabolic Pathways
Author: Michael Krogh Jensen,Jay D. Keasling
Publsiher: Humana Press
Total Pages: 354
Release: 2017-11-24
ISBN 10: 9781493972944
ISBN 13: 1493972944
Language: EN, FR, DE, ES & NL

Synthetic Metabolic Pathways Book Review:

This volume outlines key steps associated with the design, building, and testing of synthetic metabolic pathways for optimal cell factory performance and robustness, and illustrates how data-driven learning from these steps can be used for rational cost-effective engineering of cell factories with improved performance. Chapters are divided into four sections focusing on the four steps of the iterative design-build-test-learn cycle related to modern cell factory engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Metabolic Pathways: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Microbial Cell Factories Engineering for Production of Biomolecules

Microbial Cell Factories Engineering for Production of Biomolecules
Author: Vijai Singh
Publsiher: Academic Press
Total Pages: 488
Release: 2021-02-26
ISBN 10: 0128214783
ISBN 13: 9780128214787
Language: EN, FR, DE, ES & NL

Microbial Cell Factories Engineering for Production of Biomolecules Book Review:

Microbial Cell Factories Engineering for Production of Biomolecules presents a compilation of chapters written by eminent scientists worldwide. Sections cover major tools and technologies for DNA synthesis, design of biosynthetic pathways, synthetic biology tools, biosensors, cell-free systems, computer-aided design, OMICS tools, CRISPR/Cas systems, and many more. Although it is not easy to find relevant information collated in a single volume, the book covers the production of a wide range of biomolecules from several MCFs, including Escherichia coli, Bacillus subtilis, Pseudomonas putida, Streptomyces, Corynebacterium, Cyanobacteria, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica, and algae, among many others. This will be an excellent platform from which scientific knowledge can grow and widen in MCF engineering research for the production of biomolecules. Needless to say, the book is a valuable source of information not only for researchers designing cell factories, but also for students, metabolic engineers, synthetic biologists, genome engineers, industrialists, stakeholders and policymakers interested in harnessing the potential of MCFs in several fields. Offers basic understanding and a clear picture of various MCFs Explains several tools and technologies, including DNA synthesis, synthetic biology tools, genome editing, biosensors, computer-aided design, and OMICS tools, among others Harnesses the potential of engineered MCFs to produce a wide range of biomolecules for industrial, therapeutic, pharmaceutical, nutraceutical and biotechnological applications Highlights the advances, challenges, and future opportunities in designing MCFs

Systems Metabolic Engineering

Systems Metabolic Engineering
Author: Hal S. Alper
Publsiher: Humana Press
Total Pages: 474
Release: 2013-02-16
ISBN 10: 9781627032988
ISBN 13: 1627032983
Language: EN, FR, DE, ES & NL

Systems Metabolic Engineering Book Review:

With the ultimate goal of systematically and robustly defining the specific perturbations necessary to alter a cellular phenotype, systems metabolic engineering has the potential to lead to a complete cell model capable of simulating cell and metabolic function as well as predicting phenotypic response to changes in media, gene knockouts/overexpressions, or the incorporation of heterologous pathways. In Systems Metabolic Engineering: Methods and Protocols, experts in the field describe the methodologies and approaches in the area of systems metabolic engineering and provide a step-by-step guide for their implementation. Four major tenants of this approach are addressed, including modeling and simulation, multiplexed genome engineering, ‘omics technologies, and large data-set incorporation and synthesis, all elucidated through the use of model host organisms. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions on their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Systems Metabolic Engineering: Methods and Protocols serves as an ideal guide for metabolic engineers, molecular biologists, and microbiologists aiming to implement the most recent approaches available in the field.

Industrial Biotechnology

Industrial Biotechnology
Author: Christoph Wittmann,James C. Liao,Sang Yup Lee,Jens Nielsen,Gregory Stephanopoulos
Publsiher: John Wiley & Sons
Total Pages: 792
Release: 2017-04-10
ISBN 10: 352734179X
ISBN 13: 9783527341795
Language: EN, FR, DE, ES & NL

Industrial Biotechnology Book Review:

The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.

Fundamentals of Systems Biology

Fundamentals of Systems Biology
Author: Markus W. Covert
Publsiher: CRC Press
Total Pages: 367
Release: 2017-10-19
ISBN 10: 1498728472
ISBN 13: 9781498728478
Language: EN, FR, DE, ES & NL

Fundamentals of Systems Biology Book Review:

For decades biology has focused on decoding cellular processes one gene at a time, but many of the most pressing biological questions, as well as diseases such as cancer and heart disease, are related to complex systems involving the interaction of hundreds, or even thousands, of gene products and other factors. How do we begin to understand this complexity? Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models introduces students to methods they can use to tackle complex systems head-on, carefully walking them through studies that comprise the foundation and frontier of systems biology. The first section of the book focuses on bringing students quickly up to speed with a variety of modeling methods in the context of a synthetic biological circuit. This innovative approach builds intuition about the strengths and weaknesses of each method and becomes critical in the book’s second half, where much more complicated network models are addressed—including transcriptional, signaling, metabolic, and even integrated multi-network models. The approach makes the work much more accessible to novices (undergraduates, medical students, and biologists new to mathematical modeling) while still having much to offer experienced modelers--whether their interests are microbes, organs, whole organisms, diseases, synthetic biology, or just about any field that investigates living systems.

Synthetic Biology

Synthetic Biology
Author: Clyde A. Hutchinson, III,Daniel G. Gibson,J. Craig Venter,Hamilton O. Smith
Publsiher: Perspectives Cshl
Total Pages: 350
Release: 2017-04-30
ISBN 10: 9781621821182
ISBN 13: 1621821188
Language: EN, FR, DE, ES & NL

Synthetic Biology Book Review:

Synthetic biology involves the rational design and construction of biological components and systemsfrom genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRISPR/Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered. The authors also explore ways to produce new organisms and products that have particular attributesfor example, microbial "molecular factories," synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit.

Biodefense in the Age of Synthetic Biology

Biodefense in the Age of Synthetic Biology
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology
Publsiher: National Academies Press
Total Pages: 188
Release: 2019-01-05
ISBN 10: 0309465184
ISBN 13: 9780309465182
Language: EN, FR, DE, ES & NL

Biodefense in the Age of Synthetic Biology Book Review:

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Enzymes in Synthetic Biology

Enzymes in Synthetic Biology
Author: Anonim
Publsiher: Academic Press
Total Pages: 457
Release: 2018-08-30
ISBN 10: 0128151498
ISBN 13: 9780128151495
Language: EN, FR, DE, ES & NL

Enzymes in Synthetic Biology Book Review:

Volume 608 of the series Methods in Enzymology covers key aspects of enzyme discovery, engineering tools and platforms, and examples of applications in the enzymology of synthetic biology. Detailed methods for laboratory use of enzymes in synthetic biology applications Informative case history examples illustrating how enzyme and metabolic engineering are used to generate new products Emphasises latest developments in laboratory automation for the engineering of biology Covers many aspects of the design, build, test, learn cycle used in synthetic biology

Biotechnology for Biofuel Production and Optimization

Biotechnology for Biofuel Production and Optimization
Author: Carrie A Eckert,Cong T Trinh
Publsiher: Elsevier
Total Pages: 572
Release: 2016-01-19
ISBN 10: 0081000537
ISBN 13: 9780081000533
Language: EN, FR, DE, ES & NL

Biotechnology for Biofuel Production and Optimization Book Review:

Biotechnology for Biofuel Production and Optimization is the compilation of current research findings that cover the entire process of biofuels production from manipulation of genes and pathways to organisms and renewable feedstocks for efficient biofuel production as well as different cultivation techniques and process scale-up considerations. This book captures recent breakthroughs in the interdisciplinary areas of systems and synthetic biology, metabolic engineering, and bioprocess engineering for renewable, cleaner sources of energy. Describes state-of-the-art engineering of metabolic pathways for the production of a variety of fuel molecules Discusses recent advances in synthetic biology and metabolic engineering for rational design, construction, evaluation of novel pathways and cell chassis Covers genome engineering technologies to address complex biofuel-tolerant phenotypes for enhanced biofuel production in engineered chassis Presents the use of novel microorganisms and expanded substrate utilization strategies for production of targeted fuel molecules Explores biohybrid methods for harvesting bioenergy Discusses bioreactor design and optimization of scale-up

Synthetic Biology of Cyanobacteria

Synthetic Biology of Cyanobacteria
Author: Weiwen Zhang,Xinyu Song
Publsiher: Springer
Total Pages: 355
Release: 2018-08-08
ISBN 10: 9811308543
ISBN 13: 9789811308543
Language: EN, FR, DE, ES & NL

Synthetic Biology of Cyanobacteria Book Review:

This volume highlights recent breakthroughs in the interdisciplinary areas of synthetic biology, metabolic engineering and bioprocess engineering for the production of green chemicals. It also presents practical experimental and computational tools for the design, construction and manipulation of cyanobacteria cell factories. The respective contributions cover new technologies in the field, such as novel genetic transformation techniques and bioinformatics analysis methods and address various aspects of cyanobacterial synthetic biology, offering a valuable resource for students and researchers in the fields of industry microbiology and biomedical engineering.