The Design and Development of Novel Drugs and Vaccines

The Design and Development of Novel Drugs and Vaccines
Author: Tarun Kumar Bhatt,Surendra Nimesh
Publsiher: Academic Press
Total Pages: 308
Release: 2021-01-21
ISBN 10: 0128214759
ISBN 13: 9780128214756
Language: EN, FR, DE, ES & NL

The Design and Development of Novel Drugs and Vaccines Book Review:

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development

Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics

Nonclinical Development of Novel Biologics  Biosimilars  Vaccines and Specialty Biologics
Author: Lisa Plitnick,Danuta Herzyk
Publsiher: Academic Press
Total Pages: 432
Release: 2013-06-27
ISBN 10: 0123948231
ISBN 13: 9780123948236
Language: EN, FR, DE, ES & NL

Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics Book Review:

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics. Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical Contains the most pertinent international regulatory guidance documents for nonclinical evaluation Covers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars" A multi-authored book with chapters written by qualified experts in their respective fields

Parasites Molecular Biology Drug and Vaccine Design

Parasites  Molecular Biology  Drug and Vaccine Design
Author: Nina Agabian,Anthony Cerami
Publsiher: Unknown
Total Pages: 504
Release: 1990
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015017994354
Language: EN, FR, DE, ES & NL

Parasites Molecular Biology Drug and Vaccine Design Book Review:

This wide-ranging collection of edited papers examines the many mechanisms that allow parasites to survive and interact in a host environment. The research explains how a more knowledgeable understanding of host-parasite interactions aids in the development of unique strategies for vaccine design and applied research in clinical diagnostics and therapeutics. Divided into five parts, the text covers gene expression during parasite differentiation and development; the potential for molecular genetics in parasite systems; molecules of the parasite membrane; molecular modeling and parasite drug design; and vaccines.

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents
Author: Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan
Publsiher: Academic Press
Total Pages: 656
Release: 2020-04-07
ISBN 10: 0128199180
ISBN 13: 9780128199183
Language: EN, FR, DE, ES & NL

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents Book Review:

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies

Novel Approaches and Strategies for Biologics  Vaccines and Cancer Therapies
Author: Manmohan Singh,Maya Salnikova
Publsiher: Academic Press
Total Pages: 520
Release: 2014-12-30
ISBN 10: 012416661X
ISBN 13: 9780124166615
Language: EN, FR, DE, ES & NL

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies Book Review:

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Novel Strategies in the Design and Production of Vaccines

Novel Strategies in the Design and Production of Vaccines
Author: Sara Cohen,Avigdor Shafferman
Publsiher: Springer Science & Business Media
Total Pages: 198
Release: 2013-06-29
ISBN 10: 1489913823
ISBN 13: 9781489913821
Language: EN, FR, DE, ES & NL

Novel Strategies in the Design and Production of Vaccines Book Review:

Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).

Post Genomic Approaches in Drug and Vaccine Development

Post Genomic Approaches in Drug and Vaccine Development
Author: Kishore R. Sakharkar,Meena K. Sakharkar ,Ramesh Chandra
Publsiher: River Publishers
Total Pages: 450
Release: 2015-04-11
ISBN 10: 8793102844
ISBN 13: 9788793102842
Language: EN, FR, DE, ES & NL

Post Genomic Approaches in Drug and Vaccine Development Book Review:

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: Drug discoveryTarget identification and prioritizationHypothesis driven multi-target drug designGenomics in vaccine developmentGene regulatory networks Vaccine design and developmentPrediction of drug side effects in silico

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1991
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015020571777
Language: EN, FR, DE, ES & NL

Biomedical Index to PHS supported Research Book Review:

Nutrition and Disease

Nutrition and Disease
Author: Kenneth Lundstrom
Publsiher: Cambridge Scholars Publishing
Total Pages: 180
Release: 2020-02-24
ISBN 10: 1527547531
ISBN 13: 9781527547537
Language: EN, FR, DE, ES & NL

Nutrition and Disease Book Review:

Nutrition is an essential part of life. It affects our health and can be applied in the prevention and treatment of disease. Substantial interventions in dietary intake and lifestyle changes have been demonstrated to cause significant decrease in disease risk in in the general population and also in patients suffering from various diseases. Traditional plant-based diets and medicines have received much attention as an alternative to modern science-based drugs, while recent technology development in bioinformatics, genomics, and proteomics has provided a better understanding of plant-based drugs, improved quality assurance and allowed the acceleration of clinical trials to bridge the gap with Western medicine. Moreover, research in nutrigenomics and epigenomics has further enhanced the knowledge of the association between nutrition and disease. The book deals with the concerns of the future well-being of our planet, the health of the global human population related to the worldwide obesity epidemic, the issues related to sustainable food production, and the need for a switch to a healthier, more plant-based diet.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 118
Release: 2014-02-06
ISBN 10: 0309292492
ISBN 13: 9780309292498
Language: EN, FR, DE, ES & NL

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book Review:

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Novel AI and Data Science Advancements for Sustainability in the Era of COVID 19

Novel AI and Data Science Advancements for Sustainability in the Era of COVID 19
Author: Victor Chang,Mohamed Abdel-Basset,Muthu Ramachandran,Nicolas Green,Gary Wills
Publsiher: Academic Press
Total Pages: 298
Release: 2022-04-05
ISBN 10: 0323903789
ISBN 13: 9780323903783
Language: EN, FR, DE, ES & NL

Novel AI and Data Science Advancements for Sustainability in the Era of COVID 19 Book Review:

Novel AI and Data Science Advancements for Sustainability in the Era of COVID-19 discusses how the role of recent technologies applied to health settings can help fight virus outbreaks. Moreover, it provides guidelines on how governments and institutions should prepare and quickly respond to drastic situations using technology to support their communities in order to maintain life and functional as efficiently as possible. The book discusses topics such as AI-driven histopathology analysis for COVID-19 diagnosis, bioinformatics for subtype rational drug design, deep learning-based treatment evaluation and outcome prediction, sensor informatics for monitoring infected patients, and machine learning for tracking and prediction models. In addition, the book presents AI solutions for hospital management during an epidemic or pandemic, along with real-world solutions and case studies of successful measures to support different types of communities. This is a valuable source for medical informaticians, bioinformaticians, clinicians and other healthcare workers and researchers who are interested in learning more on how recently developed technologies can help us fight and minimize the effects of global pandemics. Discusses AI advancements in predictive and decision modeling and how to design mobile apps to track contagion spread Presents the smart contract concept in blockchain and cryptography technology to guarantee security and privacy of people’s data once their information has been used to fight the pandemic Encompasses guidelines for emergency preparedness, planning, recovery and continuity management of communities to support people in emergencies like a virus outbreak

Parasitic Flatworms

Parasitic Flatworms
Author: Aaron G. Maule,Nikki J. Marks
Publsiher: CABI
Total Pages: 448
Release: 2006
ISBN 10: 0851990274
ISBN 13: 9780851990279
Language: EN, FR, DE, ES & NL

Parasitic Flatworms Book Review:

This book examines recent research into the molecular biology, genomics and transcriptomics of, and novel control strategies for, flatworm parasites. These include Cestodes (tapeworms) and Trematodes (flukes, schistosomes etc), which are the cause of a number of diseases of medical and veterinary importance. The book explores three main areas: phylogeny, genetics and transcriptomes; immunobiology, host-parasite interaction and control; and protein function, metabolism and physiology. Where appropriate, comparisons are made between different parasitic flatworms and between parasitic and free-living species. The book concludes by exploring future avenues for research. Contributors to the book include leading authorities from Europe, North and South America, and Australia.

Frontiers in Anti Infective Agents Volume 6

Frontiers in Anti Infective Agents  Volume 6
Author: Parvesh Singh
Publsiher: Bentham Science Publishers
Total Pages: 220
Release: 2021-11-17
ISBN 10: 9814998435
ISBN 13: 9789814998437
Language: EN, FR, DE, ES & NL

Frontiers in Anti Infective Agents Volume 6 Book Review:

Anti-infective agents are a distinct class of pharmacologically important molecules that have served mankind in different capacities to combat life-threatening pathological conditions. They include antibacterial, antifungal, antiviral, antituberculosis, antimalarial, and urinary anti-infective agents. However, evolutionary changes, adaptations, and the development of new strains of pathogenic microorganisms have reduced the therapeutic efficacy of existing drugs, thus, limiting their clinical utility over the years. Frontiers in Anti-Infective Agents Volume 6 is a collection of notable research efforts, successful anti-infective drug development programs, and a comprehensive overview of successful and unsuccessful clinical trials conducted in this domain. This volume continues from the last one with interesting reviews on 1) “Reverse Vaccinology” for vaccination design using computational data to identify vaccine targets, 2) leptospirosis, 3) phage therapy for bacterial infections, 4) quorum sensing inhibitors from natural products, and 5) nitrogen and oxygen-based heterocyclic compounds that can act as anti-infective agents. The volume, therefore, covers a range of frontier topics on anti-infective research and development. This compilation is a timely reference for postgraduate scholars and researchers seeking updates in specific areas of anti-infective drug development. Allied healthcare professionals (clinical and public healthcare professionals) can also benefit from the information presented within.

Department of Defense Appropriations for Fiscal Year 2002

Department of Defense Appropriations for Fiscal Year 2002
Author: United States,United States. Congress. Senate. Committee on Appropriations. Subcommittee on Defense
Publsiher: Unknown
Total Pages: 1089
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: UCAL:B5104758
Language: EN, FR, DE, ES & NL

Department of Defense Appropriations for Fiscal Year 2002 Book Review:

Apicomplexan Parasites

Apicomplexan Parasites
Author: Katja Becker
Publsiher: John Wiley & Sons
Total Pages: 550
Release: 2011-01-19
ISBN 10: 3527633901
ISBN 13: 9783527633906
Language: EN, FR, DE, ES & NL

Apicomplexan Parasites Book Review:

This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.

Design of Experiments and Advanced Statistical Techniques in Clinical Research

Design of Experiments and Advanced Statistical Techniques in Clinical Research
Author: Basavarajaiah D. M.,Bhamidipati Narasimha Murthy
Publsiher: Springer Nature
Total Pages: 356
Release: 2020-11-05
ISBN 10: 9811582106
ISBN 13: 9789811582103
Language: EN, FR, DE, ES & NL

Design of Experiments and Advanced Statistical Techniques in Clinical Research Book Review:

Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.

Index Medicus

Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 1928374650XXX
ISBN 13: OSU:32436011091988
Language: EN, FR, DE, ES & NL

Index Medicus Book Review:

Comparative Genomics

Comparative Genomics
Author: James R. Brown
Publsiher: CRC Press
Total Pages: 400
Release: 2007-12-03
ISBN 10: 9781420008876
ISBN 13: 1420008870
Language: EN, FR, DE, ES & NL

Comparative Genomics Book Review:

When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both highly premature and wonderfully inaccurate. In the last ten years, we’ve witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. Moreover, genomic sequences, which are becoming available for several species have proven to be highly relevant to drug research with regard to a number of otherwise intractable conditions. Rather than offering a comprehensive volume covering every aspect of comparative genomics, Comparative Genomics: Basic and Applied Research embodies the diverse interests of prominent researchers in the field. Compiling first hand descriptions of their pioneering work, the text focuses on commonalities and synergies across the broad field of comparative genomics. Among its many topics it covers— · Revolutionary advances in DNA-sequencing technology · Bold new approaches to the organization and analysis of large phylogenetic data sets · The impact of comparative genomics on our understanding of evolution · Efforts toward developing novel antimicrobial drugs, through the use of bacterial pathogen genomes Ultimately, future breakthroughs in comparative genomics will depend upon the continued interaction and interdependency of applied and basic research. This seminal volume demonstrates both the means and the fruits of that cooperation, and in doing so defines and lays the groundwork for continued progress.

National Institutes of Health Fiscal Year 2002 Plan for HIV related Research

National Institutes of Health Fiscal Year 2002 Plan for HIV related Research
Author: National Institutes of Health (U.S.). Office of AIDS Research
Publsiher: Unknown
Total Pages: 262
Release: 2000
ISBN 10: 1928374650XXX
ISBN 13: PURD:32754069273146
Language: EN, FR, DE, ES & NL

National Institutes of Health Fiscal Year 2002 Plan for HIV related Research Book Review:

National Institutes of Health Fiscal Year Plan for HIV related Research

National Institutes of Health Fiscal Year     Plan for HIV related Research
Author: National Institutes of Health (U.S.). Office of AIDS Research
Publsiher: Unknown
Total Pages: 135
Release: 2001
ISBN 10: 1928374650XXX
ISBN 13: UCBK:C069483667
Language: EN, FR, DE, ES & NL

National Institutes of Health Fiscal Year Plan for HIV related Research Book Review: