Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 612
Release: 2000-10-13
ISBN 10: 9780080541099
ISBN 13: 0080541097
Language: EN, FR, DE, ES & NL

Separation Methods in Drug Synthesis and Purification Book Review:

Separation Methods in Drug Synthesis and Purification

Chirality in Drug Research

Chirality in Drug Research
Author: Eric Francotte,Wolfgang Lindner
Publsiher: Wiley-VCH
Total Pages: 370
Release: 2006-11-10
ISBN 10: 9783527310760
ISBN 13: 3527310762
Language: EN, FR, DE, ES & NL

Chirality in Drug Research Book Review:

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Separation Technologies for the Industries of the Future

Separation Technologies for the Industries of the Future
Author: National Research Council,Division on Engineering and Physical Sciences,National Materials Advisory Board,Commission on Engineering and Technical Systems,Committee on Industrial Technology Assessments,Panel on Separation Technology for Industrial Reuse and Recycling
Publsiher: National Academies Press
Total Pages: 128
Release: 1999-02-08
ISBN 10: 0309063779
ISBN 13: 9780309063777
Language: EN, FR, DE, ES & NL

Separation Technologies for the Industries of the Future Book Review:

Separation processesâ€"or processes that use physical, chemical, or electrical forces to isolate or concentrate selected constituents of a mixtureâ€"are essential to the chemical, petroleum refining, and materials processing industries. In this volume, an expert panel reviews the separation process needs of seven industries and identifies technologies that hold promise for meeting these needs, as well as key technologies that could enable separations. In addition, the book recommends criteria for the selection of separations research projects for the Department of Energy's Office of Industrial Technology.

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
Author: Satinder Ahuja
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2011-03-31
ISBN 10: 9781118097755
ISBN 13: 1118097750
Language: EN, FR, DE, ES & NL

Chiral Separation Methods for Pharmaceutical and Biotechnological Products Book Review:

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

The British National Bibliography

The British National Bibliography
Author: Arthur James Wells
Publsiher: Unknown
Total Pages: 329
Release: 2000
ISBN 10:
ISBN 13: UOM:39015079755800
Language: EN, FR, DE, ES & NL

The British National Bibliography Book Review:

Journal of Chromatography

Journal of Chromatography
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: CHI:61563615
Language: EN, FR, DE, ES & NL

Journal of Chromatography Book Review:

Modern Thin Layer Chromatography

Modern Thin Layer Chromatography
Author: Nelu Grinberg
Publsiher: CRC Press
Total Pages: 504
Release: 1990-04-27
ISBN 10: 9780824781385
ISBN 13: 0824781384
Language: EN, FR, DE, ES & NL

Modern Thin Layer Chromatography Book Review:

Provides chemists with an in-depth account of chromatographic phenomena and a detailed reference guide to the various choices in optimizing chromatographic separations of enantiomers. Clarifies how thin-layer chromatography differs from, but can be used as a pilot procedure for, high-performance liq

Liposome Based Drug Delivery Systems

Liposome Based Drug Delivery Systems
Author: Wan-Liang Lu,Xiang-Rong Qi
Publsiher: Springer
Total Pages: 400
Release: 2019-02-13
ISBN 10: 9783662493182
ISBN 13: 3662493187
Language: EN, FR, DE, ES & NL

Liposome Based Drug Delivery Systems Book Review:

This volume mainly describes the protocols for fabrication of liposomal drug delivery system, and consists of three parts, namely, the advances in liposome-based drug delivery system, the general protocols for fabrication of drug-loading liposomes, and the protocols for preparation of functionalized liposome-based drug delivery system. It unearths the formulation of drug-loading liposomes, describes the detailed operation of liposomal formulation, and demonstrates their potential applications. This handbook is targeted at scientists, research students, and young investigators in pharmaceutical enterprises.

Membrane Processes in Biotechnology and Pharmaceutics

Membrane Processes in Biotechnology and Pharmaceutics
Author: Catherine Charcosset
Publsiher: Elsevier
Total Pages: 336
Release: 2012
ISBN 10: 0444563342
ISBN 13: 9780444563347
Language: EN, FR, DE, ES & NL

Membrane Processes in Biotechnology and Pharmaceutics Book Review:

Chapter 1: Principles on membrane and membrane processes -- Chapter 2: Ultrafiltration -- Chapter 3: Microfiltration -- Chapter 4: Virus Filtration -- Chapter 5: Membrane chromatography -- Chapter 6: Membranes for the Preparation of Emulsions and Particles -- Chapter 7: Other Membrane Processes -- Chapter 8: Some Perspectives.

Octanol Water Partition Coefficients

Octanol Water Partition Coefficients
Author: James Sangster
Publsiher: John Wiley & Sons
Total Pages: 178
Release: 1997-05-28
ISBN 10: 9780471973973
ISBN 13: 0471973971
Language: EN, FR, DE, ES & NL

Octanol Water Partition Coefficients Book Review:

The octanol-water partition coefficient is a laboratory-measured property of a substance. It provides a thermodynamic measure of the tendency of the substance to prefer a non-aqueous or oily milieu rather than water (i.e. its hydrophilic/lipophilic balance). Partition coefficients are used extensively in medicinal chemistry, drug design, ecotoxicology and environmental chemistry. The partition coefficient is recognized by governmental and international agencies (U.S. Environmental Protection Agency, OECD) as a physical property of organic pollutants equal in importance to vapour pressure, water solubility and toxicity. Octanol-Water Partition Coefficients is a comprehensive and up-to-date survey of the thermodynamics of partitioning and of the octanol-water pair. In addition, all current methods of measurement are reviewed, strengths and weaknesses are noted and recommendations for particular applications are given. Current methods of calculation of partition coefficients are similarly surveyed and described. Five of the most popular computerized methods are tested for predictive accuracy for drugs, pollutants, aminoacids, etc. The book will be of interest not only to solution chemists, but to any chemists who use partition coefficients. It provides a thorough understanding of the fundamentals and offers clear guidance on the choice of methods of measurement and calculation. Contents: Introduction, Thermodynamics and Extrathermodynamics of Partitioning, Experimental Methods of Measurement, Discussion of Measurement Methods, Methods of Calculating Partitioning Coefficients, Discussion of LogKow Predictive Methods The Wiley Series in Solution Chemistry fills the increasing need to present authoritative, comprehensive and fully up-to-date accounts of the many aspects of solution chemistry. Internationally recognized experts from research or teaching institutions in various countries are invited to contribute to the series.

Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry
Author: Georg Hempel
Publsiher: Elsevier
Total Pages: 378
Release: 2004-05-15
ISBN 10: 0080530540
ISBN 13: 9780080530543
Language: EN, FR, DE, ES & NL

Drug Monitoring and Clinical Chemistry Book Review:

Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field

RNA Purification and Analysis

RNA Purification and Analysis
Author: Douglas T. Gjerde,Lee Hoang,David Hornby
Publsiher: John Wiley & Sons
Total Pages: 206
Release: 2009-07-10
ISBN 10: 3527627200
ISBN 13: 9783527627202
Language: EN, FR, DE, ES & NL

RNA Purification and Analysis Book Review:

This first book on the market covers the many new and important RNA species discovered over the past five years, explaining current methods for the enrichment, separation and purification of these novel RNAs. Building up from general principles of RNA biochemistry and biophysics, this book addresses the practical aspects relevant to the laboratory researcher throughout, while discussing the performance and potential problems of the methods discussed. An appendix contains a glossary with the important terms and techniques used in RNA analysis. By explaining the basic and working principles of the methods, the book allows biochemists and molecular biologists to gain much more expertise than by simply repeating a pre-formulated protocol, enabling them to select the procedure and materials best suited to the RNA analysis task at hand. As a result, they will be able to develop new protocols where needed and optimize and fine-tune the general purpose standard protocols that come with the purification equipment and instrumentation.

Organic Solvent Nanofiltration

Organic Solvent Nanofiltration
Author: Andrew Livingston,Ludmila G Peeva,Malladi Sairam
Publsiher: Newnes
Total Pages: 310
Release: 2013-11-12
ISBN 10: 9780444537447
ISBN 13: 0444537449
Language: EN, FR, DE, ES & NL

Organic Solvent Nanofiltration Book Review:

Separation of molecules present in organic solvents by membrane (nano)filtration has great potential in industries ranging from refining to fine chemical and pharmaceutical synthesis and is currently an area of intensive studies. This will be the first concise reference book offering a critical analysis on this topic. Nanofiltration, is a pressure driven membrane process used to remove solutes with molecular weight in the range of 200-1,000 g mol-1 typically from aqueous streams. A recent innovation is the extension of nanofiltration processes to organic solvents an emerging technology referred to as Organic Solvent Nanofiltration (OSN). Separation of molecules present in organic solvents by nanofiltration has great potential in various processes such as petroleum refining, fine chemical and pharmaceutical synthesis, catalyst recycle, enrichment of aromatics etc. This book summarizes the developments in the field of OSN. It describes materials and methods used for the preparation of organic solvent stable membranes. Various techniques for manufacturing of OSN membranes, their physico-chemical and performance related characterization and membrane transport mechanisms will be discussed and critically evaluated. A summary of the commercially available OSN membranes, their separation properties and manufacturers will also be presented. Finally a detailed overview of the OSN applications in various industrial and laboratory scale processes as well as their future prospective will be presented. Complete coverage of the field of organic Solvent Nanofiltration: theory and industrial applications Provides all you want to know in this fast developing application of membranes in industrial filtration and water purification Applications of membranes - summary of the existing applications and proposed new applications; review and critical analysis of the data on currently available OSN membranes. The benefit of this feature to the users is outlined in the comment of one referee: "I use these types of books as an instant reference, resource and fact checker when I am writing or researching topics in membrane technology. I also read the content carefully to keep myself at the state-of-the-art in the technology. R&D is an expensive and time consuming endeavor so anything learned from the literature is valuable when it helps to guide my efforts". Contains a large number of diagrams /figures (60 approx) which offer graphical explanations of the processes and the mechanisms underlying the processess provides practical and easy to understand examples of practical applications. The user can easily adapt these to his/her specific application Worked examples 15 (approx) Guide the reader through the various parameters, and show the reader the effect of these parameters in the overall design of the process Includes multimedia content, videos and active tables and diagrams Enable the user to add his/her own data and conditions and get results relevant to his/her situation. Tables (25 approx) Provides review and critical analysis of the data on currently available OSN membranes Glossary Summary of the main terms used in OSN

Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II
Author: John B. Taylor,D. J. Triggle
Publsiher: Elsevier Science Ltd
Total Pages: 7200
Release: 2007
ISBN 10: 9780080445137
ISBN 13: 0080445136
Language: EN, FR, DE, ES & NL

Comprehensive medicinal chemistry II Book Review:

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Bioanalytical Separations

Bioanalytical Separations
Author: Anonim
Publsiher: Elsevier
Total Pages: 442
Release: 2003-09-03
ISBN 10: 9780080527864
ISBN 13: 0080527868
Language: EN, FR, DE, ES & NL

Bioanalytical Separations Book Review:

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use - Future trends are identified, in terms of the potential impact of new technologies

Preparative Chromatography

Preparative Chromatography
Author: H. Schmidt-Traub,Michael Schulte,Andreas Seidel-Morgenstern
Publsiher: John Wiley & Sons
Total Pages: 648
Release: 2020-02-12
ISBN 10: 3527816313
ISBN 13: 9783527816316
Language: EN, FR, DE, ES & NL

Preparative Chromatography Book Review:

The third edition of this popular work is revised to include the latest developments in this fast-changing field. Its interdisciplinary approach elegantly combines the chemistry and engineering to explore the fundamentals and optimization processes involved.

Journal of Analytical Chemistry of the USSR

Journal of Analytical Chemistry of the USSR
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1976
ISBN 10:
ISBN 13: UCLA:L0064450802
Language: EN, FR, DE, ES & NL

Journal of Analytical Chemistry of the USSR Book Review:

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: PSU:000055228831
Language: EN, FR, DE, ES & NL

Genetic Engineering Biotechnology News Book Review:

Modern HPLC for Practicing Scientists

Modern HPLC for Practicing Scientists
Author: Michael W. Dong
Publsiher: John Wiley & Sons
Total Pages: 304
Release: 2016-04-06
ISBN 10: 111929360X
ISBN 13: 9781119293606
Language: EN, FR, DE, ES & NL

Modern HPLC for Practicing Scientists Book Review:

A comprehesive yet concise guide to Modern HPLC Written for practitioners by a practitioner, Modern HPLC for Practicing Scientists is a concise text which presents the most important High-Performance Liquid Chromatography (HPLC) fundamentals, applications, and developments. It describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. Moreover, the book serves well as an updated reference guide for busy laboratory analysts and researchers. Topics covered include: HPLC operation Method development Maintenance and troubleshooting Modern trends in HPLC such as quick-turnaround and "greener" methods Regulatory aspects While broad in scope, this book focuses particularly on reversed-phase HPLC, the most common separation mode, and on applications for the pharmaceutical industry, the largest user segment. Accessible to both novice and intermedate HPLC users, information is delivered in a straightforward manner illustrated with an abundance of diagrams, chromatograms, tables, and case studies, and supported with selected key references and Web resources. With intuitive explanations and clear figures, Modern HPLC for Practicing Scientists is an essential resource for practitioners of all levels who need to understand and utilize this versatile analytical technology.

Continuous Manufacturing of Pharmaceuticals

Continuous Manufacturing of Pharmaceuticals
Author: Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publsiher: John Wiley & Sons
Total Pages: 620
Release: 2017-09-05
ISBN 10: 1119001323
ISBN 13: 9781119001324
Language: EN, FR, DE, ES & NL

Continuous Manufacturing of Pharmaceuticals Book Review:

10.7.3 State of Control