Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis
Author: Yi Yang
Publsiher: Academic Press
Total Pages: 376
Release: 2015-09-01
ISBN 10: 0128011815
ISBN 13: 9780128011812
Language: EN, FR, DE, ES & NL

Side Reactions in Peptide Synthesis Book Review:

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration

Chemistry of Peptide Synthesis

Chemistry of Peptide Synthesis
Author: N. Leo Benoiton
Publsiher: CRC Press
Total Pages: 304
Release: 2016-04-19
ISBN 10: 1420027697
ISBN 13: 9781420027693
Language: EN, FR, DE, ES & NL

Chemistry of Peptide Synthesis Book Review:

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th

Principles of Peptide Synthesis

Principles of Peptide Synthesis
Author: Miklos Bodanszky
Publsiher: Springer Science & Business Media
Total Pages: 329
Release: 2012-12-06
ISBN 10: 3642780563
ISBN 13: 9783642780561
Language: EN, FR, DE, ES & NL

Principles of Peptide Synthesis Book Review:

Principles of Peptide Synthesis is a very successful book by one of the pioneers of contemporary bioorganic synthesis. Its first edition proved a valuable source that is kept close to the work bench for frequent consulting. Any researcher planning the formation of the peptide bond, be it for the synthesis of a peptide chain or a cyclic peptide, benefits from the author's experience. The concise and critical treatment of the steps involved: protection, activation and bond formation require careful planning to avoid racemization and undesired side reactions. The second edition has been completely revised and updated. New procedures that have been developed since the first edition was published and that did not fit into the original are added in a separate chapter. This separation of old and new make it possible to assess new ideas and discern novel trends.

Solid Phase Peptide Synthesis

Solid Phase Peptide Synthesis
Author: Gregg B. Fields
Publsiher: Academic Press
Total Pages: 780
Release: 1997-11-04
ISBN 10:
ISBN 13: UVA:X004150724
Language: EN, FR, DE, ES & NL

Solid Phase Peptide Synthesis Book Review:

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides

Peptides 1982

Peptides 1982
Author: Karel Bláha,Petr Maloň
Publsiher: De Gruyter
Total Pages: 846
Release: 1983
ISBN 10:
ISBN 13: UOM:39015010070418
Language: EN, FR, DE, ES & NL

Peptides 1982 Book Review:

Principles of Peptide Synthesis

Principles of Peptide Synthesis
Author: M. Bodanszky
Publsiher: Springer Science & Business Media
Total Pages: 308
Release: 2012-12-06
ISBN 10: 3642967639
ISBN 13: 9783642967634
Language: EN, FR, DE, ES & NL

Principles of Peptide Synthesis Book Review:

A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on some experimental project that requires the construction of peptide chains. Not less useful are the monographs which were compiled to aid the adept practitioner and to provide him with references to the growing literature of a very active field. Is there any need for a new book on peptide synthesis? Should we add a new volume to an already impressive and certainly useful series? The answer is not obvious. The author has already participated in two similar en deavors. The first edition! of "Peptide Synthesis", with M. A. Ondetti as coauthor, was meant to serve as an introduction for the beginner. It was rather well received by researchers who joined the field of peptide chemistry and were looking for initiation. While working on the 2 second edition with Drs. Klausner and Ondetti, we became painfully aware of the impossibility of the task.

Major Methods of Peptide Bond Formation

Major Methods of Peptide Bond Formation
Author: Erhard Gross,Johannes Meienhofer
Publsiher: Elsevier
Total Pages: 454
Release: 2014-05-10
ISBN 10: 1483217965
ISBN 13: 9781483217963
Language: EN, FR, DE, ES & NL

Major Methods of Peptide Bond Formation Book Review:

The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

The Peptides

The Peptides
Author: Eberhard Schröder,Klaus Lübke
Publsiher: Elsevier
Total Pages: 510
Release: 2014-05-12
ISBN 10: 1483261727
ISBN 13: 9781483261720
Language: EN, FR, DE, ES & NL

The Peptides Book Review:

The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis of peptides by activation of the amino group, and peptide synthesis by activation of the carboxyl group. The manuscript elaborates on the synthesis of cyclic peptides, depsipeptides, peptoids, and the plastein reaction. Topics include synthesis of plastein-active peptides, glycopeptides, phosphopeptides, and S-peptides. The publication is a dependable source of data for readers interested in the methods of peptide synthesis.

The Chemical Synthesis of Peptides

The Chemical Synthesis of Peptides
Author: Dr Mari C Jones,John Jones,John H. Jones
Publsiher: Oxford University Press
Total Pages: 228
Release: 1991
ISBN 10:
ISBN 13: UOM:39015031709291
Language: EN, FR, DE, ES & NL

The Chemical Synthesis of Peptides Book Review:

Peptides have many roles in medicine, and their potential for future application is even greater. They are involved in the regulation of fertility, the control of pain, the stimulation of growth, cancer therapy, cardiovascular problems, connective tissue diseases, digestive disorders, mental illness, and infections by microbial or viral agents. The preparation of such compounds by manipulating biological systems (genetic engineering) is an increasingly sophisticated art, but each case requires developmental work, and the approach is at present almost powerless with structural types that don't occur naturally. Chemical synthesis, on the other hand, is in principle applicable to any target, and is likely to remain very important in the peptide area for the foreseeable future. The emphasis throughout this book is on the chemical principles behind the more important methods of peptide synthesis. It provides a critical, concise, and up-to-date survey of the field. The term peptide is interpreted liberally, as embracing not only conventional sequences of up to a few dozen natural amino acids, but also protein-scale molecules and structures comprising other residues or unusual features, for example, cyclopeptides and conjugated peptides. The synthetic methods considered here are treated within a modern mechanistic framework, and illustrated with carefully selected case studies, and this valuable account will be of interest to all those working in the field of peptide synthesis.

Aspects of the Merrifield Peptide Synthesis

Aspects of the Merrifield Peptide Synthesis
Author: C. Birr
Publsiher: Springer Science & Business Media
Total Pages: 102
Release: 2012-12-06
ISBN 10: 3642670040
ISBN 13: 9783642670046
Language: EN, FR, DE, ES & NL

Aspects of the Merrifield Peptide Synthesis Book Review:

This book was written in the context of the daily confrontation with problems in the utilization of polymeric supports for the synthesis of pep tides. Therefore, views and experiences which usually are not mentioned in scientific journals are collected in these pages. The author has deliberately discussed in detail the possible influence of the polymer phase on the varying reaction conditions in the Merrifield synthesis; this aspect is neglected in most publications dealing with peptide synthesis. However, in view of the growing body of information on the chemistry of polymer-supported peptide syntheses, the international readership should regard the author's arguments as open to discussion. I am very much indebted to all of my colleagues with whom I have had the opportunity to cooperate in studying the potential of the Merrifield synthesis. Above all I like to express my gratitude to my teacher, Professor Dr. Theodor Wieland, Heidelberg, for his boundless encouragement and support in my ef forts in the field of peptide synthesis, particularly in its polymer phase bound version. Last but not at least I wish to thank Miss Hildegard Leyden. With in finite patience and great accuracy she typed the manuscript in addition to her daily duties. The work which influenced this book was performed under the auspices of the Max-Planck-Gesellschaft, of which the financial support is gratefully ac knowledged.

Fmoc Solid Phase Peptide Synthesis

Fmoc Solid Phase Peptide Synthesis
Author: W. Chan,Peter White
Publsiher: OUP Oxford
Total Pages: 370
Release: 1999-12-16
ISBN 10: 0199637245
ISBN 13: 9780199637249
Language: EN, FR, DE, ES & NL

Fmoc Solid Phase Peptide Synthesis Book Review:

Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.

Amino Acid and Peptide Synthesis

Amino Acid and Peptide Synthesis
Author: John H. Jones,John Jones
Publsiher: Oxford University Press, USA
Total Pages: 86
Release: 1992
ISBN 10:
ISBN 13: UOM:39015029145375
Language: EN, FR, DE, ES & NL

Amino Acid and Peptide Synthesis Book Review:

The principal methods for the synthesis of amino acids and peptides are outlined in this concise introduction. With its emphasis on chemical principles and strategies, the book should be of value to all undergraduate chemistry students.

Chemistry of Peptide Synthesis

Chemistry of Peptide Synthesis
Author: N. Leo Benoiton
Publsiher: CRC Press
Total Pages: 304
Release: 2005-08-12
ISBN 10: 9781574444544
ISBN 13: 1574444549
Language: EN, FR, DE, ES & NL

Chemistry of Peptide Synthesis Book Review:

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author’s role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather than memorization. The text uses clear language and schematics to present concepts progressively, carefully excluding unnecessary details and providing a historical context in which to appreciate the development of the field. The author first outlines the fundamentals of peptide synthesis, focusing on the intermediates in aminolysis reactions. Gradually the text builds into discussions of the applicability of coupling reactions, stereomutation, methods of deprotection, solid-phase synthesis, side-chain protection and side reactions, and amplification on coupling methods. The book clarifies the differences between oxazolones from amino-acid derivatives and segments and the implications of their formation on the chiral integrity of products. The author offers a critical analysis of the mechanisms of coupling reactions and the desirability of preactivation. The text explains hindrance and the nucleophilicity of tertiary amines and rationalizes their use. The book also explores mechanisms of acidolysis and the dual role of nucleophiles as reactants and scavengers. Chemistry of Peptide Synthesis supplies a broad, yet straightforward approach that appeals to those with limited knowledge of organic chemistry or chemists from other fields as well as in-depth coverage that can be appreciated by experienced peptidologists.

Chemical Approaches to the Synthesis of Peptides and Proteins

Chemical Approaches to the Synthesis of Peptides and Proteins
Author: Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt
Publsiher: CRC Press
Total Pages: 304
Release: 1997-04-23
ISBN 10: 9780849391422
ISBN 13: 0849391423
Language: EN, FR, DE, ES & NL

Chemical Approaches to the Synthesis of Peptides and Proteins Book Review:

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

The Peptides Special methods in peptide synthesis pt A

The Peptides  Special methods in peptide synthesis  pt  A
Author: Erhard Gross,Johannes Meienhofer
Publsiher: Unknown
Total Pages: 329
Release: 1979
ISBN 10:
ISBN 13: STANFORD:36105003313025
Language: EN, FR, DE, ES & NL

The Peptides Special methods in peptide synthesis pt A Book Review:

The Peptides

The Peptides
Author: Erhard Gross,Johannes Meienhofer
Publsiher: Unknown
Total Pages: 508
Release: 1983
ISBN 10: 9780123042057
ISBN 13: 0123042054
Language: EN, FR, DE, ES & NL

The Peptides Book Review:

Peptide Applications in Biomedicine Biotechnology and Bioengineering

Peptide Applications in Biomedicine  Biotechnology and Bioengineering
Author: Sotirios Koutsopoulos
Publsiher: Woodhead Publishing
Total Pages: 656
Release: 2017-11-16
ISBN 10: 0081007426
ISBN 13: 9780081007426
Language: EN, FR, DE, ES & NL

Peptide Applications in Biomedicine Biotechnology and Bioengineering Book Review:

Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

The World of Peptides

The World of Peptides
Author: Theodor Wieland,Miklos Bodanszky
Publsiher: Springer Science & Business Media
Total Pages: 298
Release: 2012-12-06
ISBN 10: 3642758509
ISBN 13: 9783642758508
Language: EN, FR, DE, ES & NL

The World of Peptides Book Review:

Almost two centuries ago proteins were recognized as the primary materials (proteios = primary) oflife, but the significance and wide role of peptides (from pepsis = digestion) in practically all life pro cesses has only become apparent in the last few decades. Biologi cally active peptides are now being discovered at rapid intervals in the brain and in other organs including the heart, in the skin of amphibians and many other tissues. Peptides and peptide-like compounds are found among toxins and antibiotics. It is unlikely that this process, an almost explosive broadening of the field, will come to a sudden halt. By now it is obvious that Nature has used the combination of a small to moderate number of amino acids to generate a great variety of agonists with specific and often highly sophisticated functions. Thus, peptide chemistry must be regarded as a discipline in its own right, a major branch of biochemistry, fairly separate from the chemistry of proteins. Because of the important role played by synthesis both in the study and in the practical preparation of peptides, their area can be considered as belonging to bio-organic chemistry as well. The already overwhelming and still increasing body of know ledge renders an account of the history of peptide chemistry more and more difficult. It appears therefore timely to look back, to take stock and to recall the important stages in the development of a new discipline.

Protection of Functional Groups in Peptide Synthesis

Protection of Functional Groups in Peptide Synthesis
Author: Erhard Gross,Johannes Meienhofer
Publsiher: Elsevier
Total Pages: 400
Release: 2014-05-10
ISBN 10: 1483217981
ISBN 13: 9781483217987
Language: EN, FR, DE, ES & NL

Protection of Functional Groups in Peptide Synthesis Book Review:

The Peptides: Analysis, Synthesis, Biology, Volume 3: Protection of Functional Groups in Peptide Synthesis focuses on protection of functional groups in peptide synthesis. This book consists of seven chapters. Chapter 1 reviews the large variety of amine protecting groups. The protection of carboxyl groups is described in Chapter 2, while the chemistry of sulfhydryl group protection in peptide synthesis is discussed in Chapter 3. Chapter 4 covers the protection of the hydroxyl groups of serine, threonine, tyrosine, and other hydroxyl-containing amino acids. Differential protection and selective deprotection in peptide synthesis is deliberated in Chapter 5. In chapter 6, the opportunities and constraints of the tactics of minimal protection of side-chain functions during peptide synthesis are reviewed. The last chapter is devoted to the interesting aspects of dual function groups. This volume is recommended for specialists and researchers concerned with peptide and protein research.

Peptide Chemistry

Peptide Chemistry
Author: Miklos Bodanszky
Publsiher: Springer Science & Business Media
Total Pages: 200
Release: 2012-12-06
ISBN 10: 364297886X
ISBN 13: 9783642978869
Language: EN, FR, DE, ES & NL

Peptide Chemistry Book Review:

Analysis of peptides and determination of their primary structure. Conformational analysis: secondary-tertiary structure. Peptide synthesis: protection, activation and coupling, undesired reactions and their prevention, design of synthetic schemes.