Recent Advances in iPSC Disease Modeling Volume 1

Recent Advances in iPSC Disease Modeling  Volume 1
Author: ALEXANDER BIRBRAIR
Publsiher: Academic Press
Total Pages: 320
Release: 2020-07-16
ISBN 10: 0128232692
ISBN 13: 9780128232699
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Disease Modeling Volume 1 Book Review:

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Recent Advances in Parkinson s Disease

Recent Advances in Parkinson s Disease
Author: Angela Cenci-Nilsson
Publsiher: Academic Press
Total Pages: 358
Release: 2020-03
ISBN 10: 0444642609
ISBN 13: 9780444642608
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinson s Disease Book Review:

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more.

Recent Advances in Parkinson s Disease Basic research

Recent Advances in Parkinson s Disease  Basic research
Author: Anders Björklund,M. Angela Cenci
Publsiher: Elsevier
Total Pages: 320
Release: 2010
ISBN 10: 0444536140
ISBN 13: 9780444536143
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinson s Disease Basic research Book Review:

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels. The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques. The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc,). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes). . The best researchers in the field provide their conclusions in the context of the latest experimental results . Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered . Of great value for researchers and experts, but also for students as a background reference

Recent Advances in iPSC Derived Cell Types Volume 4

Recent Advances in iPSC Derived Cell Types  Volume 4
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 282
Release: 2021-02-21
ISBN 10: 0128224541
ISBN 13: 9780128224540
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Derived Cell Types Volume 4 Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, βpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine and therapeutics. Covers the following cell types derived from iPSCs: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, βpancreatic cells, and more. Contributions from stem cell leaders around the world

Medical Applications of iPS Cells

Medical Applications of iPS Cells
Author: Haruhisa Inoue,Yukio Nakamura
Publsiher: Springer
Total Pages: 190
Release: 2019-04-01
ISBN 10: 9811336725
ISBN 13: 9789811336720
Language: EN, FR, DE, ES & NL

Medical Applications of iPS Cells Book Review:

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Minoru Tomizawa
Publsiher: BoD – Books on Demand
Total Pages: 532
Release: 2016-07-20
ISBN 10: 9535124714
ISBN 13: 9789535124719
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Recent Advances in iPSCs for Therapy Volume 3

Recent Advances in iPSCs for Therapy  Volume 3
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 368
Release: 2021-01-30
ISBN 10: 032385186X
ISBN 13: 9780323851862
Language: EN, FR, DE, ES & NL

Recent Advances in iPSCs for Therapy Volume 3 Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. • Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics • Covers the possible use of iPSCs for hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more • Contributions from stem cell leaders around the world

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Deepa Bhartiya,Nibedita Lenka
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-08-28
ISBN 10: 9535111922
ISBN 13: 9789535111924
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Patient Specific Stem Cells

Patient Specific Stem Cells
Author: Deepak A. Lamba
Publsiher: CRC Press
Total Pages: 280
Release: 2017-04-07
ISBN 10: 1315402165
ISBN 13: 9781315402161
Language: EN, FR, DE, ES & NL

Patient Specific Stem Cells Book Review:

One of the biggest challenges faced in medical research had been to create accurate and relevant models of human disease. A number of good animal models have been developed to understand the pathophysiology. However, not all of them reflect the human disorder, a classic case being Usher’s syndrome where the mutant mice do not have the same visual and auditory defects that patients face. There are others which have been even more difficult to model due to the multi-factorial nature of the condition and due to lack of discovery of a single causative gene such as age-related macular degeneration or Alzheimer’s syndrome. Thus a more relevant and accurate system will allow us to make better predictions on relevant therapeutic approaches. The discovery of human pluripotent stem cells in 1998 followed by the technological advances to reprogram somatic cells to pluripotent-stem cell-like cells in 2006 has completely revolutionized the way we can now think about modelling human development and disease. This now coupled with genome editing technologies such as TALENS and CRISPRs have now set us up to develop in vitro models both 2D as well as 3D organoids, which can more precisely reflect the disease in the patients. These combinatorial technologies are already providing us with better tools and therapeutics in drug discovery or gene therapy. This book summarizes both the technological advances in the field of generation of patient specific lines as well as various gene editing approaches followed by its applicability in various systems. The book will serve as a reference for the current state of the field as it: -Provides a comprehensive overview of the status of the field of patients derived induced pluripotent stem cells. -Describes the use of cardiac cells as a main featured component within the book. -Examines drug toxicity analysis as a working example throughout the book.

Tissue Regeneration

Tissue Regeneration
Author: Hussein Abdelhay Essayed Kaoud
Publsiher: BoD – Books on Demand
Total Pages: 206
Release: 2018-06-06
ISBN 10: 1789232600
ISBN 13: 9781789232608
Language: EN, FR, DE, ES & NL

Tissue Regeneration Book Review:

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Huntington s Disease

Huntington s Disease
Author: Nagehan Ersoy Tunalı
Publsiher: BoD – Books on Demand
Total Pages: 152
Release: 2017-03-22
ISBN 10: 9535130498
ISBN 13: 9789535130499
Language: EN, FR, DE, ES & NL

Huntington s Disease Book Review:

Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD.

Cooperation of Liver Cells in Health and Disease

Cooperation of Liver Cells in Health and Disease
Author: Z. Kmiec
Publsiher: Springer Science & Business Media
Total Pages: 151
Release: 2013-06-29
ISBN 10: 3642565530
ISBN 13: 9783642565533
Language: EN, FR, DE, ES & NL

Cooperation of Liver Cells in Health and Disease Book Review:

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Neurodevelopmental Disorders

Neurodevelopmental Disorders
Author: Emanuel DiCicco-Bloom,James H. Millonig
Publsiher: Springer Nature
Total Pages: 305
Release: 2020-06-24
ISBN 10: 3030454932
ISBN 13: 9783030454937
Language: EN, FR, DE, ES & NL

Neurodevelopmental Disorders Book Review:

This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.

Stem Cells Heterogeneity Novel Concepts

Stem Cells Heterogeneity   Novel Concepts
Author: Alexander Birbrair
Publsiher: Springer
Total Pages: 225
Release: 2019-04-23
ISBN 10: 3030110966
ISBN 13: 9783030110963
Language: EN, FR, DE, ES & NL

Stem Cells Heterogeneity Novel Concepts Book Review:

This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

Muscle Cell and Tissue

Muscle Cell and Tissue
Author: Kunihiro Sakuma
Publsiher: BoD – Books on Demand
Total Pages: 486
Release: 2015-09-02
ISBN 10: 9535121561
ISBN 13: 9789535121565
Language: EN, FR, DE, ES & NL

Muscle Cell and Tissue Book Review:

In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.

Advances in Genome Editing

Advances in Genome Editing
Author: Jennifer A. Doudna
Publsiher: Unknown
Total Pages: 329
Release: 2016
ISBN 10: 9781618962331
ISBN 13: 1618962337
Language: EN, FR, DE, ES & NL

Advances in Genome Editing Book Review:

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis
Publsiher: Springer
Total Pages: 542
Release: 2017-07-21
ISBN 10: 3319571931
ISBN 13: 9783319571935
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Engineering and Application of Pluripotent Stem Cells

Engineering and Application of Pluripotent Stem Cells
Author: Ulrich Martin,Robert Zweigerdt,Ina Gruh
Publsiher: Springer
Total Pages: 228
Release: 2018-02-28
ISBN 10: 3319735918
ISBN 13: 9783319735917
Language: EN, FR, DE, ES & NL

Engineering and Application of Pluripotent Stem Cells Book Review:

​This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening. This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

Tumor Organoids

Tumor Organoids
Author: Shay Soker,Aleksander Skardal
Publsiher: Humana Press
Total Pages: 213
Release: 2017-10-20
ISBN 10: 3319605119
ISBN 13: 9783319605111
Language: EN, FR, DE, ES & NL

Tumor Organoids Book Review:

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Pericyte Biology Novel Concepts

Pericyte Biology   Novel Concepts
Author: Alexander Birbrair
Publsiher: Springer
Total Pages: 170
Release: 2018-12-06
ISBN 10: 3030026019
ISBN 13: 9783030026011
Language: EN, FR, DE, ES & NL

Pericyte Biology Novel Concepts Book Review:

This volume explores novel concepts of pericyte biology. The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on what we know so far about the pericytes. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology in Disease, Pericyte Biology - Novel Concepts presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific diseases.