Piperidine Based Drug Discovery

Piperidine Based Drug Discovery
Author: Ruben Vardanyan
Publsiher: Elsevier
Total Pages: 358
Release: 2017-06-12
ISBN 10: 0128134283
ISBN 13: 9780128134283
Language: EN, FR, DE, ES & NL

Piperidine Based Drug Discovery Book Review:

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Fragment based Drug Discovery

Fragment based Drug Discovery
Author: Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Publsiher: John Wiley & Sons
Total Pages: 528
Release: 2016-02-23
ISBN 10: 352733775X
ISBN 13: 9783527337750
Language: EN, FR, DE, ES & NL

Fragment based Drug Discovery Book Review:

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science
Author: Dr. Inamuddin,Rajender Boddula,Mohd Imran Ahamed,Abdullah M. Asiri
Publsiher: Elsevier
Total Pages: 374
Release: 2020-12-01
ISBN 10: 0128218991
ISBN 13: 9780128218990
Language: EN, FR, DE, ES & NL

Green Sustainable Process for Chemical and Environmental Engineering and Science Book Review:

Green Sustainable Process for Chemical and Environmental Engineering and Science: Solvents for the Pharmaceutical Industry aims at providing a detailed overview of applications of green solvents in pharmaceutical industries. It also focuses on providing a detailed literature survey on the green solvents for pharmaceutical analysis, drug design, synthesis, and production, etc. It summarizes the applications of various greens solvents such as water, cyrene, vegetable oils, ionic liquids, ethyl lactate, eutectic solvents, and glycerol in contrast to toxic solvents. This book provides an overview of the use of green solvents for the sustainable and environmentally friendly development of synthetic methodologies for biomedical and pharmaceutical industries. Up-to-date developments towards the development of solvents for pharmaceutical industry Includes latest advances in pharmaceutical analysis and synthesis using green solvents Outlines eco-friendly green solvents for medicinal applications State-of-the-art overview on the exploration of green solvents for pharmaceutical industries

Carbohydrate based Drug Discovery 2 Volume Set

Carbohydrate based Drug Discovery  2 Volume Set
Author: Chi-Huey Wong
Publsiher: Wiley-VCH
Total Pages: 947
Release: 2003-10-17
ISBN 10:
ISBN 13: UOM:39015053020254
Language: EN, FR, DE, ES & NL

Carbohydrate based Drug Discovery 2 Volume Set Book Review:

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Structure based Design of Drugs and Other Bioactive Molecules

Structure based Design of Drugs and Other Bioactive Molecules
Author: Arun K. Ghosh,Sandra Gemma
Publsiher: John Wiley & Sons
Total Pages: 474
Release: 2014-08-11
ISBN 10: 3527333657
ISBN 13: 9783527333653
Language: EN, FR, DE, ES & NL

Structure based Design of Drugs and Other Bioactive Molecules Book Review:

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.

Synthesis of Essential Drugs

Synthesis of Essential Drugs
Author: Ruben Vardanyan,Victor Hruby
Publsiher: Elsevier
Total Pages: 634
Release: 2006-03-10
ISBN 10: 9780080462127
ISBN 13: 008046212X
Language: EN, FR, DE, ES & NL

Synthesis of Essential Drugs Book Review:

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

Privileged Scaffolds in Medicinal Chemistry

Privileged Scaffolds in Medicinal Chemistry
Author: Stefan Bräse
Publsiher: Royal Society of Chemistry
Total Pages: 468
Release: 2015-11-20
ISBN 10: 1782620303
ISBN 13: 9781782620303
Language: EN, FR, DE, ES & NL

Privileged Scaffolds in Medicinal Chemistry Book Review:

One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be described as privileged in the sense that it is especially effective at altering the course of disease. Other privileged molecular structures have since been discovered, and since these compounds are so effective at interacting with numerous classes of proteins, they may be an effective starting point to look for new drugs against the supposedly "undruggable" proteins. Following introductory chapters presenting an overview, a historical perspective and the theoretical background and findings, main chapters describe the structure of privileged structures in turn and discuss major drug classes associated with them and their syntheses. This book provides comprehensive coverage of the subject through chapters contributed by expert authors from both academia and industry and will be an excellent reference source for medicinal chemists of a range of disciplines and experiences.

Synthesis of Best Seller Drugs

Synthesis of Best Seller Drugs
Author: Ruben Vardanyan,Victor Hruby
Publsiher: Academic Press
Total Pages: 868
Release: 2016-01-07
ISBN 10: 0124115241
ISBN 13: 9780124115248
Language: EN, FR, DE, ES & NL

Synthesis of Best Seller Drugs Book Review:

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Methods and Techniques in Drug Discovery

Methods and Techniques in Drug Discovery
Author: John Sterling,Ellyn J. T. D. Kerr,Shannon Simons
Publsiher: Unknown
Total Pages: 266
Release: 2005
ISBN 10:
ISBN 13: STANFORD:36105114585073
Language: EN, FR, DE, ES & NL

Methods and Techniques in Drug Discovery Book Review:

Structure Function Analysis of G Protein Coupled Receptors

Structure Function Analysis of G Protein Coupled Receptors
Author: Jürgen Wess
Publsiher: Wiley-Liss
Total Pages: 440
Release: 1999-06-15
ISBN 10: 9780471252283
ISBN 13: 047125228X
Language: EN, FR, DE, ES & NL

Structure Function Analysis of G Protein Coupled Receptors Book Review:

G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity. This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters. Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes: * An overview of mutagenesis techniques * Examples of molecular modeling techniques * Using peptides as tools for the study of GPCR interactions * Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin * A complete description of the electron-crystalographic analysis of two-dimensional rhodopsin crystals * The use of nuclear magnetic resonance techniques to study GPCR structure

Fragment based Approaches in Drug Discovery

Fragment based Approaches in Drug Discovery
Author: Wolfgang Jahnke,Daniel A. Erlanson
Publsiher: John Wiley & Sons
Total Pages: 391
Release: 2006-12-13
ISBN 10: 3527608605
ISBN 13: 9783527608607
Language: EN, FR, DE, ES & NL

Fragment based Approaches in Drug Discovery Book Review:

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
Author: Jie Jack Li
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2013-04-26
ISBN 10: 1118354435
ISBN 13: 9781118354438
Language: EN, FR, DE, ES & NL

Heterocyclic Chemistry in Drug Discovery Book Review:

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Pyridine

Pyridine
Author: Pratima Parashar Pandey
Publsiher: BoD – Books on Demand
Total Pages: 84
Release: 2018-07-18
ISBN 10: 1789234220
ISBN 13: 9781789234220
Language: EN, FR, DE, ES & NL

Pyridine Book Review:

This book is designed and styled in order to give researchers a vast horizon about pyridine. A deep look in the structural analysis of pyridine provides a base for all the building blocks derived from it and its applications. Pyridines and pyridine moieties are found in many natural products, such as vitamins, coenzymes, alkaloids, many drugs, and pesticides. The book is divided into three parts: the first takes to the introduction, the second part deals with composition of various compounds using heterocyclic ring of pyridine, and the third part discusses about applications of pyridine compounds.

Directory of Graduate Research

Directory of Graduate Research
Author: American Chemical Society. Committee on Professional Training
Publsiher: Unknown
Total Pages: 329
Release: 2005
ISBN 10:
ISBN 13: UCSD:31822036045805
Language: EN, FR, DE, ES & NL

Directory of Graduate Research Book Review:

Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

Medicinal Chemistry and Drug Discovery Nervous system agents

Medicinal Chemistry and Drug Discovery  Nervous system agents
Author: Alfred Burger
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: UOM:39015056276895
Language: EN, FR, DE, ES & NL

Medicinal Chemistry and Drug Discovery Nervous system agents Book Review:

Diversity Oriented Synthesis

Diversity Oriented Synthesis
Author: Andrea Basso,Seung Bum Park,Lisa Moni
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-03-22
ISBN 10: 2889457885
ISBN 13: 9782889457885
Language: EN, FR, DE, ES & NL

Diversity Oriented Synthesis Book Review:

Has the concept of Diversity Oriented Synthesis remained unchanged over these two decades, or do we observe improvements or deviations from the original guidelines drawn by the pioneers? The aim of this Research Topic is to collect contributions on the state-of-the-art and progress of Diversity Oriented Synthesis, and to foresee its shape in the next decade.

Peptides as Drugs

Peptides as Drugs
Author: Bernd Groner
Publsiher: John Wiley & Sons
Total Pages: 242
Release: 2009-11-18
ISBN 10: 3527626840
ISBN 13: 9783527626847
Language: EN, FR, DE, ES & NL

Peptides as Drugs Book Review:

By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.

Medicinal Chemistry and Drug Discovery Cardiovascular agents and endocrines

Medicinal Chemistry and Drug Discovery  Cardiovascular agents and endocrines
Author: Alfred Burger
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: UOM:39015056276929
Language: EN, FR, DE, ES & NL

Medicinal Chemistry and Drug Discovery Cardiovascular agents and endocrines Book Review:

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry
Author: Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
Publsiher: Elsevier
Total Pages: 902
Release: 2015-07-01
ISBN 10: 012417213X
ISBN 13: 9780124172135
Language: EN, FR, DE, ES & NL

The Practice of Medicinal Chemistry Book Review:

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery
Author: Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Publsiher: MDPI
Total Pages: 406
Release: 2020-03-13
ISBN 10: 3039282883
ISBN 13: 9783039282883
Language: EN, FR, DE, ES & NL

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery Book Review:

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.