Personalized Computational Hemodynamics

Personalized Computational Hemodynamics
Author: Yuri Vassilevski,Maxim Olshanskii,Sergey Simakov,Andrey Kolobov,Alexander Danilov
Publsiher: Academic Press
Total Pages: 280
Release: 2020-04-19
ISBN 10: 0128156546
ISBN 13: 9780128156544
Language: EN, FR, DE, ES & NL

Personalized Computational Hemodynamics Book Review:

Personalized Computational Hemodynamics: Models, Methods, and Applications for Vascular Surgery and Antitumor Therapy offers practices and advances surrounding the multiscale modeling of hemodynamics and their personalization with conventional clinical data. Focusing on three physiological disciplines, readers will learn how to derive a suitable mathematical model and personalize its parameters to account for pathologies and diseases. Written by leading experts, this book mirrors the top trends in mathematical modeling with clinical applications. In addition, the book features the major results of the "Research group in simulation of blood flow and vascular pathologies" at the Institute of Numerical Mathematics of the Russian Academy of Sciences. Two important features distinguish this book from other monographs on numerical methods for biomedical applications. First, the variety of medical disciplines targeted by the mathematical modeling and computer simulations, including cardiology, vascular neurology and oncology. Second, for all mathematical models, the authors consider extensions and parameter tuning that account for vascular pathologies. Examines a variety of medical disciplines targeted by mathematical modeling and computer simulation Discusses how the results of numerical simulations are used to support clinical decision-making Covers hemodynamics relating to various subject areas, including vascular surgery and oncological tumor treatments

Patient specific Hemodynamic Computations Application to Personalized Diagnosis of Cardiovascular Pathologies

Patient specific Hemodynamic Computations  Application to Personalized Diagnosis of Cardiovascular Pathologies
Author: Lucian Mihai Itu,Puneet Sharma,Constantin Suciu
Publsiher: Springer
Total Pages: 227
Release: 2017-05-31
ISBN 10: 3319568531
ISBN 13: 9783319568539
Language: EN, FR, DE, ES & NL

Patient specific Hemodynamic Computations Application to Personalized Diagnosis of Cardiovascular Pathologies Book Review:

Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.

Mathematical Modelling in Biomedicine

Mathematical Modelling in Biomedicine
Author: Vitaly Volpert
Publsiher: MDPI
Total Pages: 224
Release: 2021-01-26
ISBN 10: 3039434934
ISBN 13: 9783039434930
Language: EN, FR, DE, ES & NL

Mathematical Modelling in Biomedicine Book Review:

Mathematical modelling in biomedicine is a rapidly developing scientific discipline at the intersection of medicine, biology, mathematics, physics, and computer science. Its progress is stimulated by fundamental scientific questions and by the applications to public health. This book represents a collection of papers devoted to mathematical modelling of various physiological problems in normal and pathological conditions. It covers a broad range of topics including cardiovascular system and diseases, heart and brain modelling, tumor growth, viral infections, and immune response. Computational models of blood circulation are used to study the influence of heart arrhythmias on coronary blood flow and on operating modes for left-ventricle-assisted devices. Wave propagation in the cardiac tissue is investigated in order to show the influence of tissue heterogeneity and fibrosis. The models of tumor growth are used to determine optimal protocols of antiangiogenic and radiotherapy. The models of viral hepatitis kinetics are considered for the parameter identification, and the evolution of viral quasi-species is investigated. The book presents the state-of-the-art in mathematical modelling in biomedicine and opens new perspectives in this passionate field of research.

Automated Solution of Differential Equations by the Finite Element Method

Automated Solution of Differential Equations by the Finite Element Method
Author: Anders Logg,Kent-Andre Mardal,Garth Wells
Publsiher: Springer Science & Business Media
Total Pages: 731
Release: 2012-02-24
ISBN 10: 3642230997
ISBN 13: 9783642230998
Language: EN, FR, DE, ES & NL

Automated Solution of Differential Equations by the Finite Element Method Book Review:

This book is a tutorial written by researchers and developers behind the FEniCS Project and explores an advanced, expressive approach to the development of mathematical software. The presentation spans mathematical background, software design and the use of FEniCS in applications. Theoretical aspects are complemented with computer code which is available as free/open source software. The book begins with a special introductory tutorial for beginners. Following are chapters in Part I addressing fundamental aspects of the approach to automating the creation of finite element solvers. Chapters in Part II address the design and implementation of the FEnicS software. Chapters in Part III present the application of FEniCS to a wide range of applications, including fluid flow, solid mechanics, electromagnetics and geophysics.

Quality Assurance in Healthcare Service Delivery Nursing and Personalized Medicine Technologies and Processes

Quality Assurance in Healthcare Service Delivery  Nursing and Personalized Medicine  Technologies and Processes
Author: Lazakidou, Athina
Publsiher: IGI Global
Total Pages: 302
Release: 2011-09-30
ISBN 10: 1613501218
ISBN 13: 9781613501214
Language: EN, FR, DE, ES & NL

Quality Assurance in Healthcare Service Delivery Nursing and Personalized Medicine Technologies and Processes Book Review:

Quality of life is difficult to define and even more difficult to measure; as such, outcomes from nursing in continuing care are not easily articulated. Quality Assurance in Healthcare Service Delivery, Nursing and Personalized Medicine: Technologies and Processes offers a framework for measuring quality of service in the healthcare industry as it pertains to nursing, with insight into how new technologies and the design of personalized medicine have improved quality of care and quality of life. Assessment and feedback are a vital part of developing and designing personalized medicine, and this book details case studies and the latest research in the field of healthcare service delivery assessment. In addition to describing assessment methodology, the book is also a compendium of the latest research into new medical technologies.

Statistical Atlases and Computational Models of the Heart Imaging and Modelling Challenges

Statistical Atlases and Computational Models of the Heart   Imaging and Modelling Challenges
Author: Oscar Camara,Tommaso Mansi,Mihaela Pop,Kawal Rhode,Maxime Sermesant,Alistair Young
Publsiher: Springer
Total Pages: 296
Release: 2014-12-31
ISBN 10: 3319146785
ISBN 13: 9783319146782
Language: EN, FR, DE, ES & NL

Statistical Atlases and Computational Models of the Heart Imaging and Modelling Challenges Book Review:

This book constitutes the thoroughly refereed post-conference proceedings of the 5th International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2014, held in conjunction with MICCAI 2014, in Boston, MA, USA, in September 2014. The 30 revised full papers were carefully reviewed and selected from numerous submissions. The papers cover a wide range of topics such as sections on cardiac image processing; atlas construction; statistical modelling of cardiac function across different patient populations; cardiac mapping; cardiac computational physiology; model customization; atlas based functional analysis; ontological schemata for data and results; integrated functional and structural analyses; as well as the pre-clinical and clinical applicability of these methods.

Artificial Intelligence for Computational Modeling of the Heart

Artificial Intelligence for Computational Modeling of the Heart
Author: Tommaso Mansi,Tiziano Passerini,Dorin Comaniciu
Publsiher: Academic Press
Total Pages: 274
Release: 2019-11-25
ISBN 10: 0128168951
ISBN 13: 9780128168950
Language: EN, FR, DE, ES & NL

Artificial Intelligence for Computational Modeling of the Heart Book Review:

Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient’s heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation

Biomedical Technology

Biomedical Technology
Author: Peter Wriggers,Thomas Lenarz
Publsiher: Springer
Total Pages: 362
Release: 2017-08-29
ISBN 10: 3319595482
ISBN 13: 9783319595481
Language: EN, FR, DE, ES & NL

Biomedical Technology Book Review:

This book provides an overview of new mathematical models, computational simulations and experimental tests in the field of biomedical technology, and covers a wide range of current research and challenges. The first part focuses on the virtual environment used to study biological systems at different scales and under multiphysics conditions. In turn, the second part is devoted to modeling and computational approaches in the field of cardiovascular medicine, e.g. simulation of turbulence in cardiovascular flow, modeling of artificial textile-reinforced heart valves, and new strategies for reducing the computational cost in the fluid-structure interaction modeling of hemodynamics. The book’s last three parts address experimental observations, numerical tests, computational simulations, and multiscale modeling approaches to dentistry, orthopedics and otology. Written by leading experts, the book reflects the remarkable advances that have been made in the field of medicine, the life sciences, engineering and computational mechanics over the past decade, and summarizes essential tools and methods (such as virtual prototyping of medical devices, advances in medical imaging, high-performance computing and new experimental test devices) to enhance medical decision-making processes and refine implant design. The contents build upon the International Conference on Biomedical Technology 2015 (ICTB 2015), the second ECCOMAS thematic conference on Biomedical Engineering, held in Hannover, Germany in October 2015.

Computational Modeling in Biomechanics

Computational Modeling in Biomechanics
Author: Suvranu De,Farshid Guilak,Mohammad Mofrad
Publsiher: Springer Science & Business Media
Total Pages: 581
Release: 2010-03-10
ISBN 10: 9789048135752
ISBN 13: 9048135753
Language: EN, FR, DE, ES & NL

Computational Modeling in Biomechanics Book Review:

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Patient Specific Modeling of the Cardiovascular System

Patient Specific Modeling of the Cardiovascular System
Author: Roy C.P. Kerckhoffs
Publsiher: Springer Science & Business Media
Total Pages: 240
Release: 2010-09-03
ISBN 10: 9781441966919
ISBN 13: 1441966919
Language: EN, FR, DE, ES & NL

Patient Specific Modeling of the Cardiovascular System Book Review:

Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Computational Bioengineering and Bioinformatics

Computational Bioengineering and Bioinformatics
Author: Nenad Filipovic
Publsiher: Springer Nature
Total Pages: 169
Release: 2020-03-11
ISBN 10: 3030436586
ISBN 13: 9783030436582
Language: EN, FR, DE, ES & NL

Computational Bioengineering and Bioinformatics Book Review:

This book explores the latest and most relevant topics in the field of computational bioengineering and bioinformatics, with a particular focus on patient-specific, disease-progression modeling. It covers computational methods for cardiovascular disease prediction, with an emphasis on biomechanics, biomedical decision support systems, data mining, personalized diagnostics, bio-signal processing, protein structure prediction, biomedical image processing, analysis and visualization, and high-performance computing. It also discusses state-of-the-art tools for disease characterization, and recent advances in areas such as biomechanics, cardiovascular engineering, patient-specific modeling, population-based modeling, multiscale modeling, image processing, data mining, biomedical decision-support systems, signal processing, biomaterials and dental biomechanics, tissue and cell engineering, computational chemistry and high-performance computing. As such, it is a valuable resource for researchers, medical and bioengineering students, and medical device and software experts

Modern Mechanobiology

Modern Mechanobiology
Author: Juhyun Lee,Sharon Gerecht,Hanjoong Jo,Tzung Hsiai
Publsiher: CRC Press
Total Pages: 250
Release: 2021-02-25
ISBN 10: 1000021262
ISBN 13: 9781000021264
Language: EN, FR, DE, ES & NL

Modern Mechanobiology Book Review:

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI
Author: Belén Casas Garcia
Publsiher: Linköping University Electronic Press
Total Pages: 71
Release: 2019-02-15
ISBN 10: 9176852172
ISBN 13: 9789176852170
Language: EN, FR, DE, ES & NL

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI Book Review:

Current diagnostic tools for assessing cardiovascular disease mostly focus on measuring a given biomarker at a specific spatial location where an abnormality is suspected. However, as a result of the dynamic and complex nature of the cardiovascular system, the analysis of isolated biomarkers is generally not sufficient to characterize the pathological mechanisms behind a disease. Model-based approaches that integrate the mechanisms through which different components interact, and present possibilities for system-level analyses, give us a better picture of a patient’s overall health status. One of the main goals of cardiovascular modelling is the development of personalized models based on clinical measurements. Recent years have seen remarkable advances in medical imaging and the use of personalized models is slowly becoming a reality. Modern imaging techniques can provide an unprecedented amount of anatomical and functional information about the heart and vessels. In this context, three-dimensional, three-directional, cine phase-contrast (PC) magnetic resonance imaging (MRI), commonly referred to as 4D Flow MRI, arises as a powerful tool for creating personalized models. 4D Flow MRI enables the measurement of time-resolved velocity information with volumetric coverage. Besides providing a rich dataset within a single acquisition, the technique permits retrospective analysis of the data at any location within the acquired volume. This thesis focuses on improving subject-specific assessment of cardiovascular function through model-based analysis of 4D Flow MRI data. By using computational models, we aimed to provide mechanistic explanations of the underlying physiological processes, derive novel or improved hemodynamic markers, and estimate quantities that typically require invasive measurements. Paper I presents an evaluation of current markers of stenosis severity using advanced models to simulate flow through a stenosis. Paper II presents a framework to personalize a reduced-order, mechanistic model of the cardiovascular system using exclusively non-invasive measurements, including 4D Flow MRI data. The modelling approach can unravel a number of clinically relevant parameters from the input data, including those representing the contraction and relaxation patterns of the left ventricle, and provide estimations of the pressure-volume loop. In Paper III, this framework is applied to study cardiovascular function at rest and during stress conditions, and the capability of the model to infer load-independent measures of heart function based on the imaging data is demonstrated. Paper IV focuses on evaluating the reliability of the model parameters as a step towards translation of the model to the clinic.

Iterative Methods for Linear Systems

Iterative Methods for Linear Systems
Author: Maxim A. Olshanskii,Eugene E. Tyrtyshnikov
Publsiher: SIAM
Total Pages: 244
Release: 2014-07-21
ISBN 10: 1611973465
ISBN 13: 9781611973464
Language: EN, FR, DE, ES & NL

Iterative Methods for Linear Systems Book Review:

Iterative Methods for Linear Systems÷offers a mathematically rigorous introduction to fundamental iterative methods for systems of linear algebraic equations. The book distinguishes itself from other texts on the topic by providing a straightforward yet comprehensive analysis of the Krylov subspace methods, approaching the development and analysis of algorithms from various algorithmic and mathematical perspectives, and going beyond the standard description of iterative methods by connecting them in a natural way to the idea of preconditioning.÷÷

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies
Author: Eduardo Soudah Prieto
Publsiher: Unknown
Total Pages: 181
Release: 2016
ISBN 10:
ISBN 13: OCLC:1120673423
Language: EN, FR, DE, ES & NL

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies Book Review:

In recent years, the study of computational hemodynamics within anatomically complex vascular regions has generated great interest among clinicians. The progress in computational fluid dynamics, image processing and high-performance computing haveallowed us to identify the candidate vascular regions for the appearance of cardiovascular diseases and to predict how this disease may evolve. Medicine currently uses a paradigm called diagnosis. In this thesis we attempt to introduce into medicine the predictive paradigm that has been used in engineering for many years. The objective of this thesis is therefore to develop predictive models based on diagnostic indicators for cardiovascular pathologies. We try to predict the evolution of aortic abdominal aneurysm, aortic coarctation and coronary artery disease in a personalized way for each patient. To understand how the cardiovascular pathology will evolve and when it will become a health risk, it is necessary to develop new technologies by merging medical imaging and computational science. We propose diagnostic indicators that can improve the diagnosis and predict the evolution of the disease more efficiently than the methods used until now. In particular, a new methodology for computing diagnostic indicators based on computational hemodynamics and medical imaging is proposed. We have worked with data of anonymous patients to create real predictive technology that will allow us to continue advancing in personalized medicine and generate more sustainable health systems. However, our final aim is to achieve an impact at a clinical level. Several groups have tried to create predictive models for cardiovascular pathologies, but they have not yet begun to use them in clinical practice. Our objective is to go further and obtain predictive variables to be used practically in the clinical field. It is to be hoped that in the future extremely precise databases of all of our anatomy and physiology will be available to doctors. These data can be used for predictive models to improve diagnosis or to improve therapies or personalized treatments.

Advances in Biomechanics and Tissue Regeneration

Advances in Biomechanics and Tissue Regeneration
Author: Mohamed Hamdy Doweidar
Publsiher: Academic Press
Total Pages: 430
Release: 2019-08-13
ISBN 10: 012816610X
ISBN 13: 9780128166109
Language: EN, FR, DE, ES & NL

Advances in Biomechanics and Tissue Regeneration Book Review:

Advances in Biomechanics and Tissue Regeneration covers a wide range of recent development and advances in the fields of biomechanics and tissue regeneration. It includes computational simulation, soft tissues, microfluidics, the cardiovascular system, experimental methods in biomechanics, mechanobiology and tissue regeneration. The state-of-the-art, theories and application are presented, making this book ideal for anyone who is deciding which direction to take their future research in this field. In addition, it is ideal for everyone who is exploring new fields or currently working on an interdisciplinary project in tissue biomechanics. Combines new trends in biomechanical modelling and tissue regeneration Offers a broad scope, covering the entire field of tissue biomechanics Contains perspectives from engineering, medicine and biology, thus giving a holistic view of the field

Computer Methods Imaging and Visualization in Biomechanics and Biomedical Engineering

Computer Methods  Imaging and Visualization in Biomechanics and Biomedical Engineering
Author: Gerard A. Ateshian
Publsiher: Springer Nature
Total Pages: 329
Release: 2021
ISBN 10: 3030431959
ISBN 13: 9783030431952
Language: EN, FR, DE, ES & NL

Computer Methods Imaging and Visualization in Biomechanics and Biomedical Engineering Book Review:

Geometrically Unfitted Finite Element Methods and Applications

Geometrically Unfitted Finite Element Methods and Applications
Author: Stéphane P. A. Bordas,Erik Burman,Mats G. Larson,Maxim A. Olshanskii
Publsiher: Springer
Total Pages: 361
Release: 2018-03-13
ISBN 10: 3319714317
ISBN 13: 9783319714318
Language: EN, FR, DE, ES & NL

Geometrically Unfitted Finite Element Methods and Applications Book Review:

This book provides a snapshot of the state of the art of the rapidly evolving field of integration of geometric data in finite element computations. The contributions to this volume, based on research presented at the UCL workshop on the topic in January 2016, include three review papers on core topics such as fictitious domain methods for elasticity, trace finite element methods for partial differential equations defined on surfaces, and Nitsche’s method for contact problems. Five chapters present original research articles on related theoretical topics, including Lagrange multiplier methods, interface problems, bulk-surface coupling, and approximation of partial differential equations on moving domains. Finally, two chapters discuss advanced applications such as crack propagation or flow in fractured poroelastic media. This is the first volume that provides a comprehensive overview of the field of unfitted finite element methods, including recent techniques such as cutFEM, traceFEM, ghost penalty, and augmented Lagrangian techniques. It is aimed at researchers in applied mathematics, scientific computing or computational engineering.

Highlights on Hemodynamics

Highlights on Hemodynamics
Author: Theodoros Aslanidis
Publsiher: BoD – Books on Demand
Total Pages: 88
Release: 2018-10-31
ISBN 10: 1789237939
ISBN 13: 9781789237931
Language: EN, FR, DE, ES & NL

Highlights on Hemodynamics Book Review:

In the era of functional hemodynamic monitoring and computational modeling, the present book published by IntechOpen® highlights some interesting aspects in the field. Divided into two sections, it presents hemodynamic topics of special interest. Thus, the authors offer the readers not only a "vigorous" review of the current literature but also a research direction for further advancement.

Personalized Anaesthesia

Personalized Anaesthesia
Author: Pedro L. Gambús,Jan F. A. Hendrickx
Publsiher: Cambridge University Press
Total Pages: 400
Release: 2020-01-31
ISBN 10: 1107579252
ISBN 13: 9781107579255
Language: EN, FR, DE, ES & NL

Personalized Anaesthesia Book Review:

Presents a modern vision of anaesthesia, integrating technology and knowledge, to change how anaesthesia is taught and practised.