Cell Biology of Extracellular Matrix

Cell Biology of Extracellular Matrix
Author: E.D. Hay
Publsiher: Springer Science & Business Media
Total Pages: 468
Release: 2013-11-11
ISBN 10: 1461537703
ISBN 13: 9781461537700
Language: EN, FR, DE, ES & NL

Cell Biology of Extracellular Matrix Book Review:

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Calcific Aortic Valve Disease

Calcific Aortic Valve Disease
Author: Elena Aikawa
Publsiher: BoD – Books on Demand
Total Pages: 542
Release: 2013-06-12
ISBN 10: 9535111507
ISBN 13: 9789535111504
Language: EN, FR, DE, ES & NL

Calcific Aortic Valve Disease Book Review:

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

The Extracellular Matrix an Overview

The Extracellular Matrix  an Overview
Author: Robert Mecham
Publsiher: Springer Science & Business Media
Total Pages: 426
Release: 2011-02-16
ISBN 10: 3642165559
ISBN 13: 9783642165559
Language: EN, FR, DE, ES & NL

The Extracellular Matrix an Overview Book Review:

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body
Author: Francesco Travascio
Publsiher: BoD – Books on Demand
Total Pages: 374
Release: 2016-06-15
ISBN 10: 9535124153
ISBN 13: 9789535124153
Language: EN, FR, DE, ES & NL

Composition and Function of the Extracellular Matrix in the Human Body Book Review:

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Extracellular Matrix

Extracellular Matrix
Author: Anonim
Publsiher: Unknown
Total Pages: 436
Release: 1985
ISBN 10: 9780845126233
ISBN 13: 0845126237
Language: EN, FR, DE, ES & NL

Extracellular Matrix Book Review:

Structure and Function of the Extracellular Matrix

Structure and Function of the Extracellular Matrix
Author: Bela Suki
Publsiher: Academic Press
Total Pages: 282
Release: 2021-12-06
ISBN 10: 0128226056
ISBN 13: 9780128226056
Language: EN, FR, DE, ES & NL

Structure and Function of the Extracellular Matrix Book Review:

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. Examines the evolutionary origins and consequences of the extracellular matrix Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning Provides an introduction to the properties and organization of the extracellular matrix components

Extracellular Matrix Organization Structure and Function

Extracellular Matrix Organization  Structure  and Function
Author: Dena Wiltz
Publsiher: Unknown
Total Pages: 135
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154237700
Language: EN, FR, DE, ES & NL

Extracellular Matrix Organization Structure and Function Book Review:

Extracellular Matrix Organization, Structure, and Function.

Extracellular Matrix

Extracellular Matrix
Author: A. H. Reddi
Publsiher: Unknown
Total Pages: 462
Release: 1985-12
ISBN 10: 9780471847687
ISBN 13: 0471847682
Language: EN, FR, DE, ES & NL

Extracellular Matrix Book Review:

Evolution of Extracellular Matrix

Evolution of Extracellular Matrix
Author: Fred W. Keeley,Robert Mecham
Publsiher: Springer Science & Business Media
Total Pages: 290
Release: 2013-03-15
ISBN 10: 3642360025
ISBN 13: 9783642360022
Language: EN, FR, DE, ES & NL

Evolution of Extracellular Matrix Book Review:

The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

Extracellular Matrix Assembly and Structure

Extracellular Matrix Assembly and Structure
Author: Peter D. Yurchenco
Publsiher: Academic Press
Total Pages: 468
Release: 2013-10-22
ISBN 10: 1483289427
ISBN 13: 9781483289427
Language: EN, FR, DE, ES & NL

Extracellular Matrix Assembly and Structure Book Review:

The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling

Extracellular Matrix Pathobiology and Signaling

Extracellular Matrix  Pathobiology and Signaling
Author: Nikos Karamanos
Publsiher: Walter de Gruyter
Total Pages: 938
Release: 2012-08-31
ISBN 10: 3110258773
ISBN 13: 9783110258776
Language: EN, FR, DE, ES & NL

Extracellular Matrix Pathobiology and Signaling Book Review:

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

Tissue Regeneration

Tissue Regeneration
Author: Hussein Abdelhay Essayed Kaoud
Publsiher: BoD – Books on Demand
Total Pages: 206
Release: 2018-06-06
ISBN 10: 1789232600
ISBN 13: 9781789232608
Language: EN, FR, DE, ES & NL

Tissue Regeneration Book Review:

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Cell Surface and Extracellular Glycoconjugates

Cell Surface and Extracellular Glycoconjugates
Author: Anonim
Publsiher: Academic Press
Total Pages: 314
Release: 2012-12-02
ISBN 10: 0323138098
ISBN 13: 9780323138093
Language: EN, FR, DE, ES & NL

Cell Surface and Extracellular Glycoconjugates Book Review:

This book serves as a much-needed guide for new investigators in the field of glycobiology as well as researchers in other disciplines attempting to define the role of glycoconjugates in their biological systems. Cell Surface and Extracellular Glycoconjugates: Structure and Function describes the determination of structure and function of glycoconjugates that occur on the cell surface and in molecules involved in cell-matrix interactions. The broad scope of thebook covers basic background and technical information in this rapidly expanding field. The text is specifically designed to inform researchers in diverse disciplines of the approaches and resources that can be employed to address problems in glycoconjugate biology. Includes coverage of the: * Structure of cell surface carbohydrates * Biosynthesis of glycoproteins * Biological signals associated with glycoproteins * Diversity of glycoprotein structure

Extracellular Matrix Biology

Extracellular Matrix Biology
Author: Richard O. Hynes,Kenneth M. Yamada
Publsiher: Unknown
Total Pages: 397
Release: 2012
ISBN 10: 9781936113385
ISBN 13: 1936113384
Language: EN, FR, DE, ES & NL

Extracellular Matrix Biology Book Review:

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in the regulation of cell function. ECM proteins bind to cell surface receptors such as integrins, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. This book covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during tumorigenesis and other disease states. The editors are both giants in the field (Dr. Hynes discovered fibronectin), who are highly respected through the cell, molecular, and cancer biology communities.

The Structure and Function of Hyaluronan binding Proteins in Extracellular Matrix Assembly

The Structure and Function of Hyaluronan binding Proteins in Extracellular Matrix Assembly
Author: Nicholas T. Seyfried
Publsiher: Unknown
Total Pages: 324
Release: 2004
ISBN 10: 1928374650XXX
ISBN 13: OCLC:74345260
Language: EN, FR, DE, ES & NL

The Structure and Function of Hyaluronan binding Proteins in Extracellular Matrix Assembly Book Review:

Extracellular Matrix Degradation

Extracellular Matrix Degradation
Author: William C. Parks,Robert Mecham
Publsiher: Springer Science & Business Media
Total Pages: 255
Release: 2011-04-07
ISBN 10: 3642168612
ISBN 13: 9783642168611
Language: EN, FR, DE, ES & NL

Extracellular Matrix Degradation Book Review:

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Extracellular Matrix in Development

Extracellular Matrix in Development
Author: Douglas W. DeSimone,Robert Mecham
Publsiher: Springer Science & Business Media
Total Pages: 253
Release: 2013-03-15
ISBN 10: 3642359353
ISBN 13: 9783642359354
Language: EN, FR, DE, ES & NL

Extracellular Matrix in Development Book Review:

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Structure and function of Collagen types

Structure and function of Collagen types
Author: Richard Maynes
Publsiher: Elsevier
Total Pages: 328
Release: 2012-12-02
ISBN 10: 0323155715
ISBN 13: 9780323155717
Language: EN, FR, DE, ES & NL

Structure and function of Collagen types Book Review:

Structure and Function of Collagen Types is a collection of articles that reviews the different types of collagens (Type I to XI). Each article focuses on a particular type of collagen and written by leading investigators in the collagen field. The book begins with a review of the fibril forming collagens (types I, II, and III) and traces the early work on the structure of these collagens to our knowledge of the structure of the collagen genes. This chapter is followed by a detailed description of type IV (basement membrane) collagen. Chapter 3 addresses the biosynthesis and chain assembly of type V collagen. The evidence that type VI collagen is assembled to form tetramers is presented in chapter 4. The subsequent article shows that type VII collagens are assembled to form partially overlapping dimers. Chapter 6 presents the structure of type VIII collagen. Chapters 7, 8, and 9 discuss the structure and characteristics of collagens that are synthesized by cartilaginous tissues and these are designated as type IX, type X, and type XI. The final chapter reviews the recombinant DNA techniques used to investigate collagen structure and the possibility to recognize new collagen types from a cDNA library. Physiologists, cell biologists, and researchers in the field of collagen will find the text very insightful.

Biochemistry of Collagens Laminins and Elastin

Biochemistry of Collagens  Laminins and Elastin
Author: Morten Karsdal
Publsiher: Academic Press
Total Pages: 434
Release: 2019-05-28
ISBN 10: 0128170697
ISBN 13: 9780128170694
Language: EN, FR, DE, ES & NL

Biochemistry of Collagens Laminins and Elastin Book Review:

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes seven new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability