Platelets

Platelets
Author: Alan D. Michelson
Publsiher: Elsevier
Total Pages: 1376
Release: 2011-08-29
ISBN 10: 9780080465869
ISBN 13: 0080465862
Language: EN, FR, DE, ES & NL

Platelets Book Review:

PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. · First edition won Best Book in Medical Science Award from the Association of American Publishers · Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias · A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Platelets

Platelets
Author: Alan D. Michelson
Publsiher: Gulf Professional Publishing
Total Pages: 956
Release: 2002
ISBN 10: 9780124939516
ISBN 13: 0124939511
Language: EN, FR, DE, ES & NL

Platelets Book Review:

2002 Best New Book in Medical Science - Professional/Scholarly Publishing Division of the Association of American Publishers Platelets is a comprehensive new textbook of 61 chapters and 1,100 pages (approx.) written by over 100 world leaders in the field. Platelets is a single definitive source of state-of-the-art knowledge about platelets. There has been no textbook that specifically and fully covers the entire field of platelet biology and clinical medicine. Platelets now fills this need. Platelets encompasses: platelet biology; platelet function testing; the role of platelets in disease; inherited and acquired disorders of platelet number and function; pharmacology of antiplatelet agents; pharmacology of agents to increase platelet numbers and/or function; platelet transfusion medicine; and gene therapy. The intended audience for Platelets includes hematologists, cardiologists, stroke physicians, blood bankers, pathologists, and researchers in thrombosis and hemostasis as well as students and fellows in these fields. * A single comprehensive source of state-of-the-art knowledge about platelets * Over 100 contributing authors from 13 countries * The authors of each chapter are world leaders in their fields * The definitive resource with 61 chapters, 1,100 pages (approx.), 12,000 references (approx.), 70 full color figures, 140 black and white figures, and 95 tables

Platelets in Thrombotic and Non Thrombotic Disorders

Platelets in Thrombotic and Non Thrombotic Disorders
Author: Paolo Gresele,Clive P. Page,Valentin Fuster,Jos Vermylen
Publsiher: Cambridge University Press
Total Pages: 1101
Release: 2002-05-30
ISBN 10: 9780521802611
ISBN 13: 052180261X
Language: EN, FR, DE, ES & NL

Platelets in Thrombotic and Non Thrombotic Disorders Book Review:

Platelets have become an important research target for clinicians and basic scientists in a range of medical disciplines. This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. It will be an essential reference for biomedical scientists and clinicians in hematology, vascular medicine, cardiology, thrombosis and related disciplines.

Platelets

Platelets
Author: Alan D. Michelson,Marco Cattaneo,Andrew Frelinger,Peter Newman
Publsiher: Academic Press
Total Pages: 1400
Release: 2019-03-15
ISBN 10: 9780128134566
ISBN 13: 0128134569
Language: EN, FR, DE, ES & NL

Platelets Book Review:

Experts from all areas of academic and medical research in hematology, oncology, cardiology, and pathology, take readers from the bench research through the role of platelets in disease, to new therapeutic approaches. Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 125 world experts from 14 countries. This award-winning reference provides clear presentations by basic scientists of the cellular, molecular, and genetic mechanisms of platelets and the subsequent pathophysiological processes such as thrombosis, hemorrhage, inflammation, and cancer. It also provides clear presentations by hematologists, oncologists, cardiologists, pathologists, and other clinicians on how antiplatelet therapy, gene therapy, and platelet transfusion can lead to new therapeutic approaches to diagnose and treat thrombosis and other cardiovascular diseases. Since the publication of the third edition, there continues to be a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. This Fourth Edition of Platelets will continue to draw all this information into a single, comprehensive and authoritative resource. Presents a comprehensive, translational source for all aspects of platelet biology, pathophysiology, and clinical manifestations in one reference work Contains new chapters on topics such as the regulators of GPVI signaling, in vivo thrombosis evaluations, pharmaco genomics of platelets, interplay between anti-platelets and anti-coagulants in clinical practice, and redox regulation of platelet function Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of platelets Provides a full color reference with 250 illustrations and over 12,000 references

Platelets and Megakaryocytes

Platelets and Megakaryocytes
Author: Jonathan M. Gibbins,Martyn P. Mahaut-Smith
Publsiher: Springer Science & Business Media
Total Pages: 888
Release: 2004
ISBN 10: 1592597823
ISBN 13: 9781592597826
Language: EN, FR, DE, ES & NL

Platelets and Megakaryocytes Book Review:

Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precursor, the megakaryocyte. In Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques leading expert researchers-many responsible for seminal discoveries in the field-offer basic and advanced techniques for studying cell signaling in the regulation and function of platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these cells. The methods include ligand-binding assays, the study of protein and lipid kinases and phosphatases, the analysis of lipid rafts in the regulation of cell signaling, and the measurement of intracellular calcium levels. There are also techniques for the study of electrophysiological events, nitric oxide signaling, venom proteins, and for the internalization of proteins into platelets through permeabilization. The application of many molecular and post-genomic methods to the study of platelets and megakaryocytes is also described. All protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Platelets and Megakaryocytes, Volume 1: Functional Assays describes in step-by-step detail basic and advanced techniques for analyzing platelet and megakaryocyte function. Comprehensive and cutting-edge, the two volumes of Platelets and Megakaryocytes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today.

Mechanisms of Stimulus Response Coupling in Platelets

Mechanisms of Stimulus   Response Coupling in Platelets
Author: J. Westwick,M. F. Scully,D. E. MacIntyre,V. V. Kakkar
Publsiher: Springer Science & Business Media
Total Pages: 444
Release: 2013-03-09
ISBN 10: 1461594421
ISBN 13: 9781461594420
Language: EN, FR, DE, ES & NL

Mechanisms of Stimulus Response Coupling in Platelets Book Review:

Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell ular response by protein phosphorylation and calcium flux. The mech anism of these latter events occurs through the activity of phospho lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico sanoids, reinforce and make irreversible the cellular response.

Biochemistry of Blood Platelets

Biochemistry of Blood Platelets
Author: Federation of European Biochemical Societies. Meeting,Federation of European Biochemical Societies
Publsiher: Academic Press
Total Pages: 191
Release: 1967
ISBN 10:
ISBN 13: UOM:39015081127493
Language: EN, FR, DE, ES & NL

Biochemistry of Blood Platelets Book Review:

Platelet Protocols

Platelet Protocols
Author: Melanie McCabe White,Lisa K. Jennings
Publsiher: Elsevier
Total Pages: 116
Release: 1999-04-21
ISBN 10: 9780080539126
ISBN 13: 0080539122
Language: EN, FR, DE, ES & NL

Platelet Protocols Book Review:

Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now. Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing. Includes: A basic introduction to platelet anatomy and physiology Testing procedures for new anti-platelet therapies Descriptions of platelet function abnormalities Therapeutic approaches to inhibition of platelet function Step-by-step methodologies with clear explanations Helpful appendixes of recipes, instructions, sources of reagents, and more

Platelets Receptors Adhesion Secretion

Platelets  Receptors  Adhesion  Secretion
Author: Jacek Hawiger
Publsiher: Unknown
Total Pages: 526
Release: 1992
ISBN 10:
ISBN 13: UVA:X002152321
Language: EN, FR, DE, ES & NL

Platelets Receptors Adhesion Secretion Book Review:

Annotation This volume contains a comprehensive collection of methods for the isolation of platelet membranes, subcellular organelles, the cytoskeleton, and for the assay and purification of platelet receptors. Key Features * Platelets are cellular elements with the highest density of receptors per membrane surface area involved in binding of adhesive molecules, clotting, enzymes, and vasoactive amines * Platelets are essential for the arrest of bleeding and for formation of intravascular thrombi contributing to heart attacks, strokes, and disseminated intravascular coagulation, and are involved in immune complex disease * Platelets are useful for studying the processes of cell adhesion, neurotransmitter uptake, stimulus-response coupling, including signal transduction and secretion.

Biochemistry of Platelets

Biochemistry of Platelets
Author: David Phillips
Publsiher: Elsevier
Total Pages: 476
Release: 2012-12-02
ISBN 10: 0323148972
ISBN 13: 9780323148979
Language: EN, FR, DE, ES & NL

Biochemistry of Platelets Book Review:

Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation.

Clinical Application of Radiolabelled Platelets

Clinical Application of Radiolabelled Platelets
Author: C. Kessler,M.R. Hardeman,H. Henningsen,J. Petrovici
Publsiher: Springer Science & Business Media
Total Pages: 301
Release: 2012-12-06
ISBN 10: 9400905815
ISBN 13: 9789400905818
Language: EN, FR, DE, ES & NL

Clinical Application of Radiolabelled Platelets Book Review:

AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) were the first to publish a paper concerning the in vivo thrombus detection with 111- In-labelled platelets. Previous attempts at scintigraphic thrombus localisation had been disappointing because of the unspecific binding of a number of the isotopes used, as well as the poor labelling efficiency or an insufficient low gamma-emitting property. Because of its physical characteristics (2.8 days half-life, 94% gamma emission) 111 Indium turned out to be the best isotope for platelet kinetic studies as well as for the measurement of platelet incorporation by Thrombi to be used up until now. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets without altering the function or the life span of the platelets. This advantage has let to an increase in the clinical applications of 1211-In labelled platelets. Today, radiolabelled platelets are used for thrombus detection in several different medical areas such as cardiology, nephrology. angiology or neurology. Even though many scientists and hospital doctors now routinely use radiolabelled platelet as a diagnostic tool, there is as yet not a standardized labelling method. In addition to this, there are neither standardized image procedures for the different clinical applications nor an agreement about specificity and sensitivity of the method. In 1983, a symposium on Radiolabelled Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and M.D.

Platelets in Cardiovascular Disease

Platelets in Cardiovascular Disease
Author: Deepak L. Bhatt
Publsiher: Imperial College Press
Total Pages: 218
Release: 2008
ISBN 10: 186094826X
ISBN 13: 9781860948268
Language: EN, FR, DE, ES & NL

Platelets in Cardiovascular Disease Book Review:

Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine.Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease.Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful.

The Non Thrombotic Role of Platelets in Health and Disease

The Non Thrombotic Role of Platelets in Health and Disease
Author: Steve W. Kerrigan,Niamh Moran
Publsiher: BoD – Books on Demand
Total Pages: 248
Release: 2015-11-18
ISBN 10: 9535122088
ISBN 13: 9789535122081
Language: EN, FR, DE, ES & NL

The Non Thrombotic Role of Platelets in Health and Disease Book Review:

Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Platelets and Megakaryocytes

Platelets and Megakaryocytes
Author: Jonathan M. Gibbins,Martyn P. Mahaut-Smith
Publsiher: Humana Press
Total Pages: 504
Release: 2010-11-10
ISBN 10: 9781617373053
ISBN 13: 1617373052
Language: EN, FR, DE, ES & NL

Platelets and Megakaryocytes Book Review:

12 The average human body has on the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in Western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well-established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Role of the Cytoskeleton in Platelet Structure and Function

Role of the Cytoskeleton in Platelet Structure and Function
Author: Joseph C. Loftus
Publsiher: Unknown
Total Pages: 412
Release: 1984
ISBN 10:
ISBN 13: WISC:89011554391
Language: EN, FR, DE, ES & NL

Role of the Cytoskeleton in Platelet Structure and Function Book Review:

Platelets as Immune Cells in Physiology and Immunopathology

Platelets as Immune Cells in Physiology and Immunopathology
Author: Olivier Garraud
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2016-01-05
ISBN 10: 2889197409
ISBN 13: 9782889197408
Language: EN, FR, DE, ES & NL

Platelets as Immune Cells in Physiology and Immunopathology Book Review:

Are platelets cells? (Not everyone agrees, since they are non-nucleate). And if platelets are cells - which all specialists consider at the time being - are they immune cells? The issue that platelets participate in immunity is no longer debated; however, the issue that they are key cells in immunity is challenged. It has even been proposed a couple of years ago that platelets can present antigen to T-lymphocytes by using their HLA class I molecules. No one has the same functional definition of platelets. The ‘Frontiers Research Topic’- coordinators’ own view is that platelets are primarily repairing cells, what they do in deploying tools of physiological inflammation. This function is better acknowledged as primary hemostasis, i.e. platelet adherence to injured or wounded vessels, followed by activation, aggregation, and constitution of the initial clot. Platelets would thus repair damaged vascular endothelium; so doing, as they patrol to detect damages, they sense danger along the vascular arborescence. As the latter is immense, platelets get close to tissues, which are not allowed to them under ‘physiological’ conditions but are readily accessible in pathology. Platelets are equipped with a variety of Pathogen Recognition Receptors such as TLRs; they have a complete signalosome, which is functional until the phosphorylation of NFkB; they have been proved to retro-transcribe RNA and synthesize de novo proteins; etc. Platelets participate to inflammation along the whole spectrum: from physiological (tissue repair, healing) to acute/severe inflammation (as can be seen in e.g. sepsis). In general, platelets engage complex interactions with most infectious pathogens. We propose there to cover those topics - from physiology to pathology, that put platelets within cells that not only take place in-, but also are key players of-, innate immunity. The relation of platelets with adaptive immunity is even more complex. Not everyone is convinced that platelets present antigens; however, platelets influence adaptive immunity since they have mutual interactions with Dendritic cells, Monocytes/Macrophages, and B-lymphocytes (the key players of antigen presentation); they also have mutual interactions with T-lymphocytes, though is issue is less clearly deciphered. We propose to also cover these topics - or to present the forum. There is another issue which is medically relevant - speaking of physiology/physiopathology-: this is fetal maternal incompatibility of platelet specific antigens (the HPA system) and the likely formation of maternal antibodies that often injure the newborn with risks of severe thrombocytopenia and intracranial hemorrhage. We propose an update on this issue as well. Last, platelets are very special because they can be directly therapeutic (by transfusion), even when being offered by a generous blood donor displaying given genetic and phenotypic parameters to a patient/recipient in need, who also display his/her own genetic and phenotypic parameters, which - for a large part - differ from the donor's ones. Besides immunization - via mechanisms probably close to the fetal maternal platelet incompatibility, but likely not similar -, transfusion has allowed the identification of the tremendous capacity of platelets to mediate inflammation: we propose to conclude the Topics with this item/forum.

The Circulating Platelet

The Circulating Platelet
Author: Louis M. Aledort
Publsiher: Unknown
Total Pages: 601
Release: 1971
ISBN 10:
ISBN 13: UOM:39015006710472
Language: EN, FR, DE, ES & NL

The Circulating Platelet Book Review:

Platelets and Thrombosis

Platelets and Thrombosis
Author: Physiological Society of Philadelphia
Publsiher: Unknown
Total Pages: 332
Release: 1974
ISBN 10:
ISBN 13: UOM:39015002418856
Language: EN, FR, DE, ES & NL

Platelets and Thrombosis Book Review:

The Circulating Platelet

The Circulating Platelet
Author: Shirley A. Johnson
Publsiher: Elsevier
Total Pages: 622
Release: 2012-12-02
ISBN 10: 0323144322
ISBN 13: 9780323144322
Language: EN, FR, DE, ES & NL

The Circulating Platelet Book Review:

The Circulating Platelet focuses on the biochemistry and physiology of platelets. Composed of contributions of authors, the compilation starts with the discussions on the origin, discovery, production, and life span of blood platelets. The discussions continue with the morphology of platelets. Concerns include peripheral, sol-gel, and organelle zones and the membrane systems. The book also looks at the energy metabolism of thrombocytes and highlights the presence of glycoproteins in blood platelets. These include polysaccharides, glucosaminoglycans, and glycoproteins. The text also discusses the properties, functions, and the physiological value of thrombosthenin. The compilation further discusses platelet aggregation and functions of platelets. Concerns include collection and processing of platelets; preparation of homogenates; and the agents that influence platelet aggregation. The role of platelets in blood clots and fibrinolysis is emphasized. The selection ends with discussions on the immunological reactions of platelets; the clinical diseases related to blood platelets; and blood transfusion and preservation. The text is vital for researchers interested in studying blood platelets.

Platelets and Their Factors

Platelets and Their Factors
Author: Franz von Bruchhausen,Ulrich Walter
Publsiher: Springer Science & Business Media
Total Pages: 753
Release: 2012-12-06
ISBN 10: 3642606393
ISBN 13: 9783642606397
Language: EN, FR, DE, ES & NL

Platelets and Their Factors Book Review:

Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.