Phytochemicals as Lead Compounds for New Drug Discovery

Phytochemicals as Lead Compounds for New Drug Discovery
Author: Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Publsiher: Elsevier
Total Pages: 378
Release: 2019-09-07
ISBN 10: 0128178914
ISBN 13: 9780128178911
Language: EN, FR, DE, ES & NL

Phytochemicals as Lead Compounds for New Drug Discovery Book Review:

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Anticancer Drug Development

Anticancer Drug Development
Author: Bruce C. Baguley,David J. Kerr
Publsiher: Elsevier
Total Pages: 397
Release: 2001-11-17
ISBN 10: 9780080490441
ISBN 13: 0080490441
Language: EN, FR, DE, ES & NL

Anticancer Drug Development Book Review:

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Plant Bioactives and Drug Discovery

Plant Bioactives and Drug Discovery
Author: Valdir Cechinel-Filho
Publsiher: John Wiley & Sons
Total Pages: 586
Release: 2012-04-11
ISBN 10: 1118259920
ISBN 13: 9781118259924
Language: EN, FR, DE, ES & NL

Plant Bioactives and Drug Discovery Book Review:

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Nanobiotechnology in Bioformulations

Nanobiotechnology in Bioformulations
Author: Ram Prasad,Vivek Kumar,Manoj Kumar,Devendra Choudhary
Publsiher: Springer
Total Pages: 491
Release: 2019-07-04
ISBN 10: 3030170616
ISBN 13: 9783030170615
Language: EN, FR, DE, ES & NL

Nanobiotechnology in Bioformulations Book Review:

With the recent shift of chemical fertilizers and pesticides to organic agriculture, the employment of microbes that perform significant beneficial functions for plants has been highlighted. This book presents timely discussion and coverage on the use of microbial formulations, which range from powdered or charcoal-based to solution and secondary metabolite-based bioformulations. Bioformulation development of biofertilizers and biopesticides coupled with the advantages of nanobiotechnology propose significant applications in the agricultural section including nanobiosensors, nanoherbicides, and smart transport systems for the regulated release of agrochemical. Moreover, the formulation of secondary metabolites against individual phytopathogens could be used irrespective of geographical positions with higher disease incidences. The prospective advantages and uses of nanobiotechnology generate tremendous interest, as it could augment production of agricultural produce while being cost-effective both energetically and economically. This bioformulation approach is incomparable to existing technology, as the bioformulation would explicitly target the particular pathogen without harming the natural microbiome of the ecosystem. Nanobiotechnology in Bioformulations covers the constraints associated with large-scale development and commercialization of bioinoculant formations. Furthermore, exclusive emphasis is be placed on next-generation efficient bioinoculants having secondary metabolite formulations with longer shelf life and advanced competence against several phytopathogens. Valuable chapters deal with bioformulation strategies that use divergent groups of the microbiome and include detailed diagrammatic and pictorial representation. This book will be highly beneficial for both experts and novices in the fields of microbial bioformulation, nanotechnology, and nano-microbiotechnology. It discusses the prevailing status and applications available for microbial researchers and scientists, agronomists, students, environmentalists, agriculturists, and agribusiness professionals, as well as to anyone devoted to sustaining the ecosystem.

Phytochemicals

Phytochemicals
Author: Venketeshwer Rao,Leticia Rao
Publsiher: BoD – Books on Demand
Total Pages: 350
Release: 2015-09-30
ISBN 10: 9535121707
ISBN 13: 9789535121701
Language: EN, FR, DE, ES & NL

Phytochemicals Book Review:

Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.

Using Old Solutions to New Problems

Using Old Solutions to New Problems
Author: Marianna Kulka
Publsiher: BoD – Books on Demand
Total Pages: 426
Release: 2013-06-19
ISBN 10: 9535111582
ISBN 13: 9789535111580
Language: EN, FR, DE, ES & NL

Using Old Solutions to New Problems Book Review:

The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a collection of an expert team of agronomists, chemists, biologists and policy makers who discuss some of the processes involved in developing a naturally-sourced bioactive compound into a drug therapy. These experts define a natural compound and elucidate the processes required to find, extract and define a naturally-derived bioactive molecule. Finally, they describe the necessity for understanding the fundamental mechanisms of disease before applying bioactive molecules in bioassay-guided drug discovery platforms.

Bioactive Compounds from Natural Sources Second Edition

Bioactive Compounds from Natural Sources  Second Edition
Author: Corrado Tringali
Publsiher: CRC Press
Total Pages: 648
Release: 2011-09-27
ISBN 10: 1439822298
ISBN 13: 9781439822296
Language: EN, FR, DE, ES & NL

Bioactive Compounds from Natural Sources Second Edition Book Review:

The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.

Phytochemicals

Phytochemicals
Author: Toshiki Asao,Md Asaduzzaman
Publsiher: BoD – Books on Demand
Total Pages: 218
Release: 2018-11-07
ISBN 10: 1789843774
ISBN 13: 9781789843774
Language: EN, FR, DE, ES & NL

Phytochemicals Book Review:

Phytochemicals provides original research work and reviews on the sources of phytochemicals, and their roles in disease prevention, supplementation, and accumulation in fruits and vegetables. The roles of anthocyanin, flavonoids, carotenoids, and taxol are presented in separate chapters. Antioxidative and free radicle scavenging activity of phytochemicals is also discussed. The medicinal properties of Opuntia, soybean, sea buckthorn, and gooseberry are presented in a number of chapters. Supplementation of plant extract with phytochemical properties in broiler meals is discussed in one chapter. The final two chapters include the impact of agricultural practices and novel processing technologies on the accumulation of phytochemicals in fruits and vegetables. This book mainly focuses on medicinal plants and the disease-preventing properties of phytochemicals, which will be a useful resource to the reader.

Advances in Drug Discovery Techniques

Advances in Drug Discovery Techniques
Author: Alan L. Harvey
Publsiher: CRC Press
Total Pages: 222
Release: 1998-08-15
ISBN 10: 9780471975090
ISBN 13: 0471975095
Language: EN, FR, DE, ES & NL

Advances in Drug Discovery Techniques Book Review:

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

Phytochemistry the Military and Health

Phytochemistry  the Military and Health
Author: Andrew G. Mtewa,Chukwuebuka Egbuna
Publsiher: Elsevier
Total Pages: 606
Release: 2021-03-15
ISBN 10: 0128232307
ISBN 13: 9780128232309
Language: EN, FR, DE, ES & NL

Phytochemistry the Military and Health Book Review:

Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses comes as a response to the gap that there has for so long existed between phytochemistry and survival of both service personnel and civilian communities during and after conflicts. Armed conflicts cause a lot of devastation to communities and should be avoided as much as it can be possible. The devastation is usually evident in service provisions such as Health, Education, Water, and Food among many others. Both service personnel and civilians are affected to various degrees. Facilities usually end up being physically destroyed, with no essential supplies and/or having dysfunctional systems. Going with untreated wounds, communicable and non-communicable diseases for weeks with no medical interventions due to the conflicts, disease burdens heavily weigh down on communities as well as security personnel. To make the situation even more complicated, masses of people are forced to migrate for safety and security reasons, likely going with diseases along wherever they go. In such instances, phytochemicals become handy in providing solutions from first aid, basic analgesia, antimicrobials, and the general improvement of health. Phytochemicals are known to play a major role in the day to day management of diseases and health. There has been much research into their effectiveness as community medicines and as alternatives to conventional drugs. However, the role that phytochemicals play in the military, counterterrorism, and security has been overlooked. Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses discusses the roles that phytochemicals play as friends and foes in the military, including insights aimed to help develop antidotes against phytochemicals and other chemical agents used maliciously as weapons. Filling a gap between drug discovery, security, and emergency medicine, this book describes which plants can be categorized for protection and controls, which can be helpful in times of conflicts and soon after conflicts, in military operations, and those that can be used as deterrents and as emergency medicines. Carefully designed to show the contribution that phytochemicals play in safety and security, this book is useful for researchers, regulators and anyone interested in plant chemistry. Covers the contribution that phytochemicals play in safety and security Contains insights that will help in the development of antidotes against phytochemical and other chemical weapons Categorizes plants in terms of their usefulness as well as the potential security risks they possess

Modern Phytomedicine

Modern Phytomedicine
Author: Iqbal Ahmad,Farrukh Aqil,Mohammad Owais
Publsiher: John Wiley & Sons
Total Pages: 404
Release: 2006-12-13
ISBN 10: 3527609539
ISBN 13: 9783527609536
Language: EN, FR, DE, ES & NL

Modern Phytomedicine Book Review:

This timely and original handbook paves the way to success in plant-based drug development, systematically addressing the issues facing a pharmaceutical scientist who wants to turn a plant compound into a safe and effective drug. Plant pharmacologists from around the world demonstrate the potentials and pitfalls involved, with many of the studies and experiments reported here published for the first time. The result is a valuable source of information unavailable elsewhere.

Himalayan Phytochemicals

Himalayan Phytochemicals
Author: Sumira Jan,Nazia Abbas
Publsiher: Elsevier
Total Pages: 316
Release: 2018-04-10
ISBN 10: 0081022360
ISBN 13: 9780081022368
Language: EN, FR, DE, ES & NL

Himalayan Phytochemicals Book Review:

Himalayan Phytochemicals: Sustainable Options for Sourcing and Developing Bioactive Compounds provides a detailed review of the important medicinal plants which have already been discovered in the Himalayan region, outlining their discovery, activity and underlying chemistry. In addition, it supports a global shift towards sustainable sourcing of natural products from delicate ecosystems. Across the world, environmental destruction and overharvesting of medicinal plants are reducing and destroying multiple important sources and potential leads before researchers have the chance to discover, explore or synthesize them effectively. By identifying this problem and discussing its impact on the Himalayan region, Himalayan Phytochemicals: Sustainable Options for Sourcing and Developing Bioactive Compounds frames the ongoing global struggle and highlights the key factors that must be considered and addressed when working with phytochemicals from endemic plant sources. Reviews both well-known and recently discovered plants of this region Highlights methods for phytochemical extraction and analysis Provides context to support a shift towards sustainable sourcing of natural products

Drug Development for Cancer and Diabetes

Drug Development for Cancer and Diabetes
Author: K. Saravanan,Chukwuebuka Egbuna,Horne Iona Averal,S. Kannan,S. Elavarasi,Bir Bahadur
Publsiher: CRC Press
Total Pages: 362
Release: 2020-08-30
ISBN 10: 1000639983
ISBN 13: 9781000639988
Language: EN, FR, DE, ES & NL

Drug Development for Cancer and Diabetes Book Review:

Key features include: Details the role of plants for the treatment and management of cancer and diabetes Discusses the role of phytocompounds as ligands for cancer and diabetic targets Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs Explores the green biosynthesis of nanoparticles and their treatment efficiency

Natural Products and Drug Discovery

Natural Products and Drug Discovery
Author: Pinarosa Avato
Publsiher: MDPI
Total Pages: 392
Release: 2020-04-22
ISBN 10: 303928746X
ISBN 13: 9783039287468
Language: EN, FR, DE, ES & NL

Natural Products and Drug Discovery Book Review:

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Natural Products and Cancer Drug Discovery

Natural Products and Cancer Drug Discovery
Author: Farid A. Badria
Publsiher: BoD – Books on Demand
Total Pages: 316
Release: 2017-07-05
ISBN 10: 9535133136
ISBN 13: 9789535133131
Language: EN, FR, DE, ES & NL

Natural Products and Cancer Drug Discovery Book Review:

This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.

Medicinal Plants and Malaria

Medicinal Plants and Malaria
Author: Woon-Chien Teng,Ho Han Kiat,Rossarin Suwanarusk,Hwee-Ling Koh
Publsiher: CRC Press
Total Pages: 500
Release: 2016-01-06
ISBN 10: 1498744699
ISBN 13: 9781498744690
Language: EN, FR, DE, ES & NL

Medicinal Plants and Malaria Book Review:

Malaria is a potentially life-threatening disease that affects millions worldwide, especially in Sub-Saharan Africa. The recent emergence and spread of multidrug resistance in parts of Southeast Asia prompts the urgent need for novel and effective therapy against the disease. Medicinal Plants and Malaria: Applications, Trends, and Prospects highlig

Evolutionary Ethnobiology

Evolutionary Ethnobiology
Author: Ulysses Paulino Albuquerque,Patrícia Muniz De Medeiros,Alejandro Casas
Publsiher: Springer
Total Pages: 204
Release: 2015-09-23
ISBN 10: 331919917X
ISBN 13: 9783319199177
Language: EN, FR, DE, ES & NL

Evolutionary Ethnobiology Book Review:

Ethnobiology is a fascinating science. To understand this vocation it needs to be studied under an evolutionary point of view that is very strong and significant, although this aspect is often poorly approached in the literature. This is the first book to compile and discuss information about evolutionary ethnobiology in English.

Current Topics in Malaria

Current Topics in Malaria
Author: Alfonso J. Rodriguez-Morales
Publsiher: Unknown
Total Pages: 506
Release: 2016-11-30
ISBN 10: 9535127896
ISBN 13: 9789535127895
Language: EN, FR, DE, ES & NL

Current Topics in Malaria Book Review:

Bioassay Methods in Natural Product Research and Drug Development

Bioassay Methods in Natural Product Research and Drug Development
Author: Lars Bohlin,Jan G. Bruhn
Publsiher: Springer Science & Business Media
Total Pages: 203
Release: 2012-12-06
ISBN 10: 9401148104
ISBN 13: 9789401148108
Language: EN, FR, DE, ES & NL

Bioassay Methods in Natural Product Research and Drug Development Book Review:

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Natural Compounds as Drugs

Natural Compounds as Drugs
Author: Frank Petersen,René Amstutz
Publsiher: Springer Science & Business Media
Total Pages: 372
Release: 2007-12-27
ISBN 10: 9783764381172
ISBN 13: 3764381175
Language: EN, FR, DE, ES & NL

Natural Compounds as Drugs Book Review:

In a real tour de force of pharmacological literature, this edited volume’s chapters highlight the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such complex chemical information, what makes them unique, as they often are, and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.