Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder
Author: Joao Luciano de Quevedo,Andre Ferrer Carvalho,Eduard Vieta
Publsiher: Academic Press
Total Pages: 470
Release: 2020-11-25
ISBN 10: 012819183X
ISBN 13: 9780128191835
Language: EN, FR, DE, ES & NL

Neurobiology of Bipolar Disorder Book Review:

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Bipolar Disorder

Bipolar Disorder
Author: Lakshmi N. Yatham,Mario Maj
Publsiher: John Wiley & Sons
Total Pages: 522
Release: 2011-06-28
ISBN 10: 1119956226
ISBN 13: 9781119956228
Language: EN, FR, DE, ES & NL

Bipolar Disorder Book Review:

Bipolar disorder is the most complex psychiatric disorder with different types of mood episodes, subtypes, varied course, and significant co-morbidity. Not surprisingly, this complexity poses unique challenges to clinicians for optimal management of those with bipolar disorder. There has been an explosion of research into the causes and treatment of this condition over the past two decades. It is a daunting task for a practising clinician to make sense of this research and to remain up to date with progress in the understanding of the neurobiology and treatment of bipolar disorder. This book synthesizes and translates the vast array of research knowledge into information that is clinically relevant and meaningful for a clinician. The book provides a comprehensive, yet focused, reference work on bipolar disorder for both trainees and practising psychiatrists. The two editors are leaders in the field who have published extensively on bipolar disorder. They have assembled a team of experts from around the world: in many instances, chapters are co-authored by people from different continents, bringing a truly international perspective to this important topic. The book covers the basic science of the pathology underlying bipolar disorder but addresses the clinical aspects of the disease throughout. The book comprises four sections: Descriptive Aspects—issues ranging from how the concept of bipolar disorder has evolved over the years to new information about neurocognitive impairment, creativity and economic productivity, and to discussion of the deliberations of the DSM-V committee on changes in diagnostic categories and criteria. Biology—the contribution of genes to this disorder, changes in circadian rhythms, what we know about brain changes and the role of oxidative stress. Biological Treatment and Psychosocial Treatment— all the latest information about pharmacological and psychological treatments and the optimal management of this condition. If you want to provide state-of-the-art care to your bipolar patients, be sure to consult this authoritative reference.

The Bipolar Book

The Bipolar Book
Author: Aysegül Yildiz
Publsiher: Oxford University Press, USA
Total Pages: 704
Release: 2015-05-28
ISBN 10: 0199300534
ISBN 13: 9780199300532
Language: EN, FR, DE, ES & NL

The Bipolar Book Book Review:

As a major mainstay of clinical focus and research today, bipolar disorder affects millions of individuals across the globe with its extreme and erratic shifts of mood, thinking and behavior. Edited by a team of experts in the field, The Bipolar Book: History, Neurobiology, and Treatment is a testament and guide to diagnosing and treating this exceedingly complex, highly prevalent disease. Featuring 45 chapters from an expert team of contributors from around the world, The Bipolar Book delves deep into the origins of the disorder and how it informs clinical practice today by focusing on such topics as bipolar disorder occurring in special populations, stigmatization of the disease, the role genetics play, postmortem studies, psychotherapy, treatments and more. Designed to be the definitive reference volume for clinicians, students and researchers, Aysegül Yildiz, Pedro Ruiz and Charles Nemeroff present The Bipolar Book as a "must have" for those caregivers who routinely deal with this devastating disease.

Bipolar Disorder From Neuroscience to Treatment

Bipolar Disorder  From Neuroscience to Treatment
Author: Allan H. Young,Mario F. Juruena
Publsiher: Springer Nature
Total Pages: 325
Release: 2021-03-29
ISBN 10: 3030721434
ISBN 13: 9783030721435
Language: EN, FR, DE, ES & NL

Bipolar Disorder From Neuroscience to Treatment Book Review:

Bipolar disorder is a common, complex and costly mental health disorder, which sits at the heart of the practice of clinical psychiatry. Effective treatments (pharmacological, psychological and brain stimulation based) have all been discovered serendipitously. With the huge advances in basic neuroscience the way is now clear for novel treatments to be developed based on brain science. This book reviews these possibilities.

Bipolar Disorder in Youth

Bipolar Disorder in Youth
Author: Stephen M. Strakowski,Melissa P. DelBello,Caleb M. Adler
Publsiher: Oxford University Press, USA
Total Pages: 382
Release: 2014-10-29
ISBN 10: 0199985359
ISBN 13: 9780199985357
Language: EN, FR, DE, ES & NL

Bipolar Disorder in Youth Book Review:

Bipolar Disorder in Youth provides a timely, focused review of the diagnosis, treatment, and neurobiology of bipolar disorder in youth. The editors and authors of each chapter represent international leaders in the care and study of this population. This book is the most comprehensive volume available discussing this important population and is a 'must' for the libraries of clinicians and scientists working with bipolar children and adolescents.

Neuroprogression in Psychiatry

Neuroprogression in Psychiatry
Author: Flávio Kapczinski,Michael Berk,Pedro Vieira da Silva Magalhães
Publsiher: Oxford University Press
Total Pages: 272
Release: 2019-03-05
ISBN 10: 0191090883
ISBN 13: 9780191090882
Language: EN, FR, DE, ES & NL

Neuroprogression in Psychiatry Book Review:

Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression. Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.

Bipolar Depression Molecular Neurobiology Clinical Diagnosis and Pharmacotherapy

Bipolar Depression  Molecular Neurobiology  Clinical Diagnosis and Pharmacotherapy
Author: Carlos A. Zarate Jr.,Husseini K. Manji
Publsiher: Springer Science & Business Media
Total Pages: 279
Release: 2009-04-16
ISBN 10: 3764385677
ISBN 13: 9783764385675
Language: EN, FR, DE, ES & NL

Bipolar Depression Molecular Neurobiology Clinical Diagnosis and Pharmacotherapy Book Review:

Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression. Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments. This volume offers researchers and clinicians key insights into this devastating disorder.

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
Author: Yogesh Dwivedi
Publsiher: CRC Press
Total Pages: 482
Release: 2012-06-25
ISBN 10: 143983881X
ISBN 13: 9781439838815
Language: EN, FR, DE, ES & NL

The Neurobiological Basis of Suicide Book Review:

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Behavioral Neurobiology of Bipolar Disorder and its Treatment

Behavioral Neurobiology of Bipolar Disorder and its Treatment
Author: Husseini K. Manji,Carlos A. Zarate Jr.
Publsiher: Springer Science & Business Media
Total Pages: 347
Release: 2010-11-10
ISBN 10: 3642157572
ISBN 13: 9783642157578
Language: EN, FR, DE, ES & NL

Behavioral Neurobiology of Bipolar Disorder and its Treatment Book Review:

This book offers the most up-to-date information about research surrounding the neurobiology of bipolar disorder as well as currently available and novel therapeutic options. The volume has assembled a widely respected group of preclinical and clinical researchers who bring their expertise to bear upon this illness by reviewing cutting-edge research and clinical evidence regarding the pathophysiology and treatment of bipolar disorder. Early chapters review the course and outcome and genetics of this highly heritable condition, including chapters on epigenetics and clinical endophenotypes. Several chapters offer a remarkably thorough and unique overview of the neurobiology of the disorder, including what is known from neuroimaging work and the development of animal models. Finally, the book covers treatment strategies for bipolar disorder, including both traditional and novel therapeutics, as well as non-pharmacological treatments. It offers both researchers and clinicians key insights into this devastating disorder.

Neurobiology of Mental Illness

Neurobiology of Mental Illness
Author: Dennis S. Charney,Eric J. Nestler,Pamela Sklar,Joseph D. Buxbaum
Publsiher: Oxford University Press
Total Pages: 1222
Release: 2013-07-04
ISBN 10: 0199934959
ISBN 13: 9780199934959
Language: EN, FR, DE, ES & NL

Neurobiology of Mental Illness Book Review:

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Bipolar Disorder

Bipolar Disorder
Author: Stephen M. Strakowski,Melissa P. DelBello,Caleb M. Adler,David E. Fleck
Publsiher: Oxford University Press
Total Pages: 400
Release: 2020-01-22
ISBN 10: 0190908106
ISBN 13: 9780190908102
Language: EN, FR, DE, ES & NL

Bipolar Disorder Book Review:

Bipolar disorder is among the most common conditions affecting humankind and one of the leading causes of disability worldwide. It is a complex and dynamic psychiatric condition that makes it difficult to both understand and manage. However, with good management, people affected by bipolar disorder can lead very successful lives. This book was written specifically with new psychiatrists and mental health practitioners in mind to facilitate their ability to care for this condition. Chapters review clinical presentation and epidemiology, etiology and neurobiology, and treatment of bipolar disorder.

Genomics Circuits and Pathways in Clinical Neuropsychiatry

Genomics  Circuits  and Pathways in Clinical Neuropsychiatry
Author: Thomas Lehner,Bruce L. Miller,Matthew W. State
Publsiher: Academic Press
Total Pages: 796
Release: 2016-06-07
ISBN 10: 0128005300
ISBN 13: 9780128005309
Language: EN, FR, DE, ES & NL

Genomics Circuits and Pathways in Clinical Neuropsychiatry Book Review:

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Neurobiology of Brain Disorders

Neurobiology of Brain Disorders
Author: Michael J. Zigmond,Clayton A. Wiley,Marie-Francoise Chesselet
Publsiher: Academic Press
Total Pages: 1134
Release: 2022-05-27
ISBN 10: 0323898254
ISBN 13: 9780323898256
Language: EN, FR, DE, ES & NL

Neurobiology of Brain Disorders Book Review:

Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more. Links basic, translational and clinical research on disorders of the nervous system Covers a vast array of neurological and psychiatric disorders, including Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson's, Huntington's, Alzheimer's, OCD, PTSD, schizophrenia, depression and pain Features new chapters on the effects of aging and isolation on brain health Expands coverage on disorders, including new chapters on fibromyalgia, chronic fatigue, and restless legs syndrome Features in-text summary points, special feature boxes and research questions

The Bipolar Brain

The Bipolar Brain
Author: Stephen Strakowski
Publsiher: Oxford University Press
Total Pages: 280
Release: 2012-07-26
ISBN 10: 0199797609
ISBN 13: 9780199797608
Language: EN, FR, DE, ES & NL

The Bipolar Brain Book Review:

In this book, experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder, leading to an integrated neurophysiologic model of this condition. This model provides a substrate for future investigations to, hopefully, lead to better understanding of this illness in order to develop improved therapies for affected individuals.

Neurobiology of Psychiatric Disorders

Neurobiology of Psychiatric Disorders
Author: Thomas E. Schlaepfer,Charles B. Nemeroff
Publsiher: Elsevier
Total Pages: 760
Release: 2012
ISBN 10: 0444520023
ISBN 13: 9780444520029
Language: EN, FR, DE, ES & NL

Neurobiology of Psychiatric Disorders Book Review:

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Neurobiology of Depression

Neurobiology of Depression
Author: Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Publsiher: Academic Press
Total Pages: 471
Release: 2019-01-03
ISBN 10: 0128133341
ISBN 13: 9780128133347
Language: EN, FR, DE, ES & NL

Neurobiology of Depression Book Review:

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Charney Nestler s Neurobiology of Mental Illness

Charney   Nestler s Neurobiology of Mental Illness
Author: Dennis S. Charney,Pamela B. Sklar
Publsiher: Oxford University Press
Total Pages: 1024
Release: 2018-01-12
ISBN 10: 019068142X
ISBN 13: 9780190681425
Language: EN, FR, DE, ES & NL

Charney Nestler s Neurobiology of Mental Illness Book Review:

Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Bipolar Disorder Vulnerability

Bipolar Disorder Vulnerability
Author: Jair Soares,Consuelo Walss-Bass,Paolo Brambilla
Publsiher: Academic Press
Total Pages: 288
Release: 2018-06-09
ISBN 10: 0128125608
ISBN 13: 9780128125601
Language: EN, FR, DE, ES & NL

Bipolar Disorder Vulnerability Book Review:

Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness. Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomics Examines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorder Explores the interaction between genomic and environmental influences that shape behavior

Psychiatric Disorders

Psychiatric Disorders
Author: Dieter Schoepf
Publsiher: BoD – Books on Demand
Total Pages: 322
Release: 2013-05-22
ISBN 10: 9535111477
ISBN 13: 9789535111474
Language: EN, FR, DE, ES & NL

Psychiatric Disorders Book Review:

Affective disorders are a subject of interest to clinicians for more than a century. The awareness of an urgent need for an evidence-based “personalized” approach of treatment is growing in the field of psychiatry. This book brings together leading experts to create a volume of equal interest and usefulness to students, clinicians and researchers alike, which should serve as common knowledge. Specific themes of major depression, bipolar disorder, and schizoaffective disorder are critically reviewed, addressing topics such as neurobiological mechanisms underlying the pathogenesis, treatment resistant depression, translational research and challenging stigma of serious mental illness. Particular emphasis is put on novel developments in Cognitive-Behavioral Therapy and on attention to causal mechanisms of behaviour change in the Cognitive Behavioral Analysis System of Psychotherapy.

Neurological Psychiatric and Developmental Disorders

Neurological  Psychiatric  and Developmental Disorders
Author: Institute of Medicine,Board on Global Health,Committee on Nervous System Disorders in Developing Countries
Publsiher: National Academies Press
Total Pages: 458
Release: 2001-01-01
ISBN 10: 9780309170932
ISBN 13: 0309170931
Language: EN, FR, DE, ES & NL

Neurological Psychiatric and Developmental Disorders Book Review:

Brain disordersâ€"neurological, psychiatric, and developmentalâ€"now affect at least 250 million people in the developing world, and this number is expected to rise as life expectancy increases. Yet public and private health systems in developing countries have paid relatively little attention to brain disorders. The negative attitudes, prejudice, and stigma that often surround many of these disorders have contributed to this neglect. Lacking proper diagnosis and treatment, millions of individual lives are lost to disability and death. Such conditions exact both personal and economic costs on families, communities, and nations. The report describes the causes and risk factors associated with brain disorders. It focuses on six representative brain disorders that are prevalent in developing countries: developmental disabilities, epilepsy, schizophrenia, bipolar disorder, depression, and stroke. The report makes detailed recommendations of ways to reduce the toll exacted by these six disorders. In broader strokes, the report also proposes six major strategies toward reducing the overall burden of brain disorders in the developing world.