Predictive Modeling of Pharmaceutical Unit Operations

Predictive Modeling of Pharmaceutical Unit Operations
Author: Preetanshu Pandey,Rahul Bharadwaj
Publsiher: Woodhead Publishing
Total Pages: 464
Release: 2016-09-26
ISBN 10: 0081001800
ISBN 13: 9780081001806
Language: EN, FR, DE, ES & NL

Predictive Modeling of Pharmaceutical Unit Operations Book Review:

The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. Explains the commonly used modeling and simulation tools Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing Practical examples of the application of modeling tools through case studies Discussion of modeling techniques used for a risk-based approach to regulatory filings Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points

Chemical Engineering in the Pharmaceutical Industry

Chemical Engineering in the Pharmaceutical Industry
Author: Mary T. am Ende,David J. am Ende
Publsiher: John Wiley & Sons
Total Pages: 688
Release: 2019-04-01
ISBN 10: 1119285518
ISBN 13: 9781119285519
Language: EN, FR, DE, ES & NL

Chemical Engineering in the Pharmaceutical Industry Book Review:

A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

Continuous Manufacturing of Pharmaceuticals

Continuous Manufacturing of Pharmaceuticals
Author: Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publsiher: John Wiley & Sons
Total Pages: 620
Release: 2017-09-05
ISBN 10: 1119001323
ISBN 13: 9781119001324
Language: EN, FR, DE, ES & NL

Continuous Manufacturing of Pharmaceuticals Book Review:

10.7.3 State of Control

Process Systems Engineering for Pharmaceutical Manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing
Author: Ravendra Singh,Zhihong Yuan
Publsiher: Elsevier
Total Pages: 698
Release: 2018-03-16
ISBN 10: 0444639667
ISBN 13: 9780444639660
Language: EN, FR, DE, ES & NL

Process Systems Engineering for Pharmaceutical Manufacturing Book Review:

Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing

The Chemical Engineer

The Chemical Engineer
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2007
ISBN 10:
ISBN 13: STANFORD:36105123654258
Language: EN, FR, DE, ES & NL

The Chemical Engineer Book Review:

Process Control

Process Control
Author: B. Wayne Bequette
Publsiher: Prentice Hall Professional
Total Pages: 769
Release: 2003
ISBN 10: 9780133536409
ISBN 13: 0133536408
Language: EN, FR, DE, ES & NL

Process Control Book Review:

Process Control: Modeling, Design, and Simulation is the first complete introduction to process control that fully integrates software tools-helping you master critical techniques hands-on, using MATLAB-based computer simulations. Author B. Wayne Bequette includes process control diagrams, dynamic modeling, feedback control, frequency response analysis techniques, control loop tuning, and start-to-finish chemical process control case studies.

Applied Predictive Analytics

Applied Predictive Analytics
Author: Dean Abbott
Publsiher: John Wiley & Sons
Total Pages: 456
Release: 2014-03-31
ISBN 10: 111872769X
ISBN 13: 9781118727690
Language: EN, FR, DE, ES & NL

Applied Predictive Analytics Book Review:

Learn the art and science of predictive analytics — techniques that get results Predictive analytics is what translates big data into meaningful, usable business information. Written by a leading expert in the field, this guide examines the science of the underlying algorithms as well as the principles and best practices that govern the art of predictive analytics. It clearly explains the theory behind predictive analytics, teaches the methods, principles, and techniques for conducting predictive analytics projects, and offers tips and tricks that are essential for successful predictive modeling. Hands-on examples and case studies are included. The ability to successfully apply predictive analytics enables businesses to effectively interpret big data; essential for competition today This guide teaches not only the principles of predictive analytics, but also how to apply them to achieve real, pragmatic solutions Explains methods, principles, and techniques for conducting predictive analytics projects from start to finish Illustrates each technique with hands-on examples and includes as series of in-depth case studies that apply predictive analytics to common business scenarios A companion website provides all the data sets used to generate the examples as well as a free trial version of software Applied Predictive Analytics arms data and business analysts and business managers with the tools they need to interpret and capitalize on big data.

Applied Predictive Modeling

Applied Predictive Modeling
Author: Max Kuhn,Kjell Johnson
Publsiher: Springer Science & Business Media
Total Pages: 600
Release: 2013-05-17
ISBN 10: 1461468493
ISBN 13: 9781461468493
Language: EN, FR, DE, ES & NL

Applied Predictive Modeling Book Review:

Applied Predictive Modeling covers the overall predictive modeling process, beginning with the crucial steps of data preprocessing, data splitting and foundations of model tuning. The text then provides intuitive explanations of numerous common and modern regression and classification techniques, always with an emphasis on illustrating and solving real data problems. The text illustrates all parts of the modeling process through many hands-on, real-life examples, and every chapter contains extensive R code for each step of the process. This multi-purpose text can be used as an introduction to predictive models and the overall modeling process, a practitioner’s reference handbook, or as a text for advanced undergraduate or graduate level predictive modeling courses. To that end, each chapter contains problem sets to help solidify the covered concepts and uses data available in the book’s R package. This text is intended for a broad audience as both an introduction to predictive models as well as a guide to applying them. Non-mathematical readers will appreciate the intuitive explanations of the techniques while an emphasis on problem-solving with real data across a wide variety of applications will aid practitioners who wish to extend their expertise. Readers should have knowledge of basic statistical ideas, such as correlation and linear regression analysis. While the text is biased against complex equations, a mathematical background is needed for advanced topics.

Experiments in Unit Operations and Processing of Foods

Experiments in Unit Operations and Processing of Foods
Author: Maria Margarida Cortez Vieira,Peter Ho
Publsiher: Springer Science & Business Media
Total Pages: 190
Release: 2008-10-20
ISBN 10: 9780387686424
ISBN 13: 0387686428
Language: EN, FR, DE, ES & NL

Experiments in Unit Operations and Processing of Foods Book Review:

In chemical engineering and related fields, a unit operation is a basic step in a process. For example in milk processing, homogenization, pasteurization, chilling, and packaging are each unit operations which are connected to create the overall process. A process may have many unit operations to obtain the desired product. The book will cover many different unit operations as they apply to food processing.

Chemical Engineering in the Pharmaceutical Industry Active Pharmaceutical Ingredients

Chemical Engineering in the Pharmaceutical Industry  Active Pharmaceutical Ingredients
Author: David J. am Ende,Mary T. am Ende
Publsiher: Wiley
Total Pages: 1168
Release: 2019-04-23
ISBN 10: 1119285860
ISBN 13: 9781119285861
Language: EN, FR, DE, ES & NL

Chemical Engineering in the Pharmaceutical Industry Active Pharmaceutical Ingredients Book Review:

A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: • Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety • Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying • Presents updated and expanded example calculations • Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industry focuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.

Engineering Aspects of Food Emulsification and Homogenization

Engineering Aspects of Food Emulsification and Homogenization
Author: Marilyn Rayner,Petr Dejmek
Publsiher: CRC Press
Total Pages: 331
Release: 2015-04-24
ISBN 10: 1466580445
ISBN 13: 9781466580442
Language: EN, FR, DE, ES & NL

Engineering Aspects of Food Emulsification and Homogenization Book Review:

Emulsions are found in a wide variety of food products, pharmaceuticals, paints, and cosmetics, thus emulsification is a truly multidisciplinary phenomenon. Therefore understanding of the process must evolve from the combination of (at least) three different scientific specializations. Engineering Aspects of Food Emulsification and Homogenization describes the state-of-the-art technology and brings together aspects from physical chemistry, fluid mechanics, and chemical engineering. The book explores the unit operations used in emulsification and homogenization processes, using fundamental theory from different fields to discuss design and function of different emulsification techniques. This book summarizes the present understanding of the involved physical–chemical processes as well as specific information about the limits and possibilities for the different types of emulsifying equipment. It covers colloidal chemistry and engineering aspects of emulsification and discusses high-energy and low-energy emulsification methods. The chapters highlight low-energy emulsification processes such as membrane emulsification that are now industrially feasible. Dramatically more energy-efficient processes are being developed, and this book clarifies their present limitations, such us scale-up and achievable droplet sizes. The present literature on emulsification is, to a large degree, influenced by the division between physical chemistry, fluid dynamics, and chemical engineering. Written by experts drawn from academia and industry, this book brings those areas together to provide a comprehensive resource that gives a deeper understanding of emulsification and homogenization in food product development.

Pharmaceutical Operations Management

Pharmaceutical Operations Management
Author: Pankaj Mohan,Jarka Glassey,Gary A. Montague
Publsiher: McGraw Hill Professional
Total Pages: 364
Release: 2006-03-16
ISBN 10: 0071712089
ISBN 13: 9780071712088
Language: EN, FR, DE, ES & NL

Pharmaceutical Operations Management Book Review:

This book brings together a winning team of international operations experts to set the framework for building a world-class manufacturing organization. Pharmaceutical Operations Management focuses on key concepts such as: Policy Execution, Risk Management, Supply chain modeling, Advance process control and Six Sigma for the pharmaceutical industry: critical techniques which will offset cost, increase efficiency and turn any manufacture into financial winner.

Quantitative Microbiology in Food Processing

Quantitative Microbiology in Food Processing
Author: Anderson de Souza Sant'Ana
Publsiher: John Wiley & Sons
Total Pages: 696
Release: 2017-02-06
ISBN 10: 1118756428
ISBN 13: 9781118756423
Language: EN, FR, DE, ES & NL

Quantitative Microbiology in Food Processing Book Review:

14.5.3 Modified atmosphere packaging (MAP)

Continuous Manufacturing for the Modernization of Pharmaceutical Production

Continuous Manufacturing for the Modernization of Pharmaceutical Production
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology
Publsiher: National Academies Press
Total Pages: 68
Release: 2019-04-05
ISBN 10: 0309487811
ISBN 13: 9780309487818
Language: EN, FR, DE, ES & NL

Continuous Manufacturing for the Modernization of Pharmaceutical Production Book Review:

On July 30-31, 2018, the National Academies of Sciences, Engineering, and Medicine held a workshop titled Continuous Manufacturing for the Modernization of Pharmaceutical Production. This workshop discussed the business and regulatory concerns associated with adopting continuous manufacturing techniques to produce biologics such as enzymes, monoclonal antibodies, and vaccines. The participants also discussed specific challenges for integration across the manufacturing system, including upstream and downstream processes, analytical techniques, and drug product development. The workshop addressed these challenges broadly across the biologics domain but focused particularly on drug categories of greatest FDA and industrial interest such as monoclonal antibodies and vaccines. This publication summarizes the presentations and discussions from the workshop.

Modeling and Analysis of Manufacturing Systems

Modeling and Analysis of Manufacturing Systems
Author: Ronald G. Askin,Ronald G.. Askin,Charles R. Standridge,Charles R.. Standridge
Publsiher: John Wiley & Sons Incorporated
Total Pages: 461
Release: 1993-01-18
ISBN 10:
ISBN 13: UOM:39015029175554
Language: EN, FR, DE, ES & NL

Modeling and Analysis of Manufacturing Systems Book Review:

Manufacturing models - Assembly lines : reliable serial systems - Transfer lines and general serial systems - Shop scheduling with many products - Flexible manufacturing systems - Machine setup and operation sequencing - Material handling systems - Warehousing : storage and retrieval systems - General manufacturing systems : analytical queueing models - General manufacturing systems : empirical simulation models.

Practical Statistics for Data Scientists

Practical Statistics for Data Scientists
Author: Peter Bruce,Andrew Bruce
Publsiher: "O'Reilly Media, Inc."
Total Pages: 318
Release: 2017-05-10
ISBN 10: 1491952911
ISBN 13: 9781491952917
Language: EN, FR, DE, ES & NL

Practical Statistics for Data Scientists Book Review:

Statistical methods are a key part of of data science, yet very few data scientists have any formal statistics training. Courses and books on basic statistics rarely cover the topic from a data science perspective. This practical guide explains how to apply various statistical methods to data science, tells you how to avoid their misuse, and gives you advice on what's important and what's not. Many data science resources incorporate statistical methods but lack a deeper statistical perspective. If you’re familiar with the R programming language, and have some exposure to statistics, this quick reference bridges the gap in an accessible, readable format. With this book, you’ll learn: Why exploratory data analysis is a key preliminary step in data science How random sampling can reduce bias and yield a higher quality dataset, even with big data How the principles of experimental design yield definitive answers to questions How to use regression to estimate outcomes and detect anomalies Key classification techniques for predicting which categories a record belongs to Statistical machine learning methods that “learn” from data Unsupervised learning methods for extracting meaning from unlabeled data

Essentials of Pharmaceutical Engineering

Essentials of Pharmaceutical Engineering
Author: Deeliprao Derle,Mrudula Bele
Publsiher: Bsp Books Pvt. Limited
Total Pages: 320
Release: 2015-06
ISBN 10: 9789352300495
ISBN 13: 9352300491
Language: EN, FR, DE, ES & NL

Essentials of Pharmaceutical Engineering Book Review:

This book mainly aims in guiding the teachers and students, the fundamental principles of Pharmaceutical Engineering. This book helps the students in overcoming the obstacles faced by them in understanding the aspects of Pharmaceutical Engineering. Topics, which usually confuse the students, are explained along with applications to broaden their mental horizon regarding the subject. This book is meant to serve as an introductory text for undergraduate students doing Bachelor of Pharmaceutical Sciences (B. Pharm). It will also prove useful to people working in pharmaceutical and allied industries. In keeping with its initiatory approach to pharmaceutical engineering, only the important aspects of the subject have been discussed in a simple and easily comprehensible manner.

26th European Symposium on Computer Aided Process Engineering

26th European Symposium on Computer Aided Process Engineering
Author: Anonim
Publsiher: Elsevier
Total Pages: 2486
Release: 2016-06-17
ISBN 10: 0444634444
ISBN 13: 9780444634443
Language: EN, FR, DE, ES & NL

26th European Symposium on Computer Aided Process Engineering Book Review:

26th European Symposium on Computer Aided Process Engineering contains the papers presented at the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event held at Portorož Slovenia, from June 12th to June 15th, 2016. Themes discussed at the conference include Process-product Synthesis, Design and Integration, Modelling, Numerical analysis, Simulation and Optimization, Process Operations and Control and Education in CAPE/PSE. Presents findings and discussions from the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event

Chemical Engineering Progress

Chemical Engineering Progress
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2009
ISBN 10:
ISBN 13: STANFORD:36105123664828
Language: EN, FR, DE, ES & NL

Chemical Engineering Progress Book Review:

Chemical Engineering in the Pharmaceutical Industry

Chemical Engineering in the Pharmaceutical Industry
Author: David J. am Ende
Publsiher: John Wiley & Sons
Total Pages: 904
Release: 2011-03-10
ISBN 10: 1118088107
ISBN 13: 9781118088104
Language: EN, FR, DE, ES & NL

Chemical Engineering in the Pharmaceutical Industry Book Review:

This book deals with various unique elements in the drugdevelopment process within chemical engineering science andpharmaceutical R&D. The book is intended to be used as aprofessional reference and potentially as a text book reference inpharmaceutical engineering and pharmaceutical sciences. Many of theexperimental methods related to pharmaceutical process developmentare learned on the job. This book is intended to provide many ofthose important concepts that R&D Engineers and manufacturingEngineers should know and be familiar if they are going to besuccessful in the Pharmaceutical Industry. These include basicanalytics for quantitation of reaction components– oftenskipped in ChE Reaction Engineering and kinetics books. In additionChemical Engineering in the Pharmaceutical Industryintroduces contemporary methods of data analysis for kineticmodeling and extends these concepts into Quality by Designstrategies for regulatory filings. For the current professionals,in-silico process modeling tools that streamlineexperimental screening approaches is also new and presented here.Continuous flow processing, although mainstream for ChE, is uniquein this context given the range of scales and the complex economicsassociated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts.These parts will address the fundamentals of analytical techniquesfor engineers, thermodynamic modeling, and finally provides anappendix with common engineering tools and examples of theirapplications.