RNA Therapeutics

RNA Therapeutics
Author: Paloma H. Giangrande,Vittorio Defranciscis,John J. Rossi
Publsiher: Academic Press
Total Pages: 512
Release: 2021-06-15
ISBN 10: 9780128215951
ISBN 13: 012821595X
Language: EN, FR, DE, ES & NL

RNA Therapeutics Book Review:

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing, and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation, and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation; the therapy development process from the lab to the clinic; and novel RNA-based therapies currently in development. Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies Provides detailed examination of approved RNA therapies and lessons learned from failed therapeutics Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing, and regulatory aspects

RNA Therapeutics

RNA Therapeutics
Author: Mouldy Sioud
Publsiher: Humana Press
Total Pages: 527
Release: 2011-03-04
ISBN 10: 9781607616641
ISBN 13: 1607616645
Language: EN, FR, DE, ES & NL

RNA Therapeutics Book Review:

Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

RNA Therapeutics

RNA Therapeutics
Author: Amanda L. Garner
Publsiher: Springer
Total Pages: 259
Release: 2017-09-26
ISBN 10: 3319680919
ISBN 13: 9783319680910
Language: EN, FR, DE, ES & NL

RNA Therapeutics Book Review:

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System

Entering the RNA Wonderland  Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System
Author: Anna Zampetaki,Lars Maegdefessel
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2020-07-22
ISBN 10: 2889638820
ISBN 13: 9782889638826
Language: EN, FR, DE, ES & NL

Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System Book Review:

RNA Nanotechnology and Therapeutics

RNA Nanotechnology and Therapeutics
Author: Peixuan Guo,Farzin Haque
Publsiher: CRC Press
Total Pages: 611
Release: 2013-07-09
ISBN 10: 1466505664
ISBN 13: 9781466505667
Language: EN, FR, DE, ES & NL

RNA Nanotechnology and Therapeutics Book Review:

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

Cooperative Strategy

Cooperative Strategy
Author: John Child,David Faulkner,Linda Hsieh,Stephen Tallman
Publsiher: Oxford University Press, USA
Total Pages: 592
Release: 2019-04-25
ISBN 10: 0198814631
ISBN 13: 9780198814634
Language: EN, FR, DE, ES & NL

Cooperative Strategy Book Review:

Cooperation has become the leading strategy adopted by business and other organizations. It is taking on new forms that are adapted to changing market expectations and technological possibilities in the rapidly evolving business environment. This new edition of Cooperative Strategy provides a comprehensive view of the practical and theoretical literature concerning cooperative strategies, and the alliance and network organizational forms that are the enablers of these strategies. It takes the reader through the stages of developing a cooperative alliance, from choosing a cooperative form and selecting partners, to establishing an alliance and managing the process of cooperation. It examines cooperative strategies in different sectors as well as internationally, and discusses performance criteria and evolution of cooperation over time. With insights from internationally recognized experts on cooperative strategy, this book presents extensive research on the topic while also addressing practical issues of alliance management. Echoing the words of the famous social psychologist Kurt Lewin that 'there is nothing so practical as a good theory', the authors provide a sound understanding of the theory and research on cooperative strategy so as to inform its practice. In this respect, this new edition follows its predecessor as an essential resource for both students and managers alike.

RNA Nanotechnology and Therapeutics

RNA Nanotechnology and Therapeutics
Author: Peixuan Guo,Farzin Haque
Publsiher: CRC Press
Total Pages: 611
Release: 2013-07-09
ISBN 10: 1466505664
ISBN 13: 9781466505667
Language: EN, FR, DE, ES & NL

RNA Nanotechnology and Therapeutics Book Review:

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

RNA Interference from Biology to Therapeutics

RNA Interference from Biology to Therapeutics
Author: Kenneth A. Howard
Publsiher: Springer Science & Business Media
Total Pages: 340
Release: 2012-10-19
ISBN 10: 1461447445
ISBN 13: 9781461447443
Language: EN, FR, DE, ES & NL

RNA Interference from Biology to Therapeutics Book Review:

The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.

RNA Interference from Biology to Therapeutics

RNA Interference from Biology to Therapeutics
Author: Kenneth A. Howard
Publsiher: Springer Science & Business Media
Total Pages: 340
Release: 2012-10-19
ISBN 10: 1461447445
ISBN 13: 9781461447443
Language: EN, FR, DE, ES & NL

RNA Interference from Biology to Therapeutics Book Review:

The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.

AGO Driven Non Coding RNAs

AGO Driven Non Coding RNAs
Author: Bibekanand Mallick
Publsiher: Academic Press
Total Pages: 387
Release: 2019-01-20
ISBN 10: 0128156708
ISBN 13: 9780128156704
Language: EN, FR, DE, ES & NL

AGO Driven Non Coding RNAs Book Review:

The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

RNA Technologies and Their Applications

RNA Technologies and Their Applications
Author: Volker A. Erdmann,Jan Barciszewski
Publsiher: Springer Science & Business Media
Total Pages: 452
Release: 2010-09-02
ISBN 10: 9783642121685
ISBN 13: 3642121683
Language: EN, FR, DE, ES & NL

RNA Technologies and Their Applications Book Review:

RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.

Nature

Nature
Author: Sir Norman Lockyer
Publsiher: Unknown
Total Pages: 329
Release: 2007-07
ISBN 10:
ISBN 13: UIUC:30112083916038
Language: EN, FR, DE, ES & NL

Nature Book Review:

Challenges in Delivery of Therapeutic Genomics and Proteomics

Challenges in Delivery of Therapeutic Genomics and Proteomics
Author: Ambikanandan Misra
Publsiher: Elsevier
Total Pages: 686
Release: 2010-09-09
ISBN 10: 9780123849656
ISBN 13: 0123849659
Language: EN, FR, DE, ES & NL

Challenges in Delivery of Therapeutic Genomics and Proteomics Book Review:

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed

DNA and RNA Nanobiotechnologies in Medicine Diagnosis and Treatment of Diseases

DNA and RNA Nanobiotechnologies in Medicine  Diagnosis and Treatment of Diseases
Author: Volker A. Erdmann,Jan Barciszewski
Publsiher: Springer Science & Business Media
Total Pages: 460
Release: 2013-06-20
ISBN 10: 3642368530
ISBN 13: 9783642368530
Language: EN, FR, DE, ES & NL

DNA and RNA Nanobiotechnologies in Medicine Diagnosis and Treatment of Diseases Book Review:

This book will provide latest insights in the functional potentials of ribonucleic acids in medine and the use of Spiegelmer and Spiegelzyme systems. It will also deal with a new type of delivery systems for cellular targeting.

Tumor penetrating Delivery of Small Interfering RNA Therapeutics

Tumor penetrating Delivery of Small Interfering RNA Therapeutics
Author: Yin Ren (Ph. D.),Harvard--MIT Program in Health Sciences and Technology
Publsiher: Unknown
Total Pages: 254
Release: 2012
ISBN 10:
ISBN 13: OCLC:809078351
Language: EN, FR, DE, ES & NL

Tumor penetrating Delivery of Small Interfering RNA Therapeutics Book Review:

Efforts to sequence cancer genomes have begun to uncover comprehensive lists of genes altered in cancer. Unfortunately, the number and complexity of identified alterations has made dissecting the underlying biology of cancer difficult, as many genes are not amenable to manipulation by small molecules or antibodies. RNA interference (RNAi) provides a direct way to assess and act on putative cancer targets. However, the translation of RNAi into the clinic has been thwarted by the "delivery" challenge, as small interfering RNA (siRNA) therapeutics must overcome clearance mechanisms and penetrate into tumor tissues to access cancer cells. This thesis sought to develop nanotechnology-based platforms to rapidly discover and validate cancer targets in vivo. First, we developed versatile surface chemistries for nanoparticle tumor targeting. Leveraging new discoveries in amplified transvascular transport, we designed a siRNA delivery system that integrates the tumor specificity and tissue-penetrating ability of tumor-penetrating peptides with membrane penetration properties of protein transduction domains to direct siRNA to tumors in vivo. Second, we utilized this delivery system to bridge the gap between cancer genomic discovery and in vivo target validation. Comprehensive analysis of ovarian cancer genomes identified candidate targets that are undruggable by traditional approaches. Tumor-penetrating delivery of siRNA against these genes potently impeded the growth of ovarian tumors in mice and improved survival, thereby credentialing their roles in tumor initiation and maintenance. Lastly, we described efforts extending this platform for clinical translation. Mechanistic studies identified functional properties that favored receptor-specific siRNA delivery. We also explored a strategy to improve the microdistribution of successively dosed siRNA therapeutics through modulating the tumor microenvironment. Finally, we investigated the utility of the system in primary human tumors derived from patients with ovarian cancer. Together, these findings illustrate that the combination of cancer genomics with the engineering of siRNA delivery nanomaterials establishes a platform for discovering genes amenable to RNAi therapies. As efforts in genome sequencing accelerate, this platform illustrates a path to clinical translation in humans.

Nucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics
Author: Marco Filice,Jesús Ruiz-Cabello
Publsiher: Elsevier
Total Pages: 491
Release: 2019-02-26
ISBN 10: 0128144718
ISBN 13: 9780128144718
Language: EN, FR, DE, ES & NL

Nucleic Acid Nanotheranostics Book Review:

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge. Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging Presents the only book to include an analysis of nanoformulations approved for clinical use

Modern Tools for Genetic Engineering

Modern Tools for Genetic Engineering
Author: Michael Kormann
Publsiher: BoD – Books on Demand
Total Pages: 226
Release: 2016-05-18
ISBN 10: 9535123920
ISBN 13: 9789535123927
Language: EN, FR, DE, ES & NL

Modern Tools for Genetic Engineering Book Review:

Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun.

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
Author: Muralidhar L. Hegde
Publsiher: BoD – Books on Demand
Total Pages: 160
Release: 2020-08-26
ISBN 10: 183880580X
ISBN 13: 9781838805807
Language: EN, FR, DE, ES & NL

Amyotrophic Lateral Sclerosis Book Review:

A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.

Innovative Medicine

Innovative Medicine
Author: Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publsiher: Springer
Total Pages: 339
Release: 2015-10-13
ISBN 10: 4431556516
ISBN 13: 9784431556510
Language: EN, FR, DE, ES & NL

Innovative Medicine Book Review:

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Therapeutic Oligonucleotides

Therapeutic Oligonucleotides
Author: Yoon S. Cho-Chung,Alan M. Gewirtz,Cy A. Stein,National Institutes of Health (U.S.). Therapeutic Oligonucleotide Interest Group
Publsiher: Unknown
Total Pages: 274
Release: 2003
ISBN 10: 9781573314701
ISBN 13: 1573314706
Language: EN, FR, DE, ES & NL

Therapeutic Oligonucleotides Book Review:

This work is concerned with various aspects of oligonucleotides including triplex DNA, transcription factor decoy, antisense DNA/RNA, ribozymes, PNA, 2',5'-oligoadenylates, RNAi, and CpG immune-stimulating oligomers, diagnostic oligonucleotide chips (DNA chips), and gene therapy vectors.