Spinal Cord Injury SCI Repair Strategies

Spinal Cord Injury  SCI  Repair Strategies
Author: Giuseppe Perale,Filippo Rossi
Publsiher: Woodhead Publishing
Total Pages: 346
Release: 2019-10-30
ISBN 10: 0081028083
ISBN 13: 9780081028087
Language: EN, FR, DE, ES & NL

Spinal Cord Injury SCI Repair Strategies Book Review:

Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma
Author: Michael G. Fehlings,Brian Kwon,Alexander R. Vaccaro,F. Cumhur Oner
Publsiher: Academic Press
Total Pages: 400
Release: 2020-12-15
ISBN 10: 9780128198353
ISBN 13: 0128198354
Language: EN, FR, DE, ES & NL

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma Book Review:

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine
Author: António Salgado
Publsiher: Elsevier
Total Pages: 710
Release: 2020-06-10
ISBN 10: 0128180854
ISBN 13: 9780128180853
Language: EN, FR, DE, ES & NL

Handbook of Innovations in Central Nervous System Regenerative Medicine Book Review:

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Promoting Neuroplasticity to Repair the Injured Spinal Cord

Promoting Neuroplasticity to Repair the Injured Spinal Cord
Author: Nina Weishaupt
Publsiher: Unknown
Total Pages: 272
Release: 2013
ISBN 10:
ISBN 13: OCLC:871700569
Language: EN, FR, DE, ES & NL

Promoting Neuroplasticity to Repair the Injured Spinal Cord Book Review:

This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay pathways to re-establish communication with target regions below the injury level. In chapter 2, I attempted to promote a detour for the cervically injured corticospinal tract (CST) via spared reticulospinal tract (RtST) axons with a combined treatment including the neurotrophins BDNF, NT-3 and rehabilitative training. Although anatomical evidence for the desired rewiring was not obtained, I found a synergistic effect of BDNF treatment and training on recovery of skilled forelimb reaching. No effect of NT-3 administered rostral to the SCI was evident. The experiment in chapter 3 was designed to answer the question whether NT-3-induced CST collateral growth rostral to an SCI can be facilitated by systemic immune activation. Results indicate that NT-3 expression can promote collateral growth from the injured CST, irrespective of immune activation. Since results from chapter 2 did not shed light on the previously suggested role of the RtST in recovery of hand/paw function after cervical SCI, I next examined whether the mostly spared RtST responds to SCI with changes in its anatomical projection pattern. While collateral projections were unchanged rostral to the SCI, I observed a marked withdrawal of collaterals from grey matter regions directly caudal to the SCI. Results from chapter 2 combined with previous reports indicate that task-specific training does often not translate into untrained tasks and may even result in undesired side effects. To elucidate the functional relationship between trained tasks further, I next investigated how training the primarily affected forelimb (PAF) and/or the less affected forelimb (LAF) after unilateral cervical SCI influences performance outcomes for each limb. Results point towards training tasks competitively recruiting available neuronal "hardware". This work identifies promising leads for promoting plasticity of important motor tracts after SCI, and also points out targets for optimization of strategies employed. These new insights contribute to the exploration of urgently needed repair strategies for SCI.

Journal of Rehabilitation Research and Development

Journal of Rehabilitation Research and Development
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: WISC:89088962329
Language: EN, FR, DE, ES & NL

Journal of Rehabilitation Research and Development Book Review:

Neurobiology of Spinal Cord Injury

Neurobiology of Spinal Cord Injury
Author: Robert G. Kalb,Stephen M. Strittmatter
Publsiher: Springer Science & Business Media
Total Pages: 284
Release: 1999-10-22
ISBN 10: 1592592007
ISBN 13: 9781592592005
Language: EN, FR, DE, ES & NL

Neurobiology of Spinal Cord Injury Book Review:

Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Biomimetic Materials And Design

Biomimetic Materials And Design
Author: Angela Dillow,Anthony Lowman
Publsiher: CRC Press
Total Pages: 696
Release: 2002-08-28
ISBN 10: 9780203908976
ISBN 13: 020390897X
Language: EN, FR, DE, ES & NL

Biomimetic Materials And Design Book Review:

Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

Spinal Cord Injury Rehabilitation

Spinal Cord Injury Rehabilitation
Author: Edelle Field-Fote
Publsiher: F.A. Davis
Total Pages: 500
Release: 2009-03-26
ISBN 10: 0803623194
ISBN 13: 9780803623194
Language: EN, FR, DE, ES & NL

Spinal Cord Injury Rehabilitation Book Review:

One of the world’s leading authorities in spinal cord injury, and a participant in the Human Brain Project brings you an evidenced-based guide to the state-of-the-art in spinal cord rehabilitation. She has assembled an expert team of clinicians, each with expertise in the content areas they address. Their work encompasses all of the new scientific knowledge and technological advances practitioners need to know to determine the most effective rehabilitation interventions for each patient and to attain maximum restoration of function in individuals with SCI.

Essentials of Spinal Cord Injury Medicine

Essentials of Spinal Cord Injury Medicine
Author: Yannis Dionyssiotis
Publsiher: BoD – Books on Demand
Total Pages: 166
Release: 2018-06-13
ISBN 10: 1789232481
ISBN 13: 9781789232486
Language: EN, FR, DE, ES & NL

Essentials of Spinal Cord Injury Medicine Book Review:

Spinal cord injury is a severe condition leading to serious neurological dysfunctions and changes a person's life in a sudden way. Understanding the pathophysiology of spinal cord injury will improve the prognosis and reintegration to the society of spinal cord-injured subjects. The book Essentials in Spinal Cord Injury Medicine includes seven chapters with valuable information addressing hot topics related to spinal cord injury, ranging from pathophysiology, nontraumatic spinal cord injury, complications to exoskeletons, and research therapies with mesenchymal stem cells. The book could be a valued reference for physiatrists, neurosurgeons, orthopedic surgeons, neurologists and physical therapists.

Indwelling Neural Implants

Indwelling Neural Implants
Author: William M. Reichert
Publsiher: CRC Press
Total Pages: 296
Release: 2007-12-17
ISBN 10: 9781420009309
ISBN 13: 1420009303
Language: EN, FR, DE, ES & NL

Indwelling Neural Implants Book Review:

Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.

Therapeutic Strategies to Spinal Cord Injury

Therapeutic Strategies to Spinal Cord Injury
Author: Pavla Jendelova
Publsiher: MDPI
Total Pages: 238
Release: 2018-11-29
ISBN 10: 3038974064
ISBN 13: 9783038974062
Language: EN, FR, DE, ES & NL

Therapeutic Strategies to Spinal Cord Injury Book Review:

This book is a printed edition of the Special Issue "Therapeutic Strategies to Spinal Cord Injury" that was published in IJMS

Recovery of Motor Function Following Spinal Cord Injury

Recovery of Motor Function Following Spinal Cord Injury
Author: Heidi Fuller,Monte Gates
Publsiher: BoD – Books on Demand
Total Pages: 330
Release: 2016-08-17
ISBN 10: 9535124978
ISBN 13: 9789535124979
Language: EN, FR, DE, ES & NL

Recovery of Motor Function Following Spinal Cord Injury Book Review:

Restoration of motor function following spinal cord injury is a complex and challenging task. By reviewing emerging cellular, pharmacological, rehabilitative, as well as surgical approaches, this book seeks to highlight promising therapeutic strategies for the repair and regeneration of motor circuitry. The multidisciplinary nature of these approaches illustrates various routes to bridging the gap between the bench and the bedside and to identify the challenges that must be overcome in order to bring about a viable therapeutic strategy for spinal cord injury patients.

Topics in Paraplegia

Topics in Paraplegia
Author: Yannis Dionyssiotis
Publsiher: BoD – Books on Demand
Total Pages: 304
Release: 2014-07-02
ISBN 10: 9535116215
ISBN 13: 9789535116219
Language: EN, FR, DE, ES & NL

Topics in Paraplegia Book Review:

Spinal cord injury related paraplegia changes a person's life in a sudden way. The most important issue for physicians, therapists and caregivers is to manage the complications that arise, and help paraplegic subjects return to a productive integrated life within society. The book Topics in Paraplegia provides modern knowledge in this direction. Addressing hot topics related to paraplegia, ranging from surgical management to research therapies with mesenchymal stem cells, this book could be a valued reference for physiatrists, neurosurgeons, orthopaedic surgeons, neurologists and physical therapists. The book is organized into four sections. The first covers the epidemiology and psychological conditions associated with paraplegia, the second discusses surgical management and common rehabilitation interventions; the third medical complications and special musculoskeletal issues, while the last outlines current research in animals and humans.

Cellular Transplantation

Cellular Transplantation
Author: Craig Halberstadt,Dwaine F. Emerich
Publsiher: Elsevier
Total Pages: 696
Release: 2011-10-10
ISBN 10: 0080469043
ISBN 13: 9780080469041
Language: EN, FR, DE, ES & NL

Cellular Transplantation Book Review:

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. Provides detailed description of clinical trials in cell transplantation Review of current therapeutic approaches Coverage of the broad range of diseases addressed by cell therapeutics Discussion of stem cell biology and its role in transplantation

Dissertation Abstracts International

Dissertation Abstracts International
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: STANFORD:36105131549656
Language: EN, FR, DE, ES & NL

Dissertation Abstracts International Book Review:

Locomotor Training

Locomotor Training
Author: Susan Harkema,Susan J. Harkema,Andrea L. Behrman,Hugues Barbeau
Publsiher: Oxford University Press, USA
Total Pages: 185
Release: 2011
ISBN 10: 0195342089
ISBN 13: 9780195342086
Language: EN, FR, DE, ES & NL

Locomotor Training Book Review:

Locomotor training is aiming to promote recovery after spinal cord injury via activation of the neuromuscular system below the level of the lesion

Neurological Aspects of Spinal Cord Injury

Neurological Aspects of Spinal Cord Injury
Author: Norbert Weidner,Rüdiger Rupp,Keith E. Tansey
Publsiher: Springer
Total Pages: 770
Release: 2017-06-06
ISBN 10: 3319462938
ISBN 13: 9783319462936
Language: EN, FR, DE, ES & NL

Neurological Aspects of Spinal Cord Injury Book Review:

This clinically focused book aims to cover for the first time all of the neurological aspects relevant to the diagnosis and treatment of spinal cord disease. Furthermore, innovative neurorestorative therapeutic strategies - aiming for repair of the damaged spinal cord and/or reorganization of the remaining nervous system - with significant potential for translation into clinical routine are presented. The book covers a comprehensive list of topics, including epidemiology, neuroanatomy, etiology of compressive and non-compressive spinal cord injury, imaging, neurophysiology, neurological sequelae, and complications with emphasis on dysfunction of the autonomic nervous system. Both clinically established and preclinical therapies are discussed in detail. The book is suited for trainees and practicing clinicians including neurologists, spine surgeons, rehabilitation specialists, neuroradiologists, and occupational/physical therapists; it will also be of value to neuroscientists involved in research into spinal cord disease.

Autonomic Dysfunction After Spinal Cord Injury

Autonomic Dysfunction After Spinal Cord Injury
Author: Lynne C. Weaver,Canio Polosa
Publsiher: Elsevier
Total Pages: 472
Release: 2005-10-11
ISBN 10: 9780080460109
ISBN 13: 0080460100
Language: EN, FR, DE, ES & NL

Autonomic Dysfunction After Spinal Cord Injury Book Review:

Autonomic dysfunction is a major and poorly understood consequence of spinal cord injury. It is a cause of very serious disability and requires much more research. It should be a focus of treatment strategies. This book will be of interest to anyone involved in research and treatment of spinal cord injury since it helps to explain the tremendously negative impact on the body caused by cord injury that is not as obvious as paralysis and loss of sensation. It contains a compilation of what is known about bladder, cardiovascular, bowel and sexual dysfunction after spinal cord injury, as it relates to the changes within the autonomic nervous system control of these functions. The book begins with a description of the time course of autonomic dysfunctions and their ramifications from the first hours after a spinal cord injury to the more stable chronic states. The next section contains three chapters that address anatomical findings that may provide some of the foundation for autonomic dysfunctions in many of the systems. The system-specific chapters then follow in four sections. Each section begins with a chapter or two defining the clinical problems experienced by people with cord injury. The following chapters present research, basic and clinical, that address the autonomic dysfunctions.

Spinal Cord Injury

Spinal Cord Injury
Author: Joost Verhaagen,John W. McDonald III
Publsiher: Newnes
Total Pages: 656
Release: 2012-12-31
ISBN 10: 0444535071
ISBN 13: 9780444535078
Language: EN, FR, DE, ES & NL

Spinal Cord Injury Book Review:

Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities

International Perspectives on Spinal Cord Injury

International Perspectives on Spinal Cord Injury
Author: World Health Organization,International Spinal Cord Society
Publsiher: World Health Organization
Total Pages: 231
Release: 2013
ISBN 10: 9241564660
ISBN 13: 9789241564663
Language: EN, FR, DE, ES & NL

International Perspectives on Spinal Cord Injury Book Review:

"Every year between 250 000 and 500 000 people suffer a spinal cord injury, with road traffic crashes, falls and violence as the three leading causes. People with spinal cord injury are two to five times more likely to die prematurely. They also have lower rates of school enrollment and economic participation than people without such injuries. Spinal cord injury has costly consequences for the individual and society, but it is preventable, survivable and need not preclude good health and social inclusion. Ensuring an adequate medical and rehabilitation response, followed by supportive services and accessible environments, can help minimize the disruption to people with spinal cord injury and their families. The aims of International perspectives on spinal cord injury are to: --assemble and summarize information on spinal cord injury, in particular the epidemiology, services, interventions and policies that are relevant, together with the lived experience of people with spinal cord injury; --make recommendations for actions based on this evidence that are consistent with the aspirations for people with disabilities as expressed in the Convention on the Rights of Persons with Disabilities.