Personalized Computational Hemodynamics

Personalized Computational Hemodynamics
Author: Yuri Vassilevski,Maxim Olshanskii,Sergey Simakov,Andrey Kolobov,Alexander Danilov
Publsiher: Academic Press
Total Pages: 280
Release: 2020-04-19
ISBN 10: 0128156546
ISBN 13: 9780128156544
Language: EN, FR, DE, ES & NL

Personalized Computational Hemodynamics Book Review:

Personalized Computational Hemodynamics: Models, Methods, and Applications for Vascular Surgery and Antitumor Therapy offers practices and advances surrounding the multiscale modeling of hemodynamics and their personalization with conventional clinical data. Focusing on three physiological disciplines, readers will learn how to derive a suitable mathematical model and personalize its parameters to account for pathologies and diseases. Written by leading experts, this book mirrors the top trends in mathematical modeling with clinical applications. In addition, the book features the major results of the "Research group in simulation of blood flow and vascular pathologies" at the Institute of Numerical Mathematics of the Russian Academy of Sciences. Two important features distinguish this book from other monographs on numerical methods for biomedical applications. First, the variety of medical disciplines targeted by the mathematical modeling and computer simulations, including cardiology, vascular neurology and oncology. Second, for all mathematical models, the authors consider extensions and parameter tuning that account for vascular pathologies. Examines a variety of medical disciplines targeted by mathematical modeling and computer simulation Discusses how the results of numerical simulations are used to support clinical decision-making Covers hemodynamics relating to various subject areas, including vascular surgery and oncological tumor treatments

Patient specific Hemodynamic Computations Application to Personalized Diagnosis of Cardiovascular Pathologies

Patient specific Hemodynamic Computations  Application to Personalized Diagnosis of Cardiovascular Pathologies
Author: Lucian Mihai Itu,Puneet Sharma,Constantin Suciu
Publsiher: Springer
Total Pages: 227
Release: 2017-05-31
ISBN 10: 3319568531
ISBN 13: 9783319568539
Language: EN, FR, DE, ES & NL

Patient specific Hemodynamic Computations Application to Personalized Diagnosis of Cardiovascular Pathologies Book Review:

Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.

Patient specific Hemodynamic Computations Application to Personalized Diagnosis of Cardiovascular Pathologies

Patient specific Hemodynamic Computations  Application to Personalized Diagnosis of Cardiovascular Pathologies
Author: Lucian Mihai Itu,Puneet Sharma,Constantin Suciu
Publsiher: Springer
Total Pages: 227
Release: 2018-08-12
ISBN 10: 9783319860190
ISBN 13: 3319860194
Language: EN, FR, DE, ES & NL

Patient specific Hemodynamic Computations Application to Personalized Diagnosis of Cardiovascular Pathologies Book Review:

Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.

Automated Solution of Differential Equations by the Finite Element Method

Automated Solution of Differential Equations by the Finite Element Method
Author: Anders Logg,Kent-Andre Mardal,Garth Wells
Publsiher: Springer Science & Business Media
Total Pages: 731
Release: 2012-02-24
ISBN 10: 3642230997
ISBN 13: 9783642230998
Language: EN, FR, DE, ES & NL

Automated Solution of Differential Equations by the Finite Element Method Book Review:

This book is a tutorial written by researchers and developers behind the FEniCS Project and explores an advanced, expressive approach to the development of mathematical software. The presentation spans mathematical background, software design and the use of FEniCS in applications. Theoretical aspects are complemented with computer code which is available as free/open source software. The book begins with a special introductory tutorial for beginners. Following are chapters in Part I addressing fundamental aspects of the approach to automating the creation of finite element solvers. Chapters in Part II address the design and implementation of the FEnicS software. Chapters in Part III present the application of FEniCS to a wide range of applications, including fluid flow, solid mechanics, electromagnetics and geophysics.

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies
Author: Eduardo Soudah Prieto
Publsiher: Unknown
Total Pages: 181
Release: 2016
ISBN 10:
ISBN 13: OCLC:1120673423
Language: EN, FR, DE, ES & NL

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies Book Review:

In recent years, the study of computational hemodynamics within anatomically complex vascular regions has generated great interest among clinicians. The progress in computational fluid dynamics, image processing and high-performance computing haveallowed us to identify the candidate vascular regions for the appearance of cardiovascular diseases and to predict how this disease may evolve. Medicine currently uses a paradigm called diagnosis. In this thesis we attempt to introduce into medicine the predictive paradigm that has been used in engineering for many years. The objective of this thesis is therefore to develop predictive models based on diagnostic indicators for cardiovascular pathologies. We try to predict the evolution of aortic abdominal aneurysm, aortic coarctation and coronary artery disease in a personalized way for each patient. To understand how the cardiovascular pathology will evolve and when it will become a health risk, it is necessary to develop new technologies by merging medical imaging and computational science. We propose diagnostic indicators that can improve the diagnosis and predict the evolution of the disease more efficiently than the methods used until now. In particular, a new methodology for computing diagnostic indicators based on computational hemodynamics and medical imaging is proposed. We have worked with data of anonymous patients to create real predictive technology that will allow us to continue advancing in personalized medicine and generate more sustainable health systems. However, our final aim is to achieve an impact at a clinical level. Several groups have tried to create predictive models for cardiovascular pathologies, but they have not yet begun to use them in clinical practice. Our objective is to go further and obtain predictive variables to be used practically in the clinical field. It is to be hoped that in the future extremely precise databases of all of our anatomy and physiology will be available to doctors. These data can be used for predictive models to improve diagnosis or to improve therapies or personalized treatments.

Computational Modeling in Biomechanics

Computational Modeling in Biomechanics
Author: Suvranu De,Farshid Guilak,Mohammad Mofrad
Publsiher: Springer Science & Business Media
Total Pages: 581
Release: 2010-03-10
ISBN 10: 9789048135752
ISBN 13: 9048135753
Language: EN, FR, DE, ES & NL

Computational Modeling in Biomechanics Book Review:

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Patient Specific Modeling of the Cardiovascular System

Patient Specific Modeling of the Cardiovascular System
Author: Roy C.P. Kerckhoffs
Publsiher: Springer Science & Business Media
Total Pages: 240
Release: 2010-09-03
ISBN 10: 9781441966919
ISBN 13: 1441966919
Language: EN, FR, DE, ES & NL

Patient Specific Modeling of the Cardiovascular System Book Review:

Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Statistical Atlases and Computational Models of the Heart Atrial Segmentation and LV Quantification Challenges

Statistical Atlases and Computational Models of the Heart  Atrial Segmentation and LV Quantification Challenges
Author: Mihaela Pop,Maxime Sermesant,Jichao Zhao,Shuo Li,Kristin McLeod,Alistair Young,Kawal Rhode,Tommaso Mansi
Publsiher: Springer
Total Pages: 487
Release: 2019-03-05
ISBN 10: 3030120295
ISBN 13: 9783030120290
Language: EN, FR, DE, ES & NL

Statistical Atlases and Computational Models of the Heart Atrial Segmentation and LV Quantification Challenges Book Review:

This book constitutes the thoroughly refereed post-workshop proceedings of the 9th International Workshop on Statistical Atlases and Computational Models of the Heart: Atrial Segmentation and LV Quantification Challenges, STACOM 2018, held in conjunction with MICCAI 2018, in Granada, Spain, in September 2018. The 52 revised full workshop papers were carefully reviewed and selected from 60 submissions. The topics of the workshop included: cardiac imaging and image processing, machine learning applied to cardiac imaging and image analysis, atlas construction, statistical modelling of cardiac function across different patient populations, cardiac computational physiology, model customization, atlas based functional analysis, ontological schemata for data and results, integrated functional and structural analyses, as well as the pre-clinical and clinical applicability of these methods.

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI
Author: Belén Casas Garcia
Publsiher: Linköping University Electronic Press
Total Pages: 71
Release: 2019-02-15
ISBN 10: 9176852172
ISBN 13: 9789176852170
Language: EN, FR, DE, ES & NL

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI Book Review:

Current diagnostic tools for assessing cardiovascular disease mostly focus on measuring a given biomarker at a specific spatial location where an abnormality is suspected. However, as a result of the dynamic and complex nature of the cardiovascular system, the analysis of isolated biomarkers is generally not sufficient to characterize the pathological mechanisms behind a disease. Model-based approaches that integrate the mechanisms through which different components interact, and present possibilities for system-level analyses, give us a better picture of a patient’s overall health status. One of the main goals of cardiovascular modelling is the development of personalized models based on clinical measurements. Recent years have seen remarkable advances in medical imaging and the use of personalized models is slowly becoming a reality. Modern imaging techniques can provide an unprecedented amount of anatomical and functional information about the heart and vessels. In this context, three-dimensional, three-directional, cine phase-contrast (PC) magnetic resonance imaging (MRI), commonly referred to as 4D Flow MRI, arises as a powerful tool for creating personalized models. 4D Flow MRI enables the measurement of time-resolved velocity information with volumetric coverage. Besides providing a rich dataset within a single acquisition, the technique permits retrospective analysis of the data at any location within the acquired volume. This thesis focuses on improving subject-specific assessment of cardiovascular function through model-based analysis of 4D Flow MRI data. By using computational models, we aimed to provide mechanistic explanations of the underlying physiological processes, derive novel or improved hemodynamic markers, and estimate quantities that typically require invasive measurements. Paper I presents an evaluation of current markers of stenosis severity using advanced models to simulate flow through a stenosis. Paper II presents a framework to personalize a reduced-order, mechanistic model of the cardiovascular system using exclusively non-invasive measurements, including 4D Flow MRI data. The modelling approach can unravel a number of clinically relevant parameters from the input data, including those representing the contraction and relaxation patterns of the left ventricle, and provide estimations of the pressure-volume loop. In Paper III, this framework is applied to study cardiovascular function at rest and during stress conditions, and the capability of the model to infer load-independent measures of heart function based on the imaging data is demonstrated. Paper IV focuses on evaluating the reliability of the model parameters as a step towards translation of the model to the clinic.

Computational Bioengineering and Bioinformatics

Computational Bioengineering and Bioinformatics
Author: Nenad Filipovic
Publsiher: Springer Nature
Total Pages: 169
Release: 2020-03-11
ISBN 10: 3030436586
ISBN 13: 9783030436582
Language: EN, FR, DE, ES & NL

Computational Bioengineering and Bioinformatics Book Review:

This book explores the latest and most relevant topics in the field of computational bioengineering and bioinformatics, with a particular focus on patient-specific, disease-progression modeling. It covers computational methods for cardiovascular disease prediction, with an emphasis on biomechanics, biomedical decision support systems, data mining, personalized diagnostics, bio-signal processing, protein structure prediction, biomedical image processing, analysis and visualization, and high-performance computing. It also discusses state-of-the-art tools for disease characterization, and recent advances in areas such as biomechanics, cardiovascular engineering, patient-specific modeling, population-based modeling, multiscale modeling, image processing, data mining, biomedical decision-support systems, signal processing, biomaterials and dental biomechanics, tissue and cell engineering, computational chemistry and high-performance computing. As such, it is a valuable resource for researchers, medical and bioengineering students, and medical device and software experts

Trends in Biomathematics Modeling Optimization and Computational Problems

Trends in Biomathematics  Modeling  Optimization and Computational Problems
Author: Rubem P. Mondaini
Publsiher: Springer
Total Pages: 423
Release: 2018-08-16
ISBN 10: 3319910922
ISBN 13: 9783319910925
Language: EN, FR, DE, ES & NL

Trends in Biomathematics Modeling Optimization and Computational Problems Book Review:

This book brings together carefully selected, peer-reviewed works on mathematical biology presented at the BIOMAT International Symposium on Mathematical and Computational Biology, which was held at the Institute of Numerical Mathematics, Russian Academy of Sciences, in October 2017, in Moscow. Topics covered include, but are not limited to, the evolution of spatial patterns on metapopulations, problems related to cardiovascular diseases and modeled by boundary control techniques in hemodynamics, algebraic modeling of the genetic code, and multi-step biochemical pathways. Also, new results are presented on topics like pattern recognition of probability distribution of amino acids, somitogenesis through reaction-diffusion models, mathematical modeling of infectious diseases, and many others. Experts, scientific practitioners, graduate students and professionals working in various interdisciplinary fields will find this book a rich resource for research and applications alike.

Modern Mechanobiology

Modern Mechanobiology
Author: Juhyun Lee,Sharon Gerecht,Hanjoong Jo,Tzung Hsiai
Publsiher: CRC Press
Total Pages: 250
Release: 2021-02-25
ISBN 10: 1000021262
ISBN 13: 9781000021264
Language: EN, FR, DE, ES & NL

Modern Mechanobiology Book Review:

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.

Iterative Methods for Linear Systems

Iterative Methods for Linear Systems
Author: Maxim A. Olshanskii,Eugene E. Tyrtyshnikov
Publsiher: SIAM
Total Pages: 244
Release: 2014-07-21
ISBN 10: 1611973465
ISBN 13: 9781611973464
Language: EN, FR, DE, ES & NL

Iterative Methods for Linear Systems Book Review:

Iterative Methods for Linear Systems÷offers a mathematically rigorous introduction to fundamental iterative methods for systems of linear algebraic equations. The book distinguishes itself from other texts on the topic by providing a straightforward yet comprehensive analysis of the Krylov subspace methods, approaching the development and analysis of algorithms from various algorithmic and mathematical perspectives, and going beyond the standard description of iterative methods by connecting them in a natural way to the idea of preconditioning.÷÷

Geometrically Unfitted Finite Element Methods and Applications

Geometrically Unfitted Finite Element Methods and Applications
Author: Stéphane P. A. Bordas,Erik Burman,Mats G. Larson,Maxim A. Olshanskii
Publsiher: Springer
Total Pages: 361
Release: 2018-03-13
ISBN 10: 3319714317
ISBN 13: 9783319714318
Language: EN, FR, DE, ES & NL

Geometrically Unfitted Finite Element Methods and Applications Book Review:

This book provides a snapshot of the state of the art of the rapidly evolving field of integration of geometric data in finite element computations. The contributions to this volume, based on research presented at the UCL workshop on the topic in January 2016, include three review papers on core topics such as fictitious domain methods for elasticity, trace finite element methods for partial differential equations defined on surfaces, and Nitsche’s method for contact problems. Five chapters present original research articles on related theoretical topics, including Lagrange multiplier methods, interface problems, bulk-surface coupling, and approximation of partial differential equations on moving domains. Finally, two chapters discuss advanced applications such as crack propagation or flow in fractured poroelastic media. This is the first volume that provides a comprehensive overview of the field of unfitted finite element methods, including recent techniques such as cutFEM, traceFEM, ghost penalty, and augmented Lagrangian techniques. It is aimed at researchers in applied mathematics, scientific computing or computational engineering.

Developments and Novel Approaches in Biomechanics and Metamaterials

Developments and Novel Approaches in Biomechanics and Metamaterials
Author: Bilen Emek Abali,Ivan Giorgio
Publsiher: Springer Nature
Total Pages: 484
Release: 2020-07-06
ISBN 10: 3030504646
ISBN 13: 9783030504649
Language: EN, FR, DE, ES & NL

Developments and Novel Approaches in Biomechanics and Metamaterials Book Review:

This book presents a selection of cutting-edge methods that allow readers to obtain novel models for nonlinear solid mechanics. Today, engineers need more accurate techniques for modeling solid body mechanics, chiefly due to innovative methods like additive manufacturing—for example, 3D printing—but also due to miniaturization. This book focuses on the formulation of continuum and discrete models for complex materials and systems, and especially the design of metamaterials. It gathers outstanding papers from the international conference IcONSOM 2019

Statistical Atlases and Computational Models of the Heart

Statistical Atlases and Computational Models of the Heart
Author: Oscar Camara,Mihaela Pop,Kawal Rhode,Maxime Sermesant,Nic Smith,Alistair Young
Publsiher: Springer Science & Business Media
Total Pages: 292
Release: 2010-09-03
ISBN 10: 364215834X
ISBN 13: 9783642158346
Language: EN, FR, DE, ES & NL

Statistical Atlases and Computational Models of the Heart Book Review:

computationalmodelswith experimentaldata. A completedatasetwasprovided in advance, containing the cardiac geometry and ?bre orientations from MRI as well as epicardial transmembrane potentials from optical mapping.

Personalized Anaesthesia

Personalized Anaesthesia
Author: Pedro L. Gambús,Jan F. A. Hendrickx
Publsiher: Cambridge University Press
Total Pages: 400
Release: 2020-01-31
ISBN 10: 1107579252
ISBN 13: 9781107579255
Language: EN, FR, DE, ES & NL

Personalized Anaesthesia Book Review:

Presents a modern vision of anaesthesia, integrating technology and knowledge, to change how anaesthesia is taught and practised.

Quality Assurance in Healthcare Service Delivery Nursing and Personalized Medicine Technologies and Processes

Quality Assurance in Healthcare Service Delivery  Nursing and Personalized Medicine  Technologies and Processes
Author: Lazakidou, Athina
Publsiher: IGI Global
Total Pages: 302
Release: 2011-09-30
ISBN 10: 1613501218
ISBN 13: 9781613501214
Language: EN, FR, DE, ES & NL

Quality Assurance in Healthcare Service Delivery Nursing and Personalized Medicine Technologies and Processes Book Review:

Quality of life is difficult to define and even more difficult to measure; as such, outcomes from nursing in continuing care are not easily articulated. Quality Assurance in Healthcare Service Delivery, Nursing and Personalized Medicine: Technologies and Processes offers a framework for measuring quality of service in the healthcare industry as it pertains to nursing, with insight into how new technologies and the design of personalized medicine have improved quality of care and quality of life. Assessment and feedback are a vital part of developing and designing personalized medicine, and this book details case studies and the latest research in the field of healthcare service delivery assessment. In addition to describing assessment methodology, the book is also a compendium of the latest research into new medical technologies.

Computational Biomechanics

Computational Biomechanics
Author: Masao Tanaka,Shigeo Wada,Masanori Nakamura
Publsiher: Springer Science & Business Media
Total Pages: 196
Release: 2012-03-22
ISBN 10: 4431540733
ISBN 13: 9784431540731
Language: EN, FR, DE, ES & NL

Computational Biomechanics Book Review:

Rapid developments have taken place in biological/biomedical measurement and imaging technologies as well as in computer analysis and information technologies. The increase in data obtained with such technologies invites the reader into a virtual world that represents realistic biological tissue or organ structures in digital form and allows for simulation and what is called “in silico medicine.” This volume is the third in a textbook series and covers both the basics of continuum mechanics of biosolids and biofluids and the theoretical core of computational methods for continuum mechanics analyses. Several biomechanics problems are provided for better understanding of computational modeling and analysis. Topics include the mechanics of solid and fluid bodies, fundamental characteristics of biosolids and biofluids, computational methods in biomechanics analysis/simulation, practical problems in orthopedic biomechanics, dental biomechanics, ophthalmic biomechanics, cardiovascular biomechanics, hemodynamics, cell mechanics, and model-, rule-, and image-based methods in computational biomechanics analysis and simulation. The book is an excellent resource for graduate school-level engineering students and young researchers in bioengineering and biomedicine.

Highlights on Hemodynamics

Highlights on Hemodynamics
Author: Theodoros Aslanidis
Publsiher: BoD – Books on Demand
Total Pages: 88
Release: 2018-10-31
ISBN 10: 1789237939
ISBN 13: 9781789237931
Language: EN, FR, DE, ES & NL

Highlights on Hemodynamics Book Review:

In the era of functional hemodynamic monitoring and computational modeling, the present book published by IntechOpen® highlights some interesting aspects in the field. Divided into two sections, it presents hemodynamic topics of special interest. Thus, the authors offer the readers not only a "vigorous" review of the current literature but also a research direction for further advancement.