Sirtuin Biology in Medicine

Sirtuin Biology in Medicine
Author: Kenneth Maiese, MD
Publsiher: Academic Press
Total Pages: 512
Release: 2019-06-15
ISBN 10: 9780128141182
ISBN 13: 0128141182
Language: EN, FR, DE, ES & NL

Sirtuin Biology in Medicine Book Review:

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease fills a significant void, providing a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will find this book to be a go-to resource for both the biology and medical applications that focus on sirtuins. Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multidiscipline views and publications on this diverse topic, covering cell development, cardiovascular and pulmonary systems, neurodegenerative disorders, cancer and metabolism

Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease
Author: Kenneth Maiese
Publsiher: Elsevier
Total Pages: 350
Release: 2021-03-01
ISBN 10: 0128224843
ISBN 13: 9780128224847
Language: EN, FR, DE, ES & NL

Sirtuin Biology in Cancer and Metabolic Disease Book Review:

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery fills a significant void that provides a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will use this reference as the “go-to resource for both the biology and medical applications that focus upon sirtuins. As sirtuins play an intricate role in the pathology, progression and treatment of several disease entities ranging from metabolic disease and diabetes, cancer, cardiovascular disease, immune system dysfunction, to reproductive dysfunction, and aging-related disorders, this book provides an ideal update on the topic. Details the basic and clinical role of sirtuins and their broad applicability for sirtuin biology to be targeted for multiple medical disease entities Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multi-discipline views and publications for this diverse topic, covering cell development, cancer and metabolism

Exam Prep for: Sirtuin Biology in Medicine

Exam Prep for: Sirtuin Biology in Medicine
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release:
ISBN 10:
ISBN 13:
Language: EN, FR, DE, ES & NL

Exam Prep for: Sirtuin Biology in Medicine Book Review:

Introductory Review on Sirtuins in Biology, Aging, and Disease

Introductory Review on Sirtuins in Biology, Aging, and Disease
Author: Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publsiher: Academic Press
Total Pages: 220
Release: 2018-04-20
ISBN 10: 012813500X
ISBN 13: 9780128135006
Language: EN, FR, DE, ES & NL

Introductory Review on Sirtuins in Biology, Aging, and Disease Book Review:

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Epigenetics in Biology and Medicine

Epigenetics in Biology and Medicine
Author: Manel Esteller
Publsiher: CRC Press
Total Pages: 312
Release: 2008-09-17
ISBN 10: 9781420007077
ISBN 13: 1420007076
Language: EN, FR, DE, ES & NL

Epigenetics in Biology and Medicine Book Review:

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

Sirtuins

Sirtuins
Author: Riekelt H. Houtkooper
Publsiher: Springer
Total Pages: 288
Release: 2016-11-17
ISBN 10: 9402409629
ISBN 13: 9789402409628
Language: EN, FR, DE, ES & NL

Sirtuins Book Review:

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Issues in Pathology, Diagnostics, and Disease: 2011 Edition

Issues in Pathology, Diagnostics, and Disease: 2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 944
Release: 2012-01-09
ISBN 10: 1464965420
ISBN 13: 9781464965425
Language: EN, FR, DE, ES & NL

Issues in Pathology, Diagnostics, and Disease: 2011 Edition Book Review:

Issues in Pathology, Diagnostics, and Disease: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pathology, Diagnostics, and Disease. The editors have built Issues in Pathology, Diagnostics, and Disease: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pathology, Diagnostics, and Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pathology, Diagnostics, and Disease: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Sirtuins in Biology and Disease

Sirtuins in Biology and Disease
Author: Tiago F. Outeiro,Aleksey G. Kazantsev
Publsiher: Frontiers E-books
Total Pages: 329
Release:
ISBN 10: 9782889191178
ISBN 13: 2889191176
Language: EN, FR, DE, ES & NL

Sirtuins in Biology and Disease Book Review:

Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

Sirtuins in Health and Disease

Sirtuins in Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 186
Release: 2018-02-03
ISBN 10: 0128122625
ISBN 13: 9780128122624
Language: EN, FR, DE, ES & NL

Sirtuins in Health and Disease Book Review:

Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins – substrate specificity and inhibitor design, and chemical probes in sirtuin research. This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research. Presents an excellent subject, excellent structural organization, and authoritative contributions from world-renowned scholars in the sirtuin field Provides the latest updates on sirtuins in health and disease

Comparative Biology of Aging

Comparative Biology of Aging
Author: Norman S. Wolf
Publsiher: Springer Science & Business Media
Total Pages: 391
Release: 2010-01-08
ISBN 10: 9789048134656
ISBN 13: 904813465X
Language: EN, FR, DE, ES & NL

Comparative Biology of Aging Book Review:

determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

Handbook of the Biology of Aging

Handbook of the Biology of Aging
Author: Matt Kaeberlein,George Martin
Publsiher: Academic Press
Total Pages: 576
Release: 2015-08-20
ISBN 10: 0124116205
ISBN 13: 9780124116207
Language: EN, FR, DE, ES & NL

Handbook of the Biology of Aging Book Review:

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Molecular Biology of Aging

Molecular Biology of Aging
Author: Leonard Guarente,Linda Partridge,Douglas C. Wallace
Publsiher: CSHL Press
Total Pages: 610
Release: 2008
ISBN 10: 0879698241
ISBN 13: 9780879698249
Language: EN, FR, DE, ES & NL

Molecular Biology of Aging Book Review:

This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Histone Deacetylases: the Biology and Clinical Implication

Histone Deacetylases: the Biology and Clinical Implication
Author: Tso-Pang Yao,Edward Seto
Publsiher: Springer Science & Business Media
Total Pages: 260
Release: 2011-08-31
ISBN 10: 9783642216312
ISBN 13: 3642216315
Language: EN, FR, DE, ES & NL

Histone Deacetylases: the Biology and Clinical Implication Book Review:

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2011 Edition

Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 770
Release: 2012-01-09
ISBN 10: 1464965722
ISBN 13: 9781464965722
Language: EN, FR, DE, ES & NL

Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2011 Edition Book Review:

Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biologicals, Therapies, and Complementary and Alternative Medicine. The editors have built Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biologicals, Therapies, and Complementary and Alternative Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Experimental Biology and Medicine

Experimental Biology and Medicine
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 2009
ISBN 10:
ISBN 13: UIUC:30112083987062
Language: EN, FR, DE, ES & NL

Experimental Biology and Medicine Book Review:

Lifespan

Lifespan
Author: David A. Sinclair,Matthew D. LaPlante
Publsiher: Atria Books
Total Pages: 432
Release: 2019-09-10
ISBN 10: 1501191977
ISBN 13: 9781501191978
Language: EN, FR, DE, ES & NL

Lifespan Book Review:

A NEW YORK TIMES BESTSELLER A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Principles of Medical Biochemistry E-Book

Principles of Medical Biochemistry E-Book
Author: Gerhard Meisenberg,William H. Simmons
Publsiher: Elsevier Health Sciences
Total Pages: 608
Release: 2011-04-15
ISBN 10: 032308107X
ISBN 13: 9780323081078
Language: EN, FR, DE, ES & NL

Principles of Medical Biochemistry E-Book Book Review:

Principles of Medical Biochemistry condenses the information you need into a comprehensive, focused, clinically-oriented textbook. Drs. Gerhard Meisenberg and William H. Simmons covers the latest developments in the field, including genome research, the molecular basis of genetic diseases, techniques of DNA sequencing and molecular diagnosis, and more. An updated and expanded collection of figures and access to USMLE test questions, clinical case studies, more online at www.studentconsult.com make this the ideal resource for understanding all aspects of biochemistry needed in medicine. Access the complete contents online at www.studentconsult.com, with downloadable illustrations, 150 USMLE-style test questions, 20 clinical case studies, chapter summaries, and integration links to related subjects. Understand biochemistry, cell biology, and genetics together in context through an integrated approach. Get only the information you need for your course with comprehensive yet focused coverage of relevant topics. Review and reinforce your learning using the glossary of technical terms, highlighted in the text and with interactive features online. Tap into the most up-to-date coverage of new developments in genome research, the molecular basis of genetic diseases, techniques of DNA sequencing and molecular diagnosis, RNA interference as a mechanism both for regulation of gene expression and for anti-viral defense, and more. Gain a clear visual understanding through new and updated figures that provide current and relevant guidance. Make the link between basic science and clinical medicine with new Clinical Example boxes in nearly every chapter.

Skeletal Biology and Medicine

Skeletal Biology and Medicine
Author: Mone Zaidi
Publsiher: Wiley-Blackwell
Total Pages: 352
Release: 2010-05-03
ISBN 10:
ISBN 13: STANFORD:36105133215082
Language: EN, FR, DE, ES & NL

Skeletal Biology and Medicine Book Review:

As part of the Annals of the New York Academy of Sciences series, this volume examines mechanisms involved in bone development and restructuring, including cellular and mechanical triggers, receptors, and signalling pathways. This volume also examines other factors associated with bone and musculoskeletal health, including physiological systems and disease states such as the immune system, inflammation, diabetes, infection and cancer. This book is ideal for Graduate students, medical students, researchers and clinicians in with an interest in anatomy, physiology, developmental biology, immunology, and musculoskeletal health NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition

Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 22
Release: 2012-12-26
ISBN 10: 1481632213
ISBN 13: 9781481632218
Language: EN, FR, DE, ES & NL

Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition Book Review:

Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Group III Histone Deacetylases in a compact format. The editors have built Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Group III Histone Deacetylases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Handbook of the Biology of Aging

Handbook of the Biology of Aging
Author: Edward J. Masoro,Steven N. Austad
Publsiher: Academic Press
Total Pages: 520
Release: 2010-12-13
ISBN 10: 9780123786395
ISBN 13: 0123786398
Language: EN, FR, DE, ES & NL

Handbook of the Biology of Aging Book Review:

Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences. The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary restriction can slow down the aging process and extend life in a wide range of species. Part 2 deals with the medical physiology of aging. It contains several chapters on the aging of the human brain. These chapters deal not only with diseases but also with normal aging changes to cerebral vasculature and myelination as well as the clinical implications of those changes. Additional chapters cover how aging affects central features of human health such as insulin secretion, pulmonary and cardiac function, and the ability to maintain body weight and body temperature. The volume is primarily directed at basic researchers who wish to keep abreast of new research outside their own subdiscipline. It will also be useful to medical, behavioral, and social gerontologists who want to learn about the discoveries of basic scientists and clinicians. Contains basic aging processes as determined by animal research as well as medical physiology of aging as known in humans Covers hot areas of research, like stem cells, integrated with longstanding areas of interest in aging like telomeres, mitochondrial function, etc. Edited by one of the fathers of gerontology (Masoro) and contributors represent top scholars in gerintology