Rearrangements with Migration to Electrophilic Heteroatomic Centers

Rearrangements with Migration to Electrophilic Heteroatomic Centers
Author: Sosale Chandrasekhar
Publsiher: Elsevier
Total Pages: 300
Release: 2022-01-15
ISBN 10: 9780128237434
ISBN 13: 0128237430
Language: EN, FR, DE, ES & NL

Rearrangements with Migration to Electrophilic Heteroatomic Centers Book Review:

Rearrangements with Migration to Electrophilic Heteroatomic Centers: Timeless Classics in Organic Synthesis covers the basic principles and synthetic applications of a critically important class of organic reactions that date back to the founding period of organic chemistry. These reactions are not only of historical and pedagogical interest, but also have great practical value to this day, being inevitable in any strategy concerning the introduction of nitrogen and oxygen functionality. The book is made up of three parts, dealing with the Beckmann reaction, the Hoffmann family of reactions and the Baeyer-Villiger reaction. Each part begins with a brief historical introduction followed by a mechanistic discussion. The synthetic applications are then discussed in detail, focusing on current developments and improvements. The book strikes a balance between delineation and exhaustiveness, with up-to-date refences for readers requiring in-depth coverage. Relevant industrial applications, including pharmaceutical processes, are included. This reference will be a key resource for organic synthesis researchers and students, working in academia and industry. Summarizes mechanistic background with an emphasis on synthetic applications Up to date references allow for locating original papers for experimental procedures Applications in the synthesis of complex molecules and natural products are included to judge the scope and limitations of each reaction

Modern Physical Organic Chemistry

Modern Physical Organic Chemistry
Author: Eric V. Anslyn,Dennis A. Dougherty
Publsiher: University Science Books
Total Pages: 1095
Release: 2006
ISBN 10: 9781891389313
ISBN 13: 1891389319
Language: EN, FR, DE, ES & NL

Modern Physical Organic Chemistry Book Review:

Making explicit the connections between physical organic chemistry and critical fields such as organometallic chemistry, materials chemistry, bioorganic chemistry and biochemistry, this book escorts the reader into an area that has been thoroughly updated in recent times.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author: Shazia Anjum,Elena Soriano,José Luis Marco-Contelles
Publsiher: Elsevier Inc. Chapters
Total Pages: 538
Release: 2013-06-25
ISBN 10: 0128084685
ISBN 13: 9780128084687
Language: EN, FR, DE, ES & NL

Studies in Natural Products Chemistry Book Review:

Molecular rearrangements occupy center stage in the development of organic synthesis and, consequently, in the impressive achievements that have resulted in the total synthesis of many complex natural products in the last decades. The purpose of this chapter, in this volume of a book series dedicated to the Studies in Natural Product Chemistry, is to show a set of selected and organized molecular rearrangements based on a personal choice of expertise related to the synthesis of complex bioactive molecules. Our selection addresses [3,3]-sigmatropic rearrangements, which continue to provide excellent opportunities for reaching high chemical diversity, operating in efficient synthetic schemes. [3,3]-Sigmatropic rearrangements, such as the Cope and Claisen rearrangements, are among the most basic and useful transformations in synthetic organic chemistry. This is possibly due to the fact that these rearrangements are efficient methods for the synthesis of quaternary, sterically hindered chiral centers, and for the stereoselective formation of carbon–carbon and carbon–heteroatom bonds. In addition, [3,3]-sigmatropic rearrangements can be easily integrated in, and adapted to, cascade processes as a simple method to prepare complex molecules in atom-efficient reactions. Consequently, in the context of [3,3]-sigmatropic rearrangements, we focus on the transformations of propargylic esters, whose rearrangements, in different experimental conditions, have been largely exploited for the synthesis of interesting key and useful intermediates. The rearrangements can be promoted by protic acids, Lewis acids, and noble metals such as Pt, Au, or Cu salts, or complexes that have recently emerged as the most popular and potent electrophilic activators of alkynes toward a number of nucleophilic agents, under homogeneous conditions.

Polar Rearrangements

Polar Rearrangements
Author: Laurence M. Harwood,Lecturer in Chemistry Laurence M Harwood
Publsiher: Oxford University Press, USA
Total Pages: 96
Release: 1992
ISBN 10: 1928374650XXX
ISBN 13: UCAL:B4477538
Language: EN, FR, DE, ES & NL

Polar Rearrangements Book Review:

The general principles of polar rearrangements are brought together in this undergraduate chemistry text, which deals with all the major rearrangements involving electron-deficient atoms or charged intermediates. Reactions involving migration to electron-deficient carbon, nitrogen, oxygen and sulphur, and sigmatropic rearrangements involving polar species, are thus treated in a coherent and consistent manner. Clear discussions of the reaction mechanisms are followed by examples of synthetic applications providing a concise yet comprehensive account of the nature and importance of these processes.

Organic Reactions Volume 102

Organic Reactions  Volume 102
Author: Anonim
Publsiher: John Wiley & Sons
Total Pages: 992
Release: 2020-07-08
ISBN 10: 1119651220
ISBN 13: 9781119651222
Language: EN, FR, DE, ES & NL

Organic Reactions Volume 102 Book Review:

The 102nd volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
Author: Anonim
Publsiher: Elsevier
Total Pages: 323
Release: 2000-07-04
ISBN 10: 0080493564
ISBN 13: 9780080493565
Language: EN, FR, DE, ES & NL

Advances in Heterocyclic Chemistry Book Review:

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

Houben Weyl Methods of Organic Chemistry Vol E 21e 4th Edition Supplement

Houben Weyl Methods of Organic Chemistry Vol  E 21e  4th Edition Supplement
Author: Anonim
Publsiher: Georg Thieme Verlag
Total Pages: 1262
Release: 2014-05-14
ISBN 10: 3131822848
ISBN 13: 9783131822840
Language: EN, FR, DE, ES & NL

Houben Weyl Methods of Organic Chemistry Vol E 21e 4th Edition Supplement Book Review:

Houben-Weyl is the acclaimed reference series for preparative methods in organic chemistry, in which all methods are organized accor ding to the class of compound or functional group to be synthesized. The Houben-Weyl volumes contain 146 000 product-specific experi mental procedures, 580 000 structures, and 700 000 references. The preparative significance of the methods for all classes of compou nds is critically evaluated. The series includes data from as far back as the early 1800s to 2003. // The content of this e-book was originally published in 1995.

Superelectrophiles and Their Chemistry

Superelectrophiles and Their Chemistry
Author: George A. Olah,Douglas A. Klumpp
Publsiher: John Wiley & Sons
Total Pages: 312
Release: 2008-01-03
ISBN 10: 9780470185117
ISBN 13: 0470185112
Language: EN, FR, DE, ES & NL

Superelectrophiles and Their Chemistry Book Review:

Superelectrophiles and Their Chemistry contains, for the first-time, a discussion of the basics of this emerging field of organic chemistry, alongside tools to help the reader apply the chemistry. Specific tools include an evaluation of the ways to increase the strength of electrophiles, the classification of superelectrophiles, the solvation issues, a review of methods for studying superelectrophilicity, with details of the superelectrophiles that have been identified and studied. Additional information includes substituent effects in activation of superelectrophiles, and solvation in chemical reactions, as well as an insightful look into future applications.

Silver Catalysis in Organic Synthesis 2 Volume Set

Silver Catalysis in Organic Synthesis  2 Volume Set
Author: Chao-Jun Li,Xihe Bi
Publsiher: John Wiley & Sons
Total Pages: 848
Release: 2019-04-29
ISBN 10: 3527342818
ISBN 13: 9783527342815
Language: EN, FR, DE, ES & NL

Silver Catalysis in Organic Synthesis 2 Volume Set Book Review:

Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.

Organic Syntheses Based on Name Reactions and Unnamed Reactions

Organic Syntheses Based on Name Reactions and Unnamed Reactions
Author: Alfred Hassner,C Stumer
Publsiher: Elsevier
Total Pages: 452
Release: 2013-10-22
ISBN 10: 1483287343
ISBN 13: 9781483287348
Language: EN, FR, DE, ES & NL

Organic Syntheses Based on Name Reactions and Unnamed Reactions Book Review:

Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form. In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions. Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.

Target Organ Toxicity

Target Organ Toxicity
Author: Cohen
Publsiher: CRC Press
Total Pages: 240
Release: 1986-08-31
ISBN 10: 9780849357756
ISBN 13: 0849357756
Language: EN, FR, DE, ES & NL

Target Organ Toxicity Book Review:

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Organometallic Chemistry of the Transition Elements

Organometallic Chemistry of the Transition Elements
Author: Florian P. Pruchnik
Publsiher: Springer Science & Business Media
Total Pages: 758
Release: 2013-06-29
ISBN 10: 1489920765
ISBN 13: 9781489920768
Language: EN, FR, DE, ES & NL

Organometallic Chemistry of the Transition Elements Book Review:

Organometallic chemistry belongs to the most rapidly developing area of chemistry today. This is due to the fact that research dealing with the structure of compounds and chemical bonding has been greatly intensified in recent years. Additionally, organometallic compounds have been widely utilized in catalysis, organic synthesis, electronics, etc. This book is based on my lectures concerning basic organometallic chemistry for fourth and fifth year chemistry students and on my lectures concerning advanced organometallic chemistry and homogeneous catalysis for Ph.D. graduate students. Many recent developments in the area of organometallic chemistry as weIl as homogeneous catalysis are presented. Essential research results dealing with a given class of organometallic compounds are discussed briefly. Results of physicochemical research methods of various organometallic compounds as weIl as their synthesis, properties, structures, reactivities, and applications are discussed more thoroughly. The selection of tabulated data is arbitrary because, often, it has been impossible to avoid omissions. Nevertheless, these data can be very helpful in understanding properties of organometaIlic compounds and their reactivities. All physical data are given in SI units; the interatomic distances are given in pm units in figures and tables. I am indebted to Professor S. A. Duraj for translating and editing this book. His remarks, discussions, and suggestions are greatly appreciated. I also express gratitude to Virginia E. Duraj for editing and proofreading.

Target Organ Toxicity Volume I

Target Organ Toxicity  Volume I
Author: Gerald M. Cohen
Publsiher: CRC Press
Total Pages: 242
Release: 2020-01-29
ISBN 10: 1000722368
ISBN 13: 9781000722369
Language: EN, FR, DE, ES & NL

Target Organ Toxicity Volume I Book Review:

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Advanced Organic Chemistry

Advanced Organic Chemistry
Author: Bernard Miller
Publsiher: Unknown
Total Pages: 338
Release: 1998
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015062417087
Language: EN, FR, DE, ES & NL

Advanced Organic Chemistry Book Review:

This text covers the principles of mechanisms of organic reactions in a qualitative way and features a chapter on heterocyclic chemistry. End of chapter exercises feature references to current literature

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author: Anonim
Publsiher: Newnes
Total Pages: 538
Release: 2013-06-25
ISBN 10: 0444626328
ISBN 13: 9780444626325
Language: EN, FR, DE, ES & NL

Studies in Natural Products Chemistry Book Review:

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable resource for natural products and medicinal chemistry

International Symposium on Bioorganic Chemistry

International Symposium on Bioorganic Chemistry
Author: International Symposium on Bioorganic Chemistry
Publsiher: Unknown
Total Pages: 325
Release: 1986
ISBN 10: 9780897663373
ISBN 13: 0897663373
Language: EN, FR, DE, ES & NL

International Symposium on Bioorganic Chemistry Book Review:

Dynamic Stereochemistry of Chiral Compounds

Dynamic Stereochemistry of Chiral Compounds
Author: Christian Wolf
Publsiher: Royal Society of Chemistry
Total Pages: 512
Release: 2008
ISBN 10: 0854042466
ISBN 13: 9780854042463
Language: EN, FR, DE, ES & NL

Dynamic Stereochemistry of Chiral Compounds Book Review:

A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.

Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences
Author: Thomas Lincoln Casey,Gilbert Van Ingen,Charles Lane Poor,Edmund Otis Hovey,Ralph Winfred Tower
Publsiher: Unknown
Total Pages: 135
Release: 1986
ISBN 10: 1928374650XXX
ISBN 13: UVA:X030312683
Language: EN, FR, DE, ES & NL

Annals of the New York Academy of Sciences Book Review:

Carbon Carbon Bond Formation

Carbon Carbon   Bond Formation
Author: G. Pattenden
Publsiher: Elsevier
Total Pages: 1209
Release: 1992-09-08
ISBN 10: 008091246X
ISBN 13: 9780080912462
Language: EN, FR, DE, ES & NL

Carbon Carbon Bond Formation Book Review:

Volume 3 covers carbon-to-carbon single bond forming reactions involving sp3, sp2 and sp carbon centers, but only those which do not involve additions to C-X &pgr;-bonds. The volume first compares and contrasts the alkylation reactions of all types of sp3 carbon nucleophiles and also covers vinyl and alkynyl carbanions. Following on from Volume 2, a separate section covers Friedel-Crafts alkylation reactions, which is complemented by discussions of polyene cyclizations and electrophilic transannular cyclizations in synthesis. Coupling reactions leading to &agr;-bond formation, and involving all types of combinations ofsp3, sp2 and sp carbon centers are next covered, including those reactions based on pinacol, acyloin and phenol oxidative coupling reactions, and also the Kolbe reaction. Rearrangement reactions, leading to carbon-to-carbon &agr;-bond formation, are often used in a clever manner in synthesis. The volume includes all those rearrangement reactions based on intermediate carbonium ions and carbanions, and also includes the benzil-benzilic acid and the Wolff rearrangements. The volume closes with coverage of carbonylation reactions, and the use of carbene insertion reactions into the C-H bond in synthesis.

The Art of Writing Reasonable Organic Reaction Mechanisms

The Art of Writing Reasonable Organic Reaction Mechanisms
Author: Robert B. Grossman
Publsiher: Springer Science & Business Media
Total Pages: 360
Release: 2007-07-31
ISBN 10: 0387954686
ISBN 13: 9780387954684
Language: EN, FR, DE, ES & NL

The Art of Writing Reasonable Organic Reaction Mechanisms Book Review:

Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.