Spine Phenotypes

Spine Phenotypes
Author: Dino Samartzis,Jaro Ilari Karppinen,Frances Mary Kingsley WILLIAMS
Publsiher: Academic Press
Total Pages: 135
Release: 2020-10
ISBN 10: 9780128227787
ISBN 13: 0128227788
Language: EN, FR, DE, ES & NL

Spine Phenotypes Book Review:

The era of personalized spine care has arrived. Within that, imaging and clinical phenotypes are key in establishing personalized algorithms for patient care. This is particularly important in developing novel diagnostics and therapeutics as well as predicting outcomes and establishing preventative measures for various spinal disorders. Spine Phenotypes is a comprehensive resource that outlines phenotype descriptions, their radiographic measurement and epidemiological classification and provides an in-depth discussion regarding spine pathology and its clinical relevance. Multi-authored, with multi-disciplinary contributions from world leaders in the field of imaging, spine research and clinical practice, each chapter is rich in visual depiction of imaging phenotypes, providing examples of some established phenotypic measurements with a range of normal and pathologic images. Spine Phenotypes will be a first of its kind reference for researchers, orthopedists, spine specialists and many more.

Atlas of Spinal Imaging Phenotypes

Atlas of Spinal Imaging Phenotypes
Author: Philip Louie,Howard S. An,Dino Samartzis
Publsiher: Elsevier Health Sciences
Total Pages: 282
Release: 2021-03-23
ISBN 10: 0323761127
ISBN 13: 9780323761123
Language: EN, FR, DE, ES & NL

Atlas of Spinal Imaging Phenotypes Book Review:

Spine-related pain is the world’s leading disabling condition, affecting every population and a frequent reason for seeking medical consultation and obtaining imaging studies. Numerous spinal phenotypes (observations/traits) and their respective measurements performed on various spine imaging have been shown to directly correlate and predict clinical outcomes. Atlas of Spinal Imaging Phenotypes: Classifications and Radiographic Measurements is a comprehensive visual resource that highlights various spinal phenotypes on imaging, describes their clinical and pathophysiological relevance, and discusses and illustrates their respective measurement techniques and classifications. Helps readers better understanding spinal phenotypes and their imaging, and how today’s knowledge will facilitate new targeted drug discovery, novel diagnostics and biomarker discovery, and outcome predictions. Features step-by-step instructions on performing the radiographic measurements with examples of normal and pathologic images to demonstrate the various presentations. Presents clinical correlation of the phenotypes as well as the radiographic measurements with landmark references. Includes validated classification systems that complement the phenotypes and radiographic measurements. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a prolific surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping.

Atlas of Spinal Imaging

Atlas of Spinal Imaging
Author: Philip K. Louie, MD,Howard S. An, MD,Dino Samartzis
Publsiher: Unknown
Total Pages: 400
Release: 2021-02
ISBN 10: 9780323761116
ISBN 13: 0323761119
Language: EN, FR, DE, ES & NL

Atlas of Spinal Imaging Book Review:

Spine-related pain is the world's leading disabling condition, affecting every population and a frequent reason for seeking medical consultation and obtaining imaging studies. Numerous spinal phenotypes (observations/traits) and their respective measurements performed on various spine imaging have been shown to directly correlate and predict clinical outcomes. Atlas of Spinal Imaging Phenotypes: Classifications and Radiographic Measurements is a comprehensive visual resource that highlights various spinal phenotypes on imaging, describes their clinical and pathophysiological relevance, and discusses and illustrates their respective measurement techniques and classifications. Helps readers better understanding spinal phenotypes and their imaging, and how today's knowledge will facilitate new targeted drug discovery, novel diagnostics and biomarker discovery, and outcome predictions. Features step-by-step instructions on performing the radiographic measurements with examples of normal and pathologic images to demonstrate the various presentations. Presents clinical correlation of the phenotypes as well as the radiographic measurements with landmark references. Includes validated classification systems that complement the phenotypes and radiographic measurements. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a prolific surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping.

Abnormal Skeletal Phenotypes

Abnormal Skeletal Phenotypes
Author: Alessandro Castriota-Scanderbeg,Bruno Dallapiccola
Publsiher: Springer Science & Business Media
Total Pages: 962
Release: 2006-03-20
ISBN 10: 3540303618
ISBN 13: 9783540303619
Language: EN, FR, DE, ES & NL

Abnormal Skeletal Phenotypes Book Review:

Taking a symptom-oriented approach, this book focuses on the radiographic changes of malformation syndromes and skeletal dysplasias. Its clear structure makes it an essential, practical guide for radiologists, geneticists, and pediatricians.

Rescue of FXS Phenotypes in Fmr1 Knockout Mice by the Small Molecule P21 activated Kinase Inhibitor FRAX486

Rescue of FXS Phenotypes in Fmr1 Knockout Mice by the Small Molecule P21 activated Kinase Inhibitor FRAX486
Author: Bridget M. Dolan
Publsiher: Unknown
Total Pages: 226
Release: 2011
ISBN 10: 1928374650XXX
ISBN 13: OCLC:783793090
Language: EN, FR, DE, ES & NL

Rescue of FXS Phenotypes in Fmr1 Knockout Mice by the Small Molecule P21 activated Kinase Inhibitor FRAX486 Book Review:

Autism is a diverse and complex family of disorders, and its prevalence is on the rise: 1 in 110 children have autism. There is no effective treatment for the symptoms which often include language and communication deficits, repetitive behavior, intellectual disability, epilepsy, attention deficits, and hyperactivity. The quest for a cure is challenging due to the heterogeneity of the disorder, but also because more than 90% of cases of autism are idiopathic, meaning the cause is unknown. Fortunately, one cause of autism has been discovered: silencing of a single gene causes an autism-like disorder called Fragile X Syndrome (FXS). The knowledge of the genetic basis of FXS allowed for the development of a mouse model of autism. The fmr1 knockout (KO) mouse displays phenotypes similar to symptoms in the human condition - including hyperactivity, repetitive behaviors, and seizures. Humans and mice share not only behavioral expression of the disease, but also analogous abnormalities in the density and morphology of dendritic spines - the sites of connections between neurons and critical substrates for learning. Abnormal dendritic spines is a common feature in FXS, idiopathic autism, and intellectual disability. Thus, this neuroanatomical abnormality may contribute to disease symptoms and severity. Here we take a hypothesis-driven, mechanism-based approach to the search for an effective therapy for FXS. We hypothesize that a treatment that rescues the dendritic spine defect may also ameliorate behavioral symptoms. Thus, we targeted a protein that regulates spines through modulation of actin cytoskeleton dynamics: p21-activated kinase (PAK). In a healthy brain, PAK and FMRP - the protein product of fmr1 - antagonize one another to regulate spine number and shape. Inhibition of PAK with a strategy utilizing mouse genetics reverses spine abnormalities as well as cognitive and behavioral symptoms in fmr1 KO mice, as we demonstrated in our previous publication. This discovery highlights PAK as a potential target for drug discovery research. In this thesis work, we build on this finding to test whether the small molecule FRAX486 - selected for its ability to inhibit PAK - can rescue behavioral, morphological, and physiological phenotypes in fmr1 KO mice. Our results demonstrate that seizures and behavioral abnormalities such as hyperactivity, repetitive movements, and habituation to a novel environment can all be rescued by FRAX486. Moreover, FRAX486 reverses spine phenotypes in adult mice, thereby supporting the hypothesis that a drug treatment which reverses the spine abnormalities can also treat neurological and behavioral symptoms.

Dendritic spines from shape to function

Dendritic spines  from shape to function
Author: Nicolas Heck,Ruth Benavides-Piccione
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-02-03
ISBN 10: 2889197662
ISBN 13: 9782889197668
Language: EN, FR, DE, ES & NL

Dendritic spines from shape to function Book Review:

One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dendrite reflects the levels of connectivity within the neuronal network. Furthermore, the relevance of studying dendritic spines is emphasized by the observation that their morphology changes with synaptic plasticity and is altered in many psychiatric disorders. The present Research Topic deals with some of the most recent findings concerning dendritic spine structure and function, showing that, in order to understand how brain neuronal activity operates, these two factors should be regarded as being intrinsically linked.

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
Author: Carlo Sala,Chiara Verpelli
Publsiher: Academic Press
Total Pages: 394
Release: 2016-04-30
ISBN 10: 0128005335
ISBN 13: 9780128005330
Language: EN, FR, DE, ES & NL

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability Book Review:

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Genetically Modified Organisms and Genetic Engineering in Research and Therapy

Genetically Modified Organisms and Genetic Engineering in Research and Therapy
Author: Pascale Piguet,P. Poindron,Philippe Poindron
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 123
Release: 2012
ISBN 10: 3805590652
ISBN 13: 9783805590655
Language: EN, FR, DE, ES & NL

Genetically Modified Organisms and Genetic Engineering in Research and Therapy Book Review:

Genetically modified organisms (GMO) raise societal, political and ethical concerns. They inspire strong resistance or, conversely, enthusiastic assent. The aim of this publication is to give an overview of genetic engineering, starting with the history of the discovery of restriction enzymes continuing with technical aspects of transgenesis to its applications in research and ethical considerations. Be it the use of single engineered cells or GMO, these applications cover a broad array, ranging from disease-oriented research (but not only), to the promising perspectives of gene therapy. Historical and technical aspects give insights into the problems inherent to the creation of GMO, and illustrate the links and limits between genetic engineering, GMOs and gene therapy. A summary article in English and French structures the links between the different chapters and concepts. Scientists interested in genetic engineering of single cells or animal models, as well as in gene therapy, will find an up-to-date review on the use and perspectives of transgenesis. However, this publication is also recommended to the public interested in the definition of GMO, which encompasses a much broader array than the genetically modified crops covered by media.

Cervical Spine

Cervical Spine
Author: Kai-Uwe Lewandrowski
Publsiher: Bentham Science Publishers
Total Pages: 280
Release: 2021-10-18
ISBN 10: 9814998648
ISBN 13: 9789814998642
Language: EN, FR, DE, ES & NL

Cervical Spine Book Review:

Contemporary Endoscopic Spine Surgery brings the reader the most up-to-date information on the endoscopy of the spine. Key opinion leaders from around the world have come together to present the clinical evidence behind their competitive endoscopic spinal surgery protocols. Chapters in the series cover a range of aspects of spine surgery including spinal pain generators, preoperative workup with modern independent predictors of favorable clinical outcomes with endoscopy, anesthesia in an outpatient setting, management of complications, and a fresh look at technology advances in a historical context. The reader will have a first-row seat during the illustrative discussions of expanded surgical indications from herniated disc to more complex clinical problems, including stenosis, instability, and deformity in patients with advanced degenerative disease of the human spine. Contemporary Endoscopic Spine Surgery is divided into three volumes: Cervical Spine, Lumbar Spine, and Advanced Technologies to capture an accurate snapshot in time of this fast-moving field. It is intended as a comprehensive go-to reference text for surgeons in graduate residency and postgraduate fellowship training programs and for practicing spine surgeons interested in looking for the scientific foundation for their practice expansion into endoscopic surgery. This volume (Cervical Spine) covers the following topics Cervical Endoscopy: Historical Perspectives, Present & Future Anesthesia For Minimally Invasive Surgery Of The Cervical Algorithms To Choose Between Anterior And Posterior Cervical Endoscopy Contemporary Clinical Decision Making In Full Endoscopic Cervical Spine Surgery Indications And Outcomes With Endoscopic Posterior Cervical Rhizotomy Anterior Endoscopic Cervical Discectomy Anterior Transcorporeal Approach Of Percutaneous Endoscopic Cervical Discectomy Anterior Endoscopic Cervical Discectomy And Foraminoplasty For Herniated Disc And Lateral Canal Stenosis Posterior Full Endoscopic Cervical Discectomy & Foraminotomy Endoscopic Decompression For Cervical Spondylotic Myelopathy

The Growing Spine

The Growing Spine
Author: Behrooz A. Akbarnia,Muharrem Yazici,George H. Thompson
Publsiher: Springer
Total Pages: 949
Release: 2015-11-02
ISBN 10: 3662482843
ISBN 13: 9783662482841
Language: EN, FR, DE, ES & NL

The Growing Spine Book Review:

The second edition of The Growing Spine has been extensively revised to cover recent advances in knowledge and management. The book is intended as a comprehensive, one-stop reference for specialists and health professionals who care for young children with spinal deformities. In addition, it will effectively help to standardize the care of these patients. Depending on the etiology, children with spinal deformities are often cared for by multiple specialists, including pediatricians, pediatric orthopaedists or orthopaedic spine surgeons, neurologists, pediatric surgeons, pediatric neurosurgeons, oncologists, and pulmonologists. The multidisciplinary nature of care is reflected in The Growing Spine, which will be of value for all involved practitioners rather than just orthopaedic specialists. It will also be an ideal reference for nurses, physical therapists, and healthcare professionals in training, who are usually unfamiliar with spinal deformities in children.

Diagnostic Imaging Spine E Book

Diagnostic Imaging  Spine E Book
Author: Jeffrey S. Ross,Kevin R. Moore
Publsiher: Elsevier Health Sciences
Total Pages: 1100
Release: 2015-08-21
ISBN 10: 0323400604
ISBN 13: 9780323400602
Language: EN, FR, DE, ES & NL

Diagnostic Imaging Spine E Book Book Review:

With constant improvements to MR image quality, it's important to have a resource reflecting the most recent developments. Diagnostic Imaging: Spine, now in its third edition, showcases the latest cutting-edge research from Dr. Jeffrey Ross and his team of experts in the field. Expanding upon the core of the highly popular second edition, this updated reference is fully revised to provide the best spine-related diagnostic support available. Covers the latest advancements in imaging the postoperative spine, including bone morphogenetic protein (BMP) utilization Includes additional genetic information, such as OMIM entry numbers, where appropriate Highlights updates to new classification and grading schemes Hundreds of full-color pathology images are carefully annotated to help pinpoint the most relevant factors New references direct you to additional trustworthy resources Bulleted lists provide guidance through the intricacies of the spine Presents brand new images and cases to keep you at the forefront of your field Medicine eBook is accessible on a variety of devices

Diagnostic Imaging Spine E Book

Diagnostic Imaging  Spine   E Book
Author: Jeffrey S. Ross,Kevin R. Moore
Publsiher: Elsevier Health Sciences
Total Pages: 1250
Release: 2020-11-16
ISBN 10: 0323794009
ISBN 13: 9780323794008
Language: EN, FR, DE, ES & NL

Diagnostic Imaging Spine E Book Book Review:

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Spine, fourth edition, is an invaluable resource for general radiologists, neuroradiologists, and trainees—anyone who requires an easily accessible, highly visual reference on today’s spinal imaging. Drs. Jeffrey Ross, Kevin Moore, and their team of highly regarded experts provide updated information on disease identification and imaging techniques to help you make informed decisions at the point of care. The text is lavishly illustrated, delineated, and referenced, making it a useful learning tool as well as a handy reference for daily practice. Serves as a one-stop resource for key concepts and information on radiologic imaging and interpretation of spine, spinal cord, and bony vertebral conditions Features more than 2,600 full-color illustrations, including radiologic, pathologic, and clinical images Contains new chapters on recent surgery protocols such as spine instability neoplastic scoring (SINS) and epidural spinal cord compression scale (ESSC) Features updates from cover to cover including revisions in accordance with new information on inflammatory and autoimmune disorders and systemic manifestations of diseases Provides expanded imaging details for metastatic diseases to accommodate recent significant changes, including new categories of oncologic surgery driven by the use of proton beam radiotherapy, PET MR as a diagnostic modality, and new FDA-approved hardware Includes new information on areas of demyelinating diseases related to better understanding of MS, neuromyelitis optica spectrum disorder, and anti-MOG disorders; a variety of spinal CSF leak pathologies that cause intracranial hypotension; genetic and disease information on schwannomatosis; and much more Uses bulleted, succinct text and highly templated chapters for quick comprehension of essential information at the point of care

Lumbar Endplate and Modic Changes Epidemiology Determinants and Pain Profiles in Southern Chinese

Lumbar Endplate and Modic Changes  Epidemiology  Determinants and Pain Profiles in Southern Chinese
Author: Pik-Sze Mok,莫碧詩
Publsiher: Open Dissertation Press
Total Pages: 135
Release: 2017-01-27
ISBN 10: 9781361356692
ISBN 13: 1361356693
Language: EN, FR, DE, ES & NL

Lumbar Endplate and Modic Changes Epidemiology Determinants and Pain Profiles in Southern Chinese Book Review:

This dissertation, "Lumbar Endplate and Modic Changes, Epidemiology, Determinants and Pain Profiles in Southern Chinese" by Pik-sze, Mok, 莫碧詩, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Intervertebral disc(IVD) degeneration is associated with low back pain (LBP).Despite the endplates are located adjacent to the IVD, the phenotypes of endplate and vertebral bone marrow changes remain unclear. The objective of this study is to assess the prevalence and the associated determinants of these phenotypes of the lumbar spine. 2449 Southern Chinese subjects (aged 10 -88 years) undergone sagittal T2-weighted magnetic resonance imaging (MRI)examination to assess the presence of endplate and vertebral bone marrow changes including Schmorl's nodes (SN) and Modic changes (MC), respectively, and scored for additional radiographic features over the lumbar spine. Subjects' demographics, clinical profile, and functional status were assessed by means of standardized questionnaires. Anovel6-domain SN morphological classification based on MRI was developed to further analyze the characteristics of SN and its association with disc degeneration (DD). The prevalence of SN was 16.4%. Males, taller and heavier individuals had a significantly increased likelihood of SN. Overall presence of SN was age-independent, but was significantly associated with DD, and linearly correlated with increase in severity of DD. SN were particularly associated with severe DD at the upper two lumbar levels (L1/2 - L2/3). Based on the SN classification system, specific SN characteristics and endplate linkage patterns were found. Of these, two SN types were identified: "Typical SN" and "Atypical SN." "Typical SN" were those smaller size SN with various shapes that were frequently located at caudal endplates of L1/2-L3/4disc levels. One variant of "Atypical SN" were those rectangular shape SN, which predominantly located at the posterior region of the rostral endplates of L1/2-L2/3disc levels. The other variant of "Atypical SN" was larger size SN with irregular shape that frequently presented at the L4/5endplates, they were also likely to be associated with marrow changes. Despite "Atypical SN" only entailed 8.3% of all identified SN, they were associated with increased severity of DD than "Typical SN." Although the overall prevalence of MC among Southern Chinese was low (5.8%), after adjustments for other confounding factors, the presence of MC was associated with the presence and severity of LBP. Interestingly, the determinants of MC at upper (L1/2 - L3/4) and lower (L4/5 - L5/S1) lumbar showed distinct difference. The presence of MC at upper lumbar levels was only associated with the disc integrity only (i.e. the presence of disc displacement, and DD score), while the presence of MC at the lower levels, apart from the disc integrity, was also associated with increasing age, the presence of SN, smoking and obesity status. This study is the largest MRI study assessing the phenotypes of endplate and vertebral bone marrow changes in-vivo. The prevalence and distribution of SN and MC vary throughout the lumbar spine, and there are level and region-specific variations regarding these phenotypes. Determinants of SN and MC may be similar but do vary, suggesting distinct etiological factors. Findings of this study broaden the understanding of the various phenotypes of the lumbar spine and its association with DD. DOI: 10.5353/th_b5328055 Subjects: Lumbar vertebrae Intervertebral disk - Diseases

Issues in Biological and Life Sciences Research 2013 Edition

Issues in Biological and Life Sciences Research  2013 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 1193
Release: 2013-05-01
ISBN 10: 1490108688
ISBN 13: 9781490108681
Language: EN, FR, DE, ES & NL

Issues in Biological and Life Sciences Research 2013 Edition Book Review:

Issues in Biological and Life Sciences Research: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Additional Research. The editors have built Issues in Biological and Life Sciences Research: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Environmental Experience and Plasticity of the Developing Brain

Environmental Experience and Plasticity of the Developing Brain
Author: Alessandro Sale
Publsiher: John Wiley & Sons
Total Pages: 240
Release: 2016-02-04
ISBN 10: 1118931661
ISBN 13: 9781118931660
Language: EN, FR, DE, ES & NL

Environmental Experience and Plasticity of the Developing Brain Book Review:

Environmental Experience and Plasticity of the Developing Brain goes beyond the genetic basis of neurodevelopment. Chapters illuminate the external factors that can dramatically impact the brain early in life and, consequently, the eventual accomplishment of developmental milestones and the construction of adult behavior and personality. Authored and edited by leaders in this rapidly growing field, Environmental Experience and Plasticity of the Developing Brain not only surveys preexisting literature on the effects of environment versus genetics, but also discusses more recent studies on the impacts of neurodevelopment in terms of maternal stimulation, environmental enrichment and sensory deprivation. The book also includes key examples of environmental impacts on preexisting genetic syndromes leading to developmental disabilities. Focus is also given to the consequences of early adverse experience in primates, as well as neurobiological and behavioral consequences in institutionalized human children and the reversibility of such consequences. Environmental Experience and Plasticity of the Developing Brain encompasses a broad area of research in the field of developmental neurobiology and offers a unique combination of different examples of environmental factors affecting brain development and behavior.

Phenotypic Plasticity Evolution

Phenotypic Plasticity   Evolution
Author: David W. Pfennig
Publsiher: CRC Press
Total Pages: 436
Release: 2021-06-04
ISBN 10: 1000387585
ISBN 13: 9781000387582
Language: EN, FR, DE, ES & NL

Phenotypic Plasticity Evolution Book Review:

Phenotypic plasticity – the ability of an individual organism to alter its features in direct response to a change in its environment – is ubiquitous. Understanding how and why this phenomenon exists is crucial because it unites all levels of biological inquiry. This book brings together researchers who approach plasticity from diverse perspectives to explore new ideas and recent findings about the causes and consequences of plasticity. Contributors also discuss such controversial topics as how plasticity shapes ecological and evolutionary processes; whether specific plastic responses can be passed to offspring; and whether plasticity has left an important imprint on the history of life. Importantly, each chapter highlights key questions for future research. Drawing on numerous studies of plasticity in natural populations of plants and animals, this book aims to foster greater appreciation for this important, but frequently misunderstood phenomenon. Key Features Written in an accessible style with numerous illustrations, including many in color Reviews the history of the study of plasticity, including Darwin’s views Most chapters conclude with recommendations for future research

Genetics for Fish Hatchery Managers

Genetics for Fish Hatchery Managers
Author: Douglas Tave
Publsiher: Unknown
Total Pages: 299
Release: 1986
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015013596930
Language: EN, FR, DE, ES & NL

Genetics for Fish Hatchery Managers Book Review:

Neurotransmitter Phenotypes of Descending Systems in the Rat Lumbar Spinal Cord

Neurotransmitter Phenotypes of Descending Systems in the Rat Lumbar Spinal Cord
Author: Amy Du Beau
Publsiher: Unknown
Total Pages: 241
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:870423705
Language: EN, FR, DE, ES & NL

Neurotransmitter Phenotypes of Descending Systems in the Rat Lumbar Spinal Cord Book Review:

Canadian Journal of Zoology

Canadian Journal of Zoology
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2001
ISBN 10: 1928374650XXX
ISBN 13: WISC:89075702928
Language: EN, FR, DE, ES & NL

Canadian Journal of Zoology Book Review:

Behavioural Phenotypes in Clinical Practice

Behavioural Phenotypes in Clinical Practice
Author: Gregory O'Brien
Publsiher: Cambridge University Press
Total Pages: 239
Release: 2002-01-21
ISBN 10: 9781898683278
ISBN 13: 1898683271
Language: EN, FR, DE, ES & NL

Behavioural Phenotypes in Clinical Practice Book Review:

Clinics in Developmental Medicine No. 157 Clinicians, educators and other specialists who work with young people with intellectual disabilities are increasingly aware of the extent to which their clients' behaviours are shaped by the respective causal syndrome. This book is a practical response to the need for interventions and ongoing care programmes to take account of this within the context of coordinated multimodal case planning. An international team of experts drawn from child health, special education, psychology, psychiatry and related disciplines explores general principles of case management, in addition to giving consideration to a large number of individual syndromes, resulting in a comprehensive review of the subject. All of the authors have been involved in original research on the themes explored, and in the development of coherent service responses to the challenges posed by behavioural phenotypes. This will be essential reading for all professionals engaged in the care and management of people with intellectual disabilities.