The Design and Development of Novel Drugs and Vaccines

The Design and Development of Novel Drugs and Vaccines
Author: Tarun Kumar Bhatt,Surendra Nimesh
Publsiher: Academic Press
Total Pages: 308
Release: 2021-01-21
ISBN 10: 0128214759
ISBN 13: 9780128214756
Language: EN, FR, DE, ES & NL

The Design and Development of Novel Drugs and Vaccines Book Review:

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development

Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics

Nonclinical Development of Novel Biologics  Biosimilars  Vaccines and Specialty Biologics
Author: Lisa Plitnick,Danuta Herzyk
Publsiher: Academic Press
Total Pages: 432
Release: 2013-06-27
ISBN 10: 0123948231
ISBN 13: 9780123948236
Language: EN, FR, DE, ES & NL

Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics Book Review:

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics. Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical Contains the most pertinent international regulatory guidance documents for nonclinical evaluation Covers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars" A multi-authored book with chapters written by qualified experts in their respective fields

Parasites Molecular Biology Drug and Vaccine Design

Parasites  Molecular Biology  Drug and Vaccine Design
Author: Nina Agabian,Anthony Cerami
Publsiher: Unknown
Total Pages: 538
Release: 1990
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015017994354
Language: EN, FR, DE, ES & NL

Parasites Molecular Biology Drug and Vaccine Design Book Review:

This wide-ranging collection of edited papers examines the many mechanisms that allow parasites to survive and interact in a host environment. The research explains how a more knowledgeable understanding of host-parasite interactions aids in the development of unique strategies for vaccine design and applied research in clinical diagnostics and therapeutics. Divided into five parts, the text covers gene expression during parasite differentiation and development; the potential for molecular genetics in parasite systems; molecules of the parasite membrane; molecular modeling and parasite drug design; and vaccines.

Drug Development for Malaria

Drug Development for Malaria
Author: Pravin Kendrekar
Publsiher: John Wiley & Sons
Total Pages: 404
Release: 2022-11-07
ISBN 10: 3527348603
ISBN 13: 9783527348602
Language: EN, FR, DE, ES & NL

Drug Development for Malaria Book Review:

Drug Development for Malaria Provides readers with first-hand advice for the development of novel antimalarial drugs This book provides a systematic overview of antimalarial drug development and presents a wealth of data and insight from drug developers across three continents, including many from countries where the disease is endemic. Throughout, the contributions have been written with the drug developer in mind, highlighting challenges but also opportunities for the successful development of effective antimalarial drugs. Case studies and method-oriented chapters provide an abundance of practical first-hand advice on how to successfully develop an antimalarial drug. Key topics covered in the book include: The performance of current drugs and therapies, the influence of formulation and targeted delivery, and strategies to overcome drug resistance. Technologies and approaches for development of novel drugs, such as assays, computer-aided drug design, known and potential drug targets, and natural sources for novel antimalarial compounds Vaccination as an alternative to drug therapy For chemists and other professionals working in industries related to medicine and pharmaceuticals, this book provides a completely comprehensive overview of the current state of novel antimalarial drugs and how they can be developed in an efficient and cost-effective manner.

Vaccine Design

Vaccine Design
Author: Rino Rappuoli,Fabio Bagnoli
Publsiher: Caister Academic Press
Total Pages: 380
Release: 2011
ISBN 10: 9781904455745
ISBN 13: 1904455743
Language: EN, FR, DE, ES & NL

Vaccine Design Book Review:

In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.

Novel Strategies in the Design and Production of Vaccines

Novel Strategies in the Design and Production of Vaccines
Author: Sara Cohen,Avigdor Shafferman
Publsiher: Springer Science & Business Media
Total Pages: 198
Release: 2013-06-29
ISBN 10: 1489913823
ISBN 13: 9781489913821
Language: EN, FR, DE, ES & NL

Novel Strategies in the Design and Production of Vaccines Book Review:

Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).

Practical Aspects of Vaccine Development

Practical Aspects of Vaccine Development
Author: Parag Kolhe,Satoshi Ohtake
Publsiher: Elsevier
Total Pages: 386
Release: 2021-09-24
ISBN 10: 0128143576
ISBN 13: 9780128143575
Language: EN, FR, DE, ES & NL

Practical Aspects of Vaccine Development Book Review:

Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 118
Release: 2014-02-06
ISBN 10: 0309292492
ISBN 13: 9780309292498
Language: EN, FR, DE, ES & NL

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book Review:

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies

Novel Approaches and Strategies for Biologics  Vaccines and Cancer Therapies
Author: Manmohan Singh,Maya Salnikova
Publsiher: Academic Press
Total Pages: 520
Release: 2014-12-30
ISBN 10: 012416661X
ISBN 13: 9780124166615
Language: EN, FR, DE, ES & NL

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies Book Review:

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Gene therapy

Gene therapy
Author: Surendra Nimesh
Publsiher: Elsevier
Total Pages: 380
Release: 2013-10-31
ISBN 10: 1908818646
ISBN 13: 9781908818645
Language: EN, FR, DE, ES & NL

Gene therapy Book Review:

Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy. Provides an overview of nanotechnology applications in gene therapy, from preparation of nanoparticles to in vitro and in vivo studies Details the tools and techniques available for preparation, characterization and in vitro and in vivo study of nanoparticles Details the limitations of nanoparticle-mediated gene therapy and proposes ways in which they may be overcome

Post genomic Approaches in Drug and Vaccine Development

Post genomic Approaches in Drug and Vaccine Development
Author: Kishore R. Sakharkar,Meena K. Sakharkar,Ramesh Chandra
Publsiher: CRC Press
Total Pages: 451
Release: 2022-09-01
ISBN 10: 1000795713
ISBN 13: 9781000795714
Language: EN, FR, DE, ES & NL

Post genomic Approaches in Drug and Vaccine Development Book Review:

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. T

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1991
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015020571777
Language: EN, FR, DE, ES & NL

Biomedical Index to PHS supported Research Book Review:

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
Author: Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
Publsiher: Woodhead Publishing
Total Pages: 256
Release: 2017-04-04
ISBN 10: 0081005636
ISBN 13: 9780081005637
Language: EN, FR, DE, ES & NL

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book Review:

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Design and Development of New Nanocarriers

Design and Development of New Nanocarriers
Author: Alexandru Mihai Grumezescu
Publsiher: William Andrew
Total Pages: 766
Release: 2017-12-12
ISBN 10: 0128136286
ISBN 13: 9780128136287
Language: EN, FR, DE, ES & NL

Design and Development of New Nanocarriers Book Review:

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Rare Diseases and Orphan Products

Rare Diseases and Orphan Products
Author: Institute of Medicine,Board on Health Sciences Policy,Committee on Accelerating Rare Diseases Research and Orphan Product Development
Publsiher: National Academies Press
Total Pages: 442
Release: 2011-04-03
ISBN 10: 0309158060
ISBN 13: 9780309158060
Language: EN, FR, DE, ES & NL

Rare Diseases and Orphan Products Book Review:

Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Novel AI and Data Science Advancements for Sustainability in the Era of COVID 19

Novel AI and Data Science Advancements for Sustainability in the Era of COVID 19
Author: Victor Chang,Mohamed Abdel-Basset,Muthu Ramachandran,Nicolas Green,Gary Wills
Publsiher: Academic Press
Total Pages: 298
Release: 2022-04-05
ISBN 10: 0323903789
ISBN 13: 9780323903783
Language: EN, FR, DE, ES & NL

Novel AI and Data Science Advancements for Sustainability in the Era of COVID 19 Book Review:

Novel AI and Data Science Advancements for Sustainability in the Era of COVID-19 discusses how the role of recent technologies applied to health settings can help fight virus outbreaks. Moreover, it provides guidelines on how governments and institutions should prepare and quickly respond to drastic situations using technology to support their communities in order to maintain life and functional as efficiently as possible. The book discusses topics such as AI-driven histopathology analysis for COVID-19 diagnosis, bioinformatics for subtype rational drug design, deep learning-based treatment evaluation and outcome prediction, sensor informatics for monitoring infected patients, and machine learning for tracking and prediction models. In addition, the book presents AI solutions for hospital management during an epidemic or pandemic, along with real-world solutions and case studies of successful measures to support different types of communities. This is a valuable source for medical informaticians, bioinformaticians, clinicians and other healthcare workers and researchers who are interested in learning more on how recently developed technologies can help us fight and minimize the effects of global pandemics. Discusses AI advancements in predictive and decision modeling and how to design mobile apps to track contagion spread Presents the smart contract concept in blockchain and cryptography technology to guarantee security and privacy of people’s data once their information has been used to fight the pandemic Encompasses guidelines for emergency preparedness, planning, recovery and continuity management of communities to support people in emergencies like a virus outbreak

Parasitic Flatworms

Parasitic Flatworms
Author: Aaron G. Maule,Nikki J. Marks
Publsiher: CABI
Total Pages: 448
Release: 2006
ISBN 10: 0851990274
ISBN 13: 9780851990279
Language: EN, FR, DE, ES & NL

Parasitic Flatworms Book Review:

This book examines recent research into the molecular biology, genomics and transcriptomics of, and novel control strategies for, flatworm parasites. These include Cestodes (tapeworms) and Trematodes (flukes, schistosomes etc), which are the cause of a number of diseases of medical and veterinary importance. The book explores three main areas: phylogeny, genetics and transcriptomes; immunobiology, host-parasite interaction and control; and protein function, metabolism and physiology. Where appropriate, comparisons are made between different parasitic flatworms and between parasitic and free-living species. The book concludes by exploring future avenues for research. Contributors to the book include leading authorities from Europe, North and South America, and Australia.

Frontiers in Anti Infective Agents Volume 6

Frontiers in Anti Infective Agents  Volume 6
Author: Parvesh Singh
Publsiher: Bentham Science Publishers
Total Pages: 220
Release: 2021-11-17
ISBN 10: 9814998435
ISBN 13: 9789814998437
Language: EN, FR, DE, ES & NL

Frontiers in Anti Infective Agents Volume 6 Book Review:

Anti-infective agents are a distinct class of pharmacologically important molecules that have served mankind in different capacities to combat life-threatening pathological conditions. They include antibacterial, antifungal, antiviral, antituberculosis, antimalarial, and urinary anti-infective agents. However, evolutionary changes, adaptations, and the development of new strains of pathogenic microorganisms have reduced the therapeutic efficacy of existing drugs, thus, limiting their clinical utility over the years. Frontiers in Anti-Infective Agents Volume 6 is a collection of notable research efforts, successful anti-infective drug development programs, and a comprehensive overview of successful and unsuccessful clinical trials conducted in this domain. This volume continues from the last one with interesting reviews on 1) “Reverse Vaccinology” for vaccination design using computational data to identify vaccine targets, 2) leptospirosis, 3) phage therapy for bacterial infections, 4) quorum sensing inhibitors from natural products, and 5) nitrogen and oxygen-based heterocyclic compounds that can act as anti-infective agents. The volume, therefore, covers a range of frontier topics on anti-infective research and development. This compilation is a timely reference for postgraduate scholars and researchers seeking updates in specific areas of anti-infective drug development. Allied healthcare professionals (clinical and public healthcare professionals) can also benefit from the information presented within.

Novel Coronavirus 2019

Novel Coronavirus 2019
Author: Amit Kumar,Ajit Kumar Saxena,Gwo Giun (Chris) Lee,Amita Kashyap,G. Jyothsna
Publsiher: Springer Nature
Total Pages: 78
Release: 2020-09-26
ISBN 10: 9811579180
ISBN 13: 9789811579189
Language: EN, FR, DE, ES & NL

Novel Coronavirus 2019 Book Review:

This book highlights the genomic findings, observations, and analysis of DNA/RNA sequences and protein structure of the dreadful virus of this decade- COVID-19. The Corona group of viruses though known species, the strain that caused the Pandemic of 2019 is a completely new strain, belonging to the same corona family with a novel genetic make-up. This makes it a new pathogen which is causing the current outbreak leaving the global scientific community clueless of any therapeutic breakthrough. NCOV enjoys life threatening pathogenicity with mysterious genetic annotations. This book details and offers insights into its viral genetic arrangement, Virulence factors, probable mutations leading to the evolution of this new strain and more. It contains chapters on Virus evolutionary status and Genetic makeup leading to its pathogenicity which can be a new insight in understanding the nature of this clever microorganism and can pave way to the development of new drugs and Vaccines or a novel diagnostic approach for the early prognosis of the disease. A dedicated chapter on annotation of NCOV-19 virulence genes, translation of the genes to protein product, annotation of the antigenic sites on these proteins is also included. In all, this brief is a complete genomic annotation insight of NCOV-19 using AI, Data analytics and Bioinformatics analysis. In the current situation, this book is an extensive preliminary resource for Medical practitioners, Researchers, Academicians, Scientists, Biochemists, Bioinformaticians and other professionals interested in understanding the genetics of Novel Coronavirus 19, the best possible drug targets, ideal vaccine candidates and novel prognostic and diagnostic biomarkers.

Department of Defense Appropriations for Fiscal Year 2002

Department of Defense Appropriations for Fiscal Year 2002
Author: United States. Congress. Senate. Committee on Appropriations. Subcommittee on Defense
Publsiher: Unknown
Total Pages: 1112
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: UCAL:B5104758
Language: EN, FR, DE, ES & NL

Department of Defense Appropriations for Fiscal Year 2002 Book Review: