Recent Advances in iPSC Disease Modeling Volume 1

Recent Advances in iPSC Disease Modeling  Volume 1
Author: ALEXANDER BIRBRAIR
Publsiher: Academic Press
Total Pages: 320
Release: 2020-07-16
ISBN 10: 0128232692
ISBN 13: 9780128232699
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Disease Modeling Volume 1 Book Review:

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease
Author: Anonim
Publsiher: Elsevier
Total Pages: 332
Release: 2010-08-20
ISBN 10: 0444536248
ISBN 13: 9780444536242
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinsons Disease Book Review:

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.

Recent Advances in iPSC Technology Volume 5

Recent Advances in iPSC Technology  Volume 5
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 334
Release: 2021-03-31
ISBN 10: 012822326X
ISBN 13: 9780128223260
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Technology Volume 5 Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies. Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics. Covers the following topics: iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the non-coding genome, modeling of blood-brain barrier with iPSCs, mathematical modelling of iPSCs, iPSCs to study human brain evolution, self-renewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. Contributed by world-renown experts in the field

Medical Applications of iPS Cells

Medical Applications of iPS Cells
Author: Haruhisa Inoue,Yukio Nakamura
Publsiher: Springer
Total Pages: 190
Release: 2019-04-01
ISBN 10: 9811336725
ISBN 13: 9789811336720
Language: EN, FR, DE, ES & NL

Medical Applications of iPS Cells Book Review:

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Stem Cells Heterogeneity Novel Concepts

Stem Cells Heterogeneity   Novel Concepts
Author: Alexander Birbrair
Publsiher: Springer
Total Pages: 225
Release: 2019-04-23
ISBN 10: 3030110966
ISBN 13: 9783030110963
Language: EN, FR, DE, ES & NL

Stem Cells Heterogeneity Novel Concepts Book Review:

This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Deepa Bhartiya,Nibedita Lenka
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-08-28
ISBN 10: 9535111922
ISBN 13: 9789535111924
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Neurodevelopmental Disorders

Neurodevelopmental Disorders
Author: Bin Chen,Kenneth Y. Kwan
Publsiher: Academic Press
Total Pages: 426
Release: 2020-05-24
ISBN 10: 0128144106
ISBN 13: 9780128144107
Language: EN, FR, DE, ES & NL

Neurodevelopmental Disorders Book Review:

Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Covers disorders of the nervous system that arise through defects in neural development

Tissue Regeneration

Tissue Regeneration
Author: Hussein Abdelhay Essayed Kaoud
Publsiher: BoD – Books on Demand
Total Pages: 206
Release: 2018-06-06
ISBN 10: 1789232600
ISBN 13: 9781789232608
Language: EN, FR, DE, ES & NL

Tissue Regeneration Book Review:

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis
Publsiher: Springer
Total Pages: 542
Release: 2017-07-21
ISBN 10: 3319571931
ISBN 13: 9783319571935
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Pluripotent Stem Cells

Pluripotent Stem Cells
Author: Minoru Tomizawa
Publsiher: BoD – Books on Demand
Total Pages: 532
Release: 2016-07-20
ISBN 10: 9535124714
ISBN 13: 9789535124719
Language: EN, FR, DE, ES & NL

Pluripotent Stem Cells Book Review:

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Cardioskeletal Myopathies in Children and Young Adults

Cardioskeletal Myopathies in Children and Young Adults
Author: John Lynn Jefferies,Burns Blaxall,Jeffrey Towbin,Jeffrey Robbins
Publsiher: Academic Press
Total Pages: 418
Release: 2016-10-22
ISBN 10: 0128005807
ISBN 13: 9780128005804
Language: EN, FR, DE, ES & NL

Cardioskeletal Myopathies in Children and Young Adults Book Review:

Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40’s-50’s and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health. Reveals the link between cardiac muscle disease and skeletal muscle disease Explains how genetics and environmental factors effect muscle function of diverse origins Designates current and novel therapeutic strategies that target both cardiac and skeletal muscle systems

Huntington s Disease

Huntington s Disease
Author: Nagehan Ersoy Tunalı
Publsiher: BoD – Books on Demand
Total Pages: 152
Release: 2017-03-22
ISBN 10: 9535130498
ISBN 13: 9789535130499
Language: EN, FR, DE, ES & NL

Huntington s Disease Book Review:

Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD.

Muscle Cell and Tissue

Muscle Cell and Tissue
Author: Kunihiro Sakuma
Publsiher: BoD – Books on Demand
Total Pages: 486
Release: 2015-09-02
ISBN 10: 9535121561
ISBN 13: 9789535121565
Language: EN, FR, DE, ES & NL

Muscle Cell and Tissue Book Review:

In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.

Cardiac Regeneration

Cardiac Regeneration
Author: Masaki Ieda,Wolfram-Hubertus Zimmermann
Publsiher: Springer
Total Pages: 274
Release: 2017-10-27
ISBN 10: 3319561065
ISBN 13: 9783319561066
Language: EN, FR, DE, ES & NL

Cardiac Regeneration Book Review:

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Bone Tissue Engineering

Bone Tissue Engineering
Author: Jeffrey O. Hollinger,Thomas A. Einhorn,Bruce Doll,Charles Sfeir
Publsiher: CRC Press
Total Pages: 352
Release: 2004-10-14
ISBN 10: 1135501912
ISBN 13: 9781135501914
Language: EN, FR, DE, ES & NL

Bone Tissue Engineering Book Review:

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Hematopoietic Stem Cell Development

Hematopoietic Stem Cell Development
Author: Isabelle Godin,Ana Cumano
Publsiher: Springer Science & Business Media
Total Pages: 178
Release: 2010-05-27
ISBN 10: 9780387335353
ISBN 13: 0387335358
Language: EN, FR, DE, ES & NL

Hematopoietic Stem Cell Development Book Review:

This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.

Liver Regeneration

Liver Regeneration
Author: Dieter Häussinger
Publsiher: Walter de Gruyter
Total Pages: 210
Release: 2011
ISBN 10: 3110250780
ISBN 13: 9783110250787
Language: EN, FR, DE, ES & NL

Liver Regeneration Book Review:

Understanding the mechanisms involved in liver regeneration is of crucial importance for clinical medicine, not only regarding carcinogenesis and diabetes treatment, but also for the use of stem cells for cell therapy and liver surgery. This graduate-level text provides an overview of the current state of knowledge of the molecular mechanisms of liver regeneration. Hepatic stem cells are introduced and the important players involved in regeneration such as oval cells, bone marrow and stellate cells are reviewed. The cell signaling pathways that initiate liver regeneration and regulate the switch between proliferation and apoptosis are presented and the role of liver stem cells in tumorigenesis is discussed. The book also treats the epigenetic regulation of liver stem cells and the roles of inflammation and angiogenesis in liver regeneration. This compact overview of the fascinating regenerative capacity of the liver will be of interest to graduate students and post-docs in molecular biology, biochemistry and medicine.

iPSCs in Tissue Engineering Volume 11

iPSCs in Tissue Engineering  Volume 11
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 300
Release: 2021-08-01
ISBN 10: 012824190X
ISBN 13: 9780128241905
Language: EN, FR, DE, ES & NL

iPSCs in Tissue Engineering Volume 11 Book Review:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs in Tissue Engineering, Volume 11 addresses how important induced pluripotent stems cells are and how can they be used in patient-specific disease models. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells from various, species such as: bovine, equine, non-human primate, rat, etc., are being used for treatment of different diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers equine, non-human primate, porcine, canine, prairie vole, rabbit, naked mole rat, and other species Contributed by world-renown experts in the field

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
Author: Muralidhar L. Hegde
Publsiher: BoD – Books on Demand
Total Pages: 160
Release: 2020-08-26
ISBN 10: 183880580X
ISBN 13: 9781838805807
Language: EN, FR, DE, ES & NL

Amyotrophic Lateral Sclerosis Book Review:

A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.

Neurodevelopmental Disorders

Neurodevelopmental Disorders
Author: Emanuel DiCicco-Bloom,James H. Millonig
Publsiher: Springer
Total Pages: 305
Release: 2020-07-31
ISBN 10: 9783030454920
ISBN 13: 3030454924
Language: EN, FR, DE, ES & NL

Neurodevelopmental Disorders Book Review:

This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.