Signal Transduction

Signal Transduction
Author: Bastien D. Gomperts,ljsbrand M. Kramer,Peter E.R. Tatham
Publsiher: Gulf Professional Publishing
Total Pages: 424
Release: 2003-10-29
ISBN 10: 9780122896323
ISBN 13: 0122896327
Language: EN, FR, DE, ES & NL

Signal Transduction Book Review:

Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work. * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

Signal Transduction

Signal Transduction
Author: Bastien D. Gomperts,ljsbrand M. Kramer,Peter E.R. Tatham
Publsiher: Academic Press
Total Pages: 840
Release: 2009-09-22
ISBN 10: 9780080919058
ISBN 13: 0080919057
Language: EN, FR, DE, ES & NL

Signal Transduction Book Review:

Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium Extensive conceptual color artwork to assist with comprehension of key topics Instrumental margin notes highlight milestones in signaling mechanisms

Signal Transduction in Plants

Signal Transduction in Plants
Author: P. Aducci
Publsiher: Birkhäuser
Total Pages: 183
Release: 2012-12-06
ISBN 10: 3034891830
ISBN 13: 9783034891837
Language: EN, FR, DE, ES & NL

Signal Transduction in Plants Book Review:

Increasing interest has been emerging in the last decade in the field of signal recognition and transduction. This is particularly true for animal systems where an impressive amount of literature is appearing and where many important pathways have been clarified at a molecular level. In the elucidation of the functions of single components of a given pathway, gene cloning has played a major role and opened the field to the genetic engineering of these complex systems. At variance with this situation, plant systems are less well elucidated, even if in recent years exciting research of developments have been initiated especially with the view toward the most promising role plants in biotechnology. Recent studies have elucidated some of the events involved in the perception of the plant hormone signals and some steps concerning its transduction. Only for three of the five hormones in plants, namely auxin, ethylene and cytokinins, have specific receptors been isolated. The use of classical molecular approaches, together with the more recently isolated mutants, have produced crucial information on receptors and shed light on possible transduction pathways. As in the case of red light, more than one pathway can be triggered by one specific signal. Many systems involved in animal signaling are now shown to be present also in plants, and in view of the fast progress in this area, it will be possible in the near future to fully describe the content of the "black boxes" in the reaction chain specifically triggered by a signal.

New Research on Signal Transduction

New Research on Signal Transduction
Author: Bruce R. Yanson
Publsiher: Nova Publishers
Total Pages: 265
Release: 2007
ISBN 10: 9781600213793
ISBN 13: 1600213790
Language: EN, FR, DE, ES & NL

New Research on Signal Transduction Book Review:

In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. In such cases the chain of steps is referred to as a "signalling cascade" or a "second messenger pathway" and often results in a small stimulus eliciting a large response. Hormones and other signalling molecules may exit the sending cell by exocytosis or other means of membrane transport. The sending cell is typically of a specialised type. Its recipients may be of one type or several, as in the case of insulin, which triggers diverse and systemic effects. This book sheds new light in this exciting field of cell transportation research.

Plant Signal Transduction

Plant Signal Transduction
Author: Dierk Scheel,Claus Wasternack
Publsiher: Oxford University Press
Total Pages: 324
Release: 2002-03-28
ISBN 10: 9780199638796
ISBN 13: 0199638799
Language: EN, FR, DE, ES & NL

Plant Signal Transduction Book Review:

Plant growth and development is controlled by environmental cues (e.g. light, salinity) that are sensed by the plant via a variety of signal transduction pathways. This book gives an up-to-date summary of the large amount of information that is now available on the processes involved in the communication of plants with their environment.

Trends in Signal Transduction Research

Trends in Signal Transduction Research
Author: Jennifer N. Meyers
Publsiher: Nova Publishers
Total Pages: 254
Release: 2007
ISBN 10: 9781600213755
ISBN 13: 1600213758
Language: EN, FR, DE, ES & NL

Trends in Signal Transduction Research Book Review:

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Signal Transduction

Signal Transduction
Author: Graeme Milligan
Publsiher: OUP Oxford
Total Pages: 424
Release: 1999-08-12
ISBN 10: 0191565873
ISBN 13: 9780191565878
Language: EN, FR, DE, ES & NL

Signal Transduction Book Review:

Since the publication of the first edition of Signal Transduction: A Practical Approach in 1992 there has been a great deal of new information about the processes of signal transduction and consequently many new methods have been developed. This new edition has therefore been updated and extended to include the major new methods now available. The first part of the book is mainly concerned with G protein-coupled receptors and covers structural studies of conformational changes and binding sites, phosphorylation and desensitisation, identification, receptor fusion proteins, and reporter gene systems. The second part includes methods for studying components of the other major families of signal transduction: adenylyl cylase and cAMP, phosphorylated inositol lipids, phosphinositide 3-kinases, phosphlipase D and phosphatidylcholine, sphingosine kinase, and inositol 1,4,5-triphosphate. Also included are chapters on baculoviral expression systems and the quantitative assay of mitogen activated protein kinases in intact cells and tissues. As with the previous edition Signal Transduction 2e covers a wide range of techniques and will be useful to both experienced researchers and newcomers.

Signal Transduction in Mast Cells and Basophils

Signal Transduction in Mast Cells and Basophils
Author: Ehud Razin,Juan Rivera
Publsiher: Springer Science & Business Media
Total Pages: 423
Release: 1999-05-11
ISBN 10: 9780387986258
ISBN 13: 0387986251
Language: EN, FR, DE, ES & NL

Signal Transduction in Mast Cells and Basophils Book Review:

Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of present day research into allergy and inflammation. This book provides a comprehensive summary of the field of signal transduction and provides insights into areas with therapeutic potential.

Signal Transduction

Signal Transduction
Author: Carl-Henrik Heldin,Mary Purton
Publsiher: Garland Science
Total Pages: 365
Release: 1998
ISBN 10: 9780748740741
ISBN 13: 0748740740
Language: EN, FR, DE, ES & NL

Signal Transduction Book Review:

Signal Transduction was published in association with The International Union of Biochemistry and Molecular Biology. In a series of twenty-three short chapters, leading researchers provide cutting-edge reviews of signal transduction, and form cell membrane receptors through to gene regulation. Written for those with a basic understanding of molecular and cell biology, the book will be of particular interest to graduate students and researchers who need to grasp the principles of signal transduction.

Signal Transduction in Cancer Metastasis

Signal Transduction in Cancer Metastasis
Author: Wen-Sheng Wu,Chi-Tan Hu
Publsiher: Springer Science & Business Media
Total Pages: 288
Release: 2010-10-04
ISBN 10: 9789048195220
ISBN 13: 9048195225
Language: EN, FR, DE, ES & NL

Signal Transduction in Cancer Metastasis Book Review:

This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Signal Transduction

Signal Transduction
Author: C.V. Clevenger
Publsiher: IOS Press
Total Pages: 86
Release: 2004
ISBN 10: 9781586034474
ISBN 13: 1586034472
Language: EN, FR, DE, ES & NL

Signal Transduction Book Review:

This publication focuses on the subject of signal transduction and its role in the pathogenesis and progression of human breast cancer. Within the past 10 years, the explosion in our knowledge of these processes has significantly altered our understanding of breast cancer, and resulted in the first receptor-based therapies. This volume examines a variety of relevant signalling pathways in mammary epithelium and explores their mechanisms and functional contribution to the evolution of this disease. The articles herein explore receptor-based signalling that occurs both at the cell surface and within the nucleus that controls the gene expression required for the breast cancer phenotype. Of course, any good series of reviews should open up more questions than they answer, and the current collection of review provides no exception. It is our desire that the discussions engendered by the reviews herein stimulate additional research on these topics. Clearly, further mechanistic understanding of these underpinnings of breast neoplasia has been and will be the wellspring for novel therapies of this disease.

Signal Transduction in the Retina

Signal Transduction in the Retina
Author: Steven J. Fliesler,Oleg G. Kisselev
Publsiher: CRC Press
Total Pages: 408
Release: 2007-12-26
ISBN 10: 9781420007169
ISBN 13: 1420007165
Language: EN, FR, DE, ES & NL

Signal Transduction in the Retina Book Review:

In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approaches that yield key information on the mechanisms underlying normal retinal physiology. This in-depth work discusses the latest techniques and applications for understanding retinal function and degradation, developing novel therapeutic strategies, and promoting cellular survival and functional retention. Drawing contributions from experts in a range of disciplines, each chapter presents a brief overview of the area discussed along with specific methodology for obtaining the primary data to understand the cellular and molecular process. Given the dominance and wealth of information on rhodopsin-based phototransduction, the book devotes substantial attention to this topic, but also evaluates a diversity of signaling mechanisms. Beginning with the molecular mechanisms of vertebrate phototransduction, this volume presents the structure of phototransduction cascade components at atomic resolution, as well as molecular interactions in multi-protein complexes and novel cell-based strategies for understanding signal shut-off and light adaptation. It discusses non-visual phototransduction and the role of melanopsin in adaptive photoresponses and circadian clock regulation. The book also compares the visual signaling processes of vertebrates and invertebrates. It examines experimental studies of insulin-based signaling in the inner and outer retina; investigates retinal development including signaling in progenitor cells, cell-cell communication in developing cells, and neovascularization; and studies lipid-derived mediators such as neuroprotectins and discusses the participation of retinal pigment epithelium in neuronal survival.

Introduction to Cellular Signal Transduction

Introduction to Cellular Signal Transduction
Author: Ari Sitaramayya
Publsiher: Springer Science & Business Media
Total Pages: 311
Release: 1999
ISBN 10: 9780817639822
ISBN 13: 0817639829
Language: EN, FR, DE, ES & NL

Introduction to Cellular Signal Transduction Book Review:

This book is designed for senior undergraduate/graduate level students interested in a basic understanding of the major participants in the cellular Signal Transductions pathways. The book is suitable for an introductory course in Signal Transduction, as well as for self-study and review. It is recommended for biology and medical students, as well as for other science majors interested in interdisciplinary research efforts, e.g. in pharmaceuticals, biochemistry and bioengineering.

Molecular Mechanisms of Signal Transduction

Molecular Mechanisms of Signal Transduction
Author: Johannes Lukas Bos
Publsiher: IOS Press
Total Pages: 285
Release: 2000
ISBN 10: 9781586030162
ISBN 13: 1586030167
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Signal Transduction Book Review:

This book contains overviews of topics that have been discussed. It includes contributions from leading experts in the field on small GTPases, protein kinesis, receptors and transcription factors. A particular focus was the influence of oxygen radicals on signalling processes. It also contains the contributions of scientists early in their career, who have made an excellent contribution to the institute.

Signal Transduction Pathways Mechanisms and Diseases

Signal Transduction  Pathways  Mechanisms and Diseases
Author: Ari Sitaramayya
Publsiher: Springer Science & Business Media
Total Pages: 437
Release: 2009-12-02
ISBN 10: 9783642021121
ISBN 13: 3642021123
Language: EN, FR, DE, ES & NL

Signal Transduction Pathways Mechanisms and Diseases Book Review:

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Bacterial Signal Transduction Networks and Drug Targets

Bacterial Signal Transduction  Networks and Drug Targets
Author: Ryutaro Utsumi
Publsiher: Springer Science & Business Media
Total Pages: 242
Release: 2008-12-05
ISBN 10: 9780387788852
ISBN 13: 0387788859
Language: EN, FR, DE, ES & NL

Bacterial Signal Transduction Networks and Drug Targets Book Review:

This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.

Signal Transduction Protocols

Signal Transduction Protocols
Author: Robert C. Dickson,Michael Dean Mendenhall
Publsiher: Springer Science & Business Media
Total Pages: 327
Release: 2004
ISBN 10: 1592598161
ISBN 13: 9781592598168
Language: EN, FR, DE, ES & NL

Signal Transduction Protocols Book Review:

Carrying on the high standards of the much-acclaimed first edition, highly experienced investigators have extensively updated the first edition with many of the new approaches that have been transforming the field. Included in this new edition are readily reproducible immunoassays, fluorescence-based assays, high-throughput methods, protein modification assays, lipid second messenger assays, and chromatin immunoprecipitation techniques.

Signal Transduction in Cancer

Signal Transduction in Cancer
Author: David A. Frank
Publsiher: Springer Science & Business Media
Total Pages: 357
Release: 2006-04-18
ISBN 10: 0306481588
ISBN 13: 9780306481581
Language: EN, FR, DE, ES & NL

Signal Transduction in Cancer Book Review:

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Signal Transduction Pathways in Autoimmunity

Signal Transduction Pathways in Autoimmunity
Author: Amnon Altman
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 197
Release: 2002
ISBN 10: 3805573081
ISBN 13: 9783805573085
Language: EN, FR, DE, ES & NL

Signal Transduction Pathways in Autoimmunity Book Review:

The chapters included in this volume represent but a few examples of the close link between aberrant signaling pathways and autoimmune diseases. They cover a variety of cells (T, B and myeloid/monocytic cells), receptors (for antigen, Fc and cytokines) and intracellular signaling molecules (kinases, phosphatases, adapters and transcription factors) in the immune system. This book brings together clinical and experimental aspects of autoimmune disease and the fundamental science of intracellular signaling pathways. Therefore, it should be of interest to clinical investigators of autoimmune diseases as wll as to basic immunologists and cell biologists interested in the molecular basis of signal transduction in the immune system.

Targeted Interference with Signal Transduction Events

Targeted Interference with Signal Transduction Events
Author: B. Groner
Publsiher: Springer Science & Business Media
Total Pages: 188
Release: 2007-08-09
ISBN 10: 3540312099
ISBN 13: 9783540312093
Language: EN, FR, DE, ES & NL

Targeted Interference with Signal Transduction Events Book Review:

This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?