Spectroscopy and Modeling of Biomolecular Building Blocks

Spectroscopy and Modeling of Biomolecular Building Blocks
Author: Jean-Pierre Schermann
Publsiher: Elsevier
Total Pages: 498
Release: 2007-10-16
ISBN 10: 9780080558226
ISBN 13: 0080558224
Language: EN, FR, DE, ES & NL

Spectroscopy and Modeling of Biomolecular Building Blocks Book Review:

Spectroscopy and Modeling of Biomolecular Building Blocks presents an overview of recent advances in the intertwining of the following research fields: photon and electron spectroscopy, quantum chemistry, modelling and mass-spectrometry. The coupling of these disciplines offers a new point of view to the understanding of isolated elementary building blocks of biomolecules and their assemblies. It allows the unambiguous separation between intrinsic properties of biomolecular systems and those induced by the presence of their environment. The first chapters provide background in modelling (I), frequency-resolved spectroscopy using microwave, infrared and UV photons, time-resolved spectroscopy in the femtosecond domain and energy-resolved electron spectroscopy (II) and production of gas-phase neutral and ionic biomolecular species, mass-spectrometry, ion mobility and BIRD techniques (III). Chapter IV is devoted to case studies of gas-phase experimental investigations coupled to quantum or classical calculations. The topics are structural studies of nucleobases and oligonucleotides, peptides and proteins, sugars; neuromolecules; non-covalent complexes; chiral systems, interactions of low-energy electrons with biomolecules in the radiation chemistry context and very large gas-phase biomolecular systems. The fifth chapter concerns the link between gas-phase and liquid-phase. Different treatments of solvation are illustrated through examples pointing out the influence of progressive addition of water molecules upon properties of nucleobases, peptides, sugars and neuromolecules. Offer a new perspective to the understanding of isolated elementary building blocks of bio molecules Includes case studies of experimental investigations coupled to quantum or classical calculations

Gas Phase IR Spectroscopy and Structure of Biological Molecules

Gas Phase IR Spectroscopy and Structure of Biological Molecules
Author: Anouk M. Rijs,Jos Oomens
Publsiher: Springer
Total Pages: 406
Release: 2015-06-03
ISBN 10: 3319192043
ISBN 13: 9783319192048
Language: EN, FR, DE, ES & NL

Gas Phase IR Spectroscopy and Structure of Biological Molecules Book Review:

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.

Fluorescent Analogs of Biomolecular Building Blocks

Fluorescent Analogs of Biomolecular Building Blocks
Author: Marcus Wilhelmsson,Yitzhak Tor
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2016-03-16
ISBN 10: 1119179343
ISBN 13: 9781119179344
Language: EN, FR, DE, ES & NL

Fluorescent Analogs of Biomolecular Building Blocks Book Review:

Fluorescent Analogs of Biomolecular Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of small-molecule fluorophores and sensors that are part of biomolecular assemblies.

Sum Frequency Generation Vibrational Spectroscopy Studies on Model Peptide Adsorption at the Hydrophobic Solid water and Hydrophilic Solid water Interfaces

Sum Frequency Generation Vibrational Spectroscopy Studies on Model Peptide Adsorption at the Hydrophobic Solid water and Hydrophilic Solid water Interfaces
Author: Roger Louis York
Publsiher: Unknown
Total Pages: 242
Release: 2007
ISBN 10:
ISBN 13: UCAL:C3511122
Language: EN, FR, DE, ES & NL

Sum Frequency Generation Vibrational Spectroscopy Studies on Model Peptide Adsorption at the Hydrophobic Solid water and Hydrophilic Solid water Interfaces Book Review:

Infrared Spectroscopy of Biomolecules

Infrared Spectroscopy of Biomolecules
Author: Henry H. Mantsch,Dennis Chapman
Publsiher: Wiley-Liss
Total Pages: 359
Release: 1996-03
ISBN 10:
ISBN 13: UOM:39015037292201
Language: EN, FR, DE, ES & NL

Infrared Spectroscopy of Biomolecules Book Review:

Infrared Spectroscopy of Biomolecules Edited by Henry H. Mantsch and Dennis Chapman Dramatic new advances in the application of infrared spectroscopy to biomolecules and instrumentation are revolutionizing this branch of molecular spectroscopy. Infrared Spectroscopy of Biomolecules provides an up-to-date, detailed look at the different spectroscopic techniques now available and offers a framework for progression in the field, including the evolution of Fourier transform methods, the development of time-resolved techniques and difference spectroscopy, as well as new modulation methods. The book begins with a fundamental introduction to the theories behind both infrared spectroscopy and the Fourier transform method, which lays the groundwork for the instrumental and mathematical chapters that follow. Once the basics of the infrared methods are established, the proceeding chapters cover the application of infrared spectroscopy to proteins, lipids, enzymes, nucleic acids, carbohydrates, and biomembranes. Other chapters in this excellent reference include: Theoretical Analyses of the Amide I Infrared Bands of Globular Proteins Slow and Fast Infrared Kinetic Studies Fourier Transform Infrared Spectroscopy of Cell Surface Polysaccharides What Can Infrared Spectroscopy Tell Us About the Structure and Composition of Intact Bacterial Cells Biomedical Infrared Spectroscopy Editors Henry Mantsch and Dennis Chapman, leading experts in the field, conclude with an exciting look at much-anticipated future developments, including the use of caged compounds and studies of oxidation reduction systems within the IR spectrometer. A solid introduction to the basics with up-to-the-minute coverage of the latest developments in the field, Infrared Spectroscopy of Biomolecules is an indispensable reference tool for biochemists, biophysicists, and structural biologists alike.

Canadian Journal of Chemistry

Canadian Journal of Chemistry
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2004
ISBN 10:
ISBN 13: NYPL:33433068382849
Language: EN, FR, DE, ES & NL

Canadian Journal of Chemistry Book Review:

Encyclopedia of Spectroscopy and Spectrometry

Encyclopedia of Spectroscopy and Spectrometry
Author: Anonim
Publsiher: Unknown
Total Pages: 2581
Release: 2000
ISBN 10:
ISBN 13: UVA:X004475174
Language: EN, FR, DE, ES & NL

Encyclopedia of Spectroscopy and Spectrometry Book Review:

Quantum Chemistry Spectroscopy

Quantum Chemistry   Spectroscopy
Author: Thomas Engel,Warren J. Hehre
Publsiher: Pearson College Division
Total Pages: 489
Release: 2010
ISBN 10:
ISBN 13: STANFORD:36105124166476
Language: EN, FR, DE, ES & NL

Quantum Chemistry Spectroscopy Book Review:

This full-color, modern physical chemistry reference offers compelling applications and arresting illustrations that capture readers' attention and demonstrate the dynamic nature of the subject. The authors focus on core topics of physical chemistry, presented within a modern framework of applications. Modern applications are drawn from biology, environmental science, and material science. Spectroscopy applications are introduced early in concert with theory; for example, IR and rotational spectroscopy are discussed immediately after the harmonic oscillator and the rigid rotar. Modern research is featured throughout, along with new developments in the field such as scanning tunneling microscopy, bandgap engineering, quantum wells, teleportation, and quantum computing. From Classical to Quantum Mechanics; The Schrödinger Equation; The Quantum Mechanical Postulates; Using Quantum Mechanics on Simple Systems; The Particle in the Box and the Real World; Commuting and Noncommuting Operators and the Surprising Consequences; A Quantum Mechanical Model for the Vibration and Rotation of Mole; The Vibrational and Rotational Spectroscopy of Diatomic Molecules; The Hydrogen Atom; Many-Electron Atoms; Quantum States for Many-electron Atoms and Atomic Spectroscopy; The Chemical Bond in Diatomic Molecules; Molecular Structure and Energy Levels for Polyatomic Molecules; Electronic Spectroscopy; Computational Chemistry; Molecular Symmetry; Nuclear Magnetic Resonance Spectroscopy. A useful reference for chemistry professionals.

Inspired by Biology

Inspired by Biology
Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Solid State Sciences Committee,Committee on Biomolecular Materials and Processes
Publsiher: National Academies Press
Total Pages: 170
Release: 2008-07-17
ISBN 10: 0309117046
ISBN 13: 9780309117043
Language: EN, FR, DE, ES & NL

Inspired by Biology Book Review:

Scientists have long desired to create synthetic systems that function with the precision and efficiency of biological systems. Using new techniques, researchers are now uncovering principles that could allow the creation of synthetic materials that can perform tasks as precise as biological systems. To assess the current work and future promise of the biology-materials science intersection, the Department of Energy and the National Science Foundation asked the NRC to identify the most compelling questions and opportunities at this interface, suggest strategies to address them, and consider connections with national priorities such as healthcare and economic growth. This book presents a discussion of principles governing biomaterial design, a description of advanced materials for selected functions such as energy and national security, an assessment of biomolecular materials research tools, and an examination of infrastructure and resources for bridging biological and materials science.

Mass Spectrometry Reviews

Mass Spectrometry Reviews
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1989
ISBN 10:
ISBN 13: UCAL:B5031487
Language: EN, FR, DE, ES & NL

Mass Spectrometry Reviews Book Review:

Electronic Structure Optical Properties and Long Range Interaction Driven Mesoscale Assembly

Electronic Structure  Optical Properties and Long Range Interaction Driven Mesoscale Assembly
Author: Yingfang Ma
Publsiher: Unknown
Total Pages: 142
Release: 2017
ISBN 10:
ISBN 13: OCLC:1026417434
Language: EN, FR, DE, ES & NL

Electronic Structure Optical Properties and Long Range Interaction Driven Mesoscale Assembly Book Review:

The construction of mesoscale assemblies using a bottom-up approach is an emerging research area in recent years, while understanding the interactions that control the organization of the constructing building blocks turns out to be a prerequisite for effective assembly design. The intrinsic electronic structures of materials determine their optical properties, which give rise to long-range interactions including electrostatic and van der Waals (vdW) components. And electrostatic along with vdW interactions, are the fundamental interactions that drive mesoscale assembly. In this research, the long range interactions of inorganic material and bio-molecules are investigated using bothexperiment and computation optical methods, and then a functional mesoscale assembly based on an inorganic substrate and biomolecular particles are built. In terms of the inorganic material, the full spectral optical properties and van der Waals-London interaction of bulk SiC crystal is investigated with a combination of vacuum ultravioletspectroscopy and Liftshiz theory-based Hamaker coefficient calculation, and compared with OLCAO electronic structure calculations of the band structure and ab initio optical properties of SiC. Cylindrical biomolecules, DNA, is selected as a biomolecular example. The effect of nitrogen base polarizability on the optical properties and electronicstructures of double-strand DNA are studied by optical characterization and ab initio density functional theory modeling; then G-quadruplex DNA consisting of human telomere sequence are characterized by spectroscopy, static light scattering and ab initio modeling, and compared with corresponding double-strand DNA, giving rise to thestructural dependent electronic structures and pH dependent pair-wise interactions. Finally, the first semi-ordered, layered, mesoscale self-assembly capable of photon management comprised of plant viruses is created and characterized. Anti-reflection and photon-trapping properties are demonstrated theoretically using computational optics modeling and experimentally using spectroscopy. I expect the methodologists and conclusions in this research will bring useful insights into the understanding of building blocks and the design of meso-scale assemblies.

Biological Macromolecular Dynamics

Biological Macromolecular Dynamics
Author: Stephen Cusack
Publsiher: Unknown
Total Pages: 174
Release: 1997
ISBN 10:
ISBN 13: STANFORD:36105020180050
Language: EN, FR, DE, ES & NL

Biological Macromolecular Dynamics Book Review:

Strain and Interfaces the Susceptibility of Fundamental Biomolecular Building Blocks to Their Intramolecular and Intermolecular Environment

Strain and Interfaces  the Susceptibility of Fundamental Biomolecular Building Blocks to Their Intramolecular and Intermolecular Environment
Author: William Kennedy Browne
Publsiher: Unknown
Total Pages: 204
Release: 2009
ISBN 10:
ISBN 13: UCAL:C3528033
Language: EN, FR, DE, ES & NL

Strain and Interfaces the Susceptibility of Fundamental Biomolecular Building Blocks to Their Intramolecular and Intermolecular Environment Book Review:

Pocket Guide to Biomolecular NMR

Pocket Guide to Biomolecular NMR
Author: Michaeleen Doucleff,Mary Hatcher-Skeers,Nicole J. Crane
Publsiher: Springer Science & Business Media
Total Pages: 159
Release: 2011-01-03
ISBN 10: 9783642162510
ISBN 13: 3642162517
Language: EN, FR, DE, ES & NL

Pocket Guide to Biomolecular NMR Book Review:

Steering clear of quantum mechanics and product operators, "Pocket Guide to Biomolecular NMR" uses intuitive, concrete analogies to explain the theory required to understand NMR studies on the structure and dynamics of biological macromolecules. For example, instead of explaining nuclear spin with angular momentum equations or Hamiltonians, the books describes nuclei as "bells" in a choir, ringing at specific frequencies depending on the atom type and their surrounding electromagnetic environment.This simple bell analogy, which is employed throughout the book, has never been used to explain NMR and makes it surprisingly easy to learn complex, bewildering NMR concepts, such as dipole-dipole coupling and CPMG pulse sequences. Other topics covered include the basics of multi-dimensional NMR, relaxation theory, and Model Free analysis. The small size and fast pace of “Pocket Guide to Biomolecular NMR” makes the book a perfect companion to traditional biophysics and biochemistry textbooks, but the book's unique perspective will provide even seasoned spectroscopists with new insights and handy “thought” short-cuts.

Biophysical Aspects of the Nature and Utility of Peptide amphiphiles

Biophysical Aspects of the Nature and Utility of Peptide amphiphiles
Author: Nathan Allyn Lockwood
Publsiher: Unknown
Total Pages: 252
Release: 2003
ISBN 10:
ISBN 13: MINN:31951P00831857B
Language: EN, FR, DE, ES & NL

Biophysical Aspects of the Nature and Utility of Peptide amphiphiles Book Review:

Biomolecular Spectroscopy

Biomolecular Spectroscopy
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1991
ISBN 10:
ISBN 13: STANFORD:36105032561214
Language: EN, FR, DE, ES & NL

Biomolecular Spectroscopy Book Review:

Biomolecular Spectroscopy II

Biomolecular Spectroscopy II
Author: Robert R. Birge
Publsiher: Society of Photo Optical
Total Pages: 228
Release: 1991
ISBN 10:
ISBN 13: UOM:39015025270276
Language: EN, FR, DE, ES & NL

Biomolecular Spectroscopy II Book Review:

Fundamentals of Protein NMR Spectroscopy

Fundamentals of Protein NMR Spectroscopy
Author: Gordon S. Rule,T. Kevin Hitchens
Publsiher: Springer Science & Business Media
Total Pages: 532
Release: 2006-02-16
ISBN 10: 1402035004
ISBN 13: 9781402035005
Language: EN, FR, DE, ES & NL

Fundamentals of Protein NMR Spectroscopy Book Review:

NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

Structural Studies of Biomolecules by Dynamic Nuclear Polarization Solid state NMR Spectroscopy

Structural Studies of Biomolecules by Dynamic Nuclear Polarization Solid state NMR Spectroscopy
Author: Daniel W. Conroy (Ph. D. in chemistry)
Publsiher: Unknown
Total Pages: 329
Release: 2019
ISBN 10:
ISBN 13: OCLC:1149541706
Language: EN, FR, DE, ES & NL

Structural Studies of Biomolecules by Dynamic Nuclear Polarization Solid state NMR Spectroscopy Book Review:

Solid-state NMR (SSNMR) spectroscopy is an incredibly powerful tool for studying the structure and dynamics of biomolecules and large macromolecular complexes. SSNMR has no inherent size restriction and is useful in studying non-crystalline protein such as membrane-bound protein or amyloid fibrils, DNA-protein complexes, and large protein assemblies such as the HIV-capsid. Meanwhile, techniques such as solution-state NMR and x-ray crystallography are strictly limited by molecular size and sample condition, and thus cannot study large biomolecules or insoluble protein aggregates, respectively. The first protein at the center of this study is the human prion protein (PrP) and its formation into an insoluble amyloid fibril. The formation of this fibril leads to a deposition of an insoluble plaque on the central nervous system which leads to the development of the prion protein disease, known as Gerstmann-Straussler-Scheinker (GSS) disease. The second system-of-interest is the nucleosome core particle (NCP) which is a DNA-protein complex and is the building-block of chromatin and chromosomes. An individual NCP is composed of dsDNA wrapped around an octamer of histone protein, mimicking the natural phenomena of DNA storage and compaction in eukaryotic cells. SSNMR is uniquely qualified in studying these biological systems in depth to characterize the amyloid fibril propagation and disease-causing mechanism of prion protein, and to explore nucleic acid base-pairing behavior at DNA-protein interfaces and the important interactions therein. Dynamic nuclear polarization (DNP) is a hyperpolarization technique for NMR spectroscopy which dramatically increases the overall sensitivity of these experiments. In DNP-SSNMR, hyperpolarization is achieved by applying microwave irradiation to free electrons, often in the form of stable-radicals, within a static magnetic field and inducing a polarization transfer to neighboring nuclear spins, especially spin-1⁄2 protons. These elevated levels of magnetization in protons can be passed on to other NMR-active nuclei, in particular carbon-13 (13C) and nitrogen-15 (15N), using standard SSNMR experimental protocols. This process can generate NMR signal enhancements ranging from 20 to 200 and may be generally applied to small molecules, solid-phase materials and biological samples. DNP offers significant time savings when performing complex SSNMR experiments and opens the door for studying dilute species, weak interactions, or minor populations which are typically below the threshold of standard NMR spectroscopy. The primary goal of this dissertation is to develop strategies to study the structures of prion protein amyloid fibrils and dsDNA by expanding on current DNP-SSNMR methodologies, as well as introducing a novel class of biradicals. First, new polarizing agents, peptide-based biradicals are synthesized, purified, characterized and are successfully employed to study small molecules, crystalline protein, and amyloid protein by DNP-SSNMR. These dinitroxides include TOAC-TOAC (TT), TOAC-Ser-TOAC (TST), TOAC-TOAC-Ser (TTS) and acetyl-TOAC-TOAC (ATT) and compare favorably to well-established, commercial polarizing agents TOTAPOL and AMUPol. Next, two samples of dsDNA are used as models to develop DNP-SSNMR techniques for uniquely characterizing Watson-Crick (WC) and Hoogsteen (HG) base-pairing in duplex DNA. The DNP sample preparation is optimized for studying nucleic acids and a variety of SSNMR experiments are performed to produce spectral fingerprints of WC and HG base-pairing. These methods are then applied to a nucleosome sample to study the populations of HG base-pairing present in chromatin. This analysis provides a roadmap for studying DNA base-pairing in vitro by DNP-SSNMR spectroscopy. Finally, the amyloid structure of the human prion protein (huPrP) with a single mutation, A117V, is analyzed by various structural biology techniques to characterize the fibrils and to begin understanding the GSS disease-associated, amyloid-fibrillar structure. The DNP-SSNMR strategies and experiments described herein can be generally applied to various biological systems, containing protein or DNA, as the overall techniques are not tailored specifically to these systems-of-interest. In addition, the novel class of biradical peptides offer versatility and simplicity for tailoring polarizing agents for specific biological samples. This dissertation should serve as a guide of useful experiments and methodologies for studying the structures of biomolecules by DNP-SSNMR spectroscopy.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 329
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review: