Transdermal Drug Delivery

Transdermal Drug Delivery
Author: Kevin Ita
Publsiher: Academic Press
Total Pages: 324
Release: 2020-06-12
ISBN 10: 0128225513
ISBN 13: 9780128225516
Language: EN, FR, DE, ES & NL

Transdermal Drug Delivery Book Review:

Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful. Captures the most recent advancements and challenges in the field of transdermal drug delivery Covers both passive and active transdermal drug delivery strategies Explores a selection of state-of-the-art transdermal drug delivery systems

Topical and Transdermal Drug Delivery

Topical and Transdermal Drug Delivery
Author: Heather A. E. Benson,Adam C. Watkinson
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2012-02-03
ISBN 10: 1118140494
ISBN 13: 9781118140499
Language: EN, FR, DE, ES & NL

Topical and Transdermal Drug Delivery Book Review:

Practical drug development approaches presented by leadingexperts Designed to support the development of new, effectivetherapeutics, Topical and Transdermal Drug Delivery: Principlesand Practice explains the principles underlying the field andthen demonstrates how these principles are put into practice in thedesign and development of new drug products. Drawing together andreviewing the latest research findings, the book focuses onpractical, tested, and proven approaches that are backed byindustry case studies and the authors' firsthand experience.Moreover, the book emphasizes the mechanistic information that isessential for successful drug product development. Topical and Transdermal Drug Delivery: Principles andPractice is divided into two parts: Part One, Current Science, Skin Permeation, andEnhancement Approaches, offers readers a fundamental understandingof the underlying science in the field. It describes the principlesand techniques needed to successfully perform experimentalapproaches, covering such issues as skin permeation, enhancement,and assessment. Part Two, Topical and Transdermal Product Development,guides readers through the complete product development processfrom concept to approval, offering practical tips and cautions fromexperts in the field. This part also discusses regulations that arespecific to the development of dermal drug products. The finalchapter explores current and future trends, forecasting newdevelopment techniques and therapeutics. Throughout the book, the authors clearly set forth the basicscience and experimental procedures, making it possible forresearchers to design their own experimental approaches andaccurately interpret their results. With contributions from experienced drug researchers, this textis highly recommended for all researchers involved in topical andtransdermal product development who need to know both the state ofthe science and the standards of practice.

Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems
Author: Jonathan Hadgraft
Publsiher: CRC Press
Total Pages: 328
Release: 2002-10-29
ISBN 10: 1135565198
ISBN 13: 9781135565190
Language: EN, FR, DE, ES & NL

Transdermal Drug Delivery Systems Book Review:

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery
Author: Ryan F. Donnelly,Thakur Raghu Raj Singh
Publsiher: John Wiley & Sons
Total Pages: 296
Release: 2015-09-28
ISBN 10: 1118734513
ISBN 13: 9781118734513
Language: EN, FR, DE, ES & NL

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery Book Review:

This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

Transdermal and Intradermal Delivery of Therapeutic Agents

Transdermal and Intradermal Delivery of Therapeutic Agents
Author: Ajay K Banga
Publsiher: CRC Press
Total Pages: 309
Release: 2011-05-16
ISBN 10: 1439805105
ISBN 13: 9781439805107
Language: EN, FR, DE, ES & NL

Transdermal and Intradermal Delivery of Therapeutic Agents Book Review:

Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology. A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers: Commercial development of devices and products based on transdermal physical enhancement technologies Selecting optimal enhancement technology for a specific drug molecule using case studies Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines Practical information on experimental procedures and challenges related to skin irritation and safety issues Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.

Handbook of Non Invasive Drug Delivery Systems

Handbook of Non Invasive Drug Delivery Systems
Author: Vitthal S. Kulkarni
Publsiher: Elsevier
Total Pages: 328
Release: 2009-12-31
ISBN 10: 9780815520269
ISBN 13: 0815520263
Language: EN, FR, DE, ES & NL

Handbook of Non Invasive Drug Delivery Systems Book Review:

With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Imaging Technologies and Transdermal Delivery in Skin Disorders

Imaging Technologies and Transdermal Delivery in Skin Disorders
Author: Chenjie Xu,Xiaomeng Wang,Manojit Pramanik
Publsiher: John Wiley & Sons
Total Pages: 504
Release: 2020-01-28
ISBN 10: 3527344608
ISBN 13: 9783527344604
Language: EN, FR, DE, ES & NL

Imaging Technologies and Transdermal Delivery in Skin Disorders Book Review:

Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical presentations, pathophysiological mechanisms, and current clinical practices used to treat diseases affecting the skin are then introduced. Common preclinical models used for studying the mechanisms of diverse skin diseases, validation of novel therapeutic targets, and screening of new drugs to treat these diseases are also covered. The book examines the latest imaging technologies for understanding in vivo skin changes, as well as technologies such as high-resolution ultrasound imaging, quantitative Magnetic Resonance Imaging, high-resolution Optical Coherence Tomography, and emerging hybrid-imaging modalities. It concludes with chapters introducing emerging drug delivery technologies and potential future innovative developments. Presents up-to-date knowledge of the skin biology and pathologies Introduces advancements in the topic of imaging technology for tracing the drug delivery process, which is rarely systematically reported by other counterparts Covers the latest development in three inter-related directions of drug delivery, imaging, and skin disease intersect for skin research Provides an overview of the latest development of diagnostic and therapeutic technologies for skin diseases Imaging Technologies and Transdermal Delivery in Skin Disorders will be of great interest to analytical chemists, materials scientists, pharmaceutical chemists, clinical chemists, biotechnologists, bioengineers, cosmetics industry, and dermatologists.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Author: Emmanuel C. Opara
Publsiher: CRC Press
Total Pages: 351
Release: 2020-02-28
ISBN 10: 0429582757
ISBN 13: 9780429582752
Language: EN, FR, DE, ES & NL

Controlled Drug Delivery Systems Book Review:

This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Non Invasive Monitoring of Transdermal Drug Delivery

Non Invasive Monitoring of Transdermal Drug Delivery
Author: Pasquale Arpaia,Taylor & Francis Group,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino
Publsiher: CRC Press
Total Pages: 216
Release: 2022-03-04
ISBN 10: 9780367765989
ISBN 13: 0367765985
Language: EN, FR, DE, ES & NL

Non Invasive Monitoring of Transdermal Drug Delivery Book Review:

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Microneedle mediated Transdermal and Intradermal Drug Delivery

Microneedle mediated Transdermal and Intradermal Drug Delivery
Author: Ryan F. Donnelly,Thakur Raghu Raj Singh,Desmond I. J. Morrow,A. David Woolfson
Publsiher: John Wiley & Sons
Total Pages: 280
Release: 2012-01-17
ISBN 10: 1119959667
ISBN 13: 9781119959663
Language: EN, FR, DE, ES & NL

Microneedle mediated Transdermal and Intradermal Drug Delivery Book Review:

Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.

Nanobiotechnology in Diagnosis Drug Delivery and Treatment

Nanobiotechnology in Diagnosis  Drug Delivery and Treatment
Author: Mahendra Rai,Mehdi Razzaghi-Abyaneh,Avinash P. Ingle
Publsiher: John Wiley & Sons
Total Pages: 416
Release: 2020-11-17
ISBN 10: 1119671868
ISBN 13: 9781119671862
Language: EN, FR, DE, ES & NL

Nanobiotechnology in Diagnosis Drug Delivery and Treatment Book Review:

Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.

Microneedles for Drug and Vaccine Delivery and Patient Monitoring

Microneedles for Drug and Vaccine Delivery and Patient Monitoring
Author: Ryan F. Donnelly,Thakur Raghu Raj Singh,Eneko Larrañeta,Maeliosa T.C. McCrudden
Publsiher: John Wiley & Sons
Total Pages: 352
Release: 2018-06-04
ISBN 10: 1119305179
ISBN 13: 9781119305170
Language: EN, FR, DE, ES & NL

Microneedles for Drug and Vaccine Delivery and Patient Monitoring Book Review:

Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.

Dermal Drug Delivery

Dermal Drug Delivery
Author: Tapash K. Ghosh
Publsiher: CRC Press
Total Pages: 447
Release: 2020-01-21
ISBN 10: 1315356643
ISBN 13: 9781315356648
Language: EN, FR, DE, ES & NL

Dermal Drug Delivery Book Review:

With the continued advancement of better-quality control and patient outcome reporting systems, changes in the development, control, and regulation of all pharmaceutical delivery systems including transdermal and topical products have been happening on a continuous basis. In light of various quality issues that have been reported by patients and practitioners resulting in the recall or removal of products from the market, both the pharmaceutical industries and regulatory agencies have been adopting new measures to address these issues. With chapters written by experts in this field, this book takes a 21st century multidisciplinary and cross-functional look at these dosage forms to improve the development, design, manufacturing, quality, clinical performance, safety, and regulation of these products. This book offers a wealth of up-to-date information organized in a logical sequence corresponding to various stages of research, development, and commercialization of dermal drug delivery products. The authors have been carefully selected from different sectors of pharmaceutical science for their expertise in their selected areas to present objectively a balanced view of the current state of these products development and commercialization via regulatory approval. Their insights will provide useful information to others to ensure the successful development of the next generation dermal drug products. Key Features: Presents current advancements including new technologies of transdermal and topical dosage forms. Presents challenges in the development of the new generation of transdermal and topical dosage forms. Introduces new technologies and QbD (quality by design) aspects of manufacturing and control strategies. Includes new perspectives on pre-clinical and clinical development, regulatory considerations, safety and quality. Discusses regulatory challenges, gaps, and future considerations for dermal drug delivery systems.

Herbal Bioactive Based Drug Delivery Systems

Herbal Bioactive Based Drug Delivery Systems
Author: Inderbir Singh Bakshi,Rajni Bala,Reecha Madaan,Rakesh K. Sindhu
Publsiher: Academic Press
Total Pages: 494
Release: 2022-03-13
ISBN 10: 0323859100
ISBN 13: 9780323859103
Language: EN, FR, DE, ES & NL

Herbal Bioactive Based Drug Delivery Systems Book Review:

Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments. Explores standardization, regulation and enhancement issues in herbal bioactives Discusses novel developments, herbal cosmetics and toxicity/interaction issues Provides a comprehensive reference on all aspects of herbal bioactives

Recent Advances in Novel Drug Carrier Systems

Recent Advances in Novel Drug Carrier Systems
Author: Ali Demir Sezer
Publsiher: BoD – Books on Demand
Total Pages: 514
Release: 2012-10-31
ISBN 10: 9535108107
ISBN 13: 9789535108108
Language: EN, FR, DE, ES & NL

Recent Advances in Novel Drug Carrier Systems Book Review:

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Topical Drug Bioavailability Bioequivalence and Penetration

Topical Drug Bioavailability  Bioequivalence  and Penetration
Author: Vinod P. Shah,Howard I. Maibach,John Jenner
Publsiher: Springer
Total Pages: 402
Release: 2015-01-30
ISBN 10: 1493912895
ISBN 13: 9781493912896
Language: EN, FR, DE, ES & NL

Topical Drug Bioavailability Bioequivalence and Penetration Book Review:

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Electrically Assisted Transdermal And Topical Drug Delivery

Electrically Assisted Transdermal And Topical Drug Delivery
Author: Ajay K Banga
Publsiher: CRC Press
Total Pages: 172
Release: 1998-06-30
ISBN 10: 9780748406876
ISBN 13: 0748406875
Language: EN, FR, DE, ES & NL

Electrically Assisted Transdermal And Topical Drug Delivery Book Review:

Percutaneous absorption is the development of transdermal drug delivery patches, as well as the treatment of skin disorders. The skin permeability of most drugs is low, but can be enhanced by several mechanisms including electric force.This volume provides coverage of assisted transdermal and topical delivery by the mechanisms of iontophoresis, electroosmosis and electroporation. It starts by introducing the terminology and outlines the historical background. A foundation of the theoretical concepts and mechanisms of iontophoresis and electroporation has been presented, followed by tips on the design of experimental systems for research in this area. Other topics discussed are human and clinical studies with iontophoresis; delivery of peptides, Proteins And Oligonucleotides; Combined Use Of Iontophoresis And electroporation for gene therapy; iontophoretic delivery of insulin for diabetes; and the current status of the commercial development on an iontophoretic patch. This book provides a wealth of theoretical and practical information not easily found in any other single source.

Recent Advances in Plasticizers

Recent Advances in Plasticizers
Author: Mohammad Luqman
Publsiher: BoD – Books on Demand
Total Pages: 226
Release: 2012-03-21
ISBN 10: 9535103636
ISBN 13: 9789535103639
Language: EN, FR, DE, ES & NL

Recent Advances in Plasticizers Book Review:

Plasticizers are used to increase the process-ability, flexibility, and durability of the material, and of course to reduce the cost in many cases. This edition covers introduction and applications of various types of plasticizers including those based on non-toxic and highly effective pyrrolidones, and a new source of Collagen based bio-plasticizers that can be obtained from discarded materials from a natural source; Jumbo Squid (Dosidicus gigas). It covers the application of plasticizers in plastic, ion-selective electrode/electrochemical sensor, transdermal drug delivery system, pharmaceutical and environmental sectors. This book can be used as an important reference by graduate students, and researchers, scientists, engineers and industrialists in polymer, electrochemical, pharmaceutical and environmental industries.

Percutaneous Absorption

Percutaneous Absorption
Author: Robert L. Bronaugh,Howard I. Maibach
Publsiher: CRC Press
Total Pages: 986
Release: 1999-05-28
ISBN 10: 9781420000948
ISBN 13: 1420000942
Language: EN, FR, DE, ES & NL

Percutaneous Absorption Book Review:

Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Drug Delivery Approaches

Drug Delivery Approaches
Author: Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts
Publsiher: John Wiley & Sons
Total Pages: 464
Release: 2021-08-04
ISBN 10: 1119772753
ISBN 13: 9781119772750
Language: EN, FR, DE, ES & NL

Drug Delivery Approaches Book Review:

Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.