Synthesis of Best Seller Drugs

Synthesis of Best Seller Drugs
Author: Ruben Vardanyan,Victor Hruby
Publsiher: Academic Press
Total Pages: 868
Release: 2016-01-07
ISBN 10: 0124115241
ISBN 13: 9780124115248
Language: EN, FR, DE, ES & NL

Synthesis of Best Seller Drugs Book Review:

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Synthesis of Essential Drugs

Synthesis of Essential Drugs
Author: Ruben Vardanyan,Victor Hruby
Publsiher: Elsevier
Total Pages: 634
Release: 2006-03-10
ISBN 10: 9780080462127
ISBN 13: 008046212X
Language: EN, FR, DE, ES & NL

Synthesis of Essential Drugs Book Review:

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

The Art of Drug Synthesis

The Art of Drug Synthesis
Author: Douglas S. Johnson,Jie Jack Li
Publsiher: John Wiley & Sons
Total Pages: 350
Release: 2013-02-26
ISBN 10: 111867846X
ISBN 13: 9781118678466
Language: EN, FR, DE, ES & NL

The Art of Drug Synthesis Book Review:

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

The Organic Chemistry of Drug Synthesis

The Organic Chemistry of Drug Synthesis
Author: Daniel Lednicer
Publsiher: John Wiley & Sons
Total Pages: 288
Release: 2007-12-14
ISBN 10: 0470180668
ISBN 13: 9780470180662
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Synthesis Book Review:

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

Strategies for Organic Drug Synthesis and Design

Strategies for Organic Drug Synthesis and Design
Author: Daniel Lednicer
Publsiher: John Wiley & Sons
Total Pages: 700
Release: 2009-03-04
ISBN 10: 9780470399590
ISBN 13: 0470399597
Language: EN, FR, DE, ES & NL

Strategies for Organic Drug Synthesis and Design Book Review:

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Contemporary Drug Synthesis

Contemporary Drug Synthesis
Author: Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Publsiher: John Wiley & Sons
Total Pages: 240
Release: 2004-12-27
ISBN 10: 0471686735
ISBN 13: 9780471686736
Language: EN, FR, DE, ES & NL

Contemporary Drug Synthesis Book Review:

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

An Introduction to Drug Synthesis

An Introduction to Drug Synthesis
Author: Graham L. Patrick
Publsiher: Unknown
Total Pages: 135
Release: 2015
ISBN 10: 9780191073472
ISBN 13: 0191073474
Language: EN, FR, DE, ES & NL

An Introduction to Drug Synthesis Book Review:

An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Piperidine Based Drug Discovery

Piperidine Based Drug Discovery
Author: Ruben Vardanyan
Publsiher: Elsevier
Total Pages: 358
Release: 2017-06-12
ISBN 10: 0128134283
ISBN 13: 9780128134283
Language: EN, FR, DE, ES & NL

Piperidine Based Drug Discovery Book Review:

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
Author: Anonim
Publsiher: Academic Press
Total Pages: 274
Release: 2018-05-21
ISBN 10: 0128155388
ISBN 13: 9780128155387
Language: EN, FR, DE, ES & NL

Advances in Heterocyclic Chemistry Book Review:

Advances in Heterocyclic Chemistry, Volume 126, is the definitive series in the field, one that is of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is used more frequently in explanations. Updates to this release include sections on The Literature of Heterocyclic Chemistry, Part XVI, 2016, The preparation and properties of heteroarylazulenes and hetero-fused azulenes, Recent developments in pyrazole chemistry, Yne, Ene-Yne Synthetic Approaches to Heterocycles, Appel Salt and Heterocycles: A review of Thirty Years of 4,5-Dichloro-1,2,3-dithiazolium Chloride Chemistry, and more. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides timely, comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

Modern Drug Synthesis

Modern Drug Synthesis
Author: Jie Jack Li,Douglas S. Johnson
Publsiher: John Wiley & Sons
Total Pages: 355
Release: 2013-03-27
ISBN 10: 1118701240
ISBN 13: 9781118701249
Language: EN, FR, DE, ES & NL

Modern Drug Synthesis Book Review:

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

An Introduction to Drug Synthesis

An Introduction to Drug Synthesis
Author: Graham L. Patrick
Publsiher: Oxford University Press, USA
Total Pages: 567
Release: 2015-01
ISBN 10: 0198708432
ISBN 13: 9780198708438
Language: EN, FR, DE, ES & NL

An Introduction to Drug Synthesis Book Review:

'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Routes to Essential Medicines

Routes to Essential Medicines
Author: Peter J. Harrington
Publsiher: John Wiley & Sons
Total Pages: 576
Release: 2021-11-02
ISBN 10: 1119722861
ISBN 13: 9781119722861
Language: EN, FR, DE, ES & NL

Routes to Essential Medicines Book Review:

This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development. Highlights nearly three hundred medicines on the latest World Health Organization (WHO) Model List of Essential Medicines and their manufacturing routes Features exercises that equip students with the skills necessary to solve similar real-world problems Includes a retrosynthetic analysis for each commodity chemical and supplies an extensive list of key journal and information sites and a library of reagents, solvents, and conditions for many common organic reactions

Pharmaceutical Process Chemistry for Synthesis

Pharmaceutical Process Chemistry for Synthesis
Author: Peter J. Harrington
Publsiher: John Wiley & Sons
Total Pages: 376
Release: 2011-02-23
ISBN 10: 9780470922866
ISBN 13: 0470922869
Language: EN, FR, DE, ES & NL

Pharmaceutical Process Chemistry for Synthesis Book Review:

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Innovative Drug Synthesis

Innovative Drug Synthesis
Author: Jie Jack Li,Douglas S. Johnson
Publsiher: John Wiley & Sons
Total Pages: 360
Release: 2015-11-19
ISBN 10: 1118820029
ISBN 13: 9781118820025
Language: EN, FR, DE, ES & NL

Innovative Drug Synthesis Book Review:

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery

Chiral Drugs

Chiral Drugs
Author: Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2011-08-08
ISBN 10: 9781118075630
ISBN 13: 1118075633
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Review:

An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Handbook of Chiral Chemicals

Handbook of Chiral Chemicals
Author: David Ager
Publsiher: CRC Press
Total Pages: 664
Release: 2005-10-21
ISBN 10: 1420027301
ISBN 13: 9781420027303
Language: EN, FR, DE, ES & NL

Handbook of Chiral Chemicals Book Review:

As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook fir

Top Drugs

Top Drugs
Author: John Saunders
Publsiher: Unknown
Total Pages: 91
Release: 2011
ISBN 10: 9780191848605
ISBN 13: 0191848603
Language: EN, FR, DE, ES & NL

Top Drugs Book Review:

Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on a manufacturing scale. This book describes how each drug works and then reviews the most efficient routes to their synthesis.

Enzymatic Reactions in Organic Media

Enzymatic Reactions in Organic Media
Author: Ari Koskinen,A. Klibanov
Publsiher: Springer Science & Business Media
Total Pages: 314
Release: 1995-12-31
ISBN 10: 9780751402599
ISBN 13: 0751402591
Language: EN, FR, DE, ES & NL

Enzymatic Reactions in Organic Media Book Review:

The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Peptides

Peptides
Author: Bernd Gutte
Publsiher: Elsevier
Total Pages: 511
Release: 1995-10-24
ISBN 10: 9780080538594
ISBN 13: 0080538592
Language: EN, FR, DE, ES & NL

Peptides Book Review:

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines

Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Coupling and Decoupling of Diverse Molecular Units in Glycosciences
Author: Zbigniew J. Witczak,Roman Bielski
Publsiher: Springer
Total Pages: 335
Release: 2017-11-20
ISBN 10: 3319655876
ISBN 13: 9783319655871
Language: EN, FR, DE, ES & NL

Coupling and Decoupling of Diverse Molecular Units in Glycosciences Book Review:

This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.