Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 612
Release: 2000-10-13
ISBN 10: 9780080541099
ISBN 13: 0080541097
Language: EN, FR, DE, ES & NL

Separation Methods in Drug Synthesis and Purification Book Review:

Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 788
Release: 2020-06-19
ISBN 10: 0444640711
ISBN 13: 9780444640710
Language: EN, FR, DE, ES & NL

Separation Methods in Drug Synthesis and Purification Book Review:

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods. Features descriptions and applications of all separation methods used in the pharmaceutical industry Written by the leading scientists in their respective fields, providing solutions for a wide range of industrial separation problems encountered within the pharmaceutical industry Thoroughly updated with brand new separation science techniques and the latest developments in the established techniques of chromatography

Handbook of Analytical Separations Separation methods in drug synthesis and purification

Handbook of Analytical Separations  Separation methods in drug synthesis and purification
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2000
ISBN 10: 9780444500076
ISBN 13: 0444500073
Language: EN, FR, DE, ES & NL

Handbook of Analytical Separations Separation methods in drug synthesis and purification Book Review:

Chirality in Drug Research

Chirality in Drug Research
Author: Eric Francotte,Wolfgang Lindner
Publsiher: John Wiley & Sons
Total Pages: 370
Release: 2007-09-24
ISBN 10: 3527608710
ISBN 13: 9783527608713
Language: EN, FR, DE, ES & NL

Chirality in Drug Research Book Review:

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Recent Advances in QSAR Studies

Recent Advances in QSAR Studies
Author: Tomasz Puzyn,Jerzy Leszczynski,Mark T. Cronin
Publsiher: Springer Science & Business Media
Total Pages: 414
Release: 2010-01-19
ISBN 10: 9781402097836
ISBN 13: 1402097832
Language: EN, FR, DE, ES & NL

Recent Advances in QSAR Studies Book Review:

This book presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part consists of a comprehensive review of QSAR methodology. The second part highlights the interdisciplinary aspects and new areas of QSAR modelling.

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
Author: Satinder Ahuja
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2011-03-31
ISBN 10: 9781118097755
ISBN 13: 1118097750
Language: EN, FR, DE, ES & NL

Chiral Separation Methods for Pharmaceutical and Biotechnological Products Book Review:

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Physico Chemical Methods in Drug Discovery and Development

Physico Chemical Methods in Drug Discovery and Development
Author: Zoran Mandic
Publsiher: IAPC Publishing
Total Pages: 482
Release: 2012
ISBN 10: 9535694200
ISBN 13: 9789535694205
Language: EN, FR, DE, ES & NL

Physico Chemical Methods in Drug Discovery and Development Book Review:

Peptide Chemistry and Drug Design

Peptide Chemistry and Drug Design
Author: Ben M. Dunn
Publsiher: John Wiley & Sons
Total Pages: 360
Release: 2015-04-06
ISBN 10: 0470317612
ISBN 13: 9780470317617
Language: EN, FR, DE, ES & NL

Peptide Chemistry and Drug Design Book Review:

Separation Techniques in Clinical Chemistry

Separation Techniques in Clinical Chemistry
Author: Hassan Y. Aboul-Enein
Publsiher: CRC Press
Total Pages: 552
Release: 2003-05-28
ISBN 10: 1135532788
ISBN 13: 9781135532789
Language: EN, FR, DE, ES & NL

Separation Techniques in Clinical Chemistry Book Review:

This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophor

Bioanalytical Separations

Bioanalytical Separations
Author: Anonim
Publsiher: Elsevier
Total Pages: 442
Release: 2003-09-03
ISBN 10: 9780080527864
ISBN 13: 0080527868
Language: EN, FR, DE, ES & NL

Bioanalytical Separations Book Review:

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use - Future trends are identified, in terms of the potential impact of new technologies

Separation Technologies for the Industries of the Future

Separation Technologies for the Industries of the Future
Author: National Research Council,Division on Engineering and Physical Sciences,National Materials Advisory Board,Commission on Engineering and Technical Systems,Committee on Industrial Technology Assessments,Panel on Separation Technology for Industrial Reuse and Recycling
Publsiher: National Academies Press
Total Pages: 128
Release: 1999-02-08
ISBN 10: 0309063779
ISBN 13: 9780309063777
Language: EN, FR, DE, ES & NL

Separation Technologies for the Industries of the Future Book Review:

Separation processesâ€"or processes that use physical, chemical, or electrical forces to isolate or concentrate selected constituents of a mixtureâ€"are essential to the chemical, petroleum refining, and materials processing industries. In this volume, an expert panel reviews the separation process needs of seven industries and identifies technologies that hold promise for meeting these needs, as well as key technologies that could enable separations. In addition, the book recommends criteria for the selection of separations research projects for the Department of Energy's Office of Industrial Technology.

Chiral Separation Techniques

Chiral Separation Techniques
Author: Ganapathy Subramanian
Publsiher: John Wiley & Sons
Total Pages: 641
Release: 2008-01-08
ISBN 10: 352761172X
ISBN 13: 9783527611720
Language: EN, FR, DE, ES & NL

Chiral Separation Techniques Book Review:

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Physicochemical and Biomimetic Properties in Drug Discovery

Physicochemical and Biomimetic Properties in Drug Discovery
Author: Klara Valko
Publsiher: John Wiley & Sons
Total Pages: 450
Release: 2013-11-25
ISBN 10: 1118770323
ISBN 13: 9781118770320
Language: EN, FR, DE, ES & NL

Physicochemical and Biomimetic Properties in Drug Discovery Book Review:

Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Integrated Strategies for Drug Discovery Using Mass Spectrometry
Author: Mike S. Lee
Publsiher: John Wiley & Sons
Total Pages: 576
Release: 2005-09-02
ISBN 10: 0471721026
ISBN 13: 9780471721024
Language: EN, FR, DE, ES & NL

Integrated Strategies for Drug Discovery Using Mass Spectrometry Book Review:

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Sampling and Sample Preparation in Field and Laboratory

Sampling and Sample Preparation in Field and Laboratory
Author: Janusz Pawliszyn
Publsiher: Elsevier
Total Pages: 1131
Release: 2002-09-23
ISBN 10: 9780444505118
ISBN 13: 0444505113
Language: EN, FR, DE, ES & NL

Sampling and Sample Preparation in Field and Laboratory Book Review:

This title is the first comprehensive book on sampling and modern sample preparation techniques and has several main objectives: to facilitate recognition of sample preparation as both an integral part of the analytical process; to present a fundamental basis and unified theoretical approach for the professional development of sample preparation; to emphasize new developments in sample preparation technology; and to highlight the future impact of sample preparation on new directions in analytical science, particularly automation, miniaturization and field implementation. Until recently, there has been relatively little scientific interest in sampling and sample preparation, however this situation is presently changing as sampling and sample preparation become integral parts of the analytical process with their own unique challenges and research opportunities. Sampling and Sample Preparation for Field and Laboratory is an essential resource for all analytical chemists, and in particular those involved in method development. Not only does it cover the fundamental aspects of extraction, it also covers applications in various matrices and includes sampling strategies and equipment and how these can be integrated into the analytical process for maximum efficiency.

Drug Bioavailability

Drug Bioavailability
Author: Han van de Waterbeemd,Hans Lennernäs,Per Artursson
Publsiher: John Wiley & Sons
Total Pages: 602
Release: 2006-03-06
ISBN 10: 3527605150
ISBN 13: 9783527605156
Language: EN, FR, DE, ES & NL

Drug Bioavailability Book Review:

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

Pharmaceutical Profiling in Drug Discovery for Lead Selection

Pharmaceutical Profiling in Drug Discovery for Lead Selection
Author: Ronald Borchardt,Edward Kerns,Christopher Lipinski,Dhrien Thakker,Binghe Wang
Publsiher: Springer Science & Business Media
Total Pages: 482
Release: 2005-12-05
ISBN 10: 9780971176799
ISBN 13: 0971176795
Language: EN, FR, DE, ES & NL

Pharmaceutical Profiling in Drug Discovery for Lead Selection Book Review:

This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Absorption and Drug Development

Absorption and Drug Development
Author: Alex Avdeef
Publsiher: John Wiley & Sons
Total Pages: 744
Release: 2012-04-11
ISBN 10: 1118286030
ISBN 13: 9781118286036
Language: EN, FR, DE, ES & NL

Absorption and Drug Development Book Review:

Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.

Chemometric Methods in Capillary Electrophoresis

Chemometric Methods in Capillary Electrophoresis
Author: Grady Hanrahan,Frank A. Gomez
Publsiher: John Wiley & Sons
Total Pages: 336
Release: 2009-10-22
ISBN 10: 9780470530184
ISBN 13: 0470530189
Language: EN, FR, DE, ES & NL

Chemometric Methods in Capillary Electrophoresis Book Review:

Use chemometric techniques to develop optimum separation conditions for capillary electrophoreses For all its advantages, capillary electrophoresis (CE) also carries significant disadvantages for the researcher. Offering a unique blend of information from authors active in a variety of developments of chemometrics in CE, Chemometric Methods in Capillary Electrophoresis presents modern chemometric methods as an alternative to help alleviate the problems commonly encountered during routine analysis and method development. Focusing on current chemometric methods utilized in CE endeavours by research-active experts in the field, the book begins with a thorough introduction to CE and chemometric-related concepts and the need for modern chemometric methods in CE. Part 1 discusses differing types of screening designs and response surface methodology¿in an¿application based format Part 2 includes vital discussion on various exploratory data analysis, prediction, and classification techniques utilized in CE-related studies Part 3 provides practical information on modelling quantitative structure relationships Part 4 explores transformation techniques, in particular fundamental studies and applications of cross-correlation and Hadamard Transform Electrophoresis Showing how chemometric methods are applied in a wide array of applications including biological, medical, pharmaceutical, food, forensic, and environmental science, Chemometric Methods in Capillary Electrophoresis is not only highly significant to capillary electrophoresis-based endeavours, but instructive for investigators active in other areas of separation science who could benefit from its informative content.

Separations Chemistry

Separations Chemistry
Author: Fedor Macášek,James D. Navratil
Publsiher: Xlibris Corporation
Total Pages: 566
Release: 2016-06-06
ISBN 10: 1514417308
ISBN 13: 9781514417300
Language: EN, FR, DE, ES & NL

Separations Chemistry Book Review:

Separation of chemical species is a gate to final success of synthesis and preparation of compounds in pure and defined state. Variability of natural and artificial mixtures to be treated is enormous. Task of chemistry is to separate components of homogeneous mixtures (the gaseous and liquid solutions). The book concentrates on understanding the basic philosophies of both equilibrium and nonequilibrium chemical thermodynamics and engineering performance that lay in principle of separation technique such as distillation, crystallization, centrifugation, sorption, membrane separations, chromatography, and liquid-liquid extraction. Specific phenomena connected with photochemical separation, isotope composition, and radioactivity are discussed as well. The book is written for advanced students of chemistry having the knowledge of physical chemistry. Calculation examples are based on the international system of units. Unique list of over 1,300 full references covers scientific literature of the eighteenth to the twenty-first centuries.