Protein Homeostasis Diseases

Protein Homeostasis Diseases
Author: Angel L. Pey
Publsiher: Academic Press
Total Pages: 450
Release: 2020-02-21
ISBN 10: 9780128191323
ISBN 13: 0128191325
Language: EN, FR, DE, ES & NL

Protein Homeostasis Diseases Book Review:

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis Diseases

Protein Homeostasis Diseases
Author: Angel L. Pey
Publsiher: Academic Press
Total Pages: 450
Release: 2020-02-13
ISBN 10: 0128191333
ISBN 13: 9780128191330
Language: EN, FR, DE, ES & NL

Protein Homeostasis Diseases Book Review:

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis

Protein Homeostasis
Author: Richard I. Morimoto,Dennis J. Selkoe,Jeffery W. Kelly
Publsiher: Unknown
Total Pages: 349
Release: 2012
ISBN 10: 9781936113064
ISBN 13: 1936113066
Language: EN, FR, DE, ES & NL

Protein Homeostasis Book Review:

Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause such mechanisms to become dysfunctional or overloaded, resulting in the accumulation and aggregation of misfolded proteins a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the entire spectrum of protein homeostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry. The contributors examine the physical biochemistry of protein folding and the roles of the various cellular compartments in protein quality control, as well as approaches for ameliorating protein misfolding and aggregation diseases. Including discussions of specific disorders such as Alzheimer's disease, Huntington's disease, and prion diseases, this book is an essential reference for not only molecular and cellular biologists but also medical scientists wishing to understand the pathological consequences of and potential therapies for protein homeostasis deficiencies in common human diseases.

Chaperones Protein Homeostasis and Protein Aggregation Diseases

Chaperones  Protein Homeostasis and Protein Aggregation Diseases
Author: Harm Harmannus Kampinga,Rijksuniversiteit Groningen
Publsiher: Unknown
Total Pages: 135
Release: 2014
ISBN 10: 9789036770996
ISBN 13: 9036770998
Language: EN, FR, DE, ES & NL

Chaperones Protein Homeostasis and Protein Aggregation Diseases Book Review:

Impairment of Protein Homeostasis in Parkinson s Disease

Impairment of Protein Homeostasis in Parkinson s Disease
Author: Maike Lichtenberg
Publsiher: Unknown
Total Pages: 135
Release: 2011
ISBN 10: 1928374650XXX
ISBN 13: OCLC:890150680
Language: EN, FR, DE, ES & NL

Impairment of Protein Homeostasis in Parkinson s Disease Book Review:

Proteostasis and Disease

Proteostasis and Disease
Author: Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
Publsiher: Springer
Total Pages: 345
Release: 2020-06-01
ISBN 10: 9783030382650
ISBN 13: 3030382656
Language: EN, FR, DE, ES & NL

Proteostasis and Disease Book Review:

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Finding Balance in Huntington s Disease

Finding Balance in Huntington s Disease
Author: Joseph Ochaba
Publsiher: Unknown
Total Pages: 254
Release: 2016
ISBN 10: 9781369174205
ISBN 13: 1369174209
Language: EN, FR, DE, ES & NL

Finding Balance in Huntington s Disease Book Review:

The disruption of protein quality control networks that ensure proper folding and degradation of cellular proteins is likely central to pathology in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other "protein misfolding" diseases (La Spada and Taylor, 2010; Wilkinson et al., 2010). A detailed understanding of the proteostasis network components and their contributions to pathology are therefore crucial to developing improved therapeutic interventions. HD is caused by the abnormal expansion of a CAG repeat within the HD gene resulting in an expanded stretch of polyglutamines in the Huntingtin (HTT) protein (Group, 1993a). A key pathological feature is the accumulation of mutant HTT protein (mHTT) (Cisbani and Cicchetti, 2012; Zhao et al., 2016). Post-translational modifications of HTT, including SUMOylation and phosphorylation (Ehrnhoefer et al., 2011; Pennuto et al., 2009), appear to contribute to mechanisms underlying mHTT function, clearance, and accumulation (O'Rourke et al., 2013; Ochaba et al., 2016; Zhao et al., 2016).The work presented here represents an innovative conceptual shift to address questions fundamental to HD and other diseases where protein homeostasis is affected. This approach may therefore provide insight into a broad spectrum of protein misfolding disorders. My dissertation utilized gain-of and loss-of-function approaches to query the importance of HTT function, modulation of PIAS1-regulatory networks, and SUMO-interaction motifs in the context of cell culture and in vivo mouse model systems to assess the impact on critical disease regulatory networks and HD pathogenesis. The precise mechanisms involved in the aforementioned have not yet been elucidated, nor has the PIAS and SUMO pathways been tested in vivo for its relevance to the following: the accumulation of neurodegenerative disease-causing proteins, neuroinflammation, protein clearance networks, or overall impact on disease phenotypes. My dissertation suggests that PIAS1 may link protein homeostasis and neuroinflammation in HD through a combination of modulating accumulation of toxic HMW species of HTT and compensating for dysfunctional inflammatory signaling cascades between neurons and microglia, potentially allowing improved flux through protein clearance pathways, of which HTT itself is likely involved in regulating.

Protein Homeostasis Second Edition

Protein Homeostasis  Second Edition
Author: Richard I. Morimoto,Jeffery W. Kelly,F. Ulrich Hartl
Publsiher: Perspectives Cshl
Total Pages: 562
Release: 2019
ISBN 10: 9781621822967
ISBN 13: 1621822966
Language: EN, FR, DE, ES & NL

Protein Homeostasis Second Edition Book Review:

The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity). Discussions of the responses by cells when errors in protein quality control occur, the medical disorders that can result (e.g., Alzheimer disease), and pharmacologic approaches to ameliorate protein conformational disorders are also included. This book is therefore an essential reference for biochemists, cell biologists, and all biomedical scientists wishing to understand the pathological consequences of and potential therapies for proteostasis deficiencies in common human diseases.

Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health Disease

Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health   Disease
Author: Anonim
Publsiher: Unknown
Total Pages: 230
Release: 2016
ISBN 10: 1928374650XXX
ISBN 13: OCLC:980316467
Language: EN, FR, DE, ES & NL

Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health Disease Book Review:

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones
Author: Gregory Lloyd Blatch,Adrienne Lesley Edkins
Publsiher: Springer
Total Pages: 276
Release: 2014-12-08
ISBN 10: 3319117319
ISBN 13: 9783319117317
Language: EN, FR, DE, ES & NL

The Networking of Chaperones by Co chaperones Book Review:

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Proteostasis and Chaperone Surveillance

Proteostasis and Chaperone Surveillance
Author: Laishram Rajendrakumar Singh,Tanveer Ali Dar,Parvaiz Ahmad
Publsiher: Springer
Total Pages: 180
Release: 2015-11-26
ISBN 10: 8132224671
ISBN 13: 9788132224679
Language: EN, FR, DE, ES & NL

Proteostasis and Chaperone Surveillance Book Review:

Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances and the essential role of molecular and chemical chaperones.

Protein Metabolism and Homeostasis in Aging

Protein Metabolism and Homeostasis in Aging
Author: Nektarios Tavernarakis
Publsiher: Springer Science & Business Media
Total Pages: 249
Release: 2011-01-11
ISBN 10: 1441970029
ISBN 13: 9781441970022
Language: EN, FR, DE, ES & NL

Protein Metabolism and Homeostasis in Aging Book Review:

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.

Immunity Tumors and Aging The Role of HSP70

Immunity  Tumors and Aging  The Role of HSP70
Author: Igor Malyshev
Publsiher: Springer Science & Business Media
Total Pages: 141
Release: 2013-01-08
ISBN 10: 9400759436
ISBN 13: 9789400759435
Language: EN, FR, DE, ES & NL

Immunity Tumors and Aging The Role of HSP70 Book Review:

The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.

A Role for Processing bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells

A Role for Processing bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells
Author: Qian Shi
Publsiher: Unknown
Total Pages: 125
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1280350582
Language: EN, FR, DE, ES & NL

A Role for Processing bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells Book Review:

The proper maintenance of protein homeostasis is critical for the normal physiology and survival of all cells. These functions are carried out by a large group of proteins that is collectively referred to as the protein quality control (PQC) system of cell. Under normal conditions, misfolded proteins are refolded, degraded, or sequestered within distinct quality control compartments. A failure to maintain proper protein homeostasis is linked to many human diseases, including cancers, autoimmune conditions and neurodegenerative disorders. For example, mutant forms of huntingtin protein are prone to misfolding, accumulation and aggregation. This misfolded aggregation is thought to be responsible for the pathology of Huntington’s disease. A better understanding of the overall PQC system is therefore likely to lead to potential routes of therapy for individuals afflicted with these disorders.

Sleep and Aging

Sleep and Aging
Author: Mark P. Mattson
Publsiher: Elsevier
Total Pages: 194
Release: 2005-07-04
ISBN 10: 9780444518767
ISBN 13: 0444518762
Language: EN, FR, DE, ES & NL

Sleep and Aging Book Review:

Alterations in sleep are common manifestations of aging that can lead to significant health problems and contribute to behavioural problems associated with age-related neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Recent advances have revealed key cellular and molecular mechanisms involved in sleep regulation, and this knowledge is helping to advance an understanding of both the normal functions of sleep and the mechanisms responsible for abnormalities in sleep in various neurological conditions and during normal aging. This volume of Advances in Cell Aging and Gerontology brings together chapters by leaders in the fields of sleep research and the neurobiology of aging. The book starts with chapters describing fundamental aspects of the neurocircuitry involved in sleep, patterns of brain activity during the different stages of sleep and disturbances of sleep during aging. The links between depression, anxiety and insomnia are reviewed in regards to the underlying neurochemical alterations that appear to involve abnormalities in neurotransmitter and neurotrophic factor signalling. The evolutionary basis of sleep is reviewed and the emerging evidence supporting a major role for sleep in learning and memory is described. The bulk of the book focuses on specific sleep disorders associated with aging and age-related neurodegenerative disorders. A comprehensive consideration of this topic is woven through a number of chapters that address both basic research and clinical aspects of sleep abnormalities during aging and in disease. The impact of sleep on the immune system is described. The articles are written in a high level of detail and are comprehensive, thus providing valuable information for a range of scientists and other well-educated people. In particular, the book will be a valuable resource for graduate students, postdoctoral and senior scientists in the fields of sleep, aging, neurodegenerative disorders and learning and memory. In addition, clinicians will find this book valuable as it provides a bridge between basic research and the treatment of the patients with sleep disorders. * Covers the fields of sleep in aging and age-related disease from neurochemistry to the clinic * Includes detailed summary diagrams that depict key concepts * Provides views of the future of research on sleep and aging, and the potential for prevention and treatment of various sleep disorders

Nature s Robots

Nature s Robots
Author: Charles Tanford,Jacqueline Reynolds
Publsiher: OUP Oxford
Total Pages: 312
Release: 2003-11-27
ISBN 10: 0191578517
ISBN 13: 9780191578519
Language: EN, FR, DE, ES & NL

Nature s Robots Book Review:

Proteins are amazingly versatile molecules. They make the chemical reactions happen that form the basis for life, they transmit signals in the body, they identify and kill foreign invaders, they form the engines that make us move, and they record visual images. All of this is now common knowledge, but it was not so a hundred years ago. Nature's Robots is an authoritative history of protein science, from the origins of protein research in the nineteenth century, when the chemical constitution of 'protein' was first studied and heatedly debated and when there was as yet no glimmer of the functional potential of substances in the 'protein' category, to the determination of the first structures of individual proteins at atomic resolution - when positions of individual atoms were first specified exactly and bonding between neighbouring atoms precisely defined. Tanford and Reynolds, who themselves made major contributions to the golden age of protein science, have written a remarkably vivid account of this history. It is a fascinating story, involving heroes from the past, working mostly alone or in small groups, usually with little support from formal research groups. It is also a story that embraces a number of historically important scientific controversies. Written in clear and accessible prose, Nature's Robots will appeal to general readers with an interest in popular science, in addition to professional scientists and historians of science.

Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases
Author: Richard I. Morimoto,Yves Christen
Publsiher: Springer Science & Business Media
Total Pages: 136
Release: 2012-12-13
ISBN 10: 3642279287
ISBN 13: 9783642279287
Language: EN, FR, DE, ES & NL

Protein Quality Control in Neurodegenerative Diseases Book Review:

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Alterations of Neuronal Activity and Protein Homeostasis in a Mouse Model of Huntington s Disease

Alterations of Neuronal Activity and Protein Homeostasis in a Mouse Model of Huntington s Disease
Author: Elena Katharina Schulz-Trieglaff
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1137014340
Language: EN, FR, DE, ES & NL

Alterations of Neuronal Activity and Protein Homeostasis in a Mouse Model of Huntington s Disease Book Review:

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
Author: Michael S. Wolfe
Publsiher: Academic Press
Total Pages: 560
Release: 2018-03-29
ISBN 10: 0128113057
ISBN 13: 9780128113059
Language: EN, FR, DE, ES & NL

The Molecular and Cellular Basis of Neurodegenerative Diseases Book Review:

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Heat Shock Factor

Heat Shock Factor
Author: Akira Nakai
Publsiher: Springer
Total Pages: 301
Release: 2016-01-06
ISBN 10: 4431558527
ISBN 13: 9784431558521
Language: EN, FR, DE, ES & NL

Heat Shock Factor Book Review:

This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases. For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF.