Recent Advances in iPSC Disease Modeling, Volume 1

Recent Advances in iPSC Disease Modeling, Volume 1
Author: ALEXANDER BIRBRAIR
Publsiher: Academic Press
Total Pages: 320
Release: 2020-07-16
ISBN 10: 0128232692
ISBN 13: 9780128232699
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Disease Modeling, Volume 1 Book Review:

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Recent Advances in Parkinson's Disease

Recent Advances in Parkinson's Disease
Author: Angela Cenci-Nilsson
Publsiher: Academic Press
Total Pages: 358
Release: 2020-03
ISBN 10: 0444642609
ISBN 13: 9780444642608
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinson's Disease Book Review:

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more.

Recent Advances in Stem Cells

Recent Advances in Stem Cells
Author: Essam M. Abdelalim
Publsiher: Springer
Total Pages: 269
Release: 2016-09-14
ISBN 10: 3319332708
ISBN 13: 9783319332703
Language: EN, FR, DE, ES & NL

Recent Advances in Stem Cells Book Review:

This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer; ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells. Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.

The Recent Advances in Human Brain Organoid System and their Applications in Disease Modeling. An Introductory Review.

The Recent Advances in Human Brain Organoid System and their Applications in Disease Modeling. An Introductory Review.
Author: Dr.Hakim Saboowala
Publsiher: Dr.Hakim Saboowala
Total Pages: 71
Release: 2019-03-12
ISBN 10:
ISBN 13:
Language: EN, FR, DE, ES & NL

The Recent Advances in Human Brain Organoid System and their Applications in Disease Modeling. An Introductory Review. Book Review:

The diseases of central nervous system (CNS) usually are of complex and diverse etiologies, and could be further complicated by variable genetic, epigenetic and environmental factors that differ among individuals. The complexity and delicacy of human brain make it challenging to recapitulate its: · Development, · Function and · Disorders. Brain organoids derived from human pluripotent stem cells (PSCs) provide a new tool to model both normal and pathological human brain, and greatly enhance our ability to study brain biology and diseases. Currently, human brain organoids are increasingly used in modeling neurological disorders and relative therapeutic discovery. An attempt has been made in this Booklet to focus on recent advances in human brain organoid system and its application in disease modeling and to discuss the limitations and future perspective of human brain organoids in modeling neurological diseases. ……. Dr. H. K. Saboowala.M.B.(Bom) M.R.S.H.(London)

Recent Advances in Parkinson's Disease: Basic research

Recent Advances in Parkinson's Disease: Basic research
Author: Anders Björklund,M. Angela Cenci
Publsiher: Elsevier
Total Pages: 320
Release: 2010
ISBN 10: 0444536140
ISBN 13: 9780444536143
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinson's Disease: Basic research Book Review:

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels. The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques. The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc,). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes). . The best researchers in the field provide their conclusions in the context of the latest experimental results . Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered . Of great value for researchers and experts, but also for students as a background reference

iPSCs for Modeling Central Nervous System Disorders, Volume 6

iPSCs for Modeling Central Nervous System Disorders, Volume 6
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 300
Release: 2021-05-01
ISBN 10: 032385642X
ISBN 13: 9780323856423
Language: EN, FR, DE, ES & NL

iPSCs for Modeling Central Nervous System Disorders, Volume 6 Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSC Central Nervous System Disease Modeling, Volume 13 addresses how important induced pluripotent stems cells are and how they can be used to model CNS disorders. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions impossible before for some human diseases. This volume addresses central nervous system disease modeling, such as: Leber’s hereditary optic neuropathy, autism, spinal muscular atrophy, Alzheimer’s disease, ALS and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers how iPSCs can be used to model CNS disorders Contributed by world-renown experts in the field

Medical Applications of iPS Cells

Medical Applications of iPS Cells
Author: Haruhisa Inoue,Yukio Nakamura
Publsiher: Springer
Total Pages: 190
Release: 2019-04-01
ISBN 10: 9811336725
ISBN 13: 9789811336720
Language: EN, FR, DE, ES & NL

Medical Applications of iPS Cells Book Review:

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Induced Pluripotent Stem Cells in Brain Diseases

Induced Pluripotent Stem Cells in Brain Diseases
Author: Vivi M. Heine,Stephanie Dooves,Dwayne Holmes,Judith Wagner
Publsiher: Springer Science & Business Media
Total Pages: 59
Release: 2011-11-23
ISBN 10: 9789400728165
ISBN 13: 9400728166
Language: EN, FR, DE, ES & NL

Induced Pluripotent Stem Cells in Brain Diseases Book Review:

Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).​

Motor Neuron Disease in Adults

Motor Neuron Disease in Adults
Author: Mark Bromberg
Publsiher: Oxford University Press
Total Pages: 352
Release: 2014-10-02
ISBN 10: 0190202262
ISBN 13: 9780190202262
Language: EN, FR, DE, ES & NL

Motor Neuron Disease in Adults Book Review:

Motor Neuron Disease in Adults reviews new information as it applies to all aspects of motor neuron disease (ALS, PLS, PMA). The choice of articles is for those that use evidence-based methods to ensure that the new information is solid and advances the topic or issue. The book can be used by anyone who provides any type of care to ALS patients. In particular, neurologists will find the latest information on diagnosis and management, as well as new information on genetics and frontotemporal lobe involvement. Allied health providers will find useful information for their discipline. Patients will also find both specific and general information to help understand what they are experiencing and how to help manage their symptoms.

Neurodevelopmental Disorders

Neurodevelopmental Disorders
Author: Emanuel DiCicco-Bloom,James H. Millonig
Publsiher: Springer Nature
Total Pages: 305
Release: 2020-06-24
ISBN 10: 3030454932
ISBN 13: 9783030454937
Language: EN, FR, DE, ES & NL

Neurodevelopmental Disorders Book Review:

This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.

Patient-Specific Induced Pluripotent Stem Cell Models

Patient-Specific Induced Pluripotent Stem Cell Models
Author: Andras Nagy,Kursad Turksen
Publsiher: Humana Press
Total Pages: 368
Release: 2015-11-08
ISBN 10: 9781493930333
ISBN 13: 1493930338
Language: EN, FR, DE, ES & NL

Patient-Specific Induced Pluripotent Stem Cell Models Book Review:

This volume captures the rapid developments in the field of induced pluripotent stem (iPS) cells, which have provided novel opportunities and approaches both for better understanding a number of human diseases and for developing new platforms for drug development and screening for such diseases. Specifically, representative protocols on various disease models have been collected from labs around the world. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization is an ideal reference for scientists working on furthering iPS research.

Tissue Regeneration

Tissue Regeneration
Author: Hussein Abdelhay Essayed Kaoud
Publsiher: BoD – Books on Demand
Total Pages: 206
Release: 2018-06-06
ISBN 10: 1789232600
ISBN 13: 9781789232608
Language: EN, FR, DE, ES & NL

Tissue Regeneration Book Review:

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Stem Cell Genetics for Biomedical Research

Stem Cell Genetics for Biomedical Research
Author: Raul Delgado-Morales
Publsiher: Springer
Total Pages: 426
Release: 2018-06-27
ISBN 10: 331990695X
ISBN 13: 9783319906959
Language: EN, FR, DE, ES & NL

Stem Cell Genetics for Biomedical Research Book Review:

This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Deepa Bhartiya,Nibedita Lenka
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-08-28
ISBN 10: 9535111922
ISBN 13: 9789535111924
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Minoru Tomizawa
Publsiher: BoD – Books on Demand
Total Pages: 532
Release: 2016-07-20
ISBN 10: 9535124714
ISBN 13: 9789535124719
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Essentials of Stem Cell Biology

Essentials of Stem Cell Biology
Author: Robert Lanza,John Gearhart,Brigid Hogan,Douglas Melton,Roger Pedersen,E. Donnall Thomas,James A. Thomson,Ian Sir Wilmut
Publsiher: Academic Press
Total Pages: 680
Release: 2009-06-05
ISBN 10: 9780080884974
ISBN 13: 0080884970
Language: EN, FR, DE, ES & NL

Essentials of Stem Cell Biology Book Review:

First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references

Generation of Disease-specific Autopsy-confirmed IPSCs Lines from Postmortem Isolated Peripheral Blood Mononuclear Cells

Generation of Disease-specific Autopsy-confirmed IPSCs Lines from Postmortem Isolated Peripheral Blood Mononuclear Cells
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 2017
ISBN 10:
ISBN 13: OCLC:1052057692
Language: EN, FR, DE, ES & NL

Generation of Disease-specific Autopsy-confirmed IPSCs Lines from Postmortem Isolated Peripheral Blood Mononuclear Cells Book Review:

Highlights: IPSC can be derived rapidly from patient samples retrieved after death. Postmortem blood drawn within 20 h after death can serve as reprogramming material. Autopsy confirmed patient samples are the gold standard for modeling heterogeneous and idiopathic disease. Abstract: Understanding the molecular mechanisms that underlie neurodegenerative disorders has been hampered by a lack of readily available model systems that replicate the complexity of the human disease. Recent advances in stem cell technology have facilitated the derivation of patient-specific stem cells from a variety of differentiated cell types. These induced pluripotent stem cells (iPSCs) are attractive disease models since they can be grown and differentiated to produce large numbers of disease-relevant cell types. However, most iPSC lines are derived in advance of, and without the benefit of, neuropathological confirmation of the donor − the gold standard for many disease classifications and measurement of disease severity. While others have reported the generation of autopsy-confirmed iPSC lines from patient explants, these methods require outgrowth of cadaver tissue, which require additional time and is often only successful ∼50% of the time. Here we report the rapid generation of autopsy-confirmed iPSC lines from peripheral blood mononuclear cells (PBMCs) drawn postmortem. Since this approach doesn't require the propagation of previously frozen cadaver tissue, iPSC can be rapidly and efficiently produced from patients with autopsy-confirmed pathology. These matched iPSC-derived patient-specific neurons and postmortem brain tissue will support studies of specific mechanisms that drive the pathogenesis of neurodegenerative diseases.

Huntington's Disease

Huntington's Disease
Author: Nagehan Ersoy Tunalı
Publsiher: BoD – Books on Demand
Total Pages: 152
Release: 2017-03-22
ISBN 10: 9535130498
ISBN 13: 9789535130499
Language: EN, FR, DE, ES & NL

Huntington's Disease Book Review:

Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD.

Advances in Genome Editing

Advances in Genome Editing
Author: Jennifer A. Doudna
Publsiher: Anonim
Total Pages: 329
Release: 2016
ISBN 10: 9781618962331
ISBN 13: 1618962337
Language: EN, FR, DE, ES & NL

Advances in Genome Editing Book Review:

Cell Biology and Translational Medicine, Volume 7

Cell Biology and Translational Medicine, Volume 7
Author: Kursad Turksen
Publsiher: Springer Nature
Total Pages: 153
Release: 2020-02-03
ISBN 10: 3030378454
ISBN 13: 9783030378455
Language: EN, FR, DE, ES & NL

Cell Biology and Translational Medicine, Volume 7 Book Review:

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series.