Precision Medicine for Autoimmune Diseases

Precision Medicine for Autoimmune Diseases
Author: Georg Lautscham
Publsiher: Academic Press
Total Pages: 366
Release: 2020-09
ISBN 10: 9780128195222
ISBN 13: 0128195223
Language: EN, FR, DE, ES & NL

Precision Medicine for Autoimmune Diseases Book Review:

Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 American will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $ 100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future.

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
Author: Michael Mahler
Publsiher: Academic Press
Total Pages: 300
Release: 2021-03-12
ISBN 10: 032385432X
ISBN 13: 9780323854320
Language: EN, FR, DE, ES & NL

Precision Medicine and Artificial Intelligence Book Review:

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
Author: Christopher Chang,Qianjin Lu
Publsiher: Springer
Total Pages: 403
Release: 2021-05-23
ISBN 10: 9789811534515
ISBN 13: 9811534519
Language: EN, FR, DE, ES & NL

Epigenetics in Allergy and Autoimmunity Book Review:

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Current Perspectives in HIV Infection

Current Perspectives in HIV Infection
Author: Shailendra K. Saxena
Publsiher: BoD – Books on Demand
Total Pages: 482
Release: 2013-04-10
ISBN 10: 9535110578
ISBN 13: 9789535110576
Language: EN, FR, DE, ES & NL

Current Perspectives in HIV Infection Book Review:

This book gives a comprehensive overview of HIV and AIDS including NeuroAIDS, as well as general concepts of pathology, immunity and immunopathology, diagnosis, treatment, epidemiology and etiology to current clinical recommendations in management of HIV/AIDS including NeuroAIDS, highlighting the ongoing issues, recent advances and future directions in diagnostic approaches and therapeutic strategies.

The Autoimmune Diseases

The Autoimmune Diseases
Author: Noel R. Rose,Ian R. Mackay
Publsiher: Unknown
Total Pages: 895
Release: 1998
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015045615823
Language: EN, FR, DE, ES & NL

The Autoimmune Diseases Book Review:

Since the First Edition of The Autoimmune Diseases was published in 1985, interest as well as knowledge about autoimmune diseases has greatly increased. This edition incorporates new material and combines the basic aspects of autoimmunity with discussion of specific autoimmune diseases in humans. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. In addition to a comprehensive discussion of various autoimmune diseases and organ systems, the editors also cover the role of autoimmunity in cancer, AIDS, and aging. Key Features * Provides comprehensive discussions of all autoimmune diseases and organ systems * Offers "bench to bedside" coverage of autoimmunity for both clinicians and research scientists * Discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels * Examines the environmental determinants of autoimmune disease * Examines the association between autoimmunity and aging, cancer, and AIDS

Personalized Treatment Options in Dermatology

Personalized Treatment Options in Dermatology
Author: Thomas Bieber,Frank Nestle
Publsiher: Springer
Total Pages: 146
Release: 2015-02-23
ISBN 10: 3662458403
ISBN 13: 9783662458402
Language: EN, FR, DE, ES & NL

Personalized Treatment Options in Dermatology Book Review:

This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.

Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease
Author: Jules J. Berman
Publsiher: Academic Press
Total Pages: 398
Release: 2018-01-26
ISBN 10: 0128143940
ISBN 13: 9780128143940
Language: EN, FR, DE, ES & NL

Precision Medicine and the Reinvention of Human Disease Book Review:

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Clinical Precision Medicine

Clinical Precision Medicine
Author: Judy S. Crabtree
Publsiher: Academic Press
Total Pages: 112
Release: 2019-11-15
ISBN 10: 0128204028
ISBN 13: 9780128204023
Language: EN, FR, DE, ES & NL

Clinical Precision Medicine Book Review:

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Epigenetic Biomarker and Personalized Precision Medicine

Epigenetic Biomarker and Personalized Precision Medicine
Author: Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-21
ISBN 10: 2889661849
ISBN 13: 9782889661848
Language: EN, FR, DE, ES & NL

Epigenetic Biomarker and Personalized Precision Medicine Book Review:

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
Author: Claudio Carini,Mark Fidock,Alain van Gool
Publsiher: CRC Press
Total Pages: 631
Release: 2019-04-16
ISBN 10: 0429576730
ISBN 13: 9780429576737
Language: EN, FR, DE, ES & NL

Handbook of Biomarkers and Precision Medicine Book Review:

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Personalized Epigenetics

Personalized Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 610
Release: 2015-04-28
ISBN 10: 0128004363
ISBN 13: 9780128004364
Language: EN, FR, DE, ES & NL

Personalized Epigenetics Book Review:

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Immune Rebalancing

Immune Rebalancing
Author: Diana Boraschi,Giselle Penton-Rol
Publsiher: Academic Press
Total Pages: 298
Release: 2016-01-25
ISBN 10: 0128033363
ISBN 13: 9780128033364
Language: EN, FR, DE, ES & NL

Immune Rebalancing Book Review:

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

The Mosaic of Autoimmunity

The Mosaic of Autoimmunity
Author: Yehuda Shoenfeld,David Isenberg
Publsiher: Elsevier Science Limited
Total Pages: 523
Release: 1989
ISBN 10: 9780444811844
ISBN 13: 0444811842
Language: EN, FR, DE, ES & NL

The Mosaic of Autoimmunity Book Review:

This book comprehensively sets out the common aetiopathogenetic mechanisms shared by many, apparently diverse, diseases of the immune system. Unlike most other texts it does not emphasise the differences between autoimmune diseases, but establishes their many common links including hormonal effects, dietary and immunogenetic influences, complement deficiencies and environmental factors. Special attention is given to the effects of ageing and the relationship with malignancies. The scope of the book is very broad so as to cover the integration of the many diverse components which interact to cause autoimmunity, and it contains many 1988 and 1989 references and over 100 figures and tables, offering an attractive, up-to-date guide to modern concepts. It will greatly assist immunologists wishing to enter the field of autoimmunity, and will serve as an invaluable reference work for those already working in it.

The Autoimmune Diseases

The Autoimmune Diseases
Author: Noel R. Rose,Ian R. Mackay
Publsiher: Academic Press
Total Pages: 1532
Release: 2019-10-15
ISBN 10: 0128122420
ISBN 13: 9780128122426
Language: EN, FR, DE, ES & NL

The Autoimmune Diseases Book Review:

The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Omics for Personalized Medicine

Omics for Personalized Medicine
Author: Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly
Publsiher: Springer Science & Business Media
Total Pages: 832
Release: 2013-10-14
ISBN 10: 8132211847
ISBN 13: 9788132211846
Language: EN, FR, DE, ES & NL

Omics for Personalized Medicine Book Review:

“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Precision Medicine for Investigators Practitioners and Providers

Precision Medicine for Investigators  Practitioners and Providers
Author: Joel Faintuch,Salomao Faintuch
Publsiher: Academic Press
Total Pages: 640
Release: 2019-11-16
ISBN 10: 0128191791
ISBN 13: 9780128191798
Language: EN, FR, DE, ES & NL

Precision Medicine for Investigators Practitioners and Providers Book Review:

Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Genome Wide Association Studies

Genome Wide Association Studies
Author: Tatsuhiko Tsunoda,Toshihiro Tanaka,Yusuke Nakamura
Publsiher: Springer Nature
Total Pages: 209
Release: 2019-10-31
ISBN 10: 9811381771
ISBN 13: 9789811381775
Language: EN, FR, DE, ES & NL

Genome Wide Association Studies Book Review:

This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.

Towards Precision Medicine in Vasculitis

Towards Precision Medicine in Vasculitis
Author: Federico Alberici,Andreas Kronbichler,Giacomo Emmi
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-01-05
ISBN 10: 2889663493
ISBN 13: 9782889663491
Language: EN, FR, DE, ES & NL

Towards Precision Medicine in Vasculitis Book Review:

Clinical and Statistical Considerations in Personalized Medicine

Clinical and Statistical Considerations in Personalized Medicine
Author: Claudio Carini,Sandeep M Menon,Mark Chang
Publsiher: CRC Press
Total Pages: 376
Release: 2014-03-27
ISBN 10: 1466593873
ISBN 13: 9781466593879
Language: EN, FR, DE, ES & NL

Clinical and Statistical Considerations in Personalized Medicine Book Review:

The Future of Clinical Research and Health Care: From Empirical to Precision Medicine Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

Genomic and Precision Medicine

Genomic and Precision Medicine
Author: Geoffrey S. Ginsburg,Huntington F Willard,Christopher W. Woods,Ephraim L. Tsalik
Publsiher: Academic Press
Total Pages: 480
Release: 2019-08-15
ISBN 10: 0128015586
ISBN 13: 9780128015582
Language: EN, FR, DE, ES & NL

Genomic and Precision Medicine Book Review:

Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Offers comprehensive coverage of infectious and inflammatory disease genomics Provides succinct commentary and key learning points to assist providers with the implementation of genomic and personalized medicine Presents an up-to-date overview on major opportunities for genomic and personalized medicine Includes case studies that highlight the practical use of genomics in the management of patients