Epigenome Editing

Epigenome Editing
Author: Albert Jeltsch,Marianne G. Rots
Publsiher: Humana Press
Total Pages: 482
Release: 2018-03-10
ISBN 10: 9781493977734
ISBN 13: 1493977733
Language: EN, FR, DE, ES & NL

Epigenome Editing Book Review:

This detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epigenome Editing: Methods and Protocols will be of great assistance to people new to the field but also to those already engaged, as epigenetic editing is still a relatively unexplored field with many issues to be resolved.

Role of DNA Methyltransferases in the Epigenome

Role of DNA Methyltransferases in the Epigenome
Author: Albert Jeltsch,Humaira Gowher
Publsiher: MDPI
Total Pages: 150
Release: 2020-03-05
ISBN 10: 3039280201
ISBN 13: 9783039280209
Language: EN, FR, DE, ES & NL

Role of DNA Methyltransferases in the Epigenome Book Review:

DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors

Targeted Genome Editing Using Site Specific Nucleases

Targeted Genome Editing Using Site Specific Nucleases
Author: Takashi Yamamoto
Publsiher: Springer
Total Pages: 205
Release: 2015-01-05
ISBN 10: 4431552278
ISBN 13: 9784431552277
Language: EN, FR, DE, ES & NL

Targeted Genome Editing Using Site Specific Nucleases Book Review:

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Neuroepigenomics in Aging and Disease

Neuroepigenomics in Aging and Disease
Author: Raul Delgado-Morales
Publsiher: Springer
Total Pages: 525
Release: 2017-05-18
ISBN 10: 3319538896
ISBN 13: 9783319538891
Language: EN, FR, DE, ES & NL

Neuroepigenomics in Aging and Disease Book Review:

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Epigenetics Methods

Epigenetics Methods
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 736
Release: 2020-07-08
ISBN 10: 0128194154
ISBN 13: 9780128194157
Language: EN, FR, DE, ES & NL

Epigenetics Methods Book Review:

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Gene Expression and Regulation in Mammalian Cells

Gene Expression and Regulation in Mammalian Cells
Author: Fumiaki Uchiumi
Publsiher: BoD – Books on Demand
Total Pages: 334
Release: 2018-02-21
ISBN 10: 9535138553
ISBN 13: 9789535138556
Language: EN, FR, DE, ES & NL

Gene Expression and Regulation in Mammalian Cells Book Review:

"Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

Transgenerational Epigenetics

Transgenerational Epigenetics
Author: Trygve Tollefsbol
Publsiher: Elsevier
Total Pages: 412
Release: 2014-05-02
ISBN 10: 0124059228
ISBN 13: 9780124059221
Language: EN, FR, DE, ES & NL

Transgenerational Epigenetics Book Review:

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies

Epigenetics in Psychiatry

Epigenetics in Psychiatry
Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publsiher: Elsevier
Total Pages: 664
Release: 2014-06-23
ISBN 10: 0124171346
ISBN 13: 9780124171343
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Book Review:

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

Quantitative Genetics Genomics and Plant Breeding 2nd Edition

Quantitative Genetics  Genomics and Plant Breeding  2nd Edition
Author: Manjit S. Kang
Publsiher: CABI
Total Pages: 431
Release: 2020-04-01
ISBN 10: 1789240212
ISBN 13: 9781789240214
Language: EN, FR, DE, ES & NL

Quantitative Genetics Genomics and Plant Breeding 2nd Edition Book Review:

This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize, root and tuber crops and pearl millet. Overall, the book focuses on using genomic information to help evaluate traits that can combat biotic/abiotic stresses, genome-wide association mapping, high-throughput genotyping/phenotyping, biofortification, use of big data, orphan crops, and gene editing techniques. The examples featured are taken from across crop science research and cover a wide geographical base.

Gene Expression and Control

Gene Expression and Control
Author: Fumiaki Uchiumi
Publsiher: BoD – Books on Demand
Total Pages: 200
Release: 2019-04-17
ISBN 10: 1789855179
ISBN 13: 9781789855173
Language: EN, FR, DE, ES & NL

Gene Expression and Control Book Review:

Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."

Epigenetics in Plants of Agronomic Importance Fundamentals and Applications

Epigenetics in Plants of Agronomic Importance  Fundamentals and Applications
Author: Raúl Alvarez-Venegas,Clelia De la Peña,Juan Armando Casas-Mollano
Publsiher: Springer
Total Pages: 152
Release: 2014-07-22
ISBN 10: 3319079719
ISBN 13: 9783319079714
Language: EN, FR, DE, ES & NL

Epigenetics in Plants of Agronomic Importance Fundamentals and Applications Book Review:

Over the past decades, chromatin remodelling has emerged as an important regulator of gene expression and plant defense. This book provides a detailed understanding of the epigenetic mechanisms involved in plants of agronomic importance. The information presented here is significant because it is expected to provide the knowledge needed to develop in the future treatments to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases and to increase crop productivity. New approaches of this kind and the development of new technologies will certainly increase our knowledge of currently known post-translational modifications and facilitate the understanding of their roles in, for example, host-pathogen interactions and crop productivity. Furthermore, we provide important insight on how the plant epigenome changes in response to developmental or environmental stimuli, how chromatin modifications are established and maintained, to which degree they are used throughout the genome, and how chromatin modifications influence each another.

Past Present and Future Trends in Cotton Breeding

Past  Present and Future Trends in Cotton Breeding
Author: Mehboob-Ur- Rahman,Yusuf Zafar
Publsiher: BoD – Books on Demand
Total Pages: 184
Release: 2018-05-02
ISBN 10: 1789230764
ISBN 13: 9781789230765
Language: EN, FR, DE, ES & NL

Past Present and Future Trends in Cotton Breeding Book Review:

Cotton, a source of natural fiber for textile industry, has a long breeding history aiming at increasing cotton fiber yield and its quality. Newly developed cotton varieties poorly respond in low-input environments. Secondly, the impact of changing climate may threaten the cotton production in the future. To address these challenges, efforts toward the development of resilient cotton varieties have been initiated using genetic and modern genomic approaches. In this book, research updates on cotton fiber types and properties, DNA markers for selecting desirable cotton plants, and cotton fiber genomics were compiled. Also, the modern breeding trends including development of transgenic cotton and the biosafety studies and possibilities of improving cotton genome using modern genome editing tools were also compressively discussed.

Genetics of Human Infertility

Genetics of Human Infertility
Author: P.H. Vogt
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 178
Release: 2017-09-12
ISBN 10: 3318060984
ISBN 13: 9783318060980
Language: EN, FR, DE, ES & NL

Genetics of Human Infertility Book Review:

Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

Plant Epigenetics

Plant Epigenetics
Author: Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski
Publsiher: Springer
Total Pages: 536
Release: 2017-04-27
ISBN 10: 3319555200
ISBN 13: 9783319555201
Language: EN, FR, DE, ES & NL

Plant Epigenetics Book Review:

This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena.

Genome Research

Genome Research
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2007
ISBN 10:
ISBN 13: NWU:35558005623976
Language: EN, FR, DE, ES & NL

Genome Research Book Review:

Epigenetics Protocols

Epigenetics Protocols
Author: Trygve O. Tollefsbol
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2004
ISBN 10: 1592598285
ISBN 13: 9781592598281
Language: EN, FR, DE, ES & NL

Epigenetics Protocols Book Review:

Recent advances in epigenetic research as well as the development of exciting new technologies have helped greatly in unraveling the many mysteries of nontraditional genetic processes. In Epigenetics Protocols, hands-on researchers describe state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer. The protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Epigenetics Protocols offers investigators readily reproducible techniques that will further promote progress in this critically important field.

Epigenetics of the Immune System

Epigenetics of the Immune System
Author: Dieter Kabelitz,Jaydeep Bhat
Publsiher: Academic Press
Total Pages: 384
Release: 2020-06-04
ISBN 10: 0128179651
ISBN 13: 9780128179659
Language: EN, FR, DE, ES & NL

Epigenetics of the Immune System Book Review:

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

CRISPR Cas Systems

CRISPR Cas Systems
Author: Rodolphe Barrangou,John van der Oost
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2012-12-13
ISBN 10: 364234657X
ISBN 13: 9783642346576
Language: EN, FR, DE, ES & NL

CRISPR Cas Systems Book Review:

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Genetically Engineered Crops

Genetically Engineered Crops
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Genetically Engineered Crops: Past Experience and Future Prospects
Publsiher: National Academies Press
Total Pages: 606
Release: 2017-01-28
ISBN 10: 0309437385
ISBN 13: 9780309437387
Language: EN, FR, DE, ES & NL

Genetically Engineered Crops Book Review:

Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.