Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
Author: Anonim
Publsiher: Academic Press
Total Pages: 292
Release: 2018-11-21
ISBN 10: 0128127384
ISBN 13: 9780128127384
Language: EN, FR, DE, ES & NL

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy Book Review:

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment

Prognostic and Therapeutic Applications of Rkip in Cancer

Prognostic and Therapeutic Applications of Rkip in Cancer
Author: Benjamin Bonavida,Stavroula Baritaki
Publsiher: Academic Press
Total Pages: 504
Release: 2020-03-02
ISBN 10: 0128196122
ISBN 13: 9780128196120
Language: EN, FR, DE, ES & NL

Prognostic and Therapeutic Applications of Rkip in Cancer Book Review:

Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides an update from experts in the field on diagnostics, prognostics and therapeutics Brings a clear overview of recent findings and references, as well as summaries, significant molecular pathways, and conclusions in each chapter Provides a general introductory chapter on contributions in the field and a chapter summary, with synthesized findings and a projection of future goals

Resistance to Tyrosine Kinase Inhibitors

Resistance to Tyrosine Kinase Inhibitors
Author: Daniele Focosi
Publsiher: Springer
Total Pages: 188
Release: 2016-11-07
ISBN 10: 3319460919
ISBN 13: 9783319460918
Language: EN, FR, DE, ES & NL

Resistance to Tyrosine Kinase Inhibitors Book Review:

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

The Resolution of Inflammation

The Resolution of Inflammation
Author: Adriano Rossi,Deborah A. Sawatzky
Publsiher: Springer Science & Business Media
Total Pages: 240
Release: 2008-03-17
ISBN 10: 9783764375065
ISBN 13: 376437506X
Language: EN, FR, DE, ES & NL

The Resolution of Inflammation Book Review:

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Advances in DNA Repair

Advances in DNA Repair
Author: Clark Chen
Publsiher: BoD – Books on Demand
Total Pages: 496
Release: 2015-11-18
ISBN 10: 9535122096
ISBN 13: 9789535122098
Language: EN, FR, DE, ES & NL

Advances in DNA Repair Book Review:

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.

New Research Directions in DNA Repair

New Research Directions in DNA Repair
Author: Clark Chen
Publsiher: BoD – Books on Demand
Total Pages: 674
Release: 2013-05-22
ISBN 10: 9535111140
ISBN 13: 9789535111146
Language: EN, FR, DE, ES & NL

New Research Directions in DNA Repair Book Review:

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1983
ISBN 10:
ISBN 13: STANFORD:36105119624737
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Autophagy in Current Trends in Cellular Physiology and Pathology

Autophagy in Current Trends in Cellular Physiology and Pathology
Author: Nikolai Gorbunov,E. Marion Schneider
Publsiher: BoD – Books on Demand
Total Pages: 526
Release: 2016-11-10
ISBN 10: 9535127268
ISBN 13: 9789535127260
Language: EN, FR, DE, ES & NL

Autophagy in Current Trends in Cellular Physiology and Pathology Book Review:

Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Cancer Drug Resistance

Cancer Drug Resistance
Author: Beverly A. Teicher
Publsiher: Springer Science & Business Media
Total Pages: 617
Release: 2007-11-09
ISBN 10: 1597450359
ISBN 13: 9781597450355
Language: EN, FR, DE, ES & NL

Cancer Drug Resistance Book Review:

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Colorectal Cancer

Colorectal Cancer
Author: Jindong Chen
Publsiher: BoD – Books on Demand
Total Pages: 128
Release: 2018-05-16
ISBN 10: 1789231000
ISBN 13: 9781789231007
Language: EN, FR, DE, ES & NL

Colorectal Cancer Book Review:

With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.

Colorectal Cancer

Colorectal Cancer
Author: Luis Rodrigo
Publsiher: BoD – Books on Demand
Total Pages: 440
Release: 2016-09-07
ISBN 10: 9535125443
ISBN 13: 9789535125440
Language: EN, FR, DE, ES & NL

Colorectal Cancer Book Review:

Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future.

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy
Author: Benjamin Bonavida
Publsiher: Springer Science & Business Media
Total Pages: 260
Release: 2013-07-04
ISBN 10: 1461470706
ISBN 13: 9781461470700
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy Book Review:

​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Protein Kinase Inhibitors in Research and Medicine

Protein Kinase Inhibitors in Research and Medicine
Author: Anonim
Publsiher: Academic Press
Total Pages: 252
Release: 2013-07-01
ISBN 10: 0123984629
ISBN 13: 9780123984623
Language: EN, FR, DE, ES & NL

Protein Kinase Inhibitors in Research and Medicine Book Review:

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Contains sections focusing on protein kinase inhibitors in research and medicine

Cumulated Index Medicus

Cumulated Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1999
ISBN 10:
ISBN 13: UIUC:30112048174665
Language: EN, FR, DE, ES & NL

Cumulated Index Medicus Book Review:

Molecular Therapies of Cancer

Molecular Therapies of Cancer
Author: Georg F. Weber
Publsiher: Springer
Total Pages: 488
Release: 2015-07-22
ISBN 10: 3319132784
ISBN 13: 9783319132785
Language: EN, FR, DE, ES & NL

Molecular Therapies of Cancer Book Review:

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC
Author: Anthony Faber
Publsiher: Academic Press
Total Pages: 250
Release: 2021-03-15
ISBN 10: 9780128228333
ISBN 13: 0128228334
Language: EN, FR, DE, ES & NL

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC Book Review:

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC, Volume 17 presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors Encompasses the current state of affairs in clinical trials to address resistance

Cell Biology

Cell Biology
Author: Stevo Najman
Publsiher: BoD – Books on Demand
Total Pages: 206
Release: 2016-01-20
ISBN 10: 9535122428
ISBN 13: 9789535122425
Language: EN, FR, DE, ES & NL

Cell Biology Book Review:

Cell biology is a multidisciplinary scientific field that its modern expansion in new knowledge and applications owes to important support of new technologies with the rapid development, such as ICTs. By integrating knowledge from nano-, molecular, micro-, and macroareas, it represents a strong foundation for almost all biological sciences and disciplines, as well as for biomedical research and application. This book is a compilation of inspiring reviews/original studies, which are divided into sections: New Methods in Cell Biology, Molecular and Cellular Regulatory Mechanisms, and Cellular Basis of Disease and Therapy. The book will be very useful for students and beginners to gain insight into new area, as well as for experts and scientists to find new facts and expand their scientific horizons through biological sciences and biomedicine.

Central Nervous System Metastases

Central Nervous System Metastases
Author: Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
Publsiher: Springer Nature
Total Pages: 421
Release: 2019-11-05
ISBN 10: 3030234177
ISBN 13: 9783030234171
Language: EN, FR, DE, ES & NL

Central Nervous System Metastases Book Review:

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Ovarian Cancer

Ovarian Cancer
Author: Omer Devaja,Andreas Papadopoulos
Publsiher: BoD – Books on Demand
Total Pages: 364
Release: 2018-10-24
ISBN 10: 1789843332
ISBN 13: 9781789843330
Language: EN, FR, DE, ES & NL

Ovarian Cancer Book Review:

Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Receptor Tyrosine Kinases Structure Functions and Role in Human Disease

Receptor Tyrosine Kinases  Structure  Functions and Role in Human Disease
Author: Deric L. Wheeler,Yosef Yarden
Publsiher: Springer
Total Pages: 440
Release: 2014-11-26
ISBN 10: 1493920537
ISBN 13: 9781493920532
Language: EN, FR, DE, ES & NL

Receptor Tyrosine Kinases Structure Functions and Role in Human Disease Book Review:

Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks.