Polycomb Group Proteins

Polycomb Group Proteins
Author: Vincenzo Pirrotta
Publsiher: Academic Press
Total Pages: 372
Release: 2017-01-01
ISBN 10: 0128098228
ISBN 13: 9780128098226
Language: EN, FR, DE, ES & NL

Polycomb Group Proteins Book Review:

Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome

Polycomb Group Proteins

Polycomb Group Proteins
Author: Vincenzo Pirrotta
Publsiher: Academic Press
Total Pages: 376
Release: 2017-01-05
ISBN 10: 9780128097373
ISBN 13: 012809737X
Language: EN, FR, DE, ES & NL

Polycomb Group Proteins Book Review:

Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome

Polycomb Group Proteins Repress the Floral Activator AGL19 in the FLC independent Vernalization Pathway

Polycomb Group Proteins Repress the Floral Activator AGL19 in the FLC independent Vernalization Pathway
Author: Nicole Schönrock
Publsiher: Unknown
Total Pages: 220
Release: 2006
ISBN 10:
ISBN 13: OCLC:428003140
Language: EN, FR, DE, ES & NL

Polycomb Group Proteins Repress the Floral Activator AGL19 in the FLC independent Vernalization Pathway Book Review:

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author: Suming Huang,Michael D Litt,C. Ann Blakey
Publsiher: Academic Press
Total Pages: 482
Release: 2015-10-19
ISBN 10: 0128004711
ISBN 13: 9780128004715
Language: EN, FR, DE, ES & NL

Epigenetic Gene Expression and Regulation Book Review:

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Etiology and Morphogenesis of Congenital Heart Disease

Etiology and Morphogenesis of Congenital Heart Disease
Author: Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Publsiher: Springer
Total Pages: 383
Release: 2016-06-24
ISBN 10: 4431546286
ISBN 13: 9784431546283
Language: EN, FR, DE, ES & NL

Etiology and Morphogenesis of Congenital Heart Disease Book Review:

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Investigating the Role of Polycomb Group Protein EZH2 in Prostate Cancer Initiation and Progression

Investigating the Role of Polycomb Group Protein EZH2 in Prostate Cancer Initiation and Progression
Author: Breanne Danielle White Karanikolas
Publsiher: Unknown
Total Pages: 296
Release: 2008
ISBN 10:
ISBN 13: UCLA:L0100104819
Language: EN, FR, DE, ES & NL

Investigating the Role of Polycomb Group Protein EZH2 in Prostate Cancer Initiation and Progression Book Review:

Puberty from Bench to Clinic

Puberty from Bench to Clinic
Author: J.-P. Bourguignon,A.-S. Parent
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 276
Release: 2015-12-17
ISBN 10: 3318027898
ISBN 13: 9783318027891
Language: EN, FR, DE, ES & NL

Puberty from Bench to Clinic Book Review:

Puberty is a unique paradigm for the understanding of gene-environment interaction and developmental programming. Therefore, normal and abnormal pubertal development can be divided and examined in three sections: the role of genetic factors, the role of environmental factors (including nutrition) and therapeutic issues in disorders of puberty. Dealing with all of these sections and framed along current key concepts in pediatric endocrinology, experts share their view on critical issues such as weighting of genetic versus environmental factors or the impact of environmental factors in relation to critical periods in development. Not only showing the consensus and controversial issues in the various areas, each chapter presents lessons for clinical management in an attempt to link basic research, physiology and pathophysiology with the clinical management of pubertal disorders. Puberty from Bench to Clinic bridges up-to-date concepts from animal and human physiology and pathology towards a better understanding and management of pubertal disorders, making it a unique resource for researchers in the field of development and reproduction, clinical scientists and practitioners in neuro-, pediatric and adolescent endocrinology as well as gynecology.

Epigenetics and Dermatology

Epigenetics and Dermatology
Author: Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publsiher: Academic Press
Total Pages: 520
Release: 2015-02-16
ISBN 10: 0128012722
ISBN 13: 9780128012727
Language: EN, FR, DE, ES & NL

Epigenetics and Dermatology Book Review:

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

The Histone Code and Beyond

The Histone Code and Beyond
Author: Shelley L. Berger,O. Nakanishi,Bernhard Haendler
Publsiher: Springer Science & Business Media
Total Pages: 215
Release: 2007-01-19
ISBN 10: 354037633X
ISBN 13: 9783540376330
Language: EN, FR, DE, ES & NL

The Histone Code and Beyond Book Review:

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Genetics of Stem Cells

Genetics of Stem Cells
Author: Anonim
Publsiher: Academic Press
Total Pages: 384
Release: 2012-12-31
ISBN 10: 0124017460
ISBN 13: 9780124017467
Language: EN, FR, DE, ES & NL

Genetics of Stem Cells Book Review:

This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells. Contributions from leading authorities Informs and updates on all the latest developments in the field

Chromatin and Chromatin Remodeling Enzymes

Chromatin and Chromatin Remodeling Enzymes
Author: Carl Wu,C. David Allis
Publsiher: Elsevier
Total Pages: 546
Release: 2004-04-07
ISBN 10: 0080497152
ISBN 13: 9780080497150
Language: EN, FR, DE, ES & NL

Chromatin and Chromatin Remodeling Enzymes Book Review:

DNA in the nucleus of plant and animal cells is stored in the form of chromatin. Chromatin and the chromatin remodelling enzymes play an important role in gene transcription. Genetic assays of chromatin modification and remodeling Histone modifying enzymes ATP-dependent chromatin remodeling enzymes

Cancer Epigenetics

Cancer Epigenetics
Author: Trygve Tollefsbol
Publsiher: CRC Press
Total Pages: 472
Release: 2008-09-19
ISBN 10: 9781420045802
ISBN 13: 1420045806
Language: EN, FR, DE, ES & NL

Cancer Epigenetics Book Review:

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers— DNA methylation and cancer Histone modifications in cancer Emerging areas of cancer epigenetics Epigenetics in the diagnosis, prognosis, and therapy of cancer Future directions in epigenetic cancer research Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.

Nuclear Mechanics and Genome Regulation

Nuclear Mechanics and Genome Regulation
Author: Anonim
Publsiher: Academic Press
Total Pages: 392
Release: 2010-10-12
ISBN 10: 9780123810106
ISBN 13: 0123810108
Language: EN, FR, DE, ES & NL

Nuclear Mechanics and Genome Regulation Book Review:

In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields

Nuclear Architecture and Dynamics

Nuclear Architecture and Dynamics
Author: Christophe Lavelle,Jean-Marc Victor
Publsiher: Academic Press
Total Pages: 618
Release: 2017-10-27
ISBN 10: 012803503X
ISBN 13: 9780128035030
Language: EN, FR, DE, ES & NL

Nuclear Architecture and Dynamics Book Review:

Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. Highlights the link between the (bio)chemistry and the (bio)physics of chromatin Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds

Handbook of Epigenetics

Handbook of Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 682
Release: 2017-07-10
ISBN 10: 0128054778
ISBN 13: 9780128054772
Language: EN, FR, DE, ES & NL

Handbook of Epigenetics Book Review:

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

The Functional Nucleus

The Functional Nucleus
Author: David P. Bazett-Jones,Graham Dellaire
Publsiher: Springer
Total Pages: 513
Release: 2016-10-17
ISBN 10: 3319388827
ISBN 13: 9783319388823
Language: EN, FR, DE, ES & NL

The Functional Nucleus Book Review:

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

Epigenetics

Epigenetics
Author: C. David Allis
Publsiher: CSHL Press
Total Pages: 502
Release: 2007-01
ISBN 10: 0879697245
ISBN 13: 9780879697242
Language: EN, FR, DE, ES & NL

Epigenetics Book Review:

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Epigenetics and Systems Biology

Epigenetics and Systems Biology
Author: Leonie Ringrose
Publsiher: Academic Press
Total Pages: 286
Release: 2017-04-25
ISBN 10: 0128030763
ISBN 13: 9780128030769
Language: EN, FR, DE, ES & NL

Epigenetics and Systems Biology Book Review:

Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies. This book breaks down the obstacles which exist between systems biology and epigenetics researchers due to information barriers and segmented research, giving real-life examples of successful combinations of systems biology and epigenetics experiments. Each section covers one type of modeling and one set of epigenetic questions on which said models have been successfully applied. In addition, the book highlights how modeling and systems biology relate to studies of RNA, DNA, and genome instability, mechanisms of DNA damage signaling and repair, and the effect of the environment on genome stability. Presents original research in a wider perspective to reveal potential for synergies between the two fields of study Provides the latest experiments in primary literature for the modeling audience Includes chapters written by experts in systems biology and epigenetics who have vast experience studying clinical applications

Epigenetics for Drug Discovery

Epigenetics for Drug Discovery
Author: Nessa Carey
Publsiher: Royal Society of Chemistry
Total Pages: 321
Release: 2015-11-20
ISBN 10: 1782628487
ISBN 13: 9781782628484
Language: EN, FR, DE, ES & NL

Epigenetics for Drug Discovery Book Review:

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia. The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs. Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy
Author: Steven Gray
Publsiher: Academic Press
Total Pages: 748
Release: 2015-07-01
ISBN 10: 0128002247
ISBN 13: 9780128002247
Language: EN, FR, DE, ES & NL

Epigenetic Cancer Therapy Book Review:

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs