YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer

YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer
Author: Benjamin Bonavida
Publsiher: Academic Press
Total Pages: 360
Release: 2020-10-20
ISBN 10: 0128226366
ISBN 13: 9780128226360
Language: EN, FR, DE, ES & NL

YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer Book Review:

YY1 Is Pivotal in the Control of the Pathogenesis and Drug Resistance of Cancer: A Critical Therapeutic Target describes the current state-of-the-art of the transcription factor YY1 that is overexpressed in the majority of cancers and a central factor that regulates all of the major features and characteristics of human cancers. This book emphasizes the biochemical, molecular and genetic underlying mechanisms by which YY1 regulates its pro-cancerous activities. In addition, it also describes the role of YY1 in the regulation of tumor cell resistance to conventional chemo and immunotherapies and the important role of inhibiting YY1 in cancer. This book is a valuable source for cancer researchers, oncologists and several members of medical and biomedical field who are interested in understanding further the role of YY1 in cancer. Provides a thorough understanding of the underlying mechanisms by which YY1 regulates cancer cell phenotype and unique characteristics Discusses the novel mechanisms of YY1 regulation of tumor cell resistance and means to overcome resistance Encompasses new examples of newly developed non-toxic and selective inhibitors targeting YY1

Childhood Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia
Author: Ajay Vora
Publsiher: Springer
Total Pages: 342
Release: 2017-04-21
ISBN 10: 3319397087
ISBN 13: 9783319397085
Language: EN, FR, DE, ES & NL

Childhood Acute Lymphoblastic Leukemia Book Review:

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Human Papillomavirus and Cervical Cancer

Human Papillomavirus and Cervical Cancer
Author: International Agency for Research on Cancer,Cancerregisteret (Denmark)
Publsiher: Oxford University Press
Total Pages: 155
Release: 1989
ISBN 10: 1928374650XXX
ISBN 13: UCSD:31822003764586
Language: EN, FR, DE, ES & NL

Human Papillomavirus and Cervical Cancer Book Review:

This volume reviews the evidence for a causal link between sexually transmitted infection with human papillomavirus (HPV) and the occurrence of cervical cancer, from a variety of different angles. Epidemiological studies and clinical, pathological, and cytological aspects of HPV infection are reviewed. Modern methods for analyzing HPV-DNA types by molecular biological techniques are described, and the statistical problems to be overcome in epidemiological work are explained. The volume was prepared by a broad team of experts from around the world, who met in Copenhagen in March 1988 to reach a consensus on the present state of understanding and to establish directions for future work.

A Theranostic and Precision Medicine Approach for Female Specific Cancers

A Theranostic and Precision Medicine Approach for Female Specific Cancers
Author: Rama Rao Malla,Ganji Purnachandra Nagaraju
Publsiher: Academic Press
Total Pages: 318
Release: 2020-11-06
ISBN 10: 0128226927
ISBN 13: 9780128226926
Language: EN, FR, DE, ES & NL

A Theranostic and Precision Medicine Approach for Female Specific Cancers Book Review:

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Human Herpesviruses

Human Herpesviruses
Author: Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2007-08-16
ISBN 10: 1139461648
ISBN 13: 9781139461641
Language: EN, FR, DE, ES & NL

Human Herpesviruses Book Review:

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Protein Phosphorylation in Human Health

Protein Phosphorylation in Human Health
Author: Cai Huang
Publsiher: BoD – Books on Demand
Total Pages: 480
Release: 2012-09-06
ISBN 10: 9535107372
ISBN 13: 9789535107378
Language: EN, FR, DE, ES & NL

Protein Phosphorylation in Human Health Book Review:

15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.

Persistent Viral Infections

Persistent Viral Infections
Author: R. Ahmed,Irvin Chen
Publsiher: Wiley-Blackwell
Total Pages: 725
Release: 1999
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015041993448
Language: EN, FR, DE, ES & NL

Persistent Viral Infections Book Review:

Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments

Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments
Author: Marco Cordani,Dawid Walerych,Jerson L. Silva,Oleg Timofeev,Mara Cirone
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-10-22
ISBN 10: 288971537X
ISBN 13: 9782889715374
Language: EN, FR, DE, ES & NL

Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments Book Review:

Mitochondrial Dysfunction

Mitochondrial Dysfunction
Author: Lawrence H. Lash,Dean P. Jones
Publsiher: Unknown
Total Pages: 502
Release: 1993
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015032446059
Language: EN, FR, DE, ES & NL

Mitochondrial Dysfunction Book Review:

Endocytosis and Signaling

Endocytosis and Signaling
Author: Christophe Lamaze,Ian Prior
Publsiher: Springer
Total Pages: 329
Release: 2018-08-10
ISBN 10: 3319967045
ISBN 13: 9783319967042
Language: EN, FR, DE, ES & NL

Endocytosis and Signaling Book Review:

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.

Molecular Genetics of Endometrial Carcinoma

Molecular Genetics of Endometrial Carcinoma
Author: Lora Hedrick Ellenson
Publsiher: Springer
Total Pages: 281
Release: 2016-12-01
ISBN 10: 3319431390
ISBN 13: 9783319431390
Language: EN, FR, DE, ES & NL

Molecular Genetics of Endometrial Carcinoma Book Review:

This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.

Autophagy in tumor and tumor microenvironment

Autophagy in tumor and tumor microenvironment
Author: Sujit Kumar Bhutia
Publsiher: Springer Nature
Total Pages: 280
Release: 2020-10-24
ISBN 10: 9811569304
ISBN 13: 9789811569302
Language: EN, FR, DE, ES & NL

Autophagy in tumor and tumor microenvironment Book Review:

This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer  Molecular Mechanisms and Therapeutic Strategies
Author: Chi Hin Cho,Tao Hu
Publsiher: Academic Press
Total Pages: 240
Release: 2020-05-24
ISBN 10: 0128199385
ISBN 13: 9780128199381
Language: EN, FR, DE, ES & NL

Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies Book Review:

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Principles of Medical Biochemistry E Book

Principles of Medical Biochemistry E Book
Author: Gerhard Meisenberg,William H. Simmons
Publsiher: Elsevier Health Sciences
Total Pages: 600
Release: 2016-09-28
ISBN 10: 0323391907
ISBN 13: 9780323391900
Language: EN, FR, DE, ES & NL

Principles of Medical Biochemistry E Book Book Review:

For nearly 30 years, Principles of Medical Biochemistry has integrated medical biochemistry with molecular genetics, cell biology, and genetics to provide complete yet concise coverage that links biochemistry with clinical medicine. The 4th Edition of this award-winning text by Drs. Gerhard Meisenberg and William H. Simmons has been fully updated with new clinical examples, expanded coverage of recent changes in the field, and many new case studies online. A highly visual format helps readers retain complex information, and USMLE-style questions (in print and online) assist with exam preparation. Just the right amount of detail on biochemistry, cell biology, and genetics – in one easy-to-digest textbook. Full-color illustrations and tables throughout help students master challenging concepts more easily. Online case studies serve as a self-assessment and review tool before exams. Online access includes nearly 150 USMLE-style questions in addition to the questions that are in the book. Glossary of technical terms. Clinical Boxes and Clinical Content demonstrate the integration of basic sciences and clinical applications, helping readers make connections between the two. New clinical examples have been added throughout the text.

Advances in Molecular Retrovirology

Advances in Molecular Retrovirology
Author: Shailendra K. Saxena
Publsiher: BoD – Books on Demand
Total Pages: 202
Release: 2016-03-16
ISBN 10: 9535122614
ISBN 13: 9789535122616
Language: EN, FR, DE, ES & NL

Advances in Molecular Retrovirology Book Review:

This book gives a comprehensive overview of recent advances in Retrovirology, as well as general concepts of molecular biology of retroviral infections, immunopathology, diagnosis, and prevention, to current clinical recommendations in management of retroviruses, including endogenous retroviruses, highlighting the ongoing issues, recent advances, with future directions in diagnostic approaches and therapeutic strategies.

Nitric Oxide NO and Cancer

Nitric Oxide  NO  and Cancer
Author: Benjamin Bonavida
Publsiher: Springer Science & Business Media
Total Pages: 250
Release: 2010-06-16
ISBN 10: 9781441914323
ISBN 13: 1441914323
Language: EN, FR, DE, ES & NL

Nitric Oxide NO and Cancer Book Review:

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

SUMO Regulation of Cellular Processes

SUMO Regulation of Cellular Processes
Author: Van G. Wilson
Publsiher: Springer
Total Pages: 415
Release: 2017-02-13
ISBN 10: 3319500449
ISBN 13: 9783319500447
Language: EN, FR, DE, ES & NL

SUMO Regulation of Cellular Processes Book Review:

This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins. The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria. Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research. This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.

Epidemiology of Diabetes

Epidemiology of Diabetes
Author: Jahangir Moini
Publsiher: Elsevier
Total Pages: 210
Release: 2019-03-19
ISBN 10: 0128173254
ISBN 13: 9780128173251
Language: EN, FR, DE, ES & NL

Epidemiology of Diabetes Book Review:

Epidemiology of Diabetes addresses the patterns, risk factors and prevention tactics for the epidemic of diabetes in the US population. Diabetes is a costly and common disease that needs serious attention and awareness. Diabetes causes devastating consequences, such as neuropathy, retinopathy, nephropathy and vasculopathy. This succinct reference focuses on current data and research on diabetes, and is essential reading for diabetes care providers, as well as health care decision-makers. The Centers for Disease Control and Prevention has reported that more than 100 million US adults are living with diabetes or prediabetes, hence this is a timely resource on the topic. Serves as a starting point for medical professionals who are addressing the patterns, risk factors, prevention and treatment of the epidemic of diabetes in the US population Discusses the epidemic and prevalence of diabetes in the United States, covering the disability, burden and mortality of diabetes Covers the epidemiology of nutrition and diet, addressing carbohydrates and fiber, fats, protein, alcohol and nutritional intervention

Colon Cancer Diagnosis and Therapy

Colon Cancer Diagnosis and Therapy
Author: Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
Publsiher: Springer Nature
Total Pages: 369
Release: 2021
ISBN 10: 3030633691
ISBN 13: 9783030633691
Language: EN, FR, DE, ES & NL

Colon Cancer Diagnosis and Therapy Book Review:

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Role of Transcription Factors in Gastrointestinal Malignancies

Role of Transcription Factors in Gastrointestinal Malignancies
Author: Ganji Purnachandra Nagaraju,Pallaval Veera Bramhachari
Publsiher: Springer
Total Pages: 517
Release: 2018-03-27
ISBN 10: 9811067287
ISBN 13: 9789811067280
Language: EN, FR, DE, ES & NL

Role of Transcription Factors in Gastrointestinal Malignancies Book Review:

This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.