Protein Trafficking in Neurons

Protein Trafficking in Neurons
Author: Andrew J. Bean
Publsiher: Elsevier
Total Pages: 464
Release: 2006-10-27
ISBN 10: 9780080465890
ISBN 13: 0080465897
Language: EN, FR, DE, ES & NL

Protein Trafficking in Neurons Book Review:

The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. Provides a comprehensive examination of membrane/protein movement in neuronal function Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease Includes a focus on Molecular Mechanisms Illustrated with color summary pictures The only book examining protein trafficking and its functional implications, written by leaders in the field

Involvement of Myosin V and Associated Proteins in Protein Trafficking and Neuronal Morphogenesis

Involvement of Myosin V and Associated Proteins in Protein Trafficking and Neuronal Morphogenesis
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2009
ISBN 10:
ISBN 13: OCLC:680293108
Language: EN, FR, DE, ES & NL

Involvement of Myosin V and Associated Proteins in Protein Trafficking and Neuronal Morphogenesis Book Review:

Proper neuronal development and function requires precise sorting and delivery of various elements from the soma to the synapse. Important mediators of intracellular transport events are the actin-based class V myosin motors, which are involved in organelle transport in various cell types. Two myosin V family members, myosin Va and Vb, are present in the brain, however, the identity of cargoes transported by these motors is unknown. The objective of this thesis was to conduct molecular and cell biological studies to identify and characterize novel myosin V cargoes in neurons. The first approach I used was to characterize the distribution of candidate protein cargoes after blocking the function of endogenous myosin Va and Vb with dominant-negative (DN) versions. I found that in developing neurons, expression of DN myosin Vb, but not DN myosin Va, resulted in the accumulation in the soma of the AMPA-type glutamate receptor subunit, GluR1, and a reduction of its surface expression. I also found that myosin Vb-mediated trafficking of GluR1 required an interaction with the GTPase Rab11. These results reveal a novel mechanism for the transport of a specific glutamate receptor subunit mediated by myosin Vb and Rab11. As an alternative approach to identify myosin Va binding partners in the brain, we conducted a yeast-two hybrid screen of a rat brain cDNA library using the cargo binding domain of myosin Va. Among the proteins identified in our screen, I selected a protein of unknown function previously identified as Rab-lysosomal-interacting protein like 2 (RILPL2) and further assessed its function. I found that RILPL2 expression in non-neuronal cells resulted in morphological changes and activation of the Rho GTPase Rac1. In developing neurons, gain or loss of RILPL2 function altered the density of dendritic spine protrusions and increased phosphorylation of the Rac1 effector Pak. These findings uncover a novel role for the myosin Va-interacting protein, RILPL2, in regulati.

Trafficking Inside Cells

Trafficking Inside Cells
Author: Nava Segev
Publsiher: Springer Science & Business Media
Total Pages: 445
Release: 2010-05-30
ISBN 10: 038793877X
ISBN 13: 9780387938776
Language: EN, FR, DE, ES & NL

Trafficking Inside Cells Book Review:

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Protein Kinesis

Protein Kinesis
Author: Anonim
Publsiher: CSHL Press
Total Pages: 843
Release: 1995
ISBN 10: 9780879690700
ISBN 13: 0879690704
Language: EN, FR, DE, ES & NL

Protein Kinesis Book Review:

Investigators provide an account of how cells control and repair the folding of newly synthesized proteins and transport them correctly to membranes, mitochondria and other cellular addresses. It also provides information on synaptic function, cell movement and other cellular functions.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
Author: Wolfgang B. Liedtke, MD, PH.D.
Publsiher: CRC Press
Total Pages: 467
Release: 2006-09-29
ISBN 10: 1420005847
ISBN 13: 9781420005844
Language: EN, FR, DE, ES & NL

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Book Review:

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Encyclopedia of Molecular Pharmacology

Encyclopedia of Molecular Pharmacology
Author: Stefan Offermanns,W. Rosenthal
Publsiher: Springer Science & Business Media
Total Pages: 1505
Release: 2008-08-14
ISBN 10: 3540389164
ISBN 13: 9783540389163
Language: EN, FR, DE, ES & NL

Encyclopedia of Molecular Pharmacology Book Review:

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Neurotransmitter Transporters

Neurotransmitter Transporters
Author: Harald Sitte,Michael Freissmuth
Publsiher: Springer Science & Business Media
Total Pages: 552
Release: 2006-08-02
ISBN 10: 3540297847
ISBN 13: 9783540297840
Language: EN, FR, DE, ES & NL

Neurotransmitter Transporters Book Review:

This book is a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters. It provides an overview of insights generated in the past five years. The volume serves as a useful compendium of current concepts and an inspiring starting point. It is a source for students interested in this emerging field as well as for experienced scientists looking for an update.

Membrane Trafficking

Membrane Trafficking
Author: Ales Vancura
Publsiher: Springer Science & Business Media
Total Pages: 405
Release: 2008-08-28
ISBN 10: 9781588299253
ISBN 13: 1588299252
Language: EN, FR, DE, ES & NL

Membrane Trafficking Book Review:

As membrane trafficking research has expanded over the past thirty years, a remarkable convergence of information has been gained by using genetic approaches in yeast cells with biochemical approaches in mammalian cells. This book reflects these advances by devoting one section of the book to yeast cells and the other to mammalian cells, with each section providing both classic and cutting-edge techniques to study macromolecular transport across the membranes.

Presenilins and Alzheimer s Disease

Presenilins and Alzheimer   s Disease
Author: Steven G. Younkin,Rudolph E. Tanzi
Publsiher: Springer Science & Business Media
Total Pages: 100
Release: 2012-12-06
ISBN 10: 3642721036
ISBN 13: 9783642721038
Language: EN, FR, DE, ES & NL

Presenilins and Alzheimer s Disease Book Review:

The role of the familial Alzheimer's Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.

Encyclopedia of Neuroscience

Encyclopedia of Neuroscience
Author: Marc D. Binder,Nobutaka Hirokawa,Uwe Windhorst
Publsiher: Springer
Total Pages: 4398
Release: 2008-10-13
ISBN 10: 9783540237358
ISBN 13: 3540237356
Language: EN, FR, DE, ES & NL

Encyclopedia of Neuroscience Book Review:

This 5000-page masterwork is literally the last word on the topic and will be an essential resource for many. Unique in its breadth and detail, this encyclopedia offers a comprehensive and highly readable guide to a complex and fast-expanding field. The five-volume reference work gathers more than 10,000 entries, including in-depth essays by internationally known experts, and short keynotes explaining essential terms and phrases. In addition, expert editors contribute detailed introductory chapters to each of 43 topic fields ranging from the fundamentals of neuroscience to fascinating developments in the new, inter-disciplinary fields of Computational Neuroscience and Neurophilosophy. Some 1,000 multi-color illustrations enhance and expand the writings.

The Neuronal Cytoskeleton Motor Proteins and Organelle Trafficking in the Axon

The Neuronal Cytoskeleton  Motor Proteins  and Organelle Trafficking in the Axon
Author: Anonim
Publsiher: Academic Press
Total Pages: 534
Release: 2016-01-12
ISBN 10: 0128033541
ISBN 13: 9780128033548
Language: EN, FR, DE, ES & NL

The Neuronal Cytoskeleton Motor Proteins and Organelle Trafficking in the Axon Book Review:

The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in neuronal cells, and includes sections on such topics as actin transport in axons and neurofilament transport. Covers an increasingly appreciated field in cell biology Includes both established and new technologies Contributed by experts in the field

Biology of the NMDA Receptor

Biology of the NMDA Receptor
Author: Antonius M. VanDongen
Publsiher: CRC Press
Total Pages: 350
Release: 2008-10-29
ISBN 10: 9781420044157
ISBN 13: 142004415X
Language: EN, FR, DE, ES & NL

Biology of the NMDA Receptor Book Review:

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.

Molecular Biology of the Neuron

Molecular Biology of the Neuron
Author: Brian Morris
Publsiher: Oxford University Press
Total Pages: 480
Release: 2004-04-08
ISBN 10: 9780198509981
ISBN 13: 0198509987
Language: EN, FR, DE, ES & NL

Molecular Biology of the Neuron Book Review:

This book is a valuable compendium of up-to-date reviews of neuronal molecular biology by leading researchers in the field. It covers all aspects of neuron structure and function, with the emphasis on genetic and molecular analysis.

The Dynamic Synapse

The Dynamic Synapse
Author: Josef T. Kittler,Stephen J. Moss
Publsiher: CRC Press
Total Pages: 336
Release: 2006-03-27
ISBN 10: 0203486285
ISBN 13: 9780203486283
Language: EN, FR, DE, ES & NL

The Dynamic Synapse Book Review:

Exploring the diverse tools and technologies used to study synaptic processes, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology delineates techniques, methods, and conceptual advances for studying neurotransmitter receptors and other synaptic proteins. It describes a broad range of molecular, biochemical, imaging, and electrophysiological approaches for studying the biology of synapses. Specific topics include the use of proteomics to study synaptic protein complexes, the development of phosphorylation state specific antibodies, post-genomic tools applied to the study of synapses and RNA interference in neurons. In addition, several chapters focus on methods for gene and protein delivery into neuronal tissue. The use of biochemical, electrophysiological and optical tagging techniques to study the movement and membrane trafficking of neurotransmitter receptors in the membrane of live nerve cells are also discussed. To complement these approaches, the application of approaches for achieving long-term alterations in the genetic complement of neurons in vivo using viral vectors or homologous recombination of ES cells are also described.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 329
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

Rab GTPases and Membrane Trafficking

Rab GTPases and Membrane Trafficking
Author: Laurence Porter,Phillip Shinnick
Publsiher: Bentham Science Publishers
Total Pages: 180
Release: 2012-05-21
ISBN 10: 1608053652
ISBN 13: 9781608053650
Language: EN, FR, DE, ES & NL

Rab GTPases and Membrane Trafficking Book Review:

"Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that"

Membrane Trafficking in Neuron Regulated by New Syntaxin 13 interacting Proteins

Membrane Trafficking in Neuron Regulated by New Syntaxin 13 interacting Proteins
Author: Pascal Steiner
Publsiher: Unknown
Total Pages: 147
Release: 2004
ISBN 10:
ISBN 13: OCLC:85347932
Language: EN, FR, DE, ES & NL

Membrane Trafficking in Neuron Regulated by New Syntaxin 13 interacting Proteins Book Review:

Prions

Prions
Author: Ivo Nikolaev Sirakov
Publsiher: BoD – Books on Demand
Total Pages: 82
Release: 2019-01-30
ISBN 10: 1789850177
ISBN 13: 9781789850178
Language: EN, FR, DE, ES & NL

Prions Book Review:

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
Author: Muralidhar L. Hegde
Publsiher: BoD – Books on Demand
Total Pages: 160
Release: 2020-08-26
ISBN 10: 183880580X
ISBN 13: 9781838805807
Language: EN, FR, DE, ES & NL

Amyotrophic Lateral Sclerosis Book Review:

A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.

The Golgi Apparatus

The Golgi Apparatus
Author: Eric Berger,J. Roth
Publsiher: Birkhäuser
Total Pages: 306
Release: 2012-12-06
ISBN 10: 3034888767
ISBN 13: 9783034888769
Language: EN, FR, DE, ES & NL

The Golgi Apparatus Book Review:

In 1898 Camillo Golgi reported his newly observed intracellular structure, the apparato reticolare interno, now universally known as the Golgi Apparatus. The method he used was an ingenious histological technique (La reazione nera) which brought him fame for the discovery of neuronal networks and culminated in the award of the Nobel Prize for Physiology and Medicine in 1906. This technique, however, was not easily reproducible and led to a long-lasting controversy about the reality of the Golgi apparatus. Its identification as a ubiquitous organelle by electron microscopy turned out to be the breakthrough and incited an enormous wave of interest in this organelle at the end of the sixties. In recent years immunochemical techniques and molecular cloning approaches opened up new avenues and led to an ongoing resurgence of interest. The role of the Golgi apparatus in modifying, broadening and refining the structural information conferred by transcription/translation is now generally accepted but still incompletely understood. During the coming years, this topic certainly will remain center stage in the field of cell biology. The centennial of the discovery of this fascinating organelle prompted us to edit a new comprehensive book on the Golgi apparatus whose complexity necessitated the contributions of leading specialists in this field. This book is aimed at a broad readership of glycobiologists as well as cell and molecular biologists and may also be interesting for advanced students of biology and life sciences.