Radiomics and its Clinical Application

Radiomics and its Clinical Application
Author: Jie Tian,Di Dong,Zhenyu Liu,Jingwei Wei
Publsiher: Academic Press
Total Pages: 225
Release: 2021-05-01
ISBN 10: 0128181028
ISBN 13: 9780128181027
Language: EN, FR, DE, ES & NL

Radiomics and its Clinical Application Book Review:

Radiomics and its Clinical Application: Artificial Intelligence and Medical Big Data describes the two key aspects of radiomic clinical practice, including precision diagnosis and the therapeutic effect and prognostic evaluation that make radiomics a powerful tool in the clinical setting. This book is a very useful resource for scientists and computer engineers in machine learning and medical image analysis, scientists focusing on antineoplastic drugs, radiologists, pathologists, oncologists and surgeons wanting to understand radiomics and its potential in clinical practice. Provides an introduction to the concepts of radiomics Presents an in-depth discussion on core technologies and methods Summarizes current radiomics research, perspectives on the future of radiomics, and the challenges ahead Includes an introduction to several platforms that are planned to be built, including cooperation, data sharing, software and application platforms

Radiomics and Radiogenomics

Radiomics and Radiogenomics
Author: Ruijiang Li,Lei Xing,Sandy Napel,Daniel L. Rubin
Publsiher: CRC Press
Total Pages: 420
Release: 2019-07-09
ISBN 10: 1351208268
ISBN 13: 9781351208260
Language: EN, FR, DE, ES & NL

Radiomics and Radiogenomics Book Review:

Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation

Artificial Intelligence in Medicine

Artificial Intelligence in Medicine
Author: Lei Xing,Maryellen L. Giger,James K Min
Publsiher: Academic Press
Total Pages: 568
Release: 2020-09-16
ISBN 10: 0128212586
ISBN 13: 9780128212585
Language: EN, FR, DE, ES & NL

Artificial Intelligence in Medicine Book Review:

Artificial Intelligence Medicine: Technical Basis and Clinical Applications presents a comprehensive overview of the field, ranging from its history and technical foundations, to specific clinical applications and finally to prospects. Artificial Intelligence (AI) is expanding across all domains at a breakneck speed. Medicine, with the availability of large multidimensional datasets, lends itself to strong potential advancement with the appropriate harnessing of AI. The integration of AI can occur throughout the continuum of medicine: from basic laboratory discovery to clinical application and healthcare delivery. Integrating AI within medicine has been met with both excitement and scepticism. By understanding how AI works, and developing an appreciation for both limitations and strengths, clinicians can harness its computational power to streamline workflow and improve patient care. It also provides the opportunity to improve upon research methodologies beyond what is currently available using traditional statistical approaches. On the other hand, computers scientists and data analysts can provide solutions, but often lack easy access to clinical insight that may help focus their efforts. This book provides vital background knowledge to help bring these two groups together, and to engage in more streamlined dialogue to yield productive collaborative solutions in the field of medicine. Provides history and overview of artificial intelligence, as narrated by pioneers in the field Discusses broad and deep background and updates on recent advances in both medicine and artificial intelligence that enabled the application of artificial intelligence Addresses the ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach

Radiomics and Radiogenomics in Neuro oncology

Radiomics and Radiogenomics in Neuro oncology
Author: Hassan Mohy-ud-Din,Saima Rathore
Publsiher: Springer Nature
Total Pages: 91
Release: 2020-02-24
ISBN 10: 3030401243
ISBN 13: 9783030401245
Language: EN, FR, DE, ES & NL

Radiomics and Radiogenomics in Neuro oncology Book Review:

This book constitutes the proceedings of the First International Workshop on Radiomics and Radiogenomics in Neuro-oncology, RNO-AI 2019, which was held in conjunction with MICCAI in Shenzhen, China, in October 2019. The 10 full papers presented in this volume were carefully reviewed and selected from 15 submissions. They deal with the development of tools that can automate the analysis and synthesis of neuro-oncologic imaging.

Handbook of Medical Image Computing and Computer Assisted Intervention

Handbook of Medical Image Computing and Computer Assisted Intervention
Author: S. Kevin Zhou,Daniel Rueckert,Gabor Fichtinger
Publsiher: Academic Press
Total Pages: 1072
Release: 2019-10-18
ISBN 10: 0128165863
ISBN 13: 9780128165867
Language: EN, FR, DE, ES & NL

Handbook of Medical Image Computing and Computer Assisted Intervention Book Review:

Handbook of Medical Image Computing and Computer Assisted Intervention presents important advanced methods and state-of-the art research in medical image computing and computer assisted intervention, providing a comprehensive reference on current technical approaches and solutions, while also offering proven algorithms for a variety of essential medical imaging applications. This book is written primarily for university researchers, graduate students and professional practitioners (assuming an elementary level of linear algebra, probability and statistics, and signal processing) working on medical image computing and computer assisted intervention. Presents the key research challenges in medical image computing and computer-assisted intervention Written by leading authorities of the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society Contains state-of-the-art technical approaches to key challenges Demonstrates proven algorithms for a whole range of essential medical imaging applications Includes source codes for use in a plug-and-play manner Embraces future directions in the fields of medical image computing and computer-assisted intervention

Clinical Nuclear Medicine

Clinical Nuclear Medicine
Author: Hans-Jürgen Biersack,Leonard M. Freeman
Publsiher: Springer Science & Business Media
Total Pages: 548
Release: 2008-01-03
ISBN 10: 9783540280262
ISBN 13: 354028026X
Language: EN, FR, DE, ES & NL

Clinical Nuclear Medicine Book Review:

This work has true international scope, being a unique European/American joint venture that focuses on the state of the art in both diagnostic and therapeutic radionuclide methodology. Pertinent clinical applications are emphasized rather than attempting to cover everything included in the several large comprehensive texts available in our field. This "practical" approach should make it an essential guide to nuclear medicine physicians, technologists, students and interested clinicians alike.

Machine Learning in Cardiovascular Medicine

Machine Learning in Cardiovascular Medicine
Author: Subhi J. Al'Aref,Gurpreet Singh,Lohendran Baskaran,Dimitri Metaxas
Publsiher: Academic Press
Total Pages: 454
Release: 2020-11-20
ISBN 10: 0128202742
ISBN 13: 9780128202746
Language: EN, FR, DE, ES & NL

Machine Learning in Cardiovascular Medicine Book Review:

Machine Learning in Cardiovascular Medicine addresses the ever-expanding applications of artificial intelligence (AI), specifically machine learning (ML), in healthcare and within cardiovascular medicine. The book focuses on emphasizing ML for biomedical applications and provides a comprehensive summary of the past and present of AI, basics of ML, and clinical applications of ML within cardiovascular medicine for predictive analytics and precision medicine. It helps readers understand how ML works along with its limitations and strengths, such that they can could harness its computational power to streamline workflow and improve patient care. It is suitable for both clinicians and engineers; providing a template for clinicians to understand areas of application of machine learning within cardiovascular research; and assist computer scientists and engineers in evaluating current and future impact of machine learning on cardiovascular medicine. Provides an overview of machine learning, both for a clinical and engineering audience Summarize recent advances in both cardiovascular medicine and artificial intelligence Discusses the advantages of using machine learning for outcomes research and image processing Addresses the ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach

Artificial Intelligence in Medical Imaging

Artificial Intelligence in Medical Imaging
Author: Erik R. Ranschaert,Sergey Morozov,Paul R. Algra
Publsiher: Springer
Total Pages: 373
Release: 2019-01-29
ISBN 10: 3319948784
ISBN 13: 9783319948782
Language: EN, FR, DE, ES & NL

Artificial Intelligence in Medical Imaging Book Review:

This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relating to the growing role of big data in radiology. Diverse real-life clinical applications of AI are then outlined for different body parts, demonstrating their ability to add value to daily radiology practices. The concluding section focuses on the impact of AI on radiology and the implications for radiologists, for example with respect to training. Written by radiologists and IT professionals, the book will be of high value for radiologists, medical/clinical physicists, IT specialists, and imaging informatics professionals.

Oncologic Imaging

Oncologic Imaging
Author: David G. Bragg,Philip Rubin,Hedvig Hricak
Publsiher: W B Saunders Company
Total Pages: 960
Release: 2002-01
ISBN 10: 9780721674940
ISBN 13: 0721674941
Language: EN, FR, DE, ES & NL

Oncologic Imaging Book Review:

Completely updated to reflect the latest developments in science and technology, the second edition of this reference presents the diagnostic imaging tools essential to the detection, diagnosis, staging, treatment planning, and post-treatment management of cancer in both adults and children. Organized by major organs and body systems, the text offers comprehensive, abundantly illustrated guidance to enable both the radiologist and clinical oncologist to better appreciate and overcome the challenges of tumor imaging.

A Guide to Outcome Modeling In Radiotherapy and Oncology

A Guide to Outcome Modeling In Radiotherapy and Oncology
Author: Issam El Naqa
Publsiher: CRC Press
Total Pages: 368
Release: 2018-04-19
ISBN 10: 0429840349
ISBN 13: 9780429840340
Language: EN, FR, DE, ES & NL

A Guide to Outcome Modeling In Radiotherapy and Oncology Book Review:

This book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to aid personalized patient care and improve their quality of life. It contains coverage of the relevant data sources available for model construction (panomics), ranging from clinical or preclinical resources to basic patient and treatment characteristics, medical imaging (radiomics), and molecular biological markers such as those involved in genomics, proteomics and metabolomics. It also includes discussions on the varying methodologies for predictive model building with analytical and data-driven approaches. This book is primarily intended to act as a tutorial for newcomers to the field of outcome modeling, as it includes in-depth how-to recipes on modeling artistry while providing sufficient instruction on how such models can approximate the physical and biological realities of clinical treatment. The book will also be of value to seasoned practitioners as a reference on the varying aspects of outcome modeling and their current applications. Features: Covers top-down approaches applying statistical, machine learning, and big data analytics and bottom-up approaches using first principles and multi-scale techniques, including numerical simulations based on Monte Carlo and automata techniques Provides an overview of the available software tools and resources for outcome model development and evaluation, and includes hands-on detailed examples throughout Presents a diverse selection of the common applications of outcome modeling in a wide variety of areas: treatment planning in radiotherapy, chemotherapy and immunotherapy, utility-based and biomarker applications, particle therapy modeling, oncological surgery, and the design of adaptive and SMART clinical trials

Tissue Phenomics Profiling Cancer Patients for Treatment Decisions

Tissue Phenomics  Profiling Cancer Patients for Treatment Decisions
Author: Gerd Binnig,Ralf Huss,Günter Schmidt
Publsiher: CRC Press
Total Pages: 224
Release: 2018-01-29
ISBN 10: 1351134256
ISBN 13: 9781351134255
Language: EN, FR, DE, ES & NL

Tissue Phenomics Profiling Cancer Patients for Treatment Decisions Book Review:

In the age of digitization our society is transformed into a new state. In particular, machine intelligence dramatically elevates our capability to create and digest information. Naturally, healthcare is also impacted by this trend and will even be more transformed into a informatic driven discipline in the future. In the most important area of histo-pathology, the interpretation of tissue slices from cancer patients, informatics will have an early and huge impact on treatment decisions and probably will act as the leading discipline for this transformation in medicine. Tissue Phenomics provides a comprehensive methodology aiming at the discovery of the most accurate tissue-based decision support algorithm by close integration of assay development, image analysis and bioinformatics, and optimization feedback loops. In this book the methodology of Tissue Phenomics and its benefits and wealth’s are described. The different components of Tissue Phenomics are explained in the different chapters. In the chapters 2 to 4 of this book different authors describe various approaches on how to convert the wealth of tissue slide pixel data into mineable information using knowledge-based and data-driven image analysis methods. Subsequently, the datafication of images and the bioinformatics part plays a crucial role in generating prognostic and predictive models for disease progression. The integration of other data sources such as genomics, radiomics and patient related information is also important and is described as well. As discussed in chapters 5 and 6, these models may classify patients in distinct groups such as those responding to a given therapy. Since Tissue Phenomics provides a huge set of potentially prognostic features (phenes), one focus of both chapters is robust feature selection methods by advanced Monte-Carlo cross validation algorithms. In chapter 7 we discuss multiple application examples of Tissue Phenomics in academic and commercial settings and its tremendous impact to advances in biomedical sciences. Building on the successes in research, chapters 8 and 9 discuss applications in clinical environments and provide a flavor to the future envision in chapter 10, where tissue datafication and subsequent patient profiling is part of every routine examination, with the goal to best match patients with the most successful therapy, as predicted by tissue phenes.

Artificial Intelligence in Decision Support Systems for Diagnosis in Medical Imaging

Artificial Intelligence in Decision Support Systems for Diagnosis in Medical Imaging
Author: Kenji Suzuki,Yisong Chen
Publsiher: Springer
Total Pages: 387
Release: 2018-01-09
ISBN 10: 331968843X
ISBN 13: 9783319688435
Language: EN, FR, DE, ES & NL

Artificial Intelligence in Decision Support Systems for Diagnosis in Medical Imaging Book Review:

This book offers the first comprehensive overview of artificial intelligence (AI) technologies in decision support systems for diagnosis based on medical images, presenting cutting-edge insights from thirteen leading research groups around the world. Medical imaging offers essential information on patients’ medical condition, and clues to causes of their symptoms and diseases. Modern imaging modalities, however, also produce a large number of images that physicians have to accurately interpret. This can lead to an “information overload” for physicians, and can complicate their decision-making. As such, intelligent decision support systems have become a vital element in medical-image-based diagnosis and treatment. Presenting extensive information on this growing field of AI, the book offers a valuable reference guide for professors, students, researchers and professionals who want to learn about the most recent developments and advances in the field.

Hodson and Geddes Cystic Fibrosis Fourth Edition

Hodson and Geddes  Cystic Fibrosis  Fourth Edition
Author: Andrew Bush,Diana Bilton,Margaret Hodson
Publsiher: CRC Press
Total Pages: 699
Release: 2015-07-02
ISBN 10: 0340764252
ISBN 13: 9780340764251
Language: EN, FR, DE, ES & NL

Hodson and Geddes Cystic Fibrosis Fourth Edition Book Review:

Hodson and Geddes' Cystic Fibrosis provides everything the respiratory clinician, pulmonologist or health professional treating patients needs in a single manageable volume. This international and authoritative work brings together current knowledge and has become established in previous editions as a leading reference in the field. This fourth edition includes a wealth of new information, figures, useful videos, and a companion eBook. The basic science that underlies the disease and its progression is outlined in detail and put into a clinical context. Diagnostic and clinical aspects are covered in depth, as well as promising advances such as gene therapies and other novel molecular based treatments. Patient monitoring and the importance of multidisciplinary care are also emphasized. This edition: Features accessible sections reflecting the multidisciplinary nature of the cystic fibrosis care team Contains a chapter written by patients and families about their experiences with the disease Includes expanded coverage of clinical areas, including chapters covering sleep, lung mechanics and the work of breathing, upper airway disease, insulin deficiency and diabetes, bone disease, and sexual and reproductive issues Discusses management both in the hospital and at home Includes a new section on monitoring and discusses the use of databases to improve patient care Covers monitoring in different age groups, exercise testing and the outcomes of clinical trials in these areas Includes chapters devoted to nursing, physiotherapy, psychology, and palliative and spiritual care Throughout, the emphasis is on providing an up-to-date and balanced review of both the clinical and basic science aspects of the subject and reflecting the multidisciplinary nature of the cystic fibrosis care team.

Handbook of Medical Image Computing and Computer Assisted Intervention

Handbook of Medical Image Computing and Computer Assisted Intervention
Author: S. Kevin Zhou,Daniel Rueckert,Gabor Fichtinger
Publsiher: Academic Press
Total Pages: 1072
Release: 2019-10-18
ISBN 10: 0128165863
ISBN 13: 9780128165867
Language: EN, FR, DE, ES & NL

Handbook of Medical Image Computing and Computer Assisted Intervention Book Review:

Handbook of Medical Image Computing and Computer Assisted Intervention presents important advanced methods and state-of-the art research in medical image computing and computer assisted intervention, providing a comprehensive reference on current technical approaches and solutions, while also offering proven algorithms for a variety of essential medical imaging applications. This book is written primarily for university researchers, graduate students and professional practitioners (assuming an elementary level of linear algebra, probability and statistics, and signal processing) working on medical image computing and computer assisted intervention. Presents the key research challenges in medical image computing and computer-assisted intervention Written by leading authorities of the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society Contains state-of-the-art technical approaches to key challenges Demonstrates proven algorithms for a whole range of essential medical imaging applications Includes source codes for use in a plug-and-play manner Embraces future directions in the fields of medical image computing and computer-assisted intervention

Glioma Imaging

Glioma Imaging
Author: Whitney B. Pope
Publsiher: Springer Nature
Total Pages: 286
Release: 2019-11-11
ISBN 10: 3030273598
ISBN 13: 9783030273590
Language: EN, FR, DE, ES & NL

Glioma Imaging Book Review:

This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice. The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn: current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits

Precision Medicine for Investigators Practitioners and Providers

Precision Medicine for Investigators  Practitioners and Providers
Author: Joel Faintuch,Salomao Faintuch
Publsiher: Academic Press
Total Pages: 640
Release: 2019-11-16
ISBN 10: 0128191791
ISBN 13: 9780128191798
Language: EN, FR, DE, ES & NL

Precision Medicine for Investigators Practitioners and Providers Book Review:

Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Machine Learning With Radiation Oncology Big Data

Machine Learning With Radiation Oncology Big Data
Author: Jun Deng,Issam El Naqa,Lei Xing
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-01-21
ISBN 10: 2889457303
ISBN 13: 9782889457304
Language: EN, FR, DE, ES & NL

Machine Learning With Radiation Oncology Big Data Book Review:

Molecular Imaging

Molecular Imaging
Author: Jie Tian
Publsiher: Springer Science & Business Media
Total Pages: 699
Release: 2013-07-23
ISBN 10: 3642343031
ISBN 13: 9783642343032
Language: EN, FR, DE, ES & NL

Molecular Imaging Book Review:

"Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China.

Molecular Imaging in Oncology

Molecular Imaging in Oncology
Author: Otmar Schober,Fabian Kiessling,Jürgen Debus
Publsiher: Springer Nature
Total Pages: 918
Release: 2020-06-27
ISBN 10: 3030426181
ISBN 13: 9783030426187
Language: EN, FR, DE, ES & NL

Molecular Imaging in Oncology Book Review:

This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit all readers who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.

Assessment of Cellular and Organ Function and Dysfunction using Direct and Derived MRI Methodologies

Assessment of Cellular and Organ Function and Dysfunction using Direct and Derived MRI Methodologies
Author: Christakis Constantinides
Publsiher: BoD – Books on Demand
Total Pages: 116
Release: 2016-10-26
ISBN 10: 9535127225
ISBN 13: 9789535127222
Language: EN, FR, DE, ES & NL

Assessment of Cellular and Organ Function and Dysfunction using Direct and Derived MRI Methodologies Book Review:

Despite the tremendous growth in the field of magnetic resonance imaging (MRI) evidenced in the initial phases of its development in the early twentieth century, scientific focus has shifted in recent years toward the study of physiology and pathophysiology that span the spatial scales of the molecule, cell, tissue, and organ. Intensified research activities over the past 15 years have justified efforts toward molecular and cellular imaging, dual-modality imaging systems, real-time acquisitions, dedicated image processing techniques and applications, and the critical evaluation of their potential translational value for use in the clinic. The integrative focus on molecular-cellular-tissue-organ function and dysfunction has taken a primary role in modern, personalized medicine, and it is envisaged to continue to do so, as accumulated knowledge from basic and clinical science work continues to elucidate molecular, cellular, and physiological/pathophysiological pathways and mechanisms. In this scientific effort, MRI continues to play a critical and synergistic role from the perspectives of basic science, diagnosis, and clinical interventional/therapeutic approaches. Within the realm of the current role of MRI in modern medicine, this book summarizes state-of-the-art direct and derived MRI methodologies and approaches as applied toward the assessment of cellular and organ function and dysfunction. The contributions in this effort are not excessive but few, comprehensive, and distinguished and of high quality. The topic areas can be generalized to find applications in other scientific areas and span both brain and cardiac applications, extending interest to wider audiences.