The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry
Author: Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
Publsiher: Elsevier
Total Pages: 902
Release: 2015-07-01
ISBN 10: 012417213X
ISBN 13: 9780124172135
Language: EN, FR, DE, ES & NL

The Practice of Medicinal Chemistry Book Review:

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry
Author: Camille Georges Wermuth
Publsiher: Elsevier
Total Pages: 736
Release: 2003-06-11
ISBN 10: 0080497772
ISBN 13: 9780080497778
Language: EN, FR, DE, ES & NL

The Practice of Medicinal Chemistry Book Review:

The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. * The only book available dealing with the practical aspects of medicinal chemistry * Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production * Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry

The Handbook of Medicinal Chemistry

The Handbook of Medicinal Chemistry
Author: Andrew Davis,Simon E Ward
Publsiher: Royal Society of Chemistry
Total Pages: 753
Release: 2015-07-07
ISBN 10: 1782621830
ISBN 13: 9781782621836
Language: EN, FR, DE, ES & NL

The Handbook of Medicinal Chemistry Book Review:

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

Basic Concepts in Medicinal Chemistry

Basic Concepts in Medicinal Chemistry
Author: Marc Harrold,Robin Zavod
Publsiher: ASHP
Total Pages: 460
Release: 2013-01-18
ISBN 10: 1585283649
ISBN 13: 9781585283644
Language: EN, FR, DE, ES & NL

Basic Concepts in Medicinal Chemistry Book Review:

Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.

Medicinal Chemistry

Medicinal Chemistry
Author: Norma K Dunlap,Donna M Huryn
Publsiher: Garland Science
Total Pages: 375
Release: 2018-04-17
ISBN 10: 1351586211
ISBN 13: 9781351586214
Language: EN, FR, DE, ES & NL

Medicinal Chemistry Book Review:

Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry.

Medicinal Chemistry

Medicinal Chemistry
Author: Frank D. King
Publsiher: Unknown
Total Pages: 448
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015056451621
Language: EN, FR, DE, ES & NL

Medicinal Chemistry Book Review:

This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.

An Introduction to Medicinal Chemistry

An Introduction to Medicinal Chemistry
Author: Graham L. Patrick
Publsiher: Oxford University Press
Total Pages: 789
Release: 2013-01-10
ISBN 10: 0199697396
ISBN 13: 9780199697397
Language: EN, FR, DE, ES & NL

An Introduction to Medicinal Chemistry Book Review:

This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.

Medicinal Chemistry

Medicinal Chemistry
Author: A.K. Ganguly,Sesha Sridevi Alluri
Publsiher: CRC Press
Total Pages: 118
Release: 2021-09-02
ISBN 10: 1000437280
ISBN 13: 9781000437287
Language: EN, FR, DE, ES & NL

Medicinal Chemistry Book Review:

Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.

Handbook of Research on Medicinal Chemistry

Handbook of Research on Medicinal Chemistry
Author: Debarshi Kar Mahapatra,Sanjay Kumar Bharti
Publsiher: Taylor & Francis
Total Pages: 626
Release: 2017-11-20
ISBN 10: 1771885459
ISBN 13: 9781771885454
Language: EN, FR, DE, ES & NL

Handbook of Research on Medicinal Chemistry Book Review:

This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and Methodologies, presents some of the latest advancements in the various fields of combinatorial chemistry, drug discovery, biochemical aspects, pharmacology of medicinal agents, current practical problems, and nutraceuticals. The editors keep the drug molecule as the central component of the volume and aim to explain the associated features essential to exhibiting pharmacological activity. With a unique combination of chapters in biology, clinical aspects, biochemistry, synthetic chemistry, medicine and technology, the volume provides broad exposure to the essential aspect of pharmaceuticals. The volume many important aspects of medicinal chemistry, including techniques in drug discovery pharmacological aspects of natural products chemical mediators: druggable targets advances in medicinal chemistry The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach, covering a range of new research and new practices in the field. The volume takes into account the latest therapeutic guidelines put forward by the World Health Organization and the U.S Food and Drug Administration.. Topics include: drug design drug discovery natural products and supplements and nutraceuticals pharmaceutical approaches to sexual dysfunction drug resistance parasites new natural compounds and identification of new targets stereochemistry aspects in medicinal chemistry common drug interactions in daily practices Handbook of Research on Medicinal Chemistry: Innovations and Methodologies will be a valuable addition to the bookshelves of pharmaceutical scientists and faculty as well as for industry professionals.

Organic Chemistry Concepts and Applications for Medicinal Chemistry

Organic Chemistry Concepts and Applications for Medicinal Chemistry
Author: Joseph E. Rice
Publsiher: Academic Press
Total Pages: 224
Release: 2014-04-14
ISBN 10: 0128008326
ISBN 13: 9780128008324
Language: EN, FR, DE, ES & NL

Organic Chemistry Concepts and Applications for Medicinal Chemistry Book Review:

Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material

The Ups and Downs in Drug Design

The Ups and Downs in Drug Design
Author: Victor E. Marquez
Publsiher: CRC Press
Total Pages: 474
Release: 2021-11-16
ISBN 10: 1000462943
ISBN 13: 9781000462944
Language: EN, FR, DE, ES & NL

The Ups and Downs in Drug Design Book Review:

The Ups and Downs in Drug Design: Adventures in Medicinal Chemistry highlights the necessity for an integrative approach in medicinal chemistry and chemical biology. As medicinal chemistry is not a monolithic science, it is important to emphasize the other various disciplines that are required for successful drug design. This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery. It is an excellent companion text for graduate and postgraduate students who would like further insight into the parameters of drug design, including the challenges that come with the project. Key Features Illustrates "real-life" examples in medicinal chemistry Integrates the use of physical, chemical, and biological concepts that are important in drug design Highlights the "ups" and "downs" that come with drug discovery Aims to inspire students who may be struggling with the challenges and thought process in drug design Intends to be an excellent companion text for graduate and postgraduate students

Medicinal Chemistry with Pharmaceutical Product Development

Medicinal Chemistry with Pharmaceutical Product Development
Author: Debarshi Kar Mahapatra,Sanjay Kumar Bharti
Publsiher: CRC Press
Total Pages: 368
Release: 2019-02-04
ISBN 10: 0429947143
ISBN 13: 9780429947148
Language: EN, FR, DE, ES & NL

Medicinal Chemistry with Pharmaceutical Product Development Book Review:

This volume focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It discusses current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for health problems. Explaining the necessary features essential for pharmacological activity, it takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. It takes into consideration the therapeutic regulations of the USP along with all the latest therapeutic guidelines put forward by WHO, and the US Food and Drug Administration.

Successful Drug Discovery

Successful Drug Discovery
Author: János Fischer,David P. Rotella
Publsiher: John Wiley & Sons
Total Pages: 256
Release: 2015-01-30
ISBN 10: 352767845X
ISBN 13: 9783527678457
Language: EN, FR, DE, ES & NL

Successful Drug Discovery Book Review:

The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.

Essentials of Organic Chemistry

Essentials of Organic Chemistry
Author: Paul M. Dewick
Publsiher: John Wiley & Sons
Total Pages: 704
Release: 2013-03-20
ISBN 10: 1118681967
ISBN 13: 9781118681961
Language: EN, FR, DE, ES & NL

Essentials of Organic Chemistry Book Review:

Essentials of Organic Chemistry is an accessible introduction tothe subject for students of Pharmacy, Medicinal Chemistry andBiological Chemistry. Designed to provide a thorough grounding infundamental chemical principles, the book focuses on key elementsof organic chemistry and carefully chosen material is illustratedwith the extensive use of pharmaceutical and biochemicalexamples. In order to establish links and similarities the book placesprominence on principles and deductive reasoning withcross-referencing. This informal text also places the main emphasison understanding and predicting reactivity rather than syntheticmethodology as well as utilising a mechanism based layout andfeaturing annotated schemes to reduce the need for textualexplanations. * tailored specifically to the needs of students of PharmacyMedical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of PharmacyMedicinal and Biological Chemistry.

Prodrugs and Targeted Delivery

Prodrugs and Targeted Delivery
Author: Jarkko Rautio
Publsiher: John Wiley & Sons
Total Pages: 520
Release: 2011-01-11
ISBN 10: 3527633189
ISBN 13: 9783527633180
Language: EN, FR, DE, ES & NL

Prodrugs and Targeted Delivery Book Review:

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Richard B. Silverman
Publsiher: Elsevier
Total Pages: 617
Release: 2012-12-02
ISBN 10: 0080513379
ISBN 13: 9780080513379
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Review:

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

An Introduction to Medicinal Chemistry

An Introduction to Medicinal Chemistry
Author: Graham L. Patrick
Publsiher: Oxford University Press, USA
Total Pages: 620
Release: 2001
ISBN 10: 9780198505334
ISBN 13: 0198505337
Language: EN, FR, DE, ES & NL

An Introduction to Medicinal Chemistry Book Review:

NEW TO THIS EDITION Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * adrenergics * drug discovery and drug development

Chemistry of Fungi

Chemistry of Fungi
Author: James R. Hanson
Publsiher: Royal Society of Chemistry
Total Pages: 221
Release: 2008-08-14
ISBN 10: 0854041362
ISBN 13: 9780854041367
Language: EN, FR, DE, ES & NL

Chemistry of Fungi Book Review:

Fungi occupy an important place in the natural world, as non-photosynthetic organisms, they obtain their nutrients from the degradation of organic material. They use many of their secondary metabolites to secure a place in a competitive natural environment and to protect themselves from predation. The diverse structures, biosyntheses and biological activities of fungal metabolites have attracted chemists for many years. Fungi are ubiquitous and their activities affect many aspects of our daily lives whether it be as sources of pharmaceuticals and food or as spoilage organisms and the causes of diseases in plants and man. The chemistry of the fungi involved in these activities has been the subject of considerable study particularly over the last fifty years. Although their ramifications can be large as in the spread of plant diseases, the quantities of the metabolites which could be isolated precluded much chemical work until the advent of spectroscopic methods. Whereas many natural products derived from plants were isolated prior to the 1960s on a scale which permitted extensive chemical degradation, this was rarely the case for fungal metabolites. This book is an introduction to the chemistry of fungal metabolites. The aim is to illustrate within the context of fungal metabolites, the historical progression from chemical to spectroscopic methods of structure elucidation, the development in biosynthetic studies from establishing sequences and mechanisms to chemical enzymology and genetics and the increasing understanding of the biological roles of natural products. The book begins with a historical introduction followed by a description of the general chemical features which contribute to the growth of fungi. There are many thousands of fungal metabolites whose structures are known and the book does not aim to list them all as there are databases to fulfill this role. The book's aim is to describe some of the more important metabolites classified according to their biosynthetic origin. Biosynthesis provides a unifying feature underlying the diverse structures of fungal metabolites and the chapters covering this area begin with a general outline of the relevant biosynthetic pathway before presenting a detailed description of particular metabolites. Investigations into these biosyntheses have utilized many subtle isotopic labelling experiments and compounds that are fungal pigments and those which are distinctive metabolites of the more conspicuous Basidiomycetes are treated separately. Many fungal metabolites are involved in the interactions of fungi with plants and others are toxic to man and some of these are described in further chapters. Fungi have the ability to transform chemicals in ways which can complement conventional reactions and the use of fungi as reagents forms the subject of the final chapter. This book will be particularly useful to anybody about to embark on a career in chemical microbiology by providing an overall perspective of fungal metabolites as well as an essential reference tool for more general chemists.

Remington

Remington
Author: Adeboye Adejare
Publsiher: Academic Press
Total Pages: 1030
Release: 2020-11-03
ISBN 10: 0128223898
ISBN 13: 9780128223895
Language: EN, FR, DE, ES & NL

Remington Book Review:

Remington: The Science and Practice of Pharmacy, Twenty Third Edition, offers a trusted, completely updated source of information for education, training, and development of pharmacists. Published for the first time with Elsevier, this edition includes coverage of biologics and biosimilars as uses of those therapeutics have increased substantially since the previous edition. Also discussed are formulations, drug delivery (including prodrugs, salts, polymorphism. With clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery and development will find this edition of Remington an essential reference. Intellectual property professionals will also find this reference helpful to cite in patents and resulting litigations. Additional graduate and postgraduate students in Pharmacy and Pharmaceutical Sciences will refer to this book in courses dealing with medicinal chemistry and pharmaceutics. Contains a comprehensive source of principles of drug discovery and development topics, especially for scientists that are new in the pharmaceutical industry such as those with trainings/degrees in chemistry and engineering Provides a detailed source for formulation scientists and compounding pharmacists, from produg to excipient issues Updates this excellent source with the latest information to verify facts and refresh on basics for professionals in the broadly defined pharmaceutical industry

Drug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks
Author: Jie Jack Li,Minmin Yang
Publsiher: CRC Press
Total Pages: 320
Release: 2021-10-21
ISBN 10: 1000416011
ISBN 13: 9781000416015
Language: EN, FR, DE, ES & NL

Drug Discovery with Privileged Building Blocks Book Review:

Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.