Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
Author: F. Javier Alvarez-Leefmans,Eric Delpire
Publsiher: Academic Press
Total Pages: 630
Release: 2009-08-22
ISBN 10: 9780080922034
ISBN 13: 0080922031
Language: EN, FR, DE, ES & NL

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book Review:

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Cell Physiology Sourcebook

Cell Physiology Sourcebook
Author: Nicholas Sperelakis
Publsiher: Academic Press
Total Pages: 970
Release: 2012-01
ISBN 10: 0123877385
ISBN 13: 9780123877383
Language: EN, FR, DE, ES & NL

Cell Physiology Sourcebook Book Review:

This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Fourth Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. Authored by leading researchers in the field Clear, concise, and comprehensive coverage of all aspects of cellular physiology, from fundamental concepts to more advanced topics Full color illustrations

Ion Channels and Transporters of Epithelia in Health and Disease

Ion Channels and Transporters of Epithelia in Health and Disease
Author: Kirk L. Hamilton,Daniel C Devor
Publsiher: Springer
Total Pages: 1019
Release: 2015-12-14
ISBN 10: 1493933663
ISBN 13: 9781493933662
Language: EN, FR, DE, ES & NL

Ion Channels and Transporters of Epithelia in Health and Disease Book Review:

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.

The olivo cerebellar system

The olivo cerebellar system
Author: Egidio D'Angelo,Elisa Galliano,Chris I De Zeeuw
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2016-04-29
ISBN 10: 288919826X
ISBN 13: 9782889198269
Language: EN, FR, DE, ES & NL

The olivo cerebellar system Book Review:

During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well as in other major brain circuits, is how single neurons and synaptic properties emerge at the network level and contribute to behavioural regulation via neuronal plasticity. Other major aspects that this Research Topic covers and discusses include the development and circuit organization of the olivo-cerebellar network, the established and recent theories of learning and motor control, and the emerging role of the cerebellum in cognitive processing. By touching on such varied and encompassing subjects, this Frontiers Special Topic aims to highlight the state of the art and stimulate future research. We hope that this unique collection of high-quality articles from experts in the field will provide scientists with a powerful basis of knowledge and inspiration to enucleate the major issues deserving further attention.

Chloride Movements Across Cellular Membranes

Chloride Movements Across Cellular Membranes
Author: Anonim
Publsiher: Elsevier
Total Pages: 392
Release: 2011-09-22
ISBN 10: 9780080475349
ISBN 13: 0080475345
Language: EN, FR, DE, ES & NL

Chloride Movements Across Cellular Membranes Book Review:

All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and interest-gaining field of membrane transport. It is addressed at a broad medically, physiologically, biologically, and biophysically interested readership. Describes the state-of-the-art in anion transport research Written by leaders in the field Presents a timely discussion of this rapidly emerging and expanding field

Astrocytes in Patho Physiology of the Nervous System

Astrocytes in  Patho Physiology of the Nervous System
Author: Vladimir Parpura,Philip G. Haydon
Publsiher: Springer Science & Business Media
Total Pages: 738
Release: 2008-12-11
ISBN 10: 9780387794921
ISBN 13: 0387794921
Language: EN, FR, DE, ES & NL

Astrocytes in Patho Physiology of the Nervous System Book Review:

Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.

Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
Author: Xin Tang
Publsiher: Academic Press
Total Pages: 650
Release: 2020-06
ISBN 10: 9780128153185
ISBN 13: 0128153180
Language: EN, FR, DE, ES & NL

Neuronal Chloride Transporters in Health and Disease Book Review:

Neuronal Chloride Transporters in Health and Disease introduces core concepts and recent advances surrounding the physiology and pathophysiology of neuronal chloride transporters, with particular focus on the KCC and NKCC families of proteins. Chloride transporter biology is reviewed, including its role in setting the transmembrane chloride gradient and in chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters also address post-translational modifications and the trafficking of chloride transporters, protein interaction partners, and the genetic and environmental factors that regulate expression in neurons. This new volume will provide readers with an up-to-date summary on recent advances in neuronal chloride transporter research, with a particular emphasis on key and emerging topics in the field.

The British National Bibliography

The British National Bibliography
Author: Arthur James Wells
Publsiher: Anonim
Total Pages: 329
Release: 2009
ISBN 10:
ISBN 13: STANFORD:36105211722686
Language: EN, FR, DE, ES & NL

The British National Bibliography Book Review:

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
Author: Venkataramana K Sidhaye,Michael Koval
Publsiher: Academic Press
Total Pages: 276
Release: 2017-03-09
ISBN 10: 0128038810
ISBN 13: 9780128038819
Language: EN, FR, DE, ES & NL

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease Book Review:

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Viral Gastroenteritis

Viral Gastroenteritis
Author: U. Desselberger,Jim Gray,J. Gray
Publsiher: Gulf Professional Publishing
Total Pages: 707
Release: 2003-08-22
ISBN 10: 9780444514448
ISBN 13: 0444514449
Language: EN, FR, DE, ES & NL

Viral Gastroenteritis Book Review:

Viruses are increasingly recognised as the cause of acute gastroenteritis in man, particularly in children. This book provides overviews and updates on current issues relating to basic research, clinical diagnosis, immunology, epidemiology, treatment and prevention of infections with gastroenteritis viruses. Data are presented and interpreted by leading research groups in 33 chapters spread over 6 sections. The book will be of interest to virologists, gut physiologists, immunologists, epidemiologists, vaccinologists, paediatricians and physicians (infectious diseases), and public health physicians. It will also capture the interests of medical and natural science students and postdoctoral scientists at various levels of their careers.

Guyton and Hall Textbook of Medical Physiology E Book

Guyton and Hall Textbook of Medical Physiology E Book
Author: John E. Hall
Publsiher: Elsevier Health Sciences
Total Pages: 1120
Release: 2010-07-19
ISBN 10: 1437726747
ISBN 13: 9781437726749
Language: EN, FR, DE, ES & NL

Guyton and Hall Textbook of Medical Physiology E Book Book Review:

The 12th edition of Guyton and Hall Textbook of Medical Physiology continues this bestselling title's long tradition as one of the world's favorite physiology textbooks. The immense success of this book is due to its description of complex physiologic principles in language that is easy to read and understand. Now with an improved color art program, thorough updates reflecting today's medicine and science, this textbook is an excellent source for mastering essential human physiology knowledge. Learn and remember vital concepts easily thanks to short, easy-to-read, masterfully edited chapters and a user-friendly full-color design. See core concepts applied to real-life situations with clinical vignettes throughout the text. Discover the newest in physiology with updates that reflect the latest advances in molecular biology, cardiovascular, neurophysiology and gastrointestinal topics. Visualize physiologic principles clearly with over 1000 bold, full-color drawings and diagrams. Distinguish core concepts from more in-depth material with a layout that uses gray shading to clearly differentiate between "need-to-know" and "nice-to-know" information.

Molecular Biochemistry and Physiology of Helminth Neuromuscular Systems

Molecular Biochemistry and Physiology of Helminth Neuromuscular Systems
Author: David Halton,Leslie H. Chappell
Publsiher: Cambridge University Press
Total Pages: 244
Release: 1997-06-13
ISBN 10: 9780521576376
ISBN 13: 0521576377
Language: EN, FR, DE, ES & NL

Molecular Biochemistry and Physiology of Helminth Neuromuscular Systems Book Review:

This collection of articles, edited by D. W. Halton, is the specially commissioned supplement to the journal Parasitology, volume 113.

GABA And Glutamate

GABA And Glutamate
Author: Janko Samardzic
Publsiher: BoD – Books on Demand
Total Pages: 138
Release: 2018-03-21
ISBN 10: 9535138219
ISBN 13: 9789535138211
Language: EN, FR, DE, ES & NL

GABA And Glutamate Book Review:

This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Seldin and Giebisch s The Kidney

Seldin and Giebisch s The Kidney
Author: Robert J. Alpern,Steven C. Hebert
Publsiher: Elsevier
Total Pages: 2928
Release: 2007-10-10
ISBN 10: 0080559506
ISBN 13: 9780080559506
Language: EN, FR, DE, ES & NL

Seldin and Giebisch s The Kidney Book Review:

A classic nephrology reference for over 20 years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch’s The Kidney is your number one source for information. * Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic. * Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics. * Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.

Handbook of Physiology The gastrointestinal system

Handbook of Physiology  The gastrointestinal system
Author: John R. Pappenheimer,American Physiological Society (1887- )
Publsiher: Anonim
Total Pages: 329
Release: 1991
ISBN 10:
ISBN 13: UCLA:L0064302896
Language: EN, FR, DE, ES & NL

Handbook of Physiology The gastrointestinal system Book Review:

Handbook of Physiology The gastrointestinal system v 1 pt 1 2 Motility and circulation

Handbook of Physiology  The gastrointestinal system  v  1  pt  1 2  Motility and circulation
Author: American Physiological Society (1887- )
Publsiher: Anonim
Total Pages: 329
Release: 1991
ISBN 10:
ISBN 13: STANFORD:36105009589990
Language: EN, FR, DE, ES & NL

Handbook of Physiology The gastrointestinal system v 1 pt 1 2 Motility and circulation Book Review:

Evolutionary Physiology and Biochemistry

Evolutionary Physiology and Biochemistry
Author: Multiple authors
Publsiher: BoD – Books on Demand
Total Pages: 242
Release: 2018-02-19
ISBN 10: 953513857X
ISBN 13: 9789535138570
Language: EN, FR, DE, ES & NL

Evolutionary Physiology and Biochemistry Book Review:

In 2016, it was 60 years since the eminent Soviet researcher, a disciple and a successor of Ivan Pavlov, Leon Orbeli had proclaimed the birth of a new branch of physiology, evolutionary physiology. In the same year, his ideas were embodied in the foundation in Leningrad, now Saint Petersburg, of the present Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences. This anniversary book includes the selected works carried out recently by his followers at the same institute. While addressing some hot aspects of evolutionary physiology and biochemistry, they demonstrate that this branch of physiology really represents a discipline in its own right.

Ion Channels in Health and Sickness

Ion Channels in Health and Sickness
Author: Fatima Shad Kaneez
Publsiher: BoD – Books on Demand
Total Pages: 202
Release: 2018-10-10
ISBN 10: 1789842271
ISBN 13: 9781789842272
Language: EN, FR, DE, ES & NL

Ion Channels in Health and Sickness Book Review:

Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

Handbook of Physiology

Handbook of Physiology
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 1977
ISBN 10:
ISBN 13: UCSD:31822005678990
Language: EN, FR, DE, ES & NL

Handbook of Physiology Book Review:

Physiology of Astroglia

Physiology of Astroglia
Author: Alexei Verkhratsky,Vladimir Parpura
Publsiher: Biota Publishing
Total Pages: 172
Release: 2015-03-01
ISBN 10: 1615046739
ISBN 13: 9781615046737
Language: EN, FR, DE, ES & NL

Physiology of Astroglia Book Review:

Astrocytes can be defined as the glia inhabiting the nervous system with the main function in the maintenance of nervous tissue homeostasis. Classified into several types according to their morphological appearance, many of astrocytes form a reticular structure known as astroglial syncytium, owing to their coupling via intercellular channels organized into gap junctions. Not only do astrocytes establish such homocellular contacts, but they also engage in intimate heterocellular interactions with neurons, most notably at synaptic sites. As synaptic structures house the very core of information transfer and processing in the nervous system, astroglial perisynaptic positioning assures that these glial cells can nourish neurons and establish bidirectional communication with them, functions outlined in the concepts of the astrocytic cradle and multi-partite synapse, respectively. Astrocytes possess a rich assortment of ligand receptors, ion and water channels, and ion and ligand transporters, which collectively contribute to astrocytic control of homeostasis and excitability. Astroglia control glutamate and adenosine homeostasis to exert modulatory actions affecting the real-time operation of synapses. Fluctuations of intracellular calcium can lead to the release of various chemical transmitters from astrocytes through a process termed gliotransmission. Sodium fluctuations are closely associated to those of calcium with both dynamic events interfacing signaling and metabolism. Astrocytes appear fully integrated into the brain cellular circuitry, being an indispensable part of neural networks.