Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease
Author: Kenneth Maiese
Publsiher: Elsevier
Total Pages: 350
Release: 2021-03-01
ISBN 10: 0128224843
ISBN 13: 9780128224847
Language: EN, FR, DE, ES & NL

Sirtuin Biology in Cancer and Metabolic Disease Book Review:

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery fills a significant void that provides a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will use this reference as the “go-to resource for both the biology and medical applications that focus upon sirtuins. As sirtuins play an intricate role in the pathology, progression and treatment of several disease entities ranging from metabolic disease and diabetes, cancer, cardiovascular disease, immune system dysfunction, to reproductive dysfunction, and aging-related disorders, this book provides an ideal update on the topic. Details the basic and clinical role of sirtuins and their broad applicability for sirtuin biology to be targeted for multiple medical disease entities Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multi-discipline views and publications for this diverse topic, covering cell development, cancer and metabolism

Introductory Review on Sirtuins in Biology, Aging, and Disease

Introductory Review on Sirtuins in Biology, Aging, and Disease
Author: Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publsiher: Academic Press
Total Pages: 220
Release: 2018-04-20
ISBN 10: 012813500X
ISBN 13: 9780128135006
Language: EN, FR, DE, ES & NL

Introductory Review on Sirtuins in Biology, Aging, and Disease Book Review:

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Sirtuin Biology in Medicine

Sirtuin Biology in Medicine
Author: Kenneth Maiese, MD
Publsiher: Academic Press
Total Pages: 512
Release: 2019-06-15
ISBN 10: 9780128141182
ISBN 13: 0128141182
Language: EN, FR, DE, ES & NL

Sirtuin Biology in Medicine Book Review:

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease fills a significant void, providing a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will find this book to be a go-to resource for both the biology and medical applications that focus on sirtuins. Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multidiscipline views and publications on this diverse topic, covering cell development, cardiovascular and pulmonary systems, neurodegenerative disorders, cancer and metabolism

Sirtuins

Sirtuins
Author: Riekelt H. Houtkooper
Publsiher: Springer
Total Pages: 288
Release: 2016-11-17
ISBN 10: 9402409629
ISBN 13: 9789402409628
Language: EN, FR, DE, ES & NL

Sirtuins Book Review:

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Sirtuins in Biology and Disease

Sirtuins in Biology and Disease
Author: Tiago F. Outeiro,Aleksey G. Kazantsev
Publsiher: Frontiers E-books
Total Pages: 329
Release:
ISBN 10: 9782889191178
ISBN 13: 2889191176
Language: EN, FR, DE, ES & NL

Sirtuins in Biology and Disease Book Review:

Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

Chemical Epigenetics

Chemical Epigenetics
Author: Antonello Mai
Publsiher: Springer Nature
Total Pages: 567
Release: 2020-03-31
ISBN 10: 3030429822
ISBN 13: 9783030429829
Language: EN, FR, DE, ES & NL

Chemical Epigenetics Book Review:

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.

Handbook of the Biology of Aging

Handbook of the Biology of Aging
Author: Edward J. Masoro,Steven N. Austad
Publsiher: Academic Press
Total Pages: 520
Release: 2010-12-13
ISBN 10: 9780123786395
ISBN 13: 0123786398
Language: EN, FR, DE, ES & NL

Handbook of the Biology of Aging Book Review:

Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences. The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary restriction can slow down the aging process and extend life in a wide range of species. Part 2 deals with the medical physiology of aging. It contains several chapters on the aging of the human brain. These chapters deal not only with diseases but also with normal aging changes to cerebral vasculature and myelination as well as the clinical implications of those changes. Additional chapters cover how aging affects central features of human health such as insulin secretion, pulmonary and cardiac function, and the ability to maintain body weight and body temperature. The volume is primarily directed at basic researchers who wish to keep abreast of new research outside their own subdiscipline. It will also be useful to medical, behavioral, and social gerontologists who want to learn about the discoveries of basic scientists and clinicians. Contains basic aging processes as determined by animal research as well as medical physiology of aging as known in humans Covers hot areas of research, like stem cells, integrated with longstanding areas of interest in aging like telomeres, mitochondrial function, etc. Edited by one of the fathers of gerontology (Masoro) and contributors represent top scholars in gerintology

Resveratrol: State-of-the-art Science And Health Applications - Actionable Targets And Mechanisms Of Resveratrol

Resveratrol: State-of-the-art Science And Health Applications - Actionable Targets And Mechanisms Of Resveratrol
Author: Wu Joseph M,Hsieh Tze-chen
Publsiher: World Scientific
Total Pages: 348
Release: 2018-12-06
ISBN 10: 9813270926
ISBN 13: 9789813270923
Language: EN, FR, DE, ES & NL

Resveratrol: State-of-the-art Science And Health Applications - Actionable Targets And Mechanisms Of Resveratrol Book Review:

Resveratrol is a structurally simple, grape-derived polyphenol with seemingly boundless biological activities. The Editors have assembled a group of renowned scientists who have illustrious careers and lifelong passions for studies of this compound. Each chapter covers topics using published and, at times, unpublished data to provide scholarly and comprehensive reviews and perspectives. Several areas with basic clinical and public health interests are highlighted. The book is intended to serve as a text and reference covering recent research findings and clinical applications in the field.The content is presented in several parts: mechanistic leads provided by laboratory studies of resveratrol; cellular and molecular targets of resveratrol; modulation of disease states by resveratrol; virtual leads and drug discovery.

Histone Deacetylases: the Biology and Clinical Implication

Histone Deacetylases: the Biology and Clinical Implication
Author: Tso-Pang Yao,Edward Seto
Publsiher: Springer Science & Business Media
Total Pages: 260
Release: 2011-08-31
ISBN 10: 9783642216312
ISBN 13: 3642216315
Language: EN, FR, DE, ES & NL

Histone Deacetylases: the Biology and Clinical Implication Book Review:

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Sirtuins in Health and Disease

Sirtuins in Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 186
Release: 2018-02-03
ISBN 10: 0128122625
ISBN 13: 9780128122624
Language: EN, FR, DE, ES & NL

Sirtuins in Health and Disease Book Review:

Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins – substrate specificity and inhibitor design, and chemical probes in sirtuin research. This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research. Presents an excellent subject, excellent structural organization, and authoritative contributions from world-renowned scholars in the sirtuin field Provides the latest updates on sirtuins in health and disease

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease
Author: Thomas Seyfried
Publsiher: John Wiley & Sons
Total Pages: 438
Release: 2012-05-18
ISBN 10: 1118310306
ISBN 13: 9781118310304
Language: EN, FR, DE, ES & NL

Cancer as a Metabolic Disease Book Review:

The book addresses controversies related to the origins of cancerand provides solutions to cancer management and prevention. Itexpands upon Otto Warburg's well-known theory that all cancer is adisease of energy metabolism. However, Warburg did not linkhis theory to the "hallmarks of cancer" and thus his theory wasdiscredited. This book aims to provide evidence, throughcase studies, that cancer is primarily a metabolic diseaserequring metabolic solutions for its management andprevention. Support for this position is derived fromcritical assessment of current cancer theories. Brain cancercase studies are presented as a proof of principle for metabolicsolutions to disease management, but similarities are drawn toother types of cancer, including breast and colon, due tothe same cellular mutations that they demonstrate.

Epigenetics in Biology and Medicine

Epigenetics in Biology and Medicine
Author: Manel Esteller
Publsiher: CRC Press
Total Pages: 312
Release: 2008-09-17
ISBN 10: 9781420007077
ISBN 13: 1420007076
Language: EN, FR, DE, ES & NL

Epigenetics in Biology and Medicine Book Review:

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

Handbook of the Biology of Aging

Handbook of the Biology of Aging
Author: Matt Kaeberlein,George Martin
Publsiher: Academic Press
Total Pages: 576
Release: 2015-08-20
ISBN 10: 0124116205
ISBN 13: 9780124116207
Language: EN, FR, DE, ES & NL

Handbook of the Biology of Aging Book Review:

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Molecular Biology of Aging

Molecular Biology of Aging
Author: Leonard Guarente,Linda Partridge,Douglas C. Wallace
Publsiher: CSHL Press
Total Pages: 610
Release: 2008
ISBN 10: 0879698241
ISBN 13: 9780879698249
Language: EN, FR, DE, ES & NL

Molecular Biology of Aging Book Review:

This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Sensing in Nature

Sensing in Nature
Author: Carlos López-Larrea
Publsiher: Springer Science & Business Media
Total Pages: 316
Release: 2012-03-07
ISBN 10: 146141704X
ISBN 13: 9781461417040
Language: EN, FR, DE, ES & NL

Sensing in Nature Book Review:

Biological systems are an emerging discipline that may provide integrative tools by assembling the hierarchy of interactions among genes, proteins and molecular networks involved in sensory systems. The aim of this volume is to provide a picture, as complete as possible, of the current state of knowledge of sensory systems in nature. The presentation in this book lies at the intersection of evolutionary biology, cell and molecular biology, physiology and genetics. Sensing in Nature is written by a distinguished panel of specialists and is intended to be read by biologists, students, scientific investigators and the medical community.

Lifespan

Lifespan
Author: David A. Sinclair,Matthew D. LaPlante
Publsiher: Atria Books
Total Pages: 432
Release: 2019-09-10
ISBN 10: 1501191977
ISBN 13: 9781501191978
Language: EN, FR, DE, ES & NL

Lifespan Book Review:

A NEW YORK TIMES BESTSELLER A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Aging

Aging
Author: Shamim I. Ahmad
Publsiher: CRC Press
Total Pages: 658
Release: 2017-10-30
ISBN 10: 1315283875
ISBN 13: 9781315283876
Language: EN, FR, DE, ES & NL

Aging Book Review:

This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.

Structure

Structure
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 2007
ISBN 10:
ISBN 13: UCLA:L0090696592
Language: EN, FR, DE, ES & NL

Structure Book Review:

Tetraspanins

Tetraspanins
Author: Fedor Berditchevski,Eric Rubinstein
Publsiher: Springer Science & Business Media
Total Pages: 418
Release: 2013-03-20
ISBN 10: 9400760701
ISBN 13: 9789400760707
Language: EN, FR, DE, ES & NL

Tetraspanins Book Review:

Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains.

Gene Expression and Regulation in Mammalian Cells

Gene Expression and Regulation in Mammalian Cells
Author: Fumiaki Uchiumi
Publsiher: BoD – Books on Demand
Total Pages: 372
Release: 2018-02-28
ISBN 10: 9535138677
ISBN 13: 9789535138679
Language: EN, FR, DE, ES & NL

Gene Expression and Regulation in Mammalian Cells Book Review:

Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.