Systems and Synthetic Metabolic Engineering

Systems and Synthetic Metabolic Engineering
Author: Yanfeng Liu,Guocheng Du,Long Liu
Publsiher: Academic Press
Total Pages: 294
Release: 2020-07-10
ISBN 10: 0128217529
ISBN 13: 9780128217528
Language: EN, FR, DE, ES & NL

Systems and Synthetic Metabolic Engineering Book Review:

Systems and Synthetic Metabolic Engineering provides an overview of the development of metabolic engineering within medicine that is fueled by systems and synthetic biology. These newly developed, successful strategies of metabolic engineering guide the audience on how to propose and test proper strategies for metabolic engineering research. In addition to introductory, regulatory and challenges in the field, the book also covers dynamic control and autonomous regulation to control cell metabolism, along with computational modeling and industrial applications. The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area. Discusses the current progress of metabolic engineering, focusing on systems biology and synthetic biology Covers introductory, regulatory, strategies, production and challenges in the field Written technically for synthetic biologists, researchers, students, industrialists, policymakers and stakeholders

Systems Metabolic Engineering

Systems Metabolic Engineering
Author: Christoph Wittmann,Sang Yup Lee
Publsiher: Springer Science & Business Media
Total Pages: 388
Release: 2012-06-15
ISBN 10: 9400745346
ISBN 13: 9789400745346
Language: EN, FR, DE, ES & NL

Systems Metabolic Engineering Book Review:

Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.

Systems Biology and Synthetic Biology

Systems Biology and Synthetic Biology
Author: Pengcheng Fu,Sven Panke
Publsiher: John Wiley & Sons
Total Pages: 672
Release: 2009-08-13
ISBN 10: 9780470437971
ISBN 13: 0470437979
Language: EN, FR, DE, ES & NL

Systems Biology and Synthetic Biology Book Review:

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.

Synthetic Biology Metabolic Engineering

Synthetic Biology     Metabolic Engineering
Author: Huimin Zhao,An-Ping Zeng
Publsiher: Springer
Total Pages: 322
Release: 2017-10-27
ISBN 10: 3319553186
ISBN 13: 9783319553184
Language: EN, FR, DE, ES & NL

Synthetic Biology Metabolic Engineering Book Review:

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Systems and Synthetic Biotechnology for Production of Nutraceuticals

Systems and Synthetic Biotechnology for Production of Nutraceuticals
Author: Long Liu
Publsiher: Springer Nature
Total Pages: 329
Release:
ISBN 10: 9811504466
ISBN 13: 9789811504464
Language: EN, FR, DE, ES & NL

Systems and Synthetic Biotechnology for Production of Nutraceuticals Book Review:

Systems Biology

Systems Biology
Author: Bor-Sen Chen,Chia-Chou Wu
Publsiher: Anonim
Total Pages: 275
Release: 2014-01-01
ISBN 10: 9781633215887
ISBN 13: 1633215881
Language: EN, FR, DE, ES & NL

Systems Biology Book Review:

Systems biology sits at the heart of new integrative paradigm in the 21st century, the book could gain an insight into (i) system structure and the mechanism of biological networks such as gene regulation, protein interactions, signaling, and metabolic pathways; (ii) system dynamics of biological networks, which provides an understanding of stability, robustness, and transduction ability through system identification, and through system analysis methods; (iii) system control methods at different levels of biological networks, which provide an understanding of systematic mechanisms to robustly control system states, minimize malfunctions, and provide potential therapeutic targets in disease treatment; (iv) systematic design methods for the modification and construction of biological networks with desired behaviors, which provide system design principles and system simulations for synthetic biology designs and systems metabolic engineering. This book not only describes the current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers but also discusses challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering.

Systems and Synthetic Biology

Systems and Synthetic Biology
Author: Vikram Singh,Pawan K. Dhar
Publsiher: Springer
Total Pages: 385
Release: 2014-12-15
ISBN 10: 9401795142
ISBN 13: 9789401795142
Language: EN, FR, DE, ES & NL

Systems and Synthetic Biology Book Review:

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Systems Biology Application in Synthetic Biology

Systems Biology Application in Synthetic Biology
Author: Shailza Singh
Publsiher: Springer
Total Pages: 160
Release: 2016-09-08
ISBN 10: 813222809X
ISBN 13: 9788132228097
Language: EN, FR, DE, ES & NL

Systems Biology Application in Synthetic Biology Book Review:

This book introduces students to methods that will help them understand behaviour in terms of cellular components and their interactions in non-intuitive ways, which calls for an interdisciplinary approach combining mathematical, chemical, computational and biological strategies. Tibor Ganti was one of the early pioneers who proposed a theoretical framework to understand living principles in terms of chemical transformation cycles and their coupling. The twenty-first century then brought with it a novel ‘systems’ paradigm, which shone new light on all previous work and was accompanied by numerous implications for the way we conceive of chemical and biological complexity today. This book seeks to equip students to take advantage of any field that investigates living systems. Based on a conceptualisation of science-oriented branches, engineering-oriented branches and biology as astoundingly complex fields, those structures laden with biochemical detail encompass a deeper theory unifying our knowledge of designed systems. Readers will be pleasantly surprised at how lucidly the topics are presented. The book offers an indispensable resource for students and professionals working in systems and synthetic biology or any of the various related fields of research.

Yeast Metabolic Engineering

Yeast Metabolic Engineering
Author: Valeria Mapelli
Publsiher: Humana Press
Total Pages: 316
Release: 2014-04-18
ISBN 10: 9781493905621
ISBN 13: 1493905627
Language: EN, FR, DE, ES & NL

Yeast Metabolic Engineering Book Review:

Yeast Metabolic Engineering: Methods and Protocols provides the widely established basic tools used in yeast metabolic engineering, while describing in deeper detail novel and innovative methods that have valuable potential to improve metabolic engineering strategies in industrial biotechnology applications. Beginning with an extensive section on molecular tools and technology for yeast engineering, this detailed volume is not limited to methods for Saccharomyces cerevisiae, but describes tools and protocols for engineering other yeasts of biotechnological interest, such as Pichia pastoris, Hansenula polymorpha and Zygosaccharomyces bailii. Tools and technologies for the investigation and determination of yeast metabolic features are described in detail as well as metabolic models and their application for yeast metabolic engineering, while a chapter describing patenting and regulations with a special glance at yeast biotechnology closes the volume. Written in the highly successful Methods in Molecular Biology series format, most chapters include an introduction to their respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Yeast Metabolic Engineering: Methods and Protocols aims to familiarize researchers with the current state of these vital and increasingly useful technologies.

Systems Biology and Biotechnology of Escherichia coli

Systems Biology and Biotechnology of Escherichia coli
Author: Sang Yup Lee
Publsiher: Springer Science & Business Media
Total Pages: 462
Release: 2009-03-20
ISBN 10: 1402093942
ISBN 13: 9781402093944
Language: EN, FR, DE, ES & NL

Systems Biology and Biotechnology of Escherichia coli Book Review:

Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms. This book will be a complete resource for anyone interested in systems biology and biotechnology.

Synthetic Biology engineering complexity and refactoring cell capabilities

Synthetic Biology engineering complexity and refactoring cell capabilities
Author: Pablo Carbonell,Jean Marie François
Publsiher: Frontiers Media SA
Total Pages: 123
Release: 2015-10-26
ISBN 10: 2889196852
ISBN 13: 9782889196852
Language: EN, FR, DE, ES & NL

Synthetic Biology engineering complexity and refactoring cell capabilities Book Review:

One of the key features of biological systems is complexity, where the behavior of high level structures is more than the sum of the direct interactions between single components. Synthetic Biologists aim to use rational design to build new systems that do not already exist in nature and that exhibit useful biological functions with different levels of complexity. One such case is metabolic engineering, where, with the advent of genetic and protein engineering, by supplying cells with chemically synthesized non-natural amino acids and sugars as new building blocks, it is now becoming feasible to introduce novel physical and chemical functions and properties into biological entities. The rules of how complex behaviors arise, however, are not yet well understood. For instance, instead of considering cells as inert chassis in which synthetic devices could be easily operated to impart new functions, the presence of these systems may impact cell physiology with reported effects on transcription, translation, metabolic fitness and optimal resource allocation. The result of these changes in the chassis may be failure of the synthetic device, unexpected or reduced device behavior, or perhaps a more permissive environment in which the synthetic device is allowed to function. While new efforts have already been made to increase standardization and characterization of biological components in order to have well known parts as building blocks for the construction of more complex devices, also new strategies are emerging to better understand the biological dynamics underlying the phenomena we observe. For example, it has been shown that the features of single biological components [i.e. promoter strength, ribosome binding affinity, etc] change depending on the context where the sequences are allocated. Thus, new technical approaches have been adopted to preserve single components activity, as genomic insulation or the utilization of prediction algorithms able to take biological context into account. There have been noteworthy advances for synthetic biology in clinical technologies, biofuel production, and pharmaceuticals production; also, metabolic engineering combined with microbial selection/adaptation and fermentation processes allowed to make remarkable progress towards bio-products formation such as bioethanol, succinate, malate and, more interestingly, heterologous products or even non-natural metabolites. However, despite the many progresses, it is still clear that ad hoc trial and error predominates over purely bottom-up, rational design approaches in the synthetic biology community. In this scenario, modelling approaches are often used as a descriptive tool rather than for the prediction of complex behaviors. The initial confidence on a pure reductionist approach to the biological world has left space to a new and deeper investigation of the complexity of biological processes to gain new insights and broaden the categories of synthetic biology. In this Research Topic we host contributions that explore and address two areas of Synthetic Biology at the intersection between rational design and natural complexity: (1) the impact of synthetic devices on the host cell, or "chassis" and (2) the impact of context on the synthetic devices. Particular attention will be given to the application of these principles to the rewiring of cell metabolism in a bottom-up fashion to produce non-natural metabolites or chemicals that should eventually serve as a substitute for petrol-derived chemicals, and, on a long-term view, to provide economical, ecological and ethical solutions to today’s energetic and societal challenges.

Industrial Biotechnology

Industrial Biotechnology
Author: Christoph Wittmann,James C. Liao
Publsiher: John Wiley & Sons
Total Pages: 792
Release: 2017-03-15
ISBN 10: 3527807802
ISBN 13: 9783527807802
Language: EN, FR, DE, ES & NL

Industrial Biotechnology Book Review:

The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.

Synthetic Metabolic Pathways

Synthetic Metabolic Pathways
Author: Michael Krogh Jensen,Jay D. Keasling
Publsiher: Humana Press
Total Pages: 354
Release: 2018-08-30
ISBN 10: 9781493984459
ISBN 13: 1493984454
Language: EN, FR, DE, ES & NL

Synthetic Metabolic Pathways Book Review:

This volume outlines key steps associated with the design, building, and testing of synthetic metabolic pathways for optimal cell factory performance and robustness, and illustrates how data-driven learning from these steps can be used for rational cost-effective engineering of cell factories with improved performance. Chapters are divided into four sections focusing on the four steps of the iterative design-build-test-learn cycle related to modern cell factory engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Metabolic Pathways: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Introduction To Metabolic And Cellular Engineering An Second Edition

Introduction To Metabolic And Cellular Engineering  An  Second Edition
Author: Cortassa Sonia Del Carmen,Aon Miguel Antonio,Aon Juan Carlos,Iglesias Alberto Alvaro,Lloyd David
Publsiher: World Scientific
Total Pages: 448
Release: 2011-12-28
ISBN 10: 9814405175
ISBN 13: 9789814405171
Language: EN, FR, DE, ES & NL

Introduction To Metabolic And Cellular Engineering An Second Edition Book Review:

Metabolic and Cellular Engineering (MCE) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in MCE are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth.In charting the progress of MCE during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for MCE. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the MCE research field.

Developing Biofuel Bioprocesses Using Systems and Synthetic Biology

Developing Biofuel Bioprocesses Using Systems and Synthetic Biology
Author: Sylvia M. Clay,Stephen S. Fong
Publsiher: Springer Science & Business Media
Total Pages: 68
Release: 2012-09-25
ISBN 10: 1461455804
ISBN 13: 9781461455806
Language: EN, FR, DE, ES & NL

Developing Biofuel Bioprocesses Using Systems and Synthetic Biology Book Review:

Advances in technological and analytical methods have fostered rapid growth of systems biology and synthetic biology. There continues to be rapid changes and discoveries in both fields with a small number of recent peer-reviewed reviews indicating some of the relationships between systems biology and synthetic biology. This proposed SpringerBrief will cover core concepts of systems biology and synthetic biology and illustrate the implementation of associated research methodologies for an integrated approach to specifically address engineering microorganisms for biofuel production.​

Synthetic Biology of Cyanobacteria

Synthetic Biology of Cyanobacteria
Author: Weiwen Zhang,Xinyu Song
Publsiher: Springer
Total Pages: 355
Release: 2018-08-08
ISBN 10: 9811308543
ISBN 13: 9789811308543
Language: EN, FR, DE, ES & NL

Synthetic Biology of Cyanobacteria Book Review:

This volume highlights recent breakthroughs in the interdisciplinary areas of synthetic biology, metabolic engineering and bioprocess engineering for the production of green chemicals. It also presents practical experimental and computational tools for the design, construction and manipulation of cyanobacteria cell factories. The respective contributions cover new technologies in the field, such as novel genetic transformation techniques and bioinformatics analysis methods and address various aspects of cyanobacterial synthetic biology, offering a valuable resource for students and researchers in the fields of industry microbiology and biomedical engineering.

The Science and Applications of Synthetic and Systems Biology

The Science and Applications of Synthetic and Systems Biology
Author: Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publsiher: National Academies Press
Total Pages: 570
Release: 2011-12-30
ISBN 10: 0309219396
ISBN 13: 9780309219396
Language: EN, FR, DE, ES & NL

The Science and Applications of Synthetic and Systems Biology Book Review:

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Metabolic Pathway Design

Metabolic Pathway Design
Author: Pablo Carbonell
Publsiher: Springer Nature
Total Pages: 168
Release: 2019-11-05
ISBN 10: 3030298655
ISBN 13: 9783030298654
Language: EN, FR, DE, ES & NL

Metabolic Pathway Design Book Review:

This textbook presents solid tools for in silico engineering biology, offering students a step-by-step guide to mastering the smart design of metabolic pathways. The first part explains the Design-Build-Test-Learn-cycle engineering approach to biology, discussing the basic tools to model biological and chemistry-based systems. Using these basic tools, the second part focuses on various computational protocols for metabolic pathway design, from enzyme selection to pathway discovery and enumeration. In the context of industrial biotechnology, the final part helps readers understand the challenges of scaling up and optimisation. By working with the free programming language Scientific Python, this book provides easily accessible tools for studying and learning the principles of modern in silico metabolic pathway design. Intended for advanced undergraduates and master’s students in biotechnology, biomedical engineering, bioinformatics and systems biology students, the introductory sections make it also useful for beginners wanting to learn the basics of scientific coding and find real-world, hands-on examples.

Enzymes in Synthetic Biology

Enzymes in Synthetic Biology
Author: Anonim
Publsiher: Academic Press
Total Pages: 457
Release: 2018-08-30
ISBN 10: 0128151498
ISBN 13: 9780128151495
Language: EN, FR, DE, ES & NL

Enzymes in Synthetic Biology Book Review:

Volume 608 of the series Methods in Enzymology covers key aspects of enzyme discovery, engineering tools and platforms, and examples of applications in the enzymology of synthetic biology. Detailed methods for laboratory use of enzymes in synthetic biology applications Informative case history examples illustrating how enzyme and metabolic engineering are used to generate new products Emphasises latest developments in laboratory automation for the engineering of biology Covers many aspects of the design, build, test, learn cycle used in synthetic biology

Fundamentals of Systems Biology

Fundamentals of Systems Biology
Author: Markus W. Covert
Publsiher: CRC Press
Total Pages: 367
Release: 2017-10-19
ISBN 10: 1498728472
ISBN 13: 9781498728478
Language: EN, FR, DE, ES & NL

Fundamentals of Systems Biology Book Review:

For decades biology has focused on decoding cellular processes one gene at a time, but many of the most pressing biological questions, as well as diseases such as cancer and heart disease, are related to complex systems involving the interaction of hundreds, or even thousands, of gene products and other factors. How do we begin to understand this complexity? Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models introduces students to methods they can use to tackle complex systems head-on, carefully walking them through studies that comprise the foundation and frontier of systems biology. The first section of the book focuses on bringing students quickly up to speed with a variety of modeling methods in the context of a synthetic biological circuit. This innovative approach builds intuition about the strengths and weaknesses of each method and becomes critical in the book’s second half, where much more complicated network models are addressed—including transcriptional, signaling, metabolic, and even integrated multi-network models. The approach makes the work much more accessible to novices (undergraduates, medical students, and biologists new to mathematical modeling) while still having much to offer experienced modelers--whether their interests are microbes, organs, whole organisms, diseases, synthetic biology, or just about any field that investigates living systems.