Stem Cells and Aging

Stem Cells and Aging
Author: Surajit Pathak
Publsiher: Academic Press
Total Pages: 200
Release: 2021-03-15
ISBN 10: 9780128200711
ISBN 13: 0128200715
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Review:

Little is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as well as attempting to define the role of dysfunctional stem cells in the aging process. Stem Cells and Aging will guide the reader to a better understanding of how stem cells age might have a key role in deciphering the normal aging process. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Adult Stem Cells in Aging Diseases and Cancer

Adult Stem Cells in Aging  Diseases and Cancer
Author: K.L. Rudolph
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 88
Release: 2014-12-22
ISBN 10: 3318027324
ISBN 13: 9783318027327
Language: EN, FR, DE, ES & NL

Adult Stem Cells in Aging Diseases and Cancer Book Review:

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Stem Cell Aging Mechanisms Consequences Rejuvenation

Stem Cell Aging  Mechanisms  Consequences  Rejuvenation
Author: Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
Publsiher: Springer
Total Pages: 354
Release: 2015-07-06
ISBN 10: 370911232X
ISBN 13: 9783709112328
Language: EN, FR, DE, ES & NL

Stem Cell Aging Mechanisms Consequences Rejuvenation Book Review:

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
Author: Rakesh Sharma
Publsiher: BoD – Books on Demand
Total Pages: 352
Release: 2018-05-02
ISBN 10: 1789230101
ISBN 13: 9781789230109
Language: EN, FR, DE, ES & NL

Stem Cells in Clinical Practice and Tissue Engineering Book Review:

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer
Author: K. Lenhard Rudolph
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2007-11-07
ISBN 10: 354073709X
ISBN 13: 9783540737094
Language: EN, FR, DE, ES & NL

Telomeres and Telomerase in Aging Disease and Cancer Book Review:

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
Author: Susie Prof. Nilsson
Publsiher: Academic Press
Total Pages: 258
Release: 2020-08-22
ISBN 10: 0128220201
ISBN 13: 9780128220207
Language: EN, FR, DE, ES & NL

The Stem Cell Niche during Ageing Book Review:

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
Author: Lucas G. Chase,Mohan C Vemuri
Publsiher: Springer Science & Business Media
Total Pages: 456
Release: 2012-12-12
ISBN 10: 1627032002
ISBN 13: 9781627032001
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Therapy Book Review:

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Frailty and Sarcopenia

Frailty and Sarcopenia
Author: Yannis Dionyssiotis
Publsiher: BoD – Books on Demand
Total Pages: 254
Release: 2017-08-30
ISBN 10: 9535134833
ISBN 13: 9789535134831
Language: EN, FR, DE, ES & NL

Frailty and Sarcopenia Book Review:

Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new advancements in the related treatments including complex issues and research. It includes high-quality chapters in all related aspects for the syndromes of sarcopenia and frailty, which adversely affect the function and overall effectiveness of the musculoskeletal system and interventions to promote rehabilitation.

Aging

Aging
Author: Shamim I. Ahmad
Publsiher: CRC Press
Total Pages: 658
Release: 2017-10-30
ISBN 10: 1315283883
ISBN 13: 9781315283883
Language: EN, FR, DE, ES & NL

Aging Book Review:

This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.

How and why We Age

How and why We Age
Author: Leonard Hayflick
Publsiher: Unknown
Total Pages: 377
Release: 1996-01-01
ISBN 10: 9780345401557
ISBN 13: 0345401557
Language: EN, FR, DE, ES & NL

How and why We Age Book Review:

A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

Stem Cells An Insider s Guide

Stem Cells  An Insider s Guide
Author: Paul Knoepfler
Publsiher: World Scientific
Total Pages: 368
Release: 2013-07-30
ISBN 10: 9814508829
ISBN 13: 9789814508827
Language: EN, FR, DE, ES & NL

Stem Cells An Insider s Guide Book Review:

Stem Cells: An Insider's Guide is an exciting new book that takes readers inside the world of stem cells guided by international stem cell expert, Dr. Paul Knoepfler. Stem cells are catalyzing a revolution in medicine. The book also tackles the exciting and hotly debated area of stem cell treatments that are capturing the public's imagination. In the future they may also transform how we age and reproduce. However, there are serious risks and ethical challenges, too. The author's goal with this insider's guide is to give readers the information needed to distinguish between the ubiquitous hype and legitimate hope found throughout the stem cell world. The book answers the most common questions that people have about stem cells. Can stem cells help my family with a serious medical problem such as Alzheimer's, Multiple Sclerosis, or Autism? Are such treatments safe? Can stem cells make me look younger or even literally stay physically young? These questions and many more are answered here.A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.

Advances in Stem Cell Aging

Advances in Stem Cell Aging
Author: K. Lenhard Rudolph
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 125
Release: 2012
ISBN 10: 3318021709
ISBN 13: 9783318021707
Language: EN, FR, DE, ES & NL

Advances in Stem Cell Aging Book Review:

Up-to-date meeting report of the Else Kr ner-Fresenius Symposium on Adult Stem Cell Aging Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells. This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kr ner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

Stem Cells and Aging

Stem Cells and Aging
Author: Kursad Turksen
Publsiher: Humana Press
Total Pages: 179
Release: 2013-02-13
ISBN 10: 9781627033169
ISBN 13: 1627033165
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Review:

Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and at the level of their impacts for regenerative medicine. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy to use, Stem Cells and Aging: Methods and Protocols serves as an ideal reference to guide investigators toward further valuable answers to the problems of our aging population.

Exosomes Stem Cells and MicroRNA

Exosomes  Stem Cells and MicroRNA
Author: Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
Publsiher: Springer
Total Pages: 152
Release: 2018-04-07
ISBN 10: 3319744704
ISBN 13: 9783319744704
Language: EN, FR, DE, ES & NL

Exosomes Stem Cells and MicroRNA Book Review:

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
Author: Suresh I.S. Rattan,Leonard Hayflick
Publsiher: Springer
Total Pages: 364
Release: 2016-05-09
ISBN 10: 3319262394
ISBN 13: 9783319262390
Language: EN, FR, DE, ES & NL

Cellular Ageing and Replicative Senescence Book Review:

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Stem Cells in Development and Disease

Stem Cells in Development and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 472
Release: 2014-01-15
ISBN 10: 0123914353
ISBN 13: 9780123914354
Language: EN, FR, DE, ES & NL

Stem Cells in Development and Disease Book Review:

This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging Covers the area of Stem Cells in Development and Disease International board of authors Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells

Bone Marrow Derived Progenitors

Bone Marrow Derived Progenitors
Author: Katalin Kauser,Andreas-Michael Zeiher
Publsiher: Springer Science & Business Media
Total Pages: 289
Release: 2007-06-07
ISBN 10: 3540689761
ISBN 13: 9783540689768
Language: EN, FR, DE, ES & NL

Bone Marrow Derived Progenitors Book Review:

The ambitious goal of this volume is to provide – in chapters written by accomplished scientists and experts in their field – a comprehensive overview of the currently available information related to the therapeutic utility of adult bone marrow-derived cells. With excitement generated almost daily about the possible uses of stem cells to treat human disease, but the controversy surrounding their use still raging, adult bone-marrow derived cells are more readily available, and have a staggering range of uses.

Models Molecules and Mechanisms in Biogerontology

Models  Molecules and Mechanisms in Biogerontology
Author: Pramod C. Rath
Publsiher: Springer
Total Pages: 436
Release: 2019-07-30
ISBN 10: 9811335850
ISBN 13: 9789811335853
Language: EN, FR, DE, ES & NL

Models Molecules and Mechanisms in Biogerontology Book Review:

This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

Stem Cells

Stem Cells
Author: Mary Clarke,Jonathan Frampton
Publsiher: Garland Science
Total Pages: 450
Release: 2020-07-27
ISBN 10: 1000062651
ISBN 13: 9781000062656
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.

The Uniqueness of the Individual

The Uniqueness of the Individual
Author: P.B. Medawar
Publsiher: Routledge
Total Pages: 188
Release: 2019-08-31
ISBN 10: 1000063844
ISBN 13: 9781000063844
Language: EN, FR, DE, ES & NL

The Uniqueness of the Individual Book Review:

Originally published in 1957, The Uniqueness of the Individual is a collection of 9 essays published from the ten years preceding publication. The essays deal with some of the central problems of biology. These are among the questions put and answered from the standpoint of modern experimental biology. What is ageing and how is it measured? What theories have been held to account for it, and with what success? Did ageing evolve, and if so how? Is Lamarckism and adequate explanation of evolutionary process? Does evolution sometimes go wrong? Do human beings evolve in a way peculiar to themselves? Other essays touch upon the problems of scientific method and of growth and transformation. This book will be of interest to natural historians, evolutionists and anthropologists.