Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
Author: Tahira Farooqui,Akhlaq A. Farooqui
Publsiher: Academic Press
Total Pages: 432
Release: 2016-07-12
ISBN 10: 0128036168
ISBN 13: 9780128036167
Language: EN, FR, DE, ES & NL

Trace Amines and Neurological Disorders Book Review:

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Neuropsychopharmacology of the Trace Amines

Neuropsychopharmacology of the Trace Amines
Author: Alan A. Boulton,Peter R. Bieck,L. Maitre,P. Riederer
Publsiher: Springer Science & Business Media
Total Pages: 510
Release: 2012-12-06
ISBN 10: 1461250102
ISBN 13: 9781461250104
Language: EN, FR, DE, ES & NL

Neuropsychopharmacology of the Trace Amines Book Review:

A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed and after their purification by physicochemical procedures that are becoming more and more efficient. The identification and quantitative analysis of minute amounts of trace amines in biological fluids or tissues is in itself a remarkable technological achievement. The enormous task that several teams of research workers have set themselves is to investigate the origin of the trace amines, to understand their metabolism, and to discover whether or not they possess an important biological role. The 2nd Trace Amines Symposium at Weitenburg Castle near Tubingen from the 15th to the 19th May 1985 was held to gain a somewhat clearer insight into the present state of knowledge. Since the first meeting in 1983 our knowledge has increased and interest is deepening. Hence the idea proposed at that first meeting, of organizing similar gather ings at regular intervals, has come to fruition. Covered in the Neuropsychopharmacology section of this book are studiesof the effects of certain trace amines on different forms of be havior, on neurotransmission mediated by . the classical neuro transmitters, on their biosynthesis or on catabolism, on their possible occurrence as a result of alternative metabolic pathways for the amino acids, and in some instances their neuroanatomical distributions.

The Combinatorial Index

The Combinatorial Index
Author: Barry A. Bunin
Publsiher: Elsevier
Total Pages: 322
Release: 1998-04-15
ISBN 10: 9780080542409
ISBN 13: 0080542409
Language: EN, FR, DE, ES & NL

The Combinatorial Index Book Review:

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods Serves as a laboratory manual for bench chemists Includes a chapter on linkers to assist in choice of linking strategy Discusses strengths and limitations of the various methods Contains a structural index showing functional group transformations in solid-phase synthesis

Biogenic Amines on Food Safety

Biogenic Amines on Food Safety
Author: Claudia Ruiz-Capillas,Ana Herrero Herranz
Publsiher: MDPI
Total Pages: 202
Release: 2019-07-16
ISBN 10: 3039210548
ISBN 13: 9783039210541
Language: EN, FR, DE, ES & NL

Biogenic Amines on Food Safety Book Review:

Biogenic amines have been known for some time. These compounds are found in varying concentrations in a wide range of foods (fish, cheese, meat, wine, beer, vegetables, etc.) and their formations are influenced by different factors associated to those foods (composition, additives, ingredients, storage, microorganism, packaging, handing, conservation, etc.). The intake of foods containing high concentrations of biogenic amines can present a health hazard. Additionally, they have been used to establish indexes in various foods in order to signal the degree of freshness and/or deterioration of food. Nowadays, there has been an increase in the number of food poisoning episodes in consumers associated with the presence of these biogenic amines, mainly associated with histamines. Food safety is one of the main concerns of the consumer and safety agencies of different countries (EFSA, FDA, FSCJ, etc.), which have, as one of their main objectives, to control these biogenic amines, principally histamine, to assure a high level of food safety. Therefore, it is necessary to deepen our understanding of the formation, monitoring and reduction of biogenic amines during the development, processing and storage of food, even the effect of biogenic amines in consumers after digestion of foods with different levels of these compounds. With this aim, we are preparing a Special Issue on the topic of "Biogenic Amines in Food Safety", and we invite researchers to contribute original and unpublished research articles and reviews articles that involve studies of biogenic amines in food, which can provide an update to our knowledge of these compounds and their impacts on food quality and food safety.

Diet and Health

Diet and Health
Author: National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
Publsiher: National Academies Press
Total Pages: 768
Release: 1989-01-01
ISBN 10: 0309039940
ISBN 13: 9780309039949
Language: EN, FR, DE, ES & NL

Diet and Health Book Review:

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
Author: Robert Vink,Mihai Nechifor
Publsiher: University of Adelaide Press
Total Pages: 342
Release: 2011
ISBN 10: 0987073052
ISBN 13: 9780987073051
Language: EN, FR, DE, ES & NL

Magnesium in the Central Nervous System Book Review:

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Neurotransmitters Drugs and Brain Function

Neurotransmitters  Drugs and Brain Function
Author: Roy Webster
Publsiher: John Wiley & Sons
Total Pages: 550
Release: 2001-11-28
ISBN 10: 9780471978190
ISBN 13: 0471978191
Language: EN, FR, DE, ES & NL

Neurotransmitters Drugs and Brain Function Book Review:

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

Chemical and Cellular Architecture

Chemical and Cellular Architecture
Author: Abel Lajtha
Publsiher: Springer Science & Business Media
Total Pages: 496
Release: 2013-04-18
ISBN 10: 1475706146
ISBN 13: 9781475706147
Language: EN, FR, DE, ES & NL

Chemical and Cellular Architecture Book Review:

After the completion of the first edition of this series, this editor thought that a new edition would not be warranted in less than IS, perhaps 20, years, but it seems that we live in a time in which rapid changes are the norm and findings in a field such as neurochemistry develop exponentially. The task of a future editor attempting to get a comprehensive neurochemical handbook for the year 2000 would be even less enviable, but by then information processing may be very different. The approach, the design, and the areas covered by each volume and each chapter are necessarily arbitrary, and it is likely that other editors or authors would have approached the coverage or the organization in a different manner. It is hoped, however, that readers will find the series helpful for beginning or for continuing work. There may be some overlap among the various chapters, but insisting on single coverage of an area would at times have restricted treatment to only one point of view and might have truncated and hurt the logical flow of some of the chapters.

Public Health Consequences of E Cigarettes

Public Health Consequences of E Cigarettes
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems
Publsiher: National Academies Press
Total Pages: 774
Release: 2018-05-18
ISBN 10: 030946837X
ISBN 13: 9780309468374
Language: EN, FR, DE, ES & NL

Public Health Consequences of E Cigarettes Book Review:

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.

Rewire Your Brain

Rewire Your Brain
Author: John B. Arden, PhD
Publsiher: John Wiley & Sons
Total Pages: 256
Release: 2010-03-22
ISBN 10: 0470487291
ISBN 13: 9780470487297
Language: EN, FR, DE, ES & NL

Rewire Your Brain Book Review:

How to rewire your brain to improve virtually every aspect of your life-based on the latest research in neuroscience and psychology on neuroplasticity and evidence-based practices Not long ago, it was thought that the brain you were born with was the brain you would die with, and that the brain cells you had at birth were the most you would ever possess. Your brain was thought to be “hardwired” to function in predetermined ways. It turns out that's not true. Your brain is not hardwired, it's "softwired" by experience. This book shows you how you can rewire parts of the brain to feel more positive about your life, remain calm during stressful times, and improve your social relationships. Written by a leader in the field of Brain-Based Therapy, it teaches you how to activate the parts of your brain that have been underactivated and calm down those areas that have been hyperactivated so that you feel positive about your life and remain calm during stressful times. You will also learn to improve your memory, boost your mood, have better relationships, and get a good night sleep. Reveals how cutting-edge developments in neuroscience, and evidence-based practices can be used to improve your everyday life Other titles by Dr. Arden include: Brain-Based Therapy-Adult, Brain-Based Therapy-Child, Improving Your Memory For Dummies and Heal Your Anxiety Workbook Dr. Arden is a leader in integrating the new developments in neuroscience with psychotherapy and Director of Training in Mental Health for Kaiser Permanente for the Northern California Region Explaining exciting new developments in neuroscience and their applications to daily living, Rewire Your Brain will guide you through the process of changing your brain so you can change your life and be free of self-imposed limitations.

Progressive Brain Disorders in Childhood

Progressive Brain Disorders in Childhood
Author: Juan M. Pascual
Publsiher: Cambridge University Press
Total Pages: 512
Release: 2017-04-20
ISBN 10: 1107042054
ISBN 13: 9781107042056
Language: EN, FR, DE, ES & NL

Progressive Brain Disorders in Childhood Book Review:

A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Calcium Signaling From Physiology to Diseases

Calcium Signaling  From Physiology to Diseases
Author: Senthilkumar Rajagopal,Murugavel Ponnusamy
Publsiher: Springer
Total Pages: 91
Release: 2017-09-28
ISBN 10: 9811051607
ISBN 13: 9789811051609
Language: EN, FR, DE, ES & NL

Calcium Signaling From Physiology to Diseases Book Review:

This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.

Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies

Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies
Author: Muhammad Sajid Hamid Akash,Kanwal Rehman,Muhammad Zaffar Hashmi
Publsiher: Springer Nature
Total Pages: 520
Release: 2020-08-04
ISBN 10: 3030459233
ISBN 13: 9783030459239
Language: EN, FR, DE, ES & NL

Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies Book Review:

This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Fluoride in Drinking Water

Fluoride in Drinking Water
Author: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Fluoride in Drinking Water
Publsiher: National Academies Press
Total Pages: 530
Release: 2007-01-22
ISBN 10: 030910128X
ISBN 13: 9780309101288
Language: EN, FR, DE, ES & NL

Fluoride in Drinking Water Book Review:

Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural sources. Fluoride is one of the drinking water contaminants regulated by the U.S. Environmental Protection Agency (EPA) because it can occur at these toxic levels. In 1986, the EPA established a maximum allowable concentration for fluoride in drinking water of 4 milligrams per liter, a guideline designed to prevent the public from being exposed to harmful levels of fluoride. Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years.

Neuropharmacology of New Psychoactive Substances NPS

Neuropharmacology of New Psychoactive Substances  NPS
Author: Michael H. Baumann,Richard A. Glennon,Jenny L. Wiley
Publsiher: Springer
Total Pages: 380
Release: 2017-04-13
ISBN 10: 3319524445
ISBN 13: 9783319524443
Language: EN, FR, DE, ES & NL

Neuropharmacology of New Psychoactive Substances NPS Book Review:

Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon.

High Calorie Diet and the Human Brain

High Calorie Diet and the Human Brain
Author: Akhlaq A. Farooqui
Publsiher: Springer
Total Pages: 308
Release: 2015-03-25
ISBN 10: 3319152548
ISBN 13: 9783319152547
Language: EN, FR, DE, ES & NL

High Calorie Diet and the Human Brain Book Review:

The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body tissues. In brain, over-nutrition, particularly with high-calorie diet, not only alters cellular homeostasis, but also results in changes in the intensity of signal transduction processes in reward centers of the brain resulting in food addiction. Over-nutrition produces detrimental effects on human health in general and brain health in particular because it chronically increases the systemic and brain inflammation and oxidative stress along with induction of insulin resistance and leptin resistance in the brain as well as visceral organs. Onset of chronic inflammation and oxidative stress not only leads to obesity and heart disease, but also promotes type II diabetes and metabolic syndrome, which are risk factors for both acute neural trauma (stroke) and chronic age-related neurodegenerative and neuropsychological disorders, such as Alzheimer disease (AD), Parkinson disease (PD) and depression.

Chemosensory Transduction

Chemosensory Transduction
Author: Frank Zufall,Steven D. Munger
Publsiher: Academic Press
Total Pages: 430
Release: 2016-02-18
ISBN 10: 0128017864
ISBN 13: 9780128017869
Language: EN, FR, DE, ES & NL

Chemosensory Transduction Book Review:

Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals. Provides a comprehensive overview for all chemosensory transduction mechanisms Valuable for academics focused on sensory biology, neurobiology, and chemosensory transduction, as well as industry researchers in new flavor, fragrance, and food testing Edited by leading experts in the field of olfactory transduction Focuses on mammals, but lower vertebrates and invertebrate model systems are also included

Toxicological Profile for Polycyclic Aromatic Hydrocarbons

Toxicological Profile for Polycyclic Aromatic Hydrocarbons
Author: Anonim
Publsiher: Unknown
Total Pages: 500
Release: 1995
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015038438415
Language: EN, FR, DE, ES & NL

Toxicological Profile for Polycyclic Aromatic Hydrocarbons Book Review:

Neuropathology of Drug Addictions and Substance Misuse Volume 2

Neuropathology of Drug Addictions and Substance Misuse Volume 2
Author: Victor R. Preedy
Publsiher: Academic Press
Total Pages: 1182
Release: 2016-03-25
ISBN 10: 0128003758
ISBN 13: 9780128003756
Language: EN, FR, DE, ES & NL

Neuropathology of Drug Addictions and Substance Misuse Volume 2 Book Review:

Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, and full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body

Amines and Their Metabolites

Amines and Their Metabolites
Author: Alan A. Boulton,Glen B. Baker,Judith M. Baker
Publsiher: Springer Science & Business Media
Total Pages: 576
Release: 1985-11-13
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015011652040
Language: EN, FR, DE, ES & NL

Amines and Their Metabolites Book Review:

Techniques u-r the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope This series is about the methods most widely used by modern-day neuroscrentrsts and 1s written by their colleagues who are practicing experts Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the widest range of subdiscrplines Collectmg these general techmques together in a single volume strikes us not only as a service, but will no doubt prove of exceptronal utilrtarian value as well Volumes 2 and 3 - scribe all current procedures for the analyses of ammes and their metabolrtes and of ammo acids, respectively. These collectrons will clearly be of value to all neuroscrentrsts working m or contemplating research in those fields. Similar reasons exist for Volume 4 on receptor bmdmg techniques since experimental - tails are provided for all types of lrgand-receptor binding, including chapters on general principles, drug discovery and - velopment, and a most useful appendix on computer programs for Scatchard, nonlinear, and competitrve displacement analyses. Volume 5 provides procedures for the assessment of enzymes- volved m brogemc amme synthesis and catabolrsm. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physrologrsts, -anatomrsts, psychopharmacologrsts, psychratrrsts, neurologrsts, and chemists (organic, analytrcal, pharmaceutrcal, medicinal), m fact, everyone involved m the neurosciences, both basic and clinical.