Protein Homeostasis Diseases

Protein Homeostasis Diseases
Author: Angel L. Pey
Publsiher: Academic Press
Total Pages: 450
Release: 2020-02-13
ISBN 10: 0128191333
ISBN 13: 9780128191330
Language: EN, FR, DE, ES & NL

Protein Homeostasis Diseases Book Review:

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis

Protein Homeostasis
Author: Richard I. Morimoto,Dennis J. Selkoe,Jeffery W. Kelly
Publsiher: Unknown
Total Pages: 349
Release: 2012
ISBN 10: 9781936113064
ISBN 13: 1936113066
Language: EN, FR, DE, ES & NL

Protein Homeostasis Book Review:

Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause such mechanisms to become dysfunctional or overloaded, resulting in the accumulation and aggregation of misfolded proteins a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the entire spectrum of protein homeostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry. The contributors examine the physical biochemistry of protein folding and the roles of the various cellular compartments in protein quality control, as well as approaches for ameliorating protein misfolding and aggregation diseases. Including discussions of specific disorders such as Alzheimer's disease, Huntington's disease, and prion diseases, this book is an essential reference for not only molecular and cellular biologists but also medical scientists wishing to understand the pathological consequences of and potential therapies for protein homeostasis deficiencies in common human diseases.

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones
Author: Gregory Lloyd Blatch,Adrienne Lesley Edkins
Publsiher: Springer
Total Pages: 276
Release: 2014-12-08
ISBN 10: 3319117319
ISBN 13: 9783319117317
Language: EN, FR, DE, ES & NL

The Networking of Chaperones by Co chaperones Book Review:

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Proteostasis and Disease

Proteostasis and Disease
Author: Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
Publsiher: Springer Nature
Total Pages: 348
Release: 2020-04-09
ISBN 10: 3030382664
ISBN 13: 9783030382667
Language: EN, FR, DE, ES & NL

Proteostasis and Disease Book Review:

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Prion

Prion
Author: Yusuf Tutar
Publsiher: BoD – Books on Demand
Total Pages: 238
Release: 2017-03-08
ISBN 10: 9535130013
ISBN 13: 9789535130017
Language: EN, FR, DE, ES & NL

Prion Book Review:

Protein aggregation causes malfunction in several biochemical processes. Genetic and spontaneous formations of these transmissible spongiform encephalopathies are fatal to humans and animals. Conformational change of normal form of the protein to misfolded form causes its accumulation. The misfolded infectious protein agent forms the pathogenesis of the disease. This book presents pathology of the disease along with current knowledge of the structure-activity mechanism in the first two sections. Dyshomeostasis of metals is implicated in the pathogenesis of prions, and this influence is discussed further to understand the prion mechanism. Genetic resistance and immunobiology of the disease are elaborated in the following section. Finally, a computational study on the dynamics of the prion propagation provides a structural basis of the mechanism.

Protein Metabolism and Homeostasis in Aging

Protein Metabolism and Homeostasis in Aging
Author: Nektarios Tavernarakis
Publsiher: Springer Science & Business Media
Total Pages: 249
Release: 2011-01-11
ISBN 10: 1441970029
ISBN 13: 9781441970022
Language: EN, FR, DE, ES & NL

Protein Metabolism and Homeostasis in Aging Book Review:

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.

Ageing Lessons from C elegans

Ageing  Lessons from C  elegans
Author: Anders Olsen,Matthew S. Gill
Publsiher: Springer
Total Pages: 439
Release: 2016-12-06
ISBN 10: 3319447033
ISBN 13: 9783319447032
Language: EN, FR, DE, ES & NL

Ageing Lessons from C elegans Book Review:

This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.

Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases
Author: Richard I. Morimoto,Yves Christen
Publsiher: Springer Science & Business Media
Total Pages: 136
Release: 2012-12-13
ISBN 10: 3642279287
ISBN 13: 9783642279287
Language: EN, FR, DE, ES & NL

Protein Quality Control in Neurodegenerative Diseases Book Review:

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Anatomy and Physiology

Anatomy and Physiology
Author: J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publsiher: Unknown
Total Pages: 329
Release: 2013-04-25
ISBN 10: 9781947172807
ISBN 13: 1947172808
Language: EN, FR, DE, ES & NL

Anatomy and Physiology Book Review:

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
Author: Michael S. Wolfe
Publsiher: Academic Press
Total Pages: 560
Release: 2018-03-29
ISBN 10: 0128113057
ISBN 13: 9780128113059
Language: EN, FR, DE, ES & NL

The Molecular and Cellular Basis of Neurodegenerative Diseases Book Review:

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Textbook of Autoinflammation

Textbook of Autoinflammation
Author: Philip J. Hashkes,Ronald M. Laxer,Anna Simon
Publsiher: Springer
Total Pages: 820
Release: 2019-02-13
ISBN 10: 3319986058
ISBN 13: 9783319986050
Language: EN, FR, DE, ES & NL

Textbook of Autoinflammation Book Review:

This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

Calcium Binding Proteins in Health and Disease

Calcium Binding Proteins in Health and Disease
Author: Anthony Norman
Publsiher: Elsevier
Total Pages: 650
Release: 2012-12-02
ISBN 10: 0323141420
ISBN 13: 9780323141420
Language: EN, FR, DE, ES & NL

Calcium Binding Proteins in Health and Disease Book Review:

Calcium-Binding Proteins in Health and Disease includes the papers prepared by the invited speakers as well as many of the free communications. The contributions are grouped according to their general subject matter, based on the classification made by the authors, e.g., Extracellular Metabolism: Calcium Homeostasis; Low-Affinity Calcium-Binding Proteins. There can be little doubt that calcium-binding proteins is a field of scientific endeavor which will continue to produce results of great interest to modern biology. This book is divided into eight sections, the first of which, tackle extracellular calcium metabolism or calcium homeostasis. The next sections focus on topics such as low-affinity calcium-binding proteins; calcium and membranes, channels and transport (pumps); the role of calcium in complex metabolic processes; and gene structure of calcium-binding proteins and their expression. Other chapters cover physical studies on calcium-binding proteins, including X-ray, crystallography, and NMR; structure-function relationships of calcium-binding proteins and their targets; and calcium-binding proteins in health and disease. This book will be of interest to practitioners in the fields of biology and medicine.

Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology  Aging  and Disease
Author: Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publsiher: Academic Press
Total Pages: 220
Release: 2018-04-20
ISBN 10: 012813500X
ISBN 13: 9780128135006
Language: EN, FR, DE, ES & NL

Introductory Review on Sirtuins in Biology Aging and Disease Book Review:

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Cell Aging Molecular Mechanisms and Implications for Disease

Cell Aging  Molecular Mechanisms and Implications for Disease
Author: Christian Behl,Christine Ziegler
Publsiher: Springer Science & Business Media
Total Pages: 108
Release: 2013-12-18
ISBN 10: 3642451799
ISBN 13: 9783642451799
Language: EN, FR, DE, ES & NL

Cell Aging Molecular Mechanisms and Implications for Disease Book Review:

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Protein Modificomics

Protein Modificomics
Author: Tanveer Ali Dar,Laishram Rajendrakumar Singh
Publsiher: Academic Press
Total Pages: 352
Release: 2019-04-15
ISBN 10: 9780128119136
ISBN 13: 0128119136
Language: EN, FR, DE, ES & NL

Protein Modificomics Book Review:

Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes. Provides thorough insights into the post translational modifications (PTMs) of proteins in both the plant and animal kingdom Presents diagrammatic representations of various protein modification and estimation mechanisms in four-color Includes coverage of diseases involving post translational modifications

Ubiquitination Governing DNA Repair

Ubiquitination Governing DNA Repair
Author: Effrossyni Boutou,Horst-Werner Stürzbecher
Publsiher: BoD – Books on Demand
Total Pages: 220
Release: 2018-08-01
ISBN 10: 1789235847
ISBN 13: 9781789235845
Language: EN, FR, DE, ES & NL

Ubiquitination Governing DNA Repair Book Review:

DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

Vitamin D

Vitamin D
Author: David Feldman,J. Wesley Pike,Francis H. Glorieux
Publsiher: Elsevier
Total Pages: 1952
Release: 2005-01-25
ISBN 10: 9780080543642
ISBN 13: 0080543642
Language: EN, FR, DE, ES & NL

Vitamin D Book Review:

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD

Protein Misfolding Diseases

Protein Misfolding Diseases
Author: Marina Ramirez-Alvarado,Jeffery W. Kelly,Christopher M. Dobson
Publsiher: John Wiley & Sons
Total Pages: 1078
Release: 2010-12-01
ISBN 10: 9781118031810
ISBN 13: 1118031814
Language: EN, FR, DE, ES & NL

Protein Misfolding Diseases Book Review:

An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.

Early Diagnosis of Alzheimer s Disease

Early Diagnosis of Alzheimer   s Disease
Author: Leonard F. M. Scinto,Kirk R. Daffner
Publsiher: Springer Science & Business Media
Total Pages: 359
Release: 2000-02-09
ISBN 10: 1592590055
ISBN 13: 9781592590056
Language: EN, FR, DE, ES & NL

Early Diagnosis of Alzheimer s Disease Book Review:

Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.

Muscle Cell and Tissue

Muscle Cell and Tissue
Author: Kunihiro Sakuma
Publsiher: BoD – Books on Demand
Total Pages: 486
Release: 2015-09-02
ISBN 10: 9535121561
ISBN 13: 9789535121565
Language: EN, FR, DE, ES & NL

Muscle Cell and Tissue Book Review:

In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.