Stem Cells and Aging

Stem Cells and Aging
Author: Surajit Pathak,Antara Banerjee
Publsiher: Academic Press
Total Pages: 320
Release: 2021-03-17
ISBN 10: 0128204133
ISBN 13: 9780128204139
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Review:

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Stem Cells and Aging

Stem Cells and Aging
Author: Surajit Pathak,Antara Banerjee
Publsiher: Elsevier
Total Pages: 320
Release: 2021-04-09
ISBN 10: 0128200715
ISBN 13: 9780128200711
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Review:

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Adult Stem Cells in Aging Diseases and Cancer

Adult Stem Cells in Aging  Diseases and Cancer
Author: K.L. Rudolph
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 88
Release: 2014-12-22
ISBN 10: 3318027324
ISBN 13: 9783318027327
Language: EN, FR, DE, ES & NL

Adult Stem Cells in Aging Diseases and Cancer Book Review:

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
Author: Susie Prof. Nilsson
Publsiher: Academic Press
Total Pages: 258
Release: 2020-08-22
ISBN 10: 0128220201
ISBN 13: 9780128220207
Language: EN, FR, DE, ES & NL

The Stem Cell Niche during Ageing Book Review:

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
Author: Lucas G. Chase,Mohan C Vemuri
Publsiher: Springer Science & Business Media
Total Pages: 456
Release: 2012-12-12
ISBN 10: 1627032002
ISBN 13: 9781627032001
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Therapy Book Review:

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Stem Cells and Aging

Stem Cells and Aging
Author: Cesar V. Borlongan,Gary K. Steinberg
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-07-14
ISBN 10: 2889710343
ISBN 13: 9782889710348
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Review:

Dr. Borlongan and Dr. Steinberg serve as consultants to stem cell-based companies, hold patents and patent applications, and have funded grants related to stem cell biologics and applications.

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
Author: Rakesh Sharma
Publsiher: BoD – Books on Demand
Total Pages: 352
Release: 2018-05-02
ISBN 10: 1789230101
ISBN 13: 9781789230109
Language: EN, FR, DE, ES & NL

Stem Cells in Clinical Practice and Tissue Engineering Book Review:

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Frailty and Sarcopenia

Frailty and Sarcopenia
Author: Yannis Dionyssiotis
Publsiher: BoD – Books on Demand
Total Pages: 254
Release: 2017-08-30
ISBN 10: 9535134833
ISBN 13: 9789535134831
Language: EN, FR, DE, ES & NL

Frailty and Sarcopenia Book Review:

Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new advancements in the related treatments including complex issues and research. It includes high-quality chapters in all related aspects for the syndromes of sarcopenia and frailty, which adversely affect the function and overall effectiveness of the musculoskeletal system and interventions to promote rehabilitation.

Exosomes Stem Cells and MicroRNA

Exosomes  Stem Cells and MicroRNA
Author: Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
Publsiher: Springer
Total Pages: 154
Release: 2018-05-12
ISBN 10: 3319744704
ISBN 13: 9783319744704
Language: EN, FR, DE, ES & NL

Exosomes Stem Cells and MicroRNA Book Review:

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Stem Cells

Stem Cells
Author: Paul Knoepfler
Publsiher: World Scientific
Total Pages: 368
Release: 2013
ISBN 10: 9814508810
ISBN 13: 9789814508810
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

Stem Cells: An Insider's Guide is an exciting new book that takes readers inside the world of stem cells guided by international stem cell expert, Dr. Paul Knoepfler. Stem cells are catalyzing a revolution in medicine. The book also tackles the exciting and hotly debated area of stem cell treatments that are capturing the public's imagination. In the future they may also transform how we age and reproduce. However, there are serious risks and ethical challenges, too. The author's goal with this insider's guide is to give readers the information needed to distinguish between the ubiquitous hype and legitimate hope found throughout the stem cell world. The book answers the most common questions that people have about stem cells. Can stem cells help my family with a serious medical problem such as Alzheimer's, Multiple Sclerosis, or Autism Are such treatments safe Can stem cells make me look younger or even literally stay physically young These questions and many more are answered here. A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.

Mesenchymal Stem Cell Senescence and Rejuvenation

Mesenchymal Stem Cell Senescence and Rejuvenation
Author: Yuelin Zhang,Songyan Liao,Qingling Fu,Mark Hamrick
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-18
ISBN 10: 2889740633
ISBN 13: 9782889740635
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Senescence and Rejuvenation Book Review:

Stem Cells A Cellular Fountain of Youth

Stem Cells  A Cellular Fountain of Youth
Author: M.P. Mattson,G. van Zant
Publsiher: Elsevier
Total Pages: 225
Release: 2002-09-04
ISBN 10: 9780444507310
ISBN 13: 0444507310
Language: EN, FR, DE, ES & NL

Stem Cells A Cellular Fountain of Youth Book Review:

This volume provides a timely and thorough review of the current state of understanding of a fascinating type of cell that is capable of forming many or all cells in the body. In humans and other mammals embryonic stem cells, the immediate offspring of the fertilized egg, are capable of forming any type of cell in the body. Moreover stem cells are present in many different tissues in adults that are capable of dividing and differentiating into the specific cell types that comprise the organ in which they reside. A major focus of the book is to provide the reader with up-to-date information on the molecular mechanisms that regulate the proliferation, differentiation and survival of stem cells, and how aging and age-related disease impacts on stem cells. Leading authorities detail the properties and therapeutic potential of embryonic stem cells and stem cells of the nervous and immune systems, muscle and bone. Particularly exciting are emerging technologies for using stem cells to treat human age-related diseases including cardiovascular disease, diabetes, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. This book will be a valuable reference for developmental biologists and for scientists and clinicians who study and treat a variety of diseases.

How and why We Age

How and why We Age
Author: Leonard Hayflick
Publsiher: Unknown
Total Pages: 377
Release: 1996-01-01
ISBN 10: 9780345401557
ISBN 13: 0345401557
Language: EN, FR, DE, ES & NL

How and why We Age Book Review:

A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer
Author: K. Lenhard Rudolph
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2007-11-07
ISBN 10: 354073709X
ISBN 13: 9783540737094
Language: EN, FR, DE, ES & NL

Telomeres and Telomerase in Aging Disease and Cancer Book Review:

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
Author: Richard K. Burt,Dominique Farge,Milton A. Ruiz,Riccardo Saccardi,John A. Snowden
Publsiher: CRC Press
Total Pages: 686
Release: 2021-11-15
ISBN 10: 1351364758
ISBN 13: 9781351364751
Language: EN, FR, DE, ES & NL

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases Book Review:

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

Aging

Aging
Author: Shamim I. Ahmad
Publsiher: CRC Press
Total Pages: 658
Release: 2017-10-30
ISBN 10: 1315283883
ISBN 13: 9781315283883
Language: EN, FR, DE, ES & NL

Aging Book Review:

This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.

Stem Cell Aging Mechanisms Consequences Rejuvenation

Stem Cell Aging  Mechanisms  Consequences  Rejuvenation
Author: Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
Publsiher: Springer
Total Pages: 354
Release: 2015-07-06
ISBN 10: 370911232X
ISBN 13: 9783709112328
Language: EN, FR, DE, ES & NL

Stem Cell Aging Mechanisms Consequences Rejuvenation Book Review:

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Stem Cells of Renewing Cell Population

Stem Cells of Renewing Cell Population
Author: A.B. Cairnie
Publsiher: Elsevier
Total Pages: 406
Release: 2012-12-02
ISBN 10: 0323151841
ISBN 13: 9780323151849
Language: EN, FR, DE, ES & NL

Stem Cells of Renewing Cell Population Book Review:

Stem Cells of Renewing Cell Populations constitutes the proceedings of the ""Stem Cells in Various Tissues"" symposium, organized as a tribute to Charles P. Leblond on the occasion of his 65th birthday. The pioneering studies of Dr. Leblond on the kinetics of cell populations led him to the identification and analysis of the behavior of the ""stem cells,"" which are at the origin of each cell line. This book focuses on the study of stem cells in various organs, including intestine, epidermis, hematopoietic and lymphoid tissues, and testis, under normal steady state conditions. It examines the behavior of stem cell in these organs, such as cell cycle and differentiation and regulation using several distinct techniques. The concluding part discusses the behavior of hematopoietic stem cell during growth and aging, as well as its distribution and dynamics in tumor-bearing tissues. Workers from many disciplines, including biologists, stem cell biologists, and regenerative medicine researchers will greatly benefit from this book.

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
Author: Suresh I.S. Rattan,Leonard Hayflick
Publsiher: Springer
Total Pages: 364
Release: 2016-05-09
ISBN 10: 3319262394
ISBN 13: 9783319262390
Language: EN, FR, DE, ES & NL

Cellular Ageing and Replicative Senescence Book Review:

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Ageless

Ageless
Author: Andrew Steele
Publsiher: Anchor
Total Pages: 352
Release: 2021-03-23
ISBN 10: 0385544936
ISBN 13: 9780385544931
Language: EN, FR, DE, ES & NL

Ageless Book Review:

“A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.