Stem Cell Epigenetics

Stem Cell Epigenetics
Author: Anonim
Publsiher: Academic Press
Total Pages: 330
Release: 2020-08-13
ISBN 10: 0128140852
ISBN 13: 9780128140857
Language: EN, FR, DE, ES & NL

Stem Cell Epigenetics Book Review:

Stem Cell Epigenetics, Volume 16, examines how epigenetics are involved in stem cell differentiation, how a stem cell rapidly transitions into a molecularly distinct cell type, and how this process may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, epigenetic regulation of reprogramming, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, epigenetics and disease modeling, organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment is discussed in detail, helping researchers and physicians bring this exciting and fast evolving field to the clinic. Provides genetic researchers, students and physicians with evidence indicating the epigenetic mechanisms involved in stem cell differentiation Highlights the specific characteristics of the epigenetic modifications and misregulations that may result in disease pathogenesis Examines the potential application of stem cell epigenetics towards developing therapeutic interventions for disease and advancing regenerative medicine Features chapter contributions by leading international experts

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Deepa Bhartiya,Nibedita Lenka
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-08-28
ISBN 10: 9535111922
ISBN 13: 9789535111924
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Exam Prep for Stem Cell Epigenetics

Exam Prep for  Stem Cell Epigenetics
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2021
ISBN 10:
ISBN 13:
Language: EN, FR, DE, ES & NL

Exam Prep for Stem Cell Epigenetics Book Review:

Epigenetics and Dermatology

Epigenetics and Dermatology
Author: Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publsiher: Academic Press
Total Pages: 520
Release: 2015-02-16
ISBN 10: 0128012722
ISBN 13: 9780128012727
Language: EN, FR, DE, ES & NL

Epigenetics and Dermatology Book Review:

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Epigenetics

Epigenetics
Author: Lyle Armstrong
Publsiher: Unknown
Total Pages: 306
Release: 2014
ISBN 10: 9780429258862
ISBN 13: 0429258860
Language: EN, FR, DE, ES & NL

Epigenetics Book Review:

"The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does. Epigenetics brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It will therefore be an invaluable source of information about all aspects of this subject for undergraduate students, graduate students, and professionals alike. Topics included are the role of epigenetics in stem cells, the involvement of epigenetics with cancer, and the role of epigenetics in mental health. Key Features - Describes the two forms of epigenetic modification, DNA methylation and histone acetylation, and how they take place. - Section on how epigenetics controls cell function, including cellular differentiation and consequently the role of epigenetics in stem cells - Section on the role of epigenetics in disease only includes diseases where there is clear evidence of epigenetic involvement - Glossary explaining all the terms involved in epigenetics - Full-color figures"--Provided by publisher.

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author: Suming Huang,Michael D Litt,C. Ann Blakey
Publsiher: Academic Press
Total Pages: 482
Release: 2015-10-19
ISBN 10: 0128004711
ISBN 13: 9780128004715
Language: EN, FR, DE, ES & NL

Epigenetic Gene Expression and Regulation Book Review:

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Leukemia Stem Cells in Hematologic Malignancies

Leukemia Stem Cells in Hematologic Malignancies
Author: Haojian Zhang,Shaoguang Li
Publsiher: Springer
Total Pages: 229
Release: 2019-07-23
ISBN 10: 9811373426
ISBN 13: 9789811373428
Language: EN, FR, DE, ES & NL

Leukemia Stem Cells in Hematologic Malignancies Book Review:

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.

Essential Current Concepts in Stem Cell Biology

Essential Current Concepts in Stem Cell Biology
Author: Beate Brand-Saberi
Publsiher: Springer Nature
Total Pages: 242
Release: 2020-01-03
ISBN 10: 3030339238
ISBN 13: 9783030339234
Language: EN, FR, DE, ES & NL

Essential Current Concepts in Stem Cell Biology Book Review:

This textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

Exam Prep for Stem Cell Epigenetics

Exam Prep for  Stem Cell Epigenetics
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2021
ISBN 10:
ISBN 13:
Language: EN, FR, DE, ES & NL

Exam Prep for Stem Cell Epigenetics Book Review:

The Biology and Therapeutic Application of Mesenchymal Cells Set

The Biology and Therapeutic Application of Mesenchymal Cells   Set
Author: Kerry Atkinson
Publsiher: John Wiley & Sons
Total Pages: 1048
Release: 2017-01-17
ISBN 10: 1118907515
ISBN 13: 9781118907511
Language: EN, FR, DE, ES & NL

The Biology and Therapeutic Application of Mesenchymal Cells Set Book Review:

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. • Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications • Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models • Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues • Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Minoru Tomizawa
Publsiher: BoD – Books on Demand
Total Pages: 532
Release: 2016-07-20
ISBN 10: 9535124714
ISBN 13: 9789535124719
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Epigenetics of the Immune System

Epigenetics of the Immune System
Author: Dieter Kabelitz,Jaydeep Bhat
Publsiher: Academic Press
Total Pages: 384
Release: 2020-06-04
ISBN 10: 0128179651
ISBN 13: 9780128179659
Language: EN, FR, DE, ES & NL

Epigenetics of the Immune System Book Review:

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Stem Cells

Stem Cells
Author: Christine Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers
Publsiher: Academic Press
Total Pages: 448
Release: 2014-05-23
ISBN 10: 0124115675
ISBN 13: 9780124115675
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

Epigenetics in Human Disease

Epigenetics in Human Disease
Author: Trygve O. Tollefsbol
Publsiher: Academic Press
Total Pages: 577
Release: 2012
ISBN 10: 0123884152
ISBN 13: 9780123884152
Language: EN, FR, DE, ES & NL

Epigenetics in Human Disease Book Review:

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Handbook of Epigenetics

Handbook of Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 682
Release: 2017-07-10
ISBN 10: 0128054778
ISBN 13: 9780128054772
Language: EN, FR, DE, ES & NL

Handbook of Epigenetics Book Review:

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
Author: J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publsiher: Academic Press
Total Pages: 374
Release: 2012-12-31
ISBN 10: 0123944058
ISBN 13: 9780123944054
Language: EN, FR, DE, ES & NL

Epigenetic Regulation in the Nervous System Book Review:

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Epigenetics and Regeneration

Epigenetics and Regeneration
Author: Anonim
Publsiher: Academic Press
Total Pages: 541
Release: 2019-05-24
ISBN 10: 0128148802
ISBN 13: 9780128148808
Language: EN, FR, DE, ES & NL

Epigenetics and Regeneration Book Review:

Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. Provides a foundational overview of epigenetics in regenerative medicine Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Epigenetics in Psychiatry

Epigenetics in Psychiatry
Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publsiher: Elsevier
Total Pages: 664
Release: 2014-06-23
ISBN 10: 0124171346
ISBN 13: 9780124171343
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Book Review:

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

An Introduction to Modern Genetics

An Introduction to Modern Genetics
Author: C. H. Waddington
Publsiher: Routledge
Total Pages: 420
Release: 2016-03-17
ISBN 10: 1317352041
ISBN 13: 9781317352044
Language: EN, FR, DE, ES & NL

An Introduction to Modern Genetics Book Review:

First published in 1939 (second impression in 1950), this book provides an account of the changes in, and main principles of, genetics at that time. These are illustrated by references to the most authoritative and then recent investigations. Special attention is paid to the way in which genetics overlaps with other fields of inquiry, since it is often in these border-line subjects that the most important advances are to be expected. The book is particularly arranged to suit the convenience of students whose previous knowledge of genetics is small, and contains annotated bibliographies of suggestions for further reading.

Medical Epigenetics

Medical Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 924
Release: 2016-06-21
ISBN 10: 0128032405
ISBN 13: 9780128032404
Language: EN, FR, DE, ES & NL

Medical Epigenetics Book Review:

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine