pH Interfering Agents as Chemosensitizers in Cancer Therapy

pH Interfering Agents as Chemosensitizers in Cancer Therapy
Author: Claudiu Supuran,Simone Carradori
Publsiher: Academic Press
Total Pages: 228
Release: 2020-09-15
ISBN 10: 0128209283
ISBN 13: 9780128209288
Language: EN, FR, DE, ES & NL

pH Interfering Agents as Chemosensitizers in Cancer Therapy Book Review:

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Therapeutic Strategies to Overcome ALK Resistance in Cancer

Therapeutic Strategies to Overcome ALK Resistance in Cancer
Author: Luc Friboulet
Publsiher: Academic Press
Total Pages: 216
Release: 2021-01-18
ISBN 10: 0128217790
ISBN 13: 9780128217795
Language: EN, FR, DE, ES & NL

Therapeutic Strategies to Overcome ALK Resistance in Cancer Book Review:

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC

Carbonic Anhydrases

Carbonic Anhydrases
Author: Claudiu Supuran,Alessio Nocentini
Publsiher: Academic Press
Total Pages: 560
Release: 2019-07-17
ISBN 10: 0128167459
ISBN 13: 9780128167458
Language: EN, FR, DE, ES & NL

Carbonic Anhydrases Book Review:

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health. Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs. Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications Describes the current biotechnological applications of CAs, including processes for CO2 capture Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

Drug Allergy Testing

Drug Allergy Testing
Author: David Khan,Aleena Banerji
Publsiher: Elsevier Health Sciences
Total Pages: 250
Release: 2017-07-05
ISBN 10: 0323497071
ISBN 13: 9780323497077
Language: EN, FR, DE, ES & NL

Drug Allergy Testing Book Review:

With a focus on improving diagnosis and treatment, Drug Allergy Testing is your new go-to resource for understanding various drug allergies and testing methods, the epidemiology of and economic impact of drug allergies, and new drug and allergy developments. Features a wealth of up-to-date information for allergists, immunologists, and primary care physicians who diagnose and treat patients with drug allergies and hypersensitivity. Covers the basics of drug allergy evaluation and management as well as specific drugs including antibiotics, ASA/NSAIDs, chemotherapeutic agents and monoclonal antibodies.

Cancer Treatment

Cancer Treatment
Author: Letícia Rangel
Publsiher: BoD – Books on Demand
Total Pages: 630
Release: 2013-05-09
ISBN 10: 9535110985
ISBN 13: 9789535110989
Language: EN, FR, DE, ES & NL

Cancer Treatment Book Review:

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.

New Research Directions in DNA Repair

New Research Directions in DNA Repair
Author: Clark Chen
Publsiher: BoD – Books on Demand
Total Pages: 674
Release: 2013-05-22
ISBN 10: 9535111140
ISBN 13: 9789535111146
Language: EN, FR, DE, ES & NL

New Research Directions in DNA Repair Book Review:

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Drug Delivery Systems in Cancer Therapy

Drug Delivery Systems in Cancer Therapy
Author: Dennis M. Brown
Publsiher: Springer Science & Business Media
Total Pages: 390
Release: 2003-09-08
ISBN 10: 1592594271
ISBN 13: 9781592594276
Language: EN, FR, DE, ES & NL

Drug Delivery Systems in Cancer Therapy Book Review:

Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Pharmacology and Therapeutics

Pharmacology and Therapeutics
Author: Sivakumar Joghi Thatha Gowder
Publsiher: BoD – Books on Demand
Total Pages: 358
Release: 2014-07-02
ISBN 10: 9535116207
ISBN 13: 9789535116202
Language: EN, FR, DE, ES & NL

Pharmacology and Therapeutics Book Review:

The book "Pharmacology and Therapeutics" targets every aspect of the mechanisms for the chemical actions of both traditional and novel drugs. This book covers six sections: Molecular Modeling and Bio-molecular Pharmacology, Immunopharmacology, Environmental Pharmacology and Toxicology, Nanotechnology and Chemotherapy, Drugs and Drug Delivery System and Addiction Pharmacology. Each of these sections is interwoven with the theoretical aspects and experimental techniques of physiology, biochemistry, nutrition, cellular and molecular biology, microbiology, immunology, genetics, and pathology. This book will be a significant source to scientists, physicians, health care professionals and students who are interested to explore the effect of chemical agents on human life.

Macromolecular Anticancer Therapeutics

Macromolecular Anticancer Therapeutics
Author: L. Harivardhan Reddy,Patrick Couvreur
Publsiher: Springer Science & Business Media
Total Pages: 500
Release: 2010-03-20
ISBN 10: 9781441905079
ISBN 13: 1441905073
Language: EN, FR, DE, ES & NL

Macromolecular Anticancer Therapeutics Book Review:

In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations, intrinsic or acquired resistance to the treatment with currently available agents via genetic and epigenetic mechanisms, and toxicity. As a result, cancer therapy using conventional therapeutics and different types of treatment regimens using this therapeutics has not led to a convincing survival benefit of the patients. In this context, Macromolecular therapeutics offer several advantages over conventional low molecular therapeutics by various ways such as, enable the use of larger doses of these agents by limiting the toxicity, by enhanced permeability and retention into tumors, by tumor targeting using tumor-specific antibodies, by specific inhibition of oncogenes using anticancer oligonucleotides etc. Cancer treatment using this macromolecular therapeutics has considerably improved the survival benefit for patients. As a result, various macromolecular therapeutics are already commercialized or are under clinical development. Although we are far from a real magic bullet today, looking at the pace of research and current success in this field of macromolecular therapeutics, it appears that we are approaching a magic bullet for the efficient treatment of cancer. Thus, we believe that the subject of this book is very timely, and that the book will fill an unmet need in the market. This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience. Thus, in a nutshell, this book details the basics of cancer, and various therapeutic strategies such as those based on macromolecular therapeutics hence can become an important reference for practitioners, oncologists, medical pharmacologists, medicinal chemists, biomedical scientists, experimental pharmacologists, pharmaceutical technologists, and particularly it can essentially become a handbook of macromolecular therapeutics for cancer therapy for graduates, post-graduates and Ph.D. students in these fields.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author: Carmen Avendano,J. Carlos Menendez
Publsiher: Elsevier
Total Pages: 768
Release: 2015-06-11
ISBN 10: 0444626670
ISBN 13: 9780444626677
Language: EN, FR, DE, ES & NL

Medicinal Chemistry of Anticancer Drugs Book Review:

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Oncology Research Incorporating Anti cancer Drug Design

Oncology Research Incorporating Anti cancer Drug Design
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1998
ISBN 10:
ISBN 13: UCLA:L0078730751
Language: EN, FR, DE, ES & NL

Oncology Research Incorporating Anti cancer Drug Design Book Review:

Inflammation and Cancer

Inflammation and Cancer
Author: Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publsiher: Springer
Total Pages: 490
Release: 2014-05-12
ISBN 10: 3034808372
ISBN 13: 9783034808378
Language: EN, FR, DE, ES & NL

Inflammation and Cancer Book Review:

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Molecular Oncology Underlying Mechanisms and Translational Advancements

Molecular Oncology  Underlying Mechanisms and Translational Advancements
Author: Ammad Ahmad Farooqi,Muhammad Ismail
Publsiher: Springer
Total Pages: 302
Release: 2017-03-29
ISBN 10: 3319530828
ISBN 13: 9783319530826
Language: EN, FR, DE, ES & NL

Molecular Oncology Underlying Mechanisms and Translational Advancements Book Review:

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Anticancer Research

Anticancer Research
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1993
ISBN 10:
ISBN 13: NWU:35558003237993
Language: EN, FR, DE, ES & NL

Anticancer Research Book Review:

Ocular Transporters and Receptors

Ocular Transporters and Receptors
Author: Ashim K Mitra
Publsiher: Elsevier
Total Pages: 276
Release: 2013-10-31
ISBN 10: 190881831X
ISBN 13: 9781908818317
Language: EN, FR, DE, ES & NL

Ocular Transporters and Receptors Book Review:

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Drug Design of Zinc Enzyme Inhibitors

Drug Design of Zinc Enzyme Inhibitors
Author: Claudiu T. Supuran,Jean-Yves Winum
Publsiher: John Wiley & Sons
Total Pages: 1040
Release: 2009-10-22
ISBN 10: 9780470508152
ISBN 13: 0470508159
Language: EN, FR, DE, ES & NL

Drug Design of Zinc Enzyme Inhibitors Book Review:

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism
Author: Claudiu T. Supuran
Publsiher: MDPI
Total Pages: 184
Release: 2019-04-08
ISBN 10: 3038978000
ISBN 13: 9783038978008
Language: EN, FR, DE, ES & NL

Carbonic Anhydrases and Metabolism Book Review:

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many parasites (fungi, protozoa), they are involved in the de novo synthesis of important metabolites (lipids, nucleic acids, etc.). The metabolic effects related to interference with CA activity, however, have been scarcely investigated. The present Special Issue of Metabolites aims to fill this gap by presenting the latest developments in the field of CAs and their role in metabolism.

NanoBioMedicine

NanoBioMedicine
Author: Shailendra K. Saxena,S. M. Paul Khurana
Publsiher: Springer Nature
Total Pages: 517
Release: 2020-02-03
ISBN 10: 9813298987
ISBN 13: 9789813298989
Language: EN, FR, DE, ES & NL

NanoBioMedicine Book Review:

This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.

Phytochemicals

Phytochemicals
Author: Venketeshwer Rao,Leticia Rao
Publsiher: BoD – Books on Demand
Total Pages: 350
Release: 2015-09-30
ISBN 10: 9535121707
ISBN 13: 9789535121701
Language: EN, FR, DE, ES & NL

Phytochemicals Book Review:

Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.

Colposcopy and Cervical Pathology

Colposcopy and Cervical Pathology
Author: Rajamanickam Rajkumar
Publsiher: BoD – Books on Demand
Total Pages: 148
Release: 2017-09-20
ISBN 10: 9535135376
ISBN 13: 9789535135371
Language: EN, FR, DE, ES & NL

Colposcopy and Cervical Pathology Book Review:

This book entitled Colposcopy and Cervical Pathology is the third successful book of the editor with InTech publishers. This book serves the purpose of providing, valuable and valid, innovative ideas/suggestions for utilizations of the "resource-rich/resource-intensive" colposcopy and cervical pathology technology in a "cost-/resource-effective" way by the health providers and planners, especially in "resource-limited/resource-poor settings." Transfer of technology from high- to low-resource settings in all the programs of preventive/community oncology services, across the world, is highly recommended and strongly advocated. The authors have well contributed to the goal of advanced science being made accessible for the benefit of common man. The InTech publishers have the distinct honor of imbibing the in-depth knowledge and vast experiences from experts of international repute and infusing it to the health providers and planners of developing countries, so that the communities of all nations are richly benefited. The book is a pearl, which deserves a precious and purposeful planning model for achieving "global health by education and empowerment."